CLUSTAL 2.1 multiple sequence alignment ENST00000199814.4 AAGAAGCCCTAGACGCGTAAATAAGACGCCGACCGGCGCGGCGCTAGCCTCGGGGCTTGA ENST00000442891.1 ------------------------------------------------------------ ENST00000199814.4 CGGGATTGTGGCGGTCCTCTCTCCCAATTCGGAAGCTACAGCTACCTCCGGACGCTCTCA ENST00000442891.1 ------------------------------------------------------------ ENST00000199814.4 AGATGGCGACCTCTCTGGGTTCCAACACCTACAACAGGCAGAACTGGGAGGATGCGGACT ENST00000442891.1 AGATGGCGACCTCTCTGGGTTCCAGCGCCTAAAACAGGCAAAACTGGGAGGACGTCGATT ************************ * **** ******** *********** * ** * ENST00000199814.4 TCCCCATTCTGTGCCAGACATGTCTTGGAGAAAACCCATATATCCGAATGACCAAAGAAA ENST00000442891.1 TCTCCATTCTGTGCCAGATATGTCTCAGAGAAAC-------------ATGACCAAGGAGA ** *************** ****** ****** ******** ** * ENST00000199814.4 AGTATGGGAAGGAATGCAAAATCTGTGCCAGGCCATTCACAGTGTTTCGCTGGTGCCCTG ENST00000442891.1 ACTATGAGAAAAAATGCAAACTCTGT--CAGGCCATTC--AGTGTTTGGCTGGTGCCCGG * **** *** ******** ***** ********** ******* ********** * ENST00000199814.4 GAGTCCGCATGCGTTTCAAGAAGACTGAAGTGTGCCAAACCTGCAGTAAATTGAAGAATG ENST00000442891.1 GGGAGCACATGCATCCCAAGAAGACTGAAGGGGGCCAAGCCTGCAG--------GAAATG * * * ***** * ************** * ***** ******* **** ENST00000199814.4 TCTGTCAGACCTGCCTCTTAGACCTAGAGTATGGCCTGCCCATCCAGGTTCGTGACGCAG ENST00000442891.1 TCTGTCAGACTTGCCTCTTAGACCTAGAGTATGAC-TGCCCATACAGGTTCATGACACAG ********** ********************** * ******* ******* **** *** ENST00000199814.4 GATTGTCTTTTAAAGATGACATGCCAAAGTCAGATGTCAACAAAGAGTACTATACACAGA ENST00000442891.1 ACTTGCCTTT-AAAGGTGAC----------------------------------TGCAGA *** **** **** **** **** ENST00000199814.4 ATATGGAGAGAGAGATTTCTAACTCTGATGGAACACGGCCAGTTGGCATGCTGGGGAAAG ENST00000442891.1 -TATGGACAGAGGAATTTCTAACCCTGATAGAACATGGCCAGTTGCTCTGCTGGGGAAAG ****** **** ********* ***** ***** ********* ************ ENST00000199814.4 CCACATCTACCAGTGACATGCTGCTCAAACTGGCCCGGACCACACCCTACTACAAAAGGA ENST00000442891.1 CCACGTCCAGTAGTGAGATGCTGCTCAAACTGGCCCGGACCACACTGTACTGGCTGAGGA **** ** * ***** **************************** **** **** ENST00000199814.4 ATCGACCCCACATTTGCTCCTTCTGGGTGAAAGGAGAGTGTAAGAGAGGAGAGGAATGTC ENST00000442891.1 ATAAGCCTTACATTTGTTCTGTCCAGGTGAAAGGAGAG---------------GACTGTC ** ** ******* ** ** ************* ** **** ENST00000199814.4 CATACAGACATGAGAAGCCTACAGATCCAGATGACCCCCT--TGCTGATCAGAATATTAA ENST00000442891.1 CGTAAAGACATGAGAAGCCTGCAGATCCCGATGACCCCCTCTTGCTGGTCAAAATATTAA * ** *************** ******* *********** ***** *** ******** ENST00000199814.4 AGACCGTTATTACGGAATCAATGATCCTGTAGCTGACAAGCTTCTAAAGCGGGCTTCAAC ENST00000442891.1 AGATCGATATTGTGGAAACAATGACCCTGTAGCAGATAAGCTTCTAAAGCAGGCTTCAAC *** ** **** **** ****** ******** ** ************* ********* ENST00000199814.4 AATGCCTCGGCTGGACCCACCAGAGGATAAAACTATCACCACACTATATGTTGGTGGTCT ENST00000442891.1 CACGCTTCATCTTGAATCACCAGCAGAGAAGGATTCCACCAGAGTGTATGTTGGTGATCT * ** ** ** ** ****** ** ** * ***** * * ********** *** ENST00000199814.4 AGGTGATACCATTACTGAGACAGATTTAAGAAATCATTTCTACCAGTTCGGAGAGATCCG ENST00000442891.1 GGCGGATACCATTACTCAGACAGATTTAAGAAATTGTCTCTGCCTGTT-GGTGAGATCCG * ************ ***************** * *** ** *** ** ******** ENST00000199814.4 GACGATCACTGTTGTGCAGAGACAGCAGTGTGC-TTTCATCCAGTTTGCCACACGGCAGG ENST00000442891.1 GATGGTCACCGTTGTGCAGAGATAGCAGTGTGCCTTTCATCCAGCTTTCCACAGGGT-GG ** * **** ************ ********** ********** ** ***** ** ** ENST00000199814.4 CTGCAGAAGTGGCTGCTGAGAAGTCCTTTAATAAGTTGATTGTAAATGGCCGCAGACTGA ENST00000442891.1 CTACAGAAGTGGGTGCCGACAAGTCCTCTAATAAACTGATTGTCAATGGCTGCAGACTCC ** ********* *** ** ******* ****** ******* ****** ******* ENST00000199814.4 ATGTGAAATGGGGAAGATCCCAGGCAGCCAGAGGAAAAGAAAAAGAGAAA---------- ENST00000442891.1 GTGTAAAATGGGGACGATTCCAAGCACTCAAGGGGAAAAAAAAAAAAAAAAAACAAAAAA *** ********* *** *** *** ** ** *** ***** * *** ENST00000199814.4 -----------------------------GATGGAACTACAGACTCTGGGATCAAACTAG ENST00000442891.1 AAAAACAAAACAAAAAACAGGTTGCGGGGGACAGAATCACAGAATCTGGGATCCTGCCAG ** *** ***** ********* * ** ENST00000199814.4 AACCTGTTCCAGGATTGCCAGGAGCTCTTCCTCCTCCTCCTGCAGCAGAAGAA------- ENST00000442891.1 AGCCTATTCCAGTGCCGCCAGGAGCTC---CTTCTCCCCCTGCAGCTATGGTGCCTACTT * *** ****** *********** ** **** ******** * ENST00000199814.4 -GAAGCCT-----------CTG---CCAACTACTTCAACTTGCCCCC------AAGTGGT ENST00000442891.1 TGGAGCCTGCTTACATGGACTGAGGCCACCTTTTCTGACTTTTCCCAGTGGCAAAATGCA * ***** *** *** ** * **** *** ** ** ENST00000199814.4 CCTC----------CAGCTGTGGTGAACATTGCT--CTG-----CCACC-GCCC------ ENST00000442891.1 CCTGACAAGGAGAATAGACGTAG-GAACCTGGCCTCCTGGACCCTCACTTGCCCAGGATT *** ** ** * **** * ** *** *** **** ENST00000199814.4 ---CCTGGCATTG----CTCCA----CCCCCAC---------------CCCCAGGTT--- ENST00000442891.1 TTTCTTGGTGCTGTGAGCTGAAGGAGTTCTTGTAAGATGGAAGCAGGGCCCCAGGATCAT * *** ** ** * * ******* * ENST00000199814.4 ----TTGG------------GCCACAC--ATGTTC----------CACCCAA----TGGG ENST00000442891.1 GTGATTGGCCTCATGTCTCTGCCTCACTAATGGTCAGGTGGTGGGCACTCAGGGCCTGGG **** *** *** *** ** *** ** **** ENST00000199814.4 A------CCACCCCC---TCCTTTCAT--GCGGGCTCCAGGACCAATCCACTA--TCCTT ENST00000442891.1 AACCCAGCCATCCCTGATTCCTTGAGTTGATGAGGCAGGGGGCTGGCCCACCTGCTCCTG * *** *** ***** * * * ** * **** **** ENST00000199814.4 CTC----AGGACCCTCAGAGGATGGGAGCTCAT---GCTGGAAAACA------------- ENST00000442891.1 CCCCACCATGGCCGTC-GTGGATGGTTGCTCTTTGAGCCTGGTAACGTCACTGGCTTGGC * * * * ** ** * ****** **** * ** * *** ENST00000199814.4 -----CAG-------CAGCCCCTA-GCACCTTGTCACCACTCT--GGGGCT----CTG-- ENST00000442891.1 TCTGCCAGGCATGCACAGGCCCTGCGTACCCACACACTGCTTTAAGGGGCTTGCCCTGCC *** *** **** * *** *** ** * ****** *** ENST00000199814.4 -TGGAAGAAAGGGCACTTAAAAC-----TCCCAGTAAATC---TTGGAATAAATATATTT ENST00000442891.1 TTGGGCCACAGTCTAGTTCTGGCCAGTGTCCCAGGAACTCAGTCCCCTGTGTATCCATCT *** * ** * ** * ****** ** ** * ** ** * ENST00000199814.4 TTCCTTCCCTTGTAGTTTCCATGGTAGC--TGAAT-------------GTGCTCAGATGT ENST00000442891.1 TAGCTGTTTCTGGGGCACCCATGGCTCCCCTGGGTCCTTTTTCTCTTAGGGCTTTGGTTG * ** ** * ****** * ** * * *** * * ENST00000199814.4 GAGCAGTCAGAGACTGA----CAGCC--ATG-CTTTCCTATACTTGT----TCAAAGGAT ENST00000442891.1 GGGAGGGCTTGGGCTGGATCGCAGCCCCATGGCTCTAGGACGCTTGCCATGTGAGAGAGG * * * * * *** ***** *** ** * * **** * * ** ENST00000199814.4 CGATGGACCGTAAATAAGCTGCCATTAACACATCTGGT-TACTGCTG--TAAC------- ENST00000442891.1 CTCTGTCACACGAATGGGCAGACATGAGGACATGTGATATGCTGCTGGCTGGCTGGGGCT * ** * *** ** * *** * **** ** * * ****** * * ENST00000199814.4 ------ATGAC-TAATAA--------------AACC---GAACGCCTG--TTCCCC-TTA ENST00000442891.1 GTGCAGATGCCACAGTCACTCTCCCCTCCAGCAGCCTCTGAGGGCCCAGCTTCCCCATTG *** * * * * * ** ** *** ****** ** ENST00000199814.4 --------CCCGTGTGG-------------------------GGGACACGCAGATGAGTG ENST00000442891.1 ATATTGATCCCATATGGCCTAGCAGTAGTACTGACTGCTTTGGGGCTGTGCAGGTCACTA *** * *** *** **** * * * ENST00000199814.4 AATT----GGAATGTCCAG--CAGA-GTTACCCTCCCAA------TTATATGTTCAT--- ENST00000442891.1 TCCTCAGAGAAACGTCAGATCCAGATGCCACCATGCAAGGGGAGTTTCTGTGGTCCTACC * * ** *** **** * *** * * * ** * ** ** * ENST00000199814.4 TTTGTATATTT----------------TTTGGTCGGGGGAAA---AATTGACCTGCAGTA ENST00000442891.1 TCTGGGTTTTCAGTGGGGTGGGCCGGGTCTGGTTGTTGGAGCCCTGCTGGGGTTGCAG-G * ** * ** * **** * *** * * ***** ENST00000199814.4 AAAAAACCT-----TTGACCATTTTTATGTCCAT--------TGGA-----TA------- ENST00000442891.1 GATGGGCCTGTCCATTGGTCCTGGCGATGTCCAGAGCAGATGTGGAAGGAATAGGAGTTC * *** *** * * ******* **** ** ENST00000199814.4 --CTTTCCTTTTTAT-----CATCTTAAAAAA----------AGATAACTAG-TACT--- ENST00000442891.1 AGCATGCCTGCTCAAAGCTGCACTGTAGAAACCATGAGCCCTGGATGTCCAGGTACATGG * * *** * * ** ** *** *** * ** *** ENST00000199814.4 --AAT------------------CATTGTAGTGGCCTAAG----TGTGATTTAACTCTTG ENST00000442891.1 GGAGTTTTGGGAGAGGACACCCACACAGAAATCGCCCAAAATCCTGGGGTCTG--TCCTG * * ** * * * *** ** ** * * * ** ** ENST00000199814.4 AAGT-----CACACC-------CTCCGAAAGA-TGAGT----AGAAA----CCAGC-ACC ENST00000442891.1 AGATAGGAACAGACTTGCTGCACTCTGGGCGGCTGAGCCCCCAGAGAGTGTCCTGCTGCC * * ** ** *** * * **** *** * ** ** ** ENST00000199814.4 ---AGCACAGCCCAGATCTTCTCTTTCCTCT---CCTTTTCCTCA-------TTT----A ENST00000442891.1 CGGGGCTCTGCAGAAGTCCCCTCATGCTGCTGGGCCTTGGCCTCAGGGTCAGCTTCTGGA ** * ** * ** *** * * ** **** ***** ** * ENST00000199814.4 TTCCTAAAG--------------------GAATCTGACCATTTTAC---------GTCTC ENST00000442891.1 CTTCTGGAGCTGGGCTGGTGGGCCACGGAGGGCCAGCCCATCCCCCTTGGGGAGGGTCTG * ** ** * * * **** * **** ENST00000199814.4 TACG---------GCCCAAAAAAA-------GACAAAAATAAAAATTCC----------- ENST00000442891.1 CATGCTGAGGGATGCCCACAGAGGCCTGGGTGCCAGGGACACTCGCTCCAGGCCCAGGAC * * ***** * * * ** * * *** ENST00000199814.4 -TTTTTA----TTCCTG-----TCAACTGGATGGAAACACAAATTT------------CA ENST00000442891.1 CTTCCTAGGGATCTTTGCGGGTTTGGCTGAA-AGAAAAGCAGATTTGGTCCACTTCTCCA ** ** * ** * *** * **** ** **** ** ENST00000199814.4 TGGAGC---TGTGTACCATCGAAGA---AACCTGGTG--TCTGG---CATGAAATTA--- ENST00000442891.1 CCAAGCCCATTTGTTCCTTGCAGGGCTGGGCCTCATGAACCTGGGCCCCTGGAGTTTTGG *** * *** ** * * * *** ** **** * ** * ** ENST00000199814.4 ----CTGTAAAGAACTTCCTGT------------AAAACAC------GTTCTTTAAC--A ENST00000442891.1 GGGTCTCTAGTGGCCCACCTGGTGTGACACTGAGGAAACACCCACAGGCTGCTGAACCCA ** ** * * **** ****** * * * *** * ENST00000199814.4 AACTGAAA------TGAAA-----AGCATTG---------GAGCGTCTGAA--TGA---- ENST00000442891.1 GAGTGAGGGGTGCGTGCAGCTTGGGGCATGGTTGCTGTCAGAGCATCTCAGGCTGCTCCT * *** ** * **** * **** *** * ** ENST00000199814.4 AAGACGTGACCTC----------CTG--CTGGGACTCTGA-------------------- ENST00000442891.1 GAGACG-GACCCCAGGGTTCAGGCTGGCTCGGGGCTCCAGGCCTCATACCCTCACCCCAG ***** **** * *** *** *** ENST00000199814.4 ------------TGGTCTTCAGC-----------ATTCACCTTCGTGTGTCTTCA---GT ENST00000442891.1 GGCGGCTCGGTCTGGGCTTCAGCCCTGGTGCAGAACCCAGCTGGGAGAGGCCTTACCTGT *** ******* * ** ** * * * * * * ** ENST00000199814.4 ------GTCTCATTGTCATCC-----------CTGCTTCTGTTTGGTCTTAGA-GTGTTT ENST00000442891.1 CACCTGGCCCCCTTGCCACCTAAGATGAGGATCTGTCTCCATAGCGCGTGAGACGCTCCT * * * *** ** * *** ** * * * *** * * ENST00000199814.4 GGATATAA---------------CTGAATTGTAGATGGTA-------------------A ENST00000442891.1 GGGCACTGGGCCCCTCTGCCATCCCGGACAATCCACGCCATGCCATGACTTCCCACACCA ** * * * * * * * * * ENST00000199814.4 AGGAA-----------ATTT-----GATGTGTTTTTTGTTTTTAAATAATTAAAAC---- ENST00000442891.1 AGGGGCCTACTGCACCGTTTCCCTGAATCCTCTCTCTGGGTCTGAGACACTGATTCTCTC *** *** ** * * ** * * * * * * * ENST00000199814.4 --------GGGTCAATTTTT ENST00000442891.1 CATTCCCTGGCTCAAGGCTT ** **** **