CLUSTAL 2.1 multiple sequence alignment ENST00000226230.5 AGCCCTCGCGGGGGCAAGGCGGCGACCGAGGCGCGTGGGTCTGGGAAGGCGCGCGGATTT ENST00000452969.1 ------------------------------------------------------------ ENST00000226230.5 GGCCCCTCTTCTCACATCAGCGGGTCCAGGCCCAACCGACAGACTATGGGGGCTCCGGCA ENST00000452969.1 ------------------------------------------------------------ ENST00000226230.5 ACCAGGCGCTGCGTGGAGTGGCTGCTGGGCCTCTACTTCCTCAGCCACATCCCCATCACC ENST00000452969.1 -----------------------------------------------CATCCT-GGCACC ***** **** ENST00000226230.5 CTGTTCATGGACCTGCAGGCGGTGCTGCCGCGCGAGCTCTACCCAGTCGAGTTTAGAAAC ENST00000452969.1 CTGTTCATGAACCTGCAGGTGATGCTGTGGGG--AGCTCTGCCTGGT---GC---GAAAA ********* ********* * ***** * * ****** ** ** * **** ENST00000226230.5 CTGCTGAAGTGGTATGCTAAGGAGTTCAAAGACCCACTGCTACAGGAGCCCCCAGCCTGG ENST00000452969.1 CTGCTGACGTGGTGGGCTAAGGCGGTCAAAC-CCCTCTGTTGCAGGATGTCCCAGTGGAC ******* ***** ******* * ***** *** *** * ***** ***** ENST00000226230.5 TTTAAGTCCTTTCTGTTTTGCGAGCTTGTGTTTCAGCTGCCTTTCTTTCCCATTGCAACG ENST00000452969.1 CTCAGGTCCTTCCTGTTTGCTGAGCTTGTGTTTCAGCTGCCTTTCTTTCCCACTGCAAAC * * ****** ****** ******************************* ***** ENST00000226230.5 TATGCCTTCCTCAAAGGAAGCTGCAAGTGGATTCGAACTCCTGCAATCATCTACTCTGTT ENST00000452969.1 CCTGCCTTCTTCCAA--AAGCTGCCGGTAGATCCAAAGCCCTGCAGACTTCTACTCAGGT ******* ** ** ******* ** *** * ** ****** * ******* * * ENST00000226230.5 CACACCATGACAACCTTAATTCCGATACTCTCCACATTTCTGTTTGAGGATTTCTCCAAA ENST00000452969.1 TGCGACATGGCAACGTGAATGCCAGTACTCTCCACATTTCTATTTGAGGATTTCGCAAAA * **** **** * *** ** **************** ************ * *** ENST00000226230.5 GCCAGTGGTTTCAAGGGACAAAGACCTGAGACTTTGCATGAACGGTTAACCCTTGTGTCT ENST00000452969.1 GCTAGTGGCTTCCAAGGACAAAGGCCTGAGACCGTGCACGAACCATTCACCCTTGCATCT ** ***** *** * ******** ******** **** **** ** ******* *** ENST00000226230.5 GTCTATGCCCCCTACTTACTCATCCCATTCATACTTTTAATTTTCATGTTGCGGAGCCCC ENST00000452969.1 GGCTGTGCACCTTACTCACACGTCCCTTTCATATGTCTGCGTTGGCTGTTGAAGAGCTCC * ** *** ** **** ** * **** ****** * * ** ***** **** ** ENST00000226230.5 TACTACAAGTATGAA------GAGAAAAGAAAAAAAAAATGAAGGAAACAACCACTGGCC ENST00000452969.1 TACTGCAAGTATGCAAGTGTGGGGAGAAAAGAAAGAAAATGAGGGAAACAACCAGTGAGC **** ******** * * ** ** * *** ******* *********** ** * ENST00000226230.5 CAGGGTAGAGATGCCTACAGGGTGGTTGCTTGTTGGATACAATACAAGGAACACTGCTCA ENST00000452969.1 CTGGG-AGGGAGGCCCGCGGGGCACTTGCCTGTGGGACCCAATACGAGGAAAACCGCTCA * *** ** ** *** * *** **** *** *** ****** ***** ** ***** ENST00000226230.5 GAACCCACGTCTTCAGCAGCATTTGAAACACTGGCAGCAATGCACAAGAGCAAGATGGTG ENST00000452969.1 GAACCCAGGTCTTCAGCAGCATTCGAAACAC------------ACAAGGGCAAGATGGTG ******* *************** ******* ***** *********** ENST00000226230.5 TCAGGAACCATGTCAAACCCTCACCTTCTTCCATTTTTTTTTTTTTTTTAAGACAGTCTC ENST00000452969.1 GCAGGAGTGTCATTAAACTCTCATCCTGCACGGGCACT-----------GGGACGGACAG ***** * **** **** * * * * *** * * ENST00000226230.5 ACTCTGTTGCCCAGGCTGGAGTAAAGGGCA--GTGG--CATGATCTCGGCTCACTGCAAC ENST00000452969.1 A-TCAGTCAGC--GGTGGGTGTGCAGTGCGCTGTGGGCTATGTCATAGGGATGTGGTACC * ** ** * ** ** ** ** ** **** *** * ** * * * ENST00000226230.5 CTCCGCCTCC---TGGGCTCAAGCCATCTTCCT-TAGCCTC-CCAAGTAG--CTAGAACT ENST00000452969.1 CAGCACATCAGTGTGTGACCAGG---TCTTGCTGTAGGATGACTGAGCAGGACCACAACA * * * ** ** * ** * **** ** *** * * ** ** * * *** ENST00000226230.5 ACA----GGTGTGTACCAACACGTATGGCTAATTTGTT-TTGTTTT----------TTTT ENST00000452969.1 GAAACTGGATGAGCTTCTAAGAGCATGGCCTGCTTGACACTGTTACAGGAAAGGGGTCCC * * ** * * * * ***** *** **** * ENST00000226230.5 G---TGTGTGTGGAGACAGGGTTTTGCCATGTTGCCCAGGTTGGTCTCGAACGCCTAGGC ENST00000452969.1 GATCCGGACCCCAAGAGAGGGTTCTTGGATCTCTCACAAGAAAGAATTCAGCGC--AAGT * * *** ****** * ** * * ** * * * * *** * * ENST00000226230.5 TCA-AGTGATCTGCCCACCTCAGTCTCCCTA---AGTGCTGGGATTACAGACGTGAA--- ENST00000452969.1 CCGCAGAGAAAAGTGAAAGCAAGTTTATTAAGAAAGTAGAGGAATAAGAGA-ATGACTAT * ** ** * * *** * * *** ** ** * *** *** ENST00000226230.5 -CCACTGGGCCCAGCCC--AAACCT-----TCACC--TTCTAAGGGCACTGGGATGA--A ENST00000452969.1 TCCATAGAG--CAGCCCTGAGGACTGCTGGTTGCCCATTTTTATGGTTTTTTTTTGATGA *** * * ****** * ** * ** ** * * ** * *** * ENST00000226230.5 CAGACCGATCGGCTTGAGGGTGGGCAA---AGGGGTG-------TGGGCTAGGTTATAAG ENST00000452969.1 CATGCTAAACAA----GGGGTGGATTATTCATGCCTCCCCTTTTTAGACCA---TATAGG ** * * * ****** * * * * * * * * **** * ENST00000226230.5 GAAG--------TGGTACCA-AATAACTGTG---TGCCTGAGTTCCACCGCAAGATTACT ENST00000452969.1 GTAACTTCCTGATGTTGCCATGGTATCTGTAAACTGTCATGGTGCTG--GTGGGAGTG-T * * ** * *** ** **** ** * ** * * ** * * ENST00000226230.5 AAAAGC-AGGACCAGACCAGAAACTGCTA--AAGAACATGGCCTG--TTTGACATGTTCA ENST00000452969.1 AGCAGTGAGGAT--GACCAGAGGCCACTCTTGTGGCCAT--CTTGGTTTTGGTGGGTT-- * ** **** ******* * ** * *** * ** **** *** ENST00000226230.5 TGAGTCACCTGACCCACAGCATATATGCTT-ATGACTAAACCCTCCACTCCTGATTCTCA ENST00000452969.1 TTAGCCGGCTCCTTTACTGCA-ACCTGTTTTATCAGCAAGGTCTTTA----TGGC-CTGT * ** * ** ** *** * ** ** ** * ** ** * ** ** ENST00000226230.5 AGAGTGTATC-ACCTGTCAGCAAA----ATGAATAGTGGGATATTTTGGGCCATTTTA-A ENST00000452969.1 AGTTTGTACTGACCTCCTATCTCATCCTGTGACTAAGAAGGCCTT---AACCATCTGGGA ** **** **** * * * *** ** * ** **** * * ENST00000226230.5 ATGTG-------AAATTTT-GCCTCTTT------AATGTTAATTCAAAACTATATCAATG ENST00000452969.1 ATGCAGCCCAGTAGGTCTCAGCCTCATTTTACCCAGCTCCTATTCAAGATGGAGTCG--- *** * * * ***** ** * ****** * ** ENST00000226230.5 TTTTCTTGTTCC--CACCTCT-AACCCAAGGAAAAAAGAGAAAACATACTATGCAAAGGA ENST00000452969.1 --CTCTGGTTCAAACACCTCTGAACATGTTCATGCATTGTTTGACCCACAGT---AGATA *** **** ******* *** * * ** ** * * * ENST00000226230.5 AGTTTAAACTTAAGTTTTC--CTTAAGGGTC-----AGCCCAACAATGACTTTCAGTCAA ENST00000452969.1 AGCCTGAGGCTAAGCCCTTGACTCATAATTCTCGAGAGCATATCACCAA---TCAGGAAA ** * * **** * ** * ** *** * ** * **** ** ENST00000226230.5 ATGGATTA-AACTGGAAAATGTTTTTGTTTCTGT-TGTAAACAGATCATCCTAGGCGA-- ENST00000452969.1 ATGAATAGTGGCAGCCAGGTATGATGGCTCATGCCTGTAATCCCAGCACTTTGGGGGACC *** ** * * * * * * * * ** ***** * * ** * ** ** ENST00000226230.5 -AAGTTTTTTTTGTTTGTTTGCTTTTAAATTAGTTTATTTCTAAATCTTAGTCTTCCACA ENST00000452969.1 AAAGTG------GGAGGGTCGCTTG-AGCCCAGG--AGTTCAAGATCAGACTGTGCAAGG **** * * * **** * ** * *** * *** * * * * * ENST00000226230.5 TTTCTAGAGGCCACCTGACACAAGTCCC------TGT--ATCTGA--AGTCT--AGCATC ENST00000452969.1 TAATGAGACCCCATCTGTGATGGTTCATACTGAGTGTCAACTTGATTGGGCTGAAGGATG * *** *** *** * ** *** * *** * ** ** ** ENST00000226230.5 TCAAG-GCTGATC-TGGAAGTGT--GCTAGTATGCTCCCTAGTGGATAACTTAATCTTTT ENST00000452969.1 CAAAGTACTGATCCTGGGTGTGTCTGTGAGGGTGTTGCC-AAAGGAGA--TTCATATTTG *** ****** *** **** * ** ** * ** * *** * ** ** *** ENST00000226230.5 AATACAGTTCC-------GTCATTCCCATC-TTGTTTTCAGAAGAGA------AGGTGGC ENST00000452969.1 AGT-CAGTGGCTGGGAAAGGCGGACCCACCCTTAATCTGGGTGGGCACCATCTAATCAGC * * **** * * * **** * ** * * * * * * ** ENST00000226230.5 TAC-AGCCAGGCATAACATATCCACTGTGTGCATAGAGG-GTCTCTTCACGTTGATG-CT ENST00000452969.1 TGCCAGCAAGGC-TAGAATATAAA--GCAGGCAGAAAAATGTAAAAAGACGAGACTGGCC * * *** **** ** **** * * *** * * ** *** ** * ENST00000226230.5 TGGCATTCCATC----AGCTTTCTCTAAGTCTT--TGCTCAAGTTCAACCTTAAAATGAT ENST00000452969.1 TAGCCTCCCAGCCTACATCTTTCTCCCGTGCTGGATGCT----TCCTGCCCTCG---GAC * ** * *** * * ******* ** **** * * ** * ** ENST00000226230.5 GTTAGACAACAGGTCCCAGTCAGTTCC----CTCTATTTTCACCCATTTTGCTCACAAGC ENST00000452969.1 ATCGGACTCCAAGTTCT--TCAGTTTTGGGACTC-AGACTGGCTCTCCTTGCTCCTCAGC * *** ** ** * ****** *** * * * * ****** *** ENST00000226230.5 CATATTGGCCCGATTAGTGGTACTGTCTGACTCACGTGTGTGATCCAAATAAA-GGTAGC ENST00000452969.1 ----TTG---CAAACAGCC-TACTGTGGGACCT-----TGTGATCGTGAGAGTTAATAAT *** * * ** ****** *** ******* * * ** ENST00000226230.5 TGCTGACCACTGCCTGGTTTGTTTTGTGGACTAGGGGATAGAGA-ATCCAGGGTTCTCTC ENST00000452969.1 TAATAAACTCCCCTTTGTGTGTGT-GTGTGTGTGTATATATATATATATATATATATATA * * * * * * * ** *** * *** * *** * * ** * * * * ENST00000226230.5 ATG-AGGAGTTAAACATATTTCAAGAGCAACAGGAAAAAAGGTACATCAAGCC--ATTTG ENST00000452969.1 AAATAGGATATATATATATATATAAAATAGGATATATATATATATATAAAATAGGATATA * **** ** * **** * * * * * * * * ** ** ** ** * ENST00000226230.5 AAAACAAAAATT-TATTGCTTCT--CCTTCCA--AAGCTTTG-TGAA---------TTTA ENST00000452969.1 TATATATATATCCTATTAGTTCTGTCCTTCTAGAAAACCCTGACTAACACACCATCTCTA * * * * ** **** **** ***** * ** * ** ** * ** ENST00000226230.5 CAAAAAA--AAGGATGAA-------AGTTTACAAACTGCT-TAGTTCCAACTAAGCATAA ENST00000452969.1 CAAAAAATAAAAAATTAGCTAGCTGAGGTGATGCACACCTGTGGTCCCAGCTATTCAGAA ******* ** ** * ** * * ** ** * ** *** *** ** ** ENST00000226230.5 GA----GGTGAGAACGT-------ACACTGCAGGGCCACCAGCAGCAGCTGTGCACTGAT ENST00000452969.1 GGCTGGGGTGGGAGGATCACTTGAGCCCTGGAGGTCGA--GGCTGCAG-TGAGCTGTGAT * **** ** * * *** *** * * ** **** ** ** **** ENST00000226230.5 GTTAAAACTGGCTCCC--CC--AGACTTGTAGTG-----CTGTCT-TCAGGGGGCTGCAT ENST00000452969.1 TGCAACACTGCATTCCAGCCTGGGAGATAGAGTGAAACTCTGTCTCTTAAAAAAATAAAT ** **** * ** ** ** * **** ****** * * * ** ENST00000226230.5 TCCTTACACGCCACCTCTTGTGACATAGGTCATTGGTCAAGCCGCTGGAATGCTACAGA- ENST00000452969.1 AAAATAAAATAAAATAAAAGTAG--TGGGACATT--TCAGGCCGTTTAAAAATTTGAAAT ** * * ** * ** **** *** **** * ** * * * ENST00000226230.5 ---GGTTTTTTTGGTT--TTGAGA----GGCT---TTTTTTTGTTTTGCCTTCCTACT-- ENST00000452969.1 TTTGGTCTTTAATATTCATTAAAAACCAGGTCATATTTTCTTGTCTCCACCTCTAGCCCG *** *** ** ** * * ** **** **** * * ** * ENST00000226230.5 --ATAAAAGCGAAATTTTCAGTTCATTTCTGAAAAATAAATTGGTCAATAAATTCA---- ENST00000452969.1 GGGGAAAAGAGAAAATA-CAGT--------GAAAAAGAGGTT------TAAACTTAGTTT ***** **** * **** ****** * ** **** * * ENST00000226230.5 --- ENST00000452969.1 TCC