CLUSTAL 2.1 multiple sequence alignment ENST00000216218.3 ATGCCCCGAGCTGGGACCGACCCTCCGGCTCCACGCCCTTTTTTTTTTTTTTTTTTAGGT ENST00000442505.1 ------------------------------------------------------------ ENST00000216218.3 CCCGGGCGTTGAGCTCTACTCAGTGCACGCAGCCACACAATATGCTCTTGGACGTCGCCC ENST00000442505.1 ------------------------------------------------------------ ENST00000216218.3 CCTGGAGGGGATGTTATCTCCCGCCTCCTTGAAGTCGCCCATTTCTGGGGTTGCCCCATC ENST00000442505.1 ------------------------------------------------------------ ENST00000216218.3 CAGGGAGCTGGTTCCTAGTTAAGAATATGAGAATGTATGCGCAGGGAGGCAGGCAACAGC ENST00000442505.1 ------------------------------------------------------------ ENST00000216218.3 ACGAACAGCCACGCTTCTAGAAGATTCTAGGGAGCGCGCAGGAGCAGCGCAGAGGGAGTA ENST00000442505.1 ------------------------------------------------------------ ENST00000216218.3 GGAATGAGCAGGCGGAGGACCCGAGGTCACGAGACCGTTGGGTGGGAGGAGCCAGCGGCC ENST00000442505.1 ------------------------------------------------------------ ENST00000216218.3 GGGGAGGTTCTAGTCTGTTCTGTCTTGCGGCAGCCGCCCCCTTCTGCGCGGTCACGCCGA ENST00000442505.1 ------------------------------------------------------------ ENST00000216218.3 GCCAGCGCCTGGGCCTGGAACCGGGCCGTAGCCCCCCCAGTTTCGCCCACCACCTCCCTA ENST00000442505.1 ------------------------------------------------------------ ENST00000216218.3 CCATGGACCCCCGCAAAGTGAACGAGCTTCGGGCCTTTGTGAAAATGTGTAAGCAGGATC ENST00000442505.1 ---CGGACCCCCACAAAGCGAATGAACTTCGGGCCTTTGTGAAAATGTGTAAACAGGATC ******** ***** *** ** ************************** ******* ENST00000216218.3 CGAGCGTTCTGCACACCGAGGAAATGCGCTTCCTGAGGGAGTGGGTGGAGAGCATGGGTG ENST00000442505.1 TGAGTGTTCCATACACCAAGGAAATGCGCTTCCTGAGAGAGTGGGTGGAGAGCATGGCGG *** **** ***** ******************* ******************* * ENST00000216218.3 GTAAAGTACCACCTGCTACTCAGAAAGCTAAATCAGAAGAAAATACCAAGGAAGAAAAAC ENST00000442505.1 GTAAAGTACCACCTGCTACTCAGAAAGCTAAATCAGAAGAAAATACCAAGGAAGAAAAAC ************************************************************ ENST00000216218.3 CTGATAGTAAGAAGGTGGAGGAAGACTTAAAGGCAGACGAACCATCAAGTGAGGAAAGTG ENST00000442505.1 CTGATAGTAAGAAGGTGGAGGAAGACTTAAAGGCAGACGAACCA---AGTGAGGAAAGTG ******************************************** ************* ENST00000216218.3 ATCTAGAAATTGATAAAGAAGGTGTGATTGAACCAGACACTGATGCTCCTCAAGAAATGG ENST00000442505.1 ATCTAGAAATTGATAATGAAGGTGTGATTGAACCAGACACTGATGCCCCTCAAGAAATGG **************** ***************************** ************* ENST00000216218.3 GAGATGAAAATGCGGAGATAACGGAGGAGATGATGGATCAGGCAAATGATAAAAAAGTGG ENST00000442505.1 GAGATGAAAATGCAGAGATAACAGAGGAGATGAGGGATCAGGCAAATGATAAGAAAGTGG ************* ******** ********** ****************** ******* ENST00000216218.3 CTGCTATTGAAGCCCTAAATGATGGTGAACTCCAGAAAGCCATTGACTTATTCACAGATG ENST00000442505.1 CTGCCATTGA-GCCCTAAATGATGGTAAACTGCAGAAAGCCATTGACTTATTCACAGATG **** ***** *************** **** **************************** ENST00000216218.3 CCATCAAGCTGAATCCTCGCTTGGCCATTTTGTATGCCAAGAGGGCCAGTGTCTTCGTCA ENST00000442505.1 CCATCAAGCTGAATCCTTGCTTGGCCATTTTGTATGCCAAGAGGGCCAGTGTCTTCGTCA ***************** ****************************************** ENST00000216218.3 AATTACAGAAGCCAAATGCTGCCATCCGAGACTGTGACAGAGCCATTGAAATAAATCCTG ENST00000442505.1 AATTACAGAAGCCAAATGCTGCCATCTGAGACTGTGACAGAGCCATTGAAATAAATCCCG ************************** ******************************* * ENST00000216218.3 ATTCAGCTCAGCCTTACAAGTGGCGGGGGAAAGCACACA--------------------- ENST00000442505.1 ATTCAGCTCAGCCTTACAAGTGGCGAGGGAAAGCACACAAACTTGGCGGGAAAGCACACA ************************* ************* ENST00000216218.3 GACTTCTAGGCCACTGGGAAGAAGCAGCCCATGATCTTGCCCTTGCCTGTAAATTGGATT ENST00000442505.1 GACTTATAGGCCACTGAGAAGAAGCAGCCCATGATCTTGCTCTTGCCTGTAAATTGGATT ***** ********** *********************** ******************* ENST00000216218.3 ATGATGAAGATGCTAGTGCAATGCTGAAAGAAGTTCAACCTAGGGCACAGAAAATTGCAG ENST00000442505.1 ATGATGAAGATGTTAGTGCAATGCTAAAAGAAGTTCAACCTAGGGCAC----AATTGCAG ************ ************ ********************** ******** ENST00000216218.3 AACATCGGAGAAAGTATGAGCGAAAACGTGAAGAGCGAGAGATCAAAGAAAGAATAGAAC ENST00000442505.1 AACACTGGAGAAAGTATGAGCGAAAACGTGAAGAGCGAGAGATCAAAGAAAGAATAGAAA **** ***************************************************** ENST00000216218.3 GAGTTAAGAAGGCTCGAGAAGAGCATGAGAGAGCCCAGAGGGAGGAAGAAGCCAGACGAC ENST00000442505.1 GAGTTAAGAAGGCTCGAGAAGAGCATGAGAGAGCCCAGAGGGAGGAAGAAGCCAGACGAC ************************************************************ ENST00000216218.3 AGTCAGGAGCTCAGTATGGCTCTTTTCCAGGTGGCTTTCCTGGGGGAATGCCTGGTAATT ENST00000442505.1 AGTCAGGAGCTCAGTATGGCTCTTTTCCAGGTGGCTTTCCTGGGGGAATGCCTGGTAATT ************************************************************ ENST00000216218.3 TTCCCGGAGGAATGCCTGGAATGGGAGGGGGCATGCCTGGAATG----GCTGGAATGCCT ENST00000442505.1 TTCCCGGAGGAATGCCTGGAATGGGAGGGGGCATGCCTGGAATGAATGGCCAGAATGCCT ******************************************** ** ******** ENST00000216218.3 GGACTCAATGAAATTCTTAGTGATCCAGAGGTTCTTGCAGCCATGCAGGATCCAGAAGTT ENST00000442505.1 GGAATCAATGAAATTCTTGGTCATCCAGAGGTTCTTGCAGCCATGCAGGATCCAGAAGTT *** ************** ** ************************************** ENST00000216218.3 ATGGTGGCTTTCCAGGATGTGGCTCAGAACCCAGCAAATATGTCAAAATACCAGAGCAAC ENST00000442505.1 ATGGCAGCCTTCCAGGATGTGGCTCAGCACCTAGCAAATATGTCACAATACCAGAACAAC **** ** ****************** *** ************* ********* **** ENST00000216218.3 CCAAAGGTTATGAATCTCATCAGTAAATTGTCAGCCAAATTTGGAGGTCAAGCGTAATGT ENST00000442505.1 CCAAAGTTTATGAATCTTATCAGTAAATTGTCAGCCAAATTTGGAGGTCAAGCATAATGT ****** ********** *********************************** ****** ENST00000216218.3 CCTTCTGATAAATAAAGCCCTTGCTGAAGGAAAAGCAACCTAGATCACCTTATGGATGTC ENST00000442505.1 CCTTCTGATAAATAAAGCCCTTGCTGAAGGGAAAGCAACCTACATCACCTTATGGATGTC ****************************** *********** ***************** ENST00000216218.3 GCAATAATACAAACCAGTGTACCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAA ENST00000442505.1 GCAATGATACAAACCAGTGTACCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAA ***** ****************************************************** ENST00000216218.3 GATAATCCC-TACCCCTCTCCCCCAAATGCAGCTGAAGCATTTTACAGTGGTTTGCCATT ENST00000442505.1 GATAATCCCCTACCCCTCTCCCCCAG-TGCAGCTGAAGCATGT-ACAGTGGTTTGCCATT ********* *************** ************** * **************** ENST00000216218.3 AGGGTATTCATTCAGATAATGTTTTCCTACTAGGAATTACAAACTTTAAACACTTTTTAA ENST00000442505.1 AGGGTATTCGTTCAGATAATGTTTTCCTACTAGGAATTACAAACTTTAAACACTTAAAAA ********* ********************************************* ** ENST00000216218.3 A------------TCTTCAAAATATTTAAAACAAATTTAAAGGGCCTGT-----TAATTC ENST00000442505.1 AAAAAAAGATCCTTGTTTGGGACACCTGAA-TGAATTTTCCTTGCTCGTAAGACCAAGAC * * ** * * * ** ***** ** ** ** * ENST00000216218.3 TTATATTTTT--CTTTACTAATCATTTTGGATTTTTTTCTTTGAATTAT-TGGCAGGGAA ENST00000442505.1 AAAAATCCTTAACATGAGCAAACCCTACGAGATTCGGCCCTTGCCTAACCTCTCAAAATC * ** ** * * * ** * * * ** * *** * * * ** ENST00000216218.3 TATACTTATGTATGGAAGATTACTGCTCTG-AGTGAA--ATAAAAGTTATTAGTGCGAGG ENST00000442505.1 CCTGCTGTCCTCCCCTGGATCTCTGCTCTGCACTCCACTGTGACAGTTCCTGGATTGCAC * ** * *** ******** * * * * * **** * * * ENST00000216218.3 CAAACATAACTCATTTGAGGATAAAGTTTGTGTTGGATATG----TGGTTCCTG----AT ENST00000442505.1 TGAGCTTCTCCCCACAGAGGGA------TGTGC-AGACATGGTTACTATTCTCGGGAAAT * * * * * **** **** ** *** *** * ** ENST00000216218.3 GCATTTTGACT--TGTCTTTTTAAATGCT--TTATCTTTTTCTTTAAAGAT-TTATTTCA ENST00000442505.1 CTCTTCTGCCCCCTGTCTTTTACCAAGCTAATTTTCATGCATTCTTCAGATCTTAGCTCA ** ** * ******** * *** ** ** * * * **** *** *** ENST00000216218.3 AT----AAAACTAATTGGGAC-CACCCGTA---TTTCAGTAG-GACCTGGGTAGGG-ATT ENST00000442505.1 ACCAAGGAAACCCTTCCTGACTCTCCCTCACCTTCTTTGTAATGTCTTCTGTAATATACT * **** * *** * *** * * * *** * * * *** * * ENST00000216218.3 GGAAGTACTTGGCAGGGCAGCAG---CAATCTTG---CTGTGTTTGAT---ATAACATGC ENST00000442505.1 GTCACTGCTCCATGTGCTTTTAAATCCCAGCCTGTCTCTGTCTTTAATTGCACATCATCC * * * ** * * * * * ** **** *** ** * * *** * ENST00000216218.3 ATC------CTTGGGCAG-GTTGCCCTTA--AATCTTACA-CTGT-GGT--GAAGGGATG ENST00000442505.1 ATGAGACTATTTGATTAGTGTCTCCCTTACAAGACTGAAAGCTCCAGGTCGGCAGGAACC ** *** ** ** ****** * ** * * ** *** * *** * ENST00000216218.3 TTTTTTTTGTAATGC----TGCAGTA-GAGTTGGAGTACT-TAGTTCTCTTGTTGTCCAG ENST00000442505.1 ACATGTCTGTTATGTCCCTTACACCACGCACAGGCATTCCGTAAATATCT-ATTGCTTA- * * *** *** * ** * * ** * * ** * *** *** * ENST00000216218.3 TATATCTAATAAGTGTTTTTCATATTATTTCCACGTAAGGGAAATAAGGTAGTACTTTTC ENST00000442505.1 TGGAATGAATGAACGA---AGGTGTGAATCCAAAGTGAGT--AACAGAGCAGCAAGTTCC * * *** * * * * * * * * ** ** ** * * ** * ** * ENST00000216218.3 TTTTTATATTTCTATGCTTAAAATTCTCTTTCCTAGT--CAAAAATTGCCCAA---ATCT ENST00000442505.1 A------GCCTTGAGGCCCAGGACTGCATTTCTCAGTTTCATGAA---CCCAATACACTG * * ** * * * **** *** ** ** ***** * ENST00000216218.3 GTGTTTGCTTTCTGCTTGCTACATTTGTCTCCCTTACTTTTCTTGAGCTAAAGACAGGCT ENST00000442505.1 GGGAGAGCCTGTTGTGAACCACACAGCACCCTCTTCTTTCTCCAGA---AGATACATTTT * * ** * ** * *** * * *** ** ** ** * * *** * ENST00000216218.3 TTTTCCACCGGCATCATCACTGCTATCATCATTAACAGCGTAATTATACAAGCATATTTA ENST00000442505.1 CTTTTTAACAGAATATACATTTTCTTCATGTTTCACATTCCA--CACCCCAGTGT---CA *** * * * ** ** * **** ** *** * * * ** * * ENST00000216218.3 ATGCTGAGTTTAATTTAATATGTAATACATATGGTAATTGTAGGGTAATACCCACAACAA ENST00000442505.1 GTGTGGGGATAGGGGTGAGGGATGTCAATTAAATTAATCAT--GGCAATCCCCTCGCCCA ** * * * * * * * ** **** * ** *** *** * * * ENST00000216218.3 CTGTAGTTTCTTACTTGGCCAAGAGAATGCTTATTTAAGTGTTAGACTTCCATTCTGGCA ENST00000442505.1 GGATTGATTGAGGAATAGGCATGA-AACACAAGGCTA---GTGAGACAT-------GAAA * * ** * * ** ** ** * ** ** **** * * * ENST00000216218.3 AAATCTTG--CCTTATCAGAAGACATTGGAAAGAGGGATTCCCTTTGGTGTTTGGTCTTC ENST00000442505.1 GGAATTTGAGTTTTATAAAGGGACA--GGAA-----GATGCTCTTGGGTGAG-GATGTGA * *** **** * **** **** *** * *** **** * * * ENST00000216218.3 TACTTAGAAAAACCTATTGCAGTTAGTTTATCTTGTAGTATTCATCTT-TGTATTCTGAA ENST00000442505.1 TACTTGGAG----CCACTGTAGTC------TCTTGTGGCCCTGAGGGAACAAAGGCCGAA ***** ** * * ** *** ****** * * * * * *** ENST00000216218.3 GATAAGGTTTGAATTAAATTGATACACACAGAGGGGAACCGATTTTTTTTATCCAATGTG ENST00000442505.1 TACATGGCA-GAGGCAAA--GGCTCCTGGTGGGGAGAACCCACCTCCT-----CAATGA- * * ** ** *** * * * ** ***** * * * ***** ENST00000216218.3 AATTATAAATGAGATAATCCACAGTTATTCATTGTGGAGTTGTTGAGACTATGAAAGACT ENST00000442505.1 ----ACACATAAAATGA-CCAC---------CCTTGAAACTGCTGATTGTATGGAACAAT * * ** * ** * **** ** * ** *** **** ** * * ENST00000216218.3 CA-TTGTCTTTGTATTCAGCTCTTAAATAGTGTAACTATATCCCCACCTCTGCTTGCTTT ENST00000442505.1 AAATTGTTTCT-TATT--GGTTTAAGCCAGGGTTTCT-CAACATCACCACTGAC-ACTTT * **** * * **** * * * * ** ** ** * * **** *** **** ENST00000216218.3 CTTTCCCTCCCCTCCAATGATAAAGAAAATGATAAATTTTCTGTTGTGCATTCAATTCT- ENST00000442505.1 GGGCCACATAA-TACTTTGTTGTGGGCAGCTGTGCATTATGTGTGGTCCTGTGCATTGTG * * * * ** * * * * *** * *** ** * * *** * ENST00000216218.3 -TATTTTAAATAAGACTAAGTATAGGCATTGT--ACCTGACATTGCTACG--TTTCTACC ENST00000442505.1 GTATGTTGAGAAGCATCAC---TGGCCACTACCCACTAGATACCAGTATGACTATCCCCC *** ** * * * * * * ** * ** ** * ** * * ** ** ENST00000216218.3 AGTGTTTCAATT-TAA--AGTGCTAGTGTTTAAAAACATTTTCAAGGGATAAGGCCTTCT ENST00000442505.1 A-CATCCCAGTTGTGACAACCACAAATGTCTTCAGACCTTGTGAA------ATGTCCCCT * * ** ** * * * * * *** * * ** ** * ** * * * ** ENST00000216218.3 GT--------ACTTTGCTTATTTGAAGAATCAGTGGTAGGAGC--AGTGAAGTAAATTCT ENST00000442505.1 GGGGAGTAAAATTGCCCCCAGTTGA-GAATGACTAGTATAAGCCAACTGAACTAAATTTT * * * * * **** **** * * *** *** * **** ****** * ENST00000216218.3 ATGGAGTACATTT--CTAAAATACCACATTTCTGAAA--------TCATAAATAAGTTTA ENST00000442505.1 CT--ATTACTTGCAGCCAAAA-GCAGCTTAACTGATACAGCACCTTTTCAACTTAGTTTA * * *** * * **** * * * **** * * ** * ****** ENST00000216218.3 TTCAGGTTCTAACCCTTTGCTGTACACAAGCAGACAGAAATGCATCTGTTAC-ATAAATG ENST00000442505.1 CCCA--TAGCAATCTCTTTTTAC-CACACCCACATC----TGCCTCTAGCACCAGAGCTG ** * ** * ** * **** ** * *** *** ** * * ** ENST00000216218.3 AGAA-AAAGCTATT-ATGCTGATGGAGCATGCTTTTTA--AATCC--TTTAAAAACACTC ENST00000442505.1 CTCATAGACCCATTCACACAATTA---CAT-CTTCCCACCAACCCCATTCAATCATAGCC * * * * *** * * * *** *** * ** ** ** ** * * * ENST00000216218.3 ACCATATAAACTTGCATTTGAGCTTGTGTGTTC---TTTTGTT---AATGTGTAGAGTTC ENST00000442505.1 TTCCTAC--TCCTGCTTTACCACTCACTTCCCCAGCCCCAGCTCCAACCATCTCTGCCTC * ** * *** ** ** * * * * * * * ** ENST00000216218.3 TCCTTTCTCGAAATTGCCAGTGTGTACTTGGCTTAACTCAAGAACAGTTTCTTCTGGATT ENST00000442505.1 CCCCTTCTC----CTGCCACT---TGCT--GTGAGAGCTGATGGCAATGCTGTCTG--TT ** ***** ***** * * ** * * * ** * **** ** ENST00000216218.3 CCTTATTTGATTTATTTAACCTAATTATATTCTAATATTGCAAATATTACCATAAGTGGG ENST00000442505.1 ACTTGCTC--TTGCTCTAACATCGCTCTCTGCTACTTCTGC--TCCTCATCAGAAGGAGG *** * ** * **** * * * * *** * *** * * ** *** ** ENST00000216218.3 TAAAAGTAAAATTCCTCTTCTGAAAATGTGTCCTG-------TGCTTTTAGATTTTTAAA ENST00000442505.1 TCAA--TAGAAGCTTCCTTC---AAACTTCCCCTGCCAAGGCTCTTTCTCCACCCCTCTA * ** ** ** **** *** * **** * ** * * * * ENST00000216218.3 TTCCATAATATAC-ATTCTTAATTTTCAACTCAA ENST00000442505.1 TTCC-CACTTCACTAATTTCATCTATCCATCCAT **** * * ** * * * * * ** * **