CLUSTAL 2.1 multiple sequence alignment ENST00000216218.3 ATGCCCCGAGCTGGGACCGACCCTCCGGCTCCACGCCCTTTTTTTTTTTTTTTTTTAGGT ENST00000453250.1 ------------------------------------------------------------ ENST00000216218.3 CCCGGGCGTTGAGCTCTACTCAGTGCACGCAGCCACACAATATGCTCTTGGACGTCGCCC ENST00000453250.1 ------------------------------------------------------------ ENST00000216218.3 CCTGGAGGGGATGTTATCTCCCGCCTCCTTGAAGTCGCCCATTTCTGGGGTTGCCCCATC ENST00000453250.1 ------------------------------------------------------------ ENST00000216218.3 CAGGGAGCTGGTTCCTAGTTAAGAATATGAGAATGTATGCGCAGGGAGGCAGGCAACAGC ENST00000453250.1 ------------------------------------------------------------ ENST00000216218.3 ACGAACAGCCACGCTTCTAGAAGATTCTAGGGAGCGCGCAGGAGCAGCGCAGAGGGAGTA ENST00000453250.1 ------------------------------------------------------------ ENST00000216218.3 GGAATGAGCAGGCGGAGGACCCGAGGTCACGAGACCGTTGGGTGGGAGGAGCCAGCGGCC ENST00000453250.1 ------------------------------------------------------------ ENST00000216218.3 GGGGAGGTTCTAGTCTGTTCTGTCTTGCGGCAGCCGCCCCCTTCTGCGCGGTCACGCCGA ENST00000453250.1 ------------------------------------------------------------ ENST00000216218.3 GCCAGCGCCTGGGCCTGGAACCGGGCCGTAGCCCCCCCAGTTTCGCCCACCACCTCCCTA ENST00000453250.1 ------------------------------------------------------------ ENST00000216218.3 CCATGGACCCCCGCAAAGTGAACGAGCTTCGGGCCTTTGTGAAAATGTGTAAGCAGGATC ENST00000453250.1 --ATGGATCCCCACCAAATGAGCAAGCCTGGGGCCTTCCTGAAAATGTGTAAGCAGGATC ***** **** * ** *** * *** * ******* ********************* ENST00000216218.3 CGAGCGTTCTGCACACCGAGGAAATGCGCTTCCTGAGGGAGTGGGTGGAGAGCATGGGTG ENST00000453250.1 TGAGTGTTCTGCACACCAAAGAAATGCACTTCCTGAAGGAATGGATGAAGAGCATGGGGG *** ************ * ******* ******** *** *** ** ********** * ENST00000216218.3 GTAAAGTACCACCTGCTACTCAGAAAGCTAAATCAGAAGAAAATACCAAGGAAGAAAAAC ENST00000453250.1 GTAAACTACCACCTGCTATTCAGAAAGCTAAATCAGAAGAAAATATCAAGGAAGGAAAAA ***** ************ ************************** ******** **** ENST00000216218.3 CTGATAGTAAGAAGGTGGAG-GAAGACTTAAAGGCAGACGAACCATCAAGTGAGGAAAGT ENST00000453250.1 CAGATAGCAGGAAGGCAGAAAGAAAACATAAAGATAGATGAACCATCAAATGAGAAAACT * ***** * ***** ** *** ** ***** *** ********** **** *** * ENST00000216218.3 GATCTAGAAATTGATAAAGAAGGTGTGATTGAACCAGACACTGATGCTCCTCAAGAAATG ENST00000453250.1 GATCTAGAAATTGATAATGAAGGTGTGATTGAACAAGACACTGATGCCCCTCAAGAAATG ***************** **************** ************ ************ ENST00000216218.3 GGAGATGAAAATGCGGAGATAACGGAGGAGATGATGGATCAGGCAAATGATAAAAAAGTG ENST00000453250.1 GGAGATGAAAATGCAGAGAAAACGGAGGAGATGATGGATCAG-CAAATGGTAAGAAAGTG ************** **** ********************** ****** *** ****** ENST00000216218.3 GCTGCTATTGAAGCCCTAAATGATGGTGAACTCCAGAAAGCCATTGACTTATTCACAGAT ENST00000453250.1 GTTGCCACTGAAACCGTAAATGATGGTGAACTG-----------TGGCTTATTCACAGAT * *** * **** ** **************** ** ************* ENST00000216218.3 GCCATCAAGCTGAATCCTCGCTTGGCCATTTTGTATGCCAAGAGGGCCAGTGTCTTCGTC ENST00000453250.1 GCCATTAAGCTGAATCCTCACTTGGCCATTCTGTGTGCCAAGAGAGCCAGTGTCTTCATC ***** ************* ********** *** ********* ************ ** ENST00000216218.3 AAATTACAGAAGCCAAATGCTGCCATCCGAGACTGTGACAGAGCCATTGAAATAAATCCT ENST00000453250.1 AAATTACAGAAGCCCAATGCTGCCAGTCAAGACAGTGACAGAGCCATTGAGATAAATCCT ************** ********** * **** **************** ********* ENST00000216218.3 GATTCAGCTCAGCCTTACAAGTGGCGGGGGAAAGCACACAGACTTCTAGGCCACTGGGAA ENST00000453250.1 GATTCAGCTCAGACTTACAAGTGGTGAGAAAACACACACAGACTTCTGGGTCTTTGGGAA ************ *********** * * ** ************* ** * ****** ENST00000216218.3 GAAGCAGCCCATGATCTTGCCCTTGCCTGTAAATTGGATTATGATGAAGATGCTAGTGCA ENST00000453250.1 GAAGCAGCCCATGCTCTTGCCCTTGCTTGGAAATTGGATTATGATGAAGATGCTAGTAAA ************* ************ ** *************************** * ENST00000216218.3 ATGCTGAAAGAAGTTCAA-CCTAGGGCACAGAAAATTGCAGAACATCGGAGAAAGTATGA ENST00000453250.1 ATGCTGAAAGAAGTTCAAATCTAGGGCCTAGAAAATTATAGAACATTGTAGAAAGTATGA ****************** ******* ******** ******* * *********** ENST00000216218.3 GCGAAAACGTGAAGAGCGAGAGATCAAAGAAAGAATAGAACGAGTTAAGAAGGCTC--GA ENST00000453250.1 GTGAAAACGTGAAGAGCAAGAGATCAACGAAAGAATAGAAAGGGTTAAGAAGGCTCTCGA * *************** ********* ************ * ************* ** ENST00000216218.3 GAAGAGCATGAGAGAGCCCAGAGGGAGGAAGAAGCCAGACGACAGTCAGGAGCTCAGTAT ENST00000453250.1 GAAAAGCATGAGAGATCCCAGAGGGAGGAAGAAGCCAGAAGATGATCCAGAGCTCAGTAT *** *********** *********************** ** ** *********** ENST00000216218.3 GGCTCTTTTCCAGGTGGCTTTCCTGGGGGAATGCCTGGTAATTTTCCCGGAGGAATGCCT ENST00000453250.1 GGCTCTTTTCCAAGTGGCCTTTCTGGGAGAATGCCTGGTAATTTTCTCAGAGAAATGCCT ************ ***** ** ***** ****************** * *** ******* ENST00000216218.3 GGAATGGGAGGGGGCATGCCTGGAATGGCTGGAATGCCTGGACTCAATGAAATTCTTAGT ENST00000453250.1 GGAATGGGAGGGGACATGTCTGGAATGGCAGGAATGCATGGACTCAA---AATTCTTAGT ************* **** ********** ******* ********* ********** ENST00000216218.3 GATCCAGAGGTTCTTGCAGCCATGCAGGATCCAGAAGTTATGGTGGCTTTCCAGGATGTG ENST00000453250.1 GA-CCAGAGGTTCTCACAGCCATGCAGGGTTCAGAAGTTATGGTGGCCTTCCAGGATGTG ** *********** ************ * **************** ************ ENST00000216218.3 GCTCAGAACCCAGCAAATATGTCAAAATACCAGAGCAACCCAAAGGTTATGAATCTCATC ENST00000453250.1 GCCCAGAACCCAGCAAATATGTCAAAATGCCAGAGCAACCCAAAGGTTAAGAATCTCATC ** ************************* ******************** ********** ENST00000216218.3 AGTAAATTGTCAGCCAAATTTGGAGGTCAAGCGTAATGTCCTTCTGATAAATAAAGCCCT ENST00000453250.1 AGTAAATTGTCAGCCAAATTTGGAGGTCAAGCGTAATGCCCTTCTGATAAATAAAGCCCT ************************************** ********************* ENST00000216218.3 TGCTGAAGGAAAAGCAACCTAGATCACCTTATGGATGTCGCAATAATACAAACCAGTGTA ENST00000453250.1 TGATAAAGGAAAAGCAACCTAGATCACCTAATGGATGTTGCAATTATGCAAACCAGTGTA ** * ************************ ******** ***** ** ************ ENST00000216218.3 CCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAAGATAATCCCTACCCCTCTCCC ENST00000453250.1 CCTCTGACCTT---ATCAAGACAGCTGGGGTGCTTTGAAGATAATCTCTACCTGTCTACC *********** ******* ************************ ***** *** ** ENST00000216218.3 CCAAATGCAGCTGAAGCATTTTACAGTGGTTTGCCATTAGGGTATTCATTCAGATAATGT ENST00000453250.1 CTGAATGCAACTAAAGCATTTTACAGCGGTTTGCCATTAGGGTATTCATGCAGATAATGC * ****** ** ************* ********************** ********* ENST00000216218.3 TTTCCTACTAGGAATTACAAACTTTAAACACTTTTTAAATCTTCAAAATATTTAAAACAA ENST00000453250.1 TTTC-TACTAGGAATTACAAACTTTAAACACTTTTTAAACCTTAAAAATATTTAAAACAA **** ********************************** *** **************** ENST00000216218.3 ATTTAAAGGGCCTGTTAATTCTTATATTTTTCTTTACTAATCATTTTGGATTTTTTTCTT ENST00000453250.1 ATTAAGAGGGTCTGTTAATTCTT-TATTTTATTTTATT--TTATTTT--TTTTTTTTTTT *** * **** ************ ****** **** * * ***** ******* ** ENST00000216218.3 TGAATTATTGGCAGGGAATATACTTATGTATGGAAGATTACTGCTCTGAGTGAAATAAAA ENST00000453250.1 TGA------GACAG--AATCTCGCTCTGTTTCCCAGGCTGGAGTGC--AGTGGCGTGA-- *** * *** *** * * *** * ** * * * **** * * ENST00000216218.3 GTTATTAGTGCGAGGCAAACATAACTCATTTGAGGATAAAGTTTGTGTTGGATATGTGGT ENST00000453250.1 --TCTCAGCTCACTGCAACCTC--CGCCTCCCAGGTTCATGCCATTCTTCTGCCTCAGCC * * ** * **** * * * * *** * * * * ** * * ENST00000216218.3 TCCTGATGCATTTTGACT-----TGTCTTTTTAAATGCTTTATCTTTTTCTTTAAAGATT ENST00000453250.1 TCCCGAGTAGCTGGGACTACAGGCGCCCGCCACCACACCCAGCTAATTTTTTTAT----- *** ** * **** * * * * *** **** ENST00000216218.3 TATTTCAATAAAACTAATTGGGACCACCCGTATT--TCAGTAGGACCTGGGTA----GGG ENST00000453250.1 --TTTTAGTAGAG---ACGGGGTTTCACCATGTTAGCCACGATGGTCTCGATCTCCTGAC *** * ** * * *** ** * ** ** * * ** * * * ENST00000216218.3 ATTG-GAAGTACTTGGCAGGGCAGCAGCAATCTTGCTGTGTTTGATATAACATGCATCCT ENST00000453250.1 CTTGTGATCTGCCCGCCTCAGTCTCC-CAAACT-GCTGGGATT-ACA-GGTGTGAGCCAT *** ** * * * * * * *** ** **** * ** * * ** * * ENST00000216218.3 TGGGCAGGTTGCCCTTAAATCTTACACTGTGGTGAAGGGATGTTTTTTTTGTAATGCTGC ENST00000453250.1 TGCCTCTCTTGACCCCGCTTTCCCCACTGTGGCCTT--TATCTCTCTTTGCCTTTGCAGC ** *** ** * ******** ** * * *** *** ** ENST00000216218.3 AGTAGAGTTGGAGTACTTAGTTCTCTTGT-TGTCCAGTATATCTAATAAGTGTTTTTCAT ENST00000453250.1 AACACCCCTTAAAGACTTGTCTCCCTTGCATGTCCACCTTCTCCTT---GTCATTCTC-T * * * * **** ** **** ****** * ** ** ** ** * ENST00000216218.3 ATTATTTCCACGTAAGGGAAATAA--GGTAGTACTTTTCT------TTTTATATTTCTAT ENST00000453250.1 CTTGAGCCCACTCTCAGGCTCTCACCACCATTACTCTACCAGTGGCCTCCATGGCACTAA ** **** ** * * * **** * * * ** *** ENST00000216218.3 GCTTAAA-----ATTCTCTTTCCTAGTCAAAAATTGCCCAAATCTGT--GTTTG--CTTT ENST00000453250.1 ATCCAGTGGTCCATTCTCTGTCCTCATCTTAGTCTATCAGCATTTGACAGACAGAACTGT * ******* **** ** * * * ** ** * * ** * ENST00000216218.3 CTGCTTGCTACATTTGTCTCCCTTACTTTTCTTGAGCTAAAGACAGGCTTTTTCCACCGG ENST00000453250.1 CTCCTCTCTGAAAT-GTGTTCTTTATTTGGCTT---CCAGAACAAAGTATTCTCC--TGG ** ** ** * * ** * * *** ** *** * * * * * ** *** ** ENST00000216218.3 CATCATCACTGCTATCATCATTAACAGCGTAATTATACAAGCATATTTAATGCTGAGTTT ENST00000453250.1 T----TTTCTTCCTTTCTCTCTA-----GTTCTT-TCCTCCTATTCTCCTTCCCTGGTTT * ** * * ** ** ** ** * * ** * * * **** ENST00000216218.3 AATTTAATATGTAATACATATGGTAATTGTAGGGTAATACC----CACAACA-ACTGTAG ENST00000453250.1 CCCCTCATTTCCCCTGC-CACA-TAACATTAGAGCA-TACCAGGACCCAGCGTACTGTA- * ** * * * * *** *** * * **** * ** * ****** ENST00000216218.3 TTTCTTACTTGGCCAAGAGAATGCTTATTTAAGTGTTAGACTTCCATTCTGGCAAAATCT ENST00000453250.1 CTCCCTCCCTGGTC-------------TTC-----TCAG----CCATTCTTATGGCTTCA * * * * *** * ** * ** ******* ** ENST00000216218.3 TGCCTTATCAGAAGACATTGGAAAGAGGGATTCCC---TTTGGTGTTTGGTCTTCTACTT ENST00000453250.1 AACATCATCTATAAGCCT--------GTAACTCCCAAATCTGAACTCCAGACT--CATTT * * *** * * * * * **** * ** * * ** * ** ENST00000216218.3 AGAAAAACCTATTGCAGTTAGTTTATCT---TGTAGTATTCATCTTTGTATTCTGAAGAT ENST00000453250.1 CAAGATACCTACT-TGATATCTCTACTTGGATGTCTCATTAGCATCTGAAACTTGAGAAC * * ***** * * * ** * *** *** * ** * *** * ENST00000216218.3 AAGGTTTGAATTAAATTGATACACACAGAGGGGAACCGATTTTTTTTATCCAATGTGAAT ENST00000453250.1 AAAACTGTACTCTGA--GATCTACTCCATTTTAAACCTGCTCCTCTCA--CAGTCTTACT ** * * * * *** ** * **** * * * * ** * * * * ENST00000216218.3 TATAAATGAGATAATC-CACAGT--TATTCATTGTGGAGTTGTTGAGACTATGAAAGACT ENST00000453250.1 CTTAAACCTGCTCCTCTCACAGTCTTACTCATTTC--AATACATGAGGCAGCTACAGCCT **** * * ** ****** ** ***** * * **** * * ** ** ENST00000216218.3 CATTGTCTTTGTATTCAGCTCTTAAATAGTGTAACTATATCCCCACCTCTGCTTGCTTTC ENST00000453250.1 CCTAGAC-----GCTCAGACC--AAGAACTTTGACAGTATCCTTAAC--TATTCACTTTC * * * * **** * ** * * * ** ***** * * * * ***** ENST00000216218.3 TTTCCCTCCCCTCCAATGAT---AAAGAAAATGAT------------AAATTT-TCTGTT ENST00000453250.1 TTTAACACCCTACACATGATCCAGAAGTAAATCTTGTCAGTATTTCAAAATCTACCTGGC *** * *** * ***** *** **** * **** * *** ENST00000216218.3 GTGCATTCAATTCTTATTTTAAATAAGACTAAGTATAGGC-ATTGTA----CCTGACATT ENST00000453250.1 ATCTACTCACTTCTCACCCTCATCCATCCTG-GTGCAAGCCATCCTAAAATCTTGTC--T * * *** **** * * * * ** ** * ** ** ** * ** * * ENST00000216218.3 GCTACGTTTCTACCAGTGTTTCAATTTAAAGTGCTAGTGTTTAAAAACATTTTCAAGGGA ENST00000453250.1 GTTATTATTGCAGCACTGTCTTAATT---GGTCTCTCTGTTTTCA--CCCTTGCC-GTTA * ** ** * ** *** * **** ** ***** * * ** * * * ENST00000216218.3 TAAGGCCTTCTGTACTTTGCTTATTTGAAGAATCAG-TGGTAGGAGCAGTGAAGTAAATT ENST00000453250.1 TAAA-CTATTCGCAGTACACCAGCC---AGAATGAGATGGTTAAAAC--TTAAGTTAGAT *** * * * * * * ***** ** **** * * * **** * * ENST00000216218.3 CTATGGAGTACATTTCTAAAATACCACATTTCTGAAATCATAAATAAGTTTATTC--AGG ENST00000453250.1 C-ATGTCACACCTCTGTTTAAAACCAC----CCAATGACTTAACTGAGTAAAAACCAAAG * *** ** * * * ** ***** * * * *** * *** * * * * ENST00000216218.3 TTCTAACCCTTTGCTGTACAC---AAGCAGACAGAAATGCATCTGTTACAT--AAATGAG ENST00000453250.1 TTCTTACAATTTCCTGGAAGCCTTATGTGATCTGGC---CTCCTATTACCTCTAGATTTC **** ** *** *** * * * * * * * ** **** * * ** ENST00000216218.3 AAAAAGCTATTATGCTG------ATGGAGCATGCTTTTTAAA--------TCCTTTAAAA ENST00000453250.1 ATCTC-CTACCACGCTCTCCCTCATTCACTCTATTCTGCACACACTGGCCTCCTCTCAAT * *** * *** ** * * * * * * **** * ** ENST00000216218.3 ACACTCACCATAT---AAAC-TTGC--ATTTGAGCTTGTG----TGTTCTTTTGTTAATG ENST00000453250.1 GCCCTAACCCTGTCAGAGACACTACCTACTTCACCCTTTGCTGTTGCTATTTCCTTTGCC * ** *** * * * ** * * * ** * * * ** ** * *** ** ENST00000216218.3 TGTAGAGTTCTCCTTTC--------TCGAAATTGCC------AGTGTGTACTTGGCTTAA ENST00000453250.1 TGGAAAGCTCTTCCCCCAAAGATCATCATAGCTCCCTCTCTTACTTCCTCCTTATCTCTA ** * ** *** * * ** * * ** * * * *** ** * ENST00000216218.3 CTCAAGAACAGTTTCTTCTGGATTCCTTATTTGATTTATTTAACCTAATTATATT---CT ENST00000453250.1 CTCAAATGTCACTT-TCAAGAATTCCCTACTCACCACAGTTAA----ATTGCATTTCCCC ***** ** * * ***** ** * * **** *** *** * ENST00000216218.3 AATAT-TGCAAATAT-TAC-----CATAAGTGGGTAAAAGTAAAA---TTCCTCTTCTGA ENST00000453250.1 AACACACACACACACACACACACACACACACACACACACACACGAGTCTCCCTCCTCTGC ** * ** * * ** ** * * * * * * **** **** ENST00000216218.3 AA-ATGTGTCCT--GTGCTTTTAGATTTTTAA-ATTCCATAAT-ATACATTC------TT ENST00000453250.1 TTCATTTCCCCTTAGCACTTTTCATTATCTAACATAGCTTAATTATTTATCTAGTTTATT ** * *** * ***** * * *** ** * **** ** ** ** ENST00000216218.3 AATTTTCAACTCAA---- ENST00000453250.1 GTTTTTCTCCTCTTGTTT ***** ***