CLUSTAL 2.1 multiple sequence alignment ENST00000243673.2 GTGCCGACCGCGGGCTGGTGGCGGGC-GGCGCGGTGCTCCGCGCGTCCGG-GCTCCCTGG ENST00000422490.1 AGGGGAGCTGCAGAAGGCACTCACACTGGCACGGCTCCCAATGCTAGTAGCAGTGTCTTG * * ** * * * * *** *** * * ** * * ** * ENST00000243673.2 CTCCTCGGGACGGCCTTGTATGC-TGTGCGCCCCGCACC--CCGGCTGCGCGCTCCGATC ENST00000422490.1 CTCC---GCCCTGCCCAGAGCACCTGCAGGCCTTGGATGGACAGACT-CATAGACTGATT **** * * *** * * ** *** * * * * ** * * *** ENST00000243673.2 CCAGCGGGAGGGGAC-GCCCGGCCCGCAGGCTCC-CAGGGGAGGGGTGGCTCCTGCAAAA ENST00000422490.1 GAAGGCAATGGAAATTGAACGATCT-TGGGCTGCGCAGAGGAGGAGGGGTGCTAGGGTAA ** ** * * ** * **** * *** ***** * ** * * ** ENST00000243673.2 TGGTCCCTCACCTCTTGCTGCTCTGTCTCCTCCCCTTGGTGCGA--GCCACC-GAGCCCC ENST00000422490.1 TG-----------CTTGATGC--TGTCCCCAGGT-TCGGAACGGATGCTGCCTGAGCTCT ** **** *** **** ** * ** ** ** ** **** * ENST00000243673.2 ACGAGGGCCGGGCCGACGAGCAGAGCGCGGAGGCGGCCCTGGCCGTGCCCAATGCCTCGC ENST00000422490.1 -------CCAGGCTGAAGAGCA---TTTGGAGCCAGCC--------------------GC ** *** ** ***** **** * *** ** ENST00000243673.2 ACTTCTTCTCTTGGAACAACTACACCTTCTCCGACTGGCAGAACTTTGTGGGCAGGAGGC ENST00000422490.1 A----TTCTCCTG-----ACCAGCGCTCTATTGCCCAGCTCAGCATTGCG---------C * ***** ** ** * ** * * ** * * *** * * ENST00000243673.2 GCTACGGCGCTGAGTCCCAGAACCCCACGGTGAAAGCCCTGCTCATTGTGGCTTACTCCT ENST00000422490.1 ACT----TGCCCACTCC---AAGCC---------AGTCCAGTCCTT-----CTTGCTGGT ** ** * *** ** ** ** ** * * * *** ** * ENST00000243673.2 TCATCATTGTCTTCTCACTCTTTGGCAACGTCCTGGTCTGTCATGTCATCTTCAAGAACC ENST00000422490.1 T-ACCGGCGTTTCTTCCCTCTT---------CCTAACC---CATA-CACCTTAGAAAACT * * * ** * ** ***** *** * *** ** *** * *** ENST00000243673.2 AGCGAATGCACTCGGCCACCAGCCTCTTCATCGTCAACCTGGCAGTTGCCGACATAATGA ENST00000422490.1 ----------------------CCGTTTC--TGCTAGCCCAG-AGCTTC-------ATG- ** *** * * ** * ** * * *** ENST00000243673.2 TCACGCTGCTCAACACCCCCTTCACTTTGGTTCGCTTTGTGAACAGCACATGGATATTTG ENST00000422490.1 ----GACGCTCCACTCCTCCTTCGCCCT---TCCC------------------------- * **** ** ** ***** * * ** * ENST00000243673.2 GGAAGGGCATGTGCCATGTCAGCCGCTTTGCCCAGTACTGCTCACTGCACGTCTCAGCAC ENST00000422490.1 -------CAGGTGCTCCCTGACCCATTAGATTAAGGACT---CGCTGTACTCCAAAGGAG ** **** * * ** * ** *** * *** ** * ** * ENST00000243673.2 TGACACTG-ACAGCC--ATTGCGGTGGATCGCCACCAGGTCATCATGCACCCCTTGAAAC ENST00000422490.1 TCAAGCTGGACACCCCAACCACA--GAATCGCC-CCAAG-------GGACTTTCCTGAAC * * *** *** ** * * * ****** *** * * ** *** ENST00000243673.2 CCCGG-ATC-TCAATCACAAAGGGTGTCATCTACATCGCTGTCATCTGGACCATGGCTAC ENST00000422490.1 TCCGGCACCATGAGTCATGAAGC------TCTG-AGTGTGCCCAGC--GGCTTTG---AT **** * * * * *** *** *** * * ** * * * ** * ENST00000243673.2 GTTCTTTTCACTCCCACATGCTATCTGCCAGAAATTATTTACCTTCAAATAC-AGTGAGG ENST00000422490.1 GATCTTATCACCTCCA----CCACCTCTCAGGTGCTATTGGC-----AGCGCTGGCTAGG * **** **** *** * * ** *** **** * * * * *** ENST00000243673.2 ACATTGTGCGCTCCCTCTGCCTGCCAGACTTCCCTGAGCCAGCTGACCTCTTCTGGAAGT ENST00000422490.1 ATA--GCCTGCTATCCATGATTGACAAGCTGCC----------TGACCACACGTGGAA-C * * * *** * ** ** ** ** ** ***** * ***** ENST00000243673.2 ACCTG-GACTTGGCCACCTTCATCCTGCTCTACATCCTGCCCCTCCTCATCATCTCTG-- ENST00000422490.1 ACTGGCGACCTGGCCAAC-------------ACATCAGGTCCC-----ATAACTTCGGAG ** * *** ****** * ***** * *** ** * ** * ENST00000243673.2 -TGGCCTACGCTCGTG-TGGCCAAGA--AACTGTGGCTGTGTAATATGATTGGCGATG-T ENST00000422490.1 ATGGTGT---CTCAGGATGAACAGGTGCAATTTTGGTTA-GTAATAGGGTACACGGTGGT *** * *** * ** ** * ** * *** * ****** * * ** ** * ENST00000243673.2 GACCACAGAGCAGTACTTTGCCCTGCGGCGCAAAAAGAAGAAGACCATCAAGATGTTGAT ENST00000422490.1 GATCTTTGT-TGCCATTTTAGGCAACTGTGTCTTAA-------ACCATCT-GATTATGAA ** * * * *** * * * * ** ****** *** *** ENST00000243673.2 GCTGGTGGTAGTCCTCTTTGCCCTCTGCTGGTTCCCCCTCAACTGCTACGTCCTCCTCCT ENST00000422490.1 GTACGAAAGGGTGCACACCGCC----ACTGG--CCTCTTCA-----------------TT * * ** * * *** **** ** * *** * ENST00000243673.2 GTCCAGCAAGGTCATCCGC-ACCAACA--ATGCCCTCTACTTTGCCTTCCACTGGTTTGC ENST00000422490.1 GTC----AATATC-TCTGTGACCAACATGATGCTGGCTTTTCTTATTTCCCCC--TTCAT *** ** ** ** * ******* **** ** * * **** * ** ENST00000243673.2 CATGA-GCAGCACCTGCTATAACCCCTTCATATACTGCTGGCTGAACGAGAACTTCAG-- ENST00000422490.1 CATGGTGCATTATCTG-TGTAATTCCTTGGTGTTTGGGAAGATGACAGGCCACTTCAGTC **** *** * *** * *** **** * * * * *** * ******* ENST00000243673.2 GATTGAGCTAAAGGCATTACTGAGCATGTGTCAAAGACCTCCCAAGCCTCAGGAGGACAG ENST00000422490.1 GCTTTGCCCAA---TACTCTTGTGCCTATGTAA--------CTGTGATT----------- * ** * ** * * ** ** * *** * * * * ENST00000243673.2 GCCACCCTCCCCAGTTCCTTCCTTCAGGGTGGCCTGGACAGAGAAGAATGATGGCCAGAG ENST00000422490.1 ACCATGGCTTCTATTTCCCT-----AGACAAATAT---CAGATATGTGTGATG-CTACA- *** * * **** * ** * **** * * ***** * * * ENST00000243673.2 GGCTCCCCTTGCCAATAACCTCCTGCCCACCTCCCAACTCCAGTCTGGGAAGACAGACCT ENST00000422490.1 ---TCCCCTGA-----AATCTTGGATT---------ACTCCAAT---ACAAGACAATGTT ****** ** ** ****** * ****** * ENST00000243673.2 GTCATCTGTGGAACCCATTGTGACGATGAGTTAGAAGAGGTTGGGAAGAGGGAGTGGGAG ENST00000422490.1 AGCATCATTA----TCATCTCGATTGTGAGT-ACCTGTGCTCC----------------- **** * *** ** ***** * * * * ENST00000243673.2 GGGTCTGTC----TCCACCTGAGGCAGGGAAAGAGAGCCTATTCTCACACATGATCTTCA ENST00000422490.1 ---TTTGTCACATTCCATTTGC--CAG---AAG--------TTTTACCAGGTGG-----A * **** **** ** *** *** ** * ** ** * ENST00000243673.2 GAGTGCTGGAAACACACTCCTGCAGAAGCTGTAGGACTCTTGAATTCCTAGGAAACTGTC ENST00000422490.1 GATTGG-GTAAGAATAACACAGTATAACCAGTG-----TTTGGATTC-TAGCAACCTGTG ** ** * ** * * * * * ** * ** *** **** *** ** **** ENST00000243673.2 CAGCCTCCTAGCCCCATGTGATGTGAAAACTAAAAGGCACCACCAACTAGACATGTGTTC ENST00000422490.1 -ACCTTGGAAGTCCCATGGAAT-----AACTTACAG--AGTAGGGGCTGGA-ATA----- * * * ** ****** ** **** * ** * * ** ** ** ENST00000243673.2 ATAAATTCCCATCTAAGAAACACTGGGAGGCACAGCAGCCTGTATCTCTGAGGAAGAGGA ENST00000422490.1 GTACATTTCCA-------AATAT----AGGTATAAAAA--TAAATTTCT----------- ** *** *** ** * *** * * * * ** *** ENST00000243673.2 GCGAGGACAACGTTGGCCCAGATGGGGGCTGAATCATTCAACTGCCTCCATCTGTGGGGC ENST00000422490.1 ------------TTTACT----TGGGATTT--ACCAT--AACGGTTTCCA--------AT ** * **** * * *** *** * **** ENST00000243673.2 AGCTGCTGCCTTACAGCCCTTCCTACTGCTGAGCATCCCTAAGGGAGACCTAAATCATAC ENST00000422490.1 AACT-----CTCATAGCATTTG--ATTATTAGAAAT---------AAGTCT---TCACA- * ** ** * *** ** * * * ** * ** *** * ENST00000243673.2 TTTGGGTGTGGTGACCCAGATGCACAGAGCTCTGCTTGAAACAGGTACACGGGCCAGGGA ENST00000422490.1 TTTGGGGGCCATAATTTCCTTATATA-----TCACATGAGA----------GGTCTGGAA ****** * * * * * * * *** * ** * ** * ENST00000243673.2 AATGCCAGCAAGCCAGAGCGGGCGTGGAGATTTTTATGCCTCACTTTCTGGAGTCACTG- ENST00000422490.1 TAGGTGAAC---CCAAAGT---CTCCCGGATTTTTA-ACTCTAGATTTTAAGCTTAATGC * * * * *** ** * ******** * * ** * * * ** ENST00000243673.2 GGCCATGA----TGAATCATAAGTCTTCAGTGGCCTAGCAATATCCAGATAAGAAAGGAC ENST00000422490.1 AGACACAAACAGTAAAT-ATGTATCTTCCTTCGGCCA--AACTTCC--ATAAAATAG--C * ** * * *** ** ***** * * * * ** *** **** * ** * ENST00000243673.2 CAACT-TGGGTTCCTTAAAACAAAGGGAAATTATTATTGCCACTTAGAAAAATTCAGAAA ENST00000422490.1 TGGCTGTAGGT--CTCAGGGAAAAGACAAA--GCTGATGTTTCTCT------TTCTGTCT ** * *** ** * **** *** * ** ** *** * ENST00000243673.2 AGCACACACTCACATACACACACACAAAATCACTCTCTTATCCCATCCATTTGTGATAAC ENST00000422490.1 GTCTTATAACC-TAGAAACATAGCTGAAGAAACTGTCTG--CCTACCCAGTT-------- * * * * * * *** * ** *** *** ** * *** ** ENST00000243673.2 ATCTGTGAACATGCTGTGGCTCTATTTGCAACATTTTCCTTCGTGTGTGTGATTGTGTGC ENST00000422490.1 -----------TCCCGTA----TACTT-CAAAATCTTC--------AGGGAAATACCTTG * * ** ** ** *** ** *** * * * * ENST00000243673.2 ATGTGTGCATGACCTTTTTTTTTTCTTTTTTTTTTTTTTTTTGAGATGGAATCTCGCTCT ENST00000422490.1 ACCTGAGAAT----TGTTTTTGCTCTTCCTCATCTTGCCATTAA--TGGCA-CTAGT--- * ** * ** * ***** **** * * ** ** * *** * ** * ENST00000243673.2 GTCACCCAGGTTGGAGTTCAGTGGCACAATCTCGGCTCACTGCAAGCTCTGCCTCCCAGG ENST00000422490.1 --------GGTTG---TTTATGGTCATG----TGGCCAAA---AAGCTGTGGATCCA--- ***** ** * * ** *** * ***** ** *** ENST00000243673.2 TTCATGCCGTTCTCCTGCCTCAGCCTCCCTA---GTAGCTGGGACTACAGGTGCCCGCCA ENST00000422490.1 -TAATGCTGTTGATG-ACATCAGCATCCACACCTATATCTGGCAGCATGGG-GAGAAGAA * **** *** * ***** *** * ** **** * * ** * * ENST00000243673.2 CCATGCCCGGCTAATCTTTTGCATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGG ENST00000422490.1 GGAGACCCTGAAGAT-----GC-----TGATGACAATGGTGCTTGTCTACAC-AATCAGC * *** * ** ** * * * ** * ** * * *** ENST00000243673.2 ATGGTCTCGATCTCCTGACCTCGTGATCCACCTGCCTAGGCCTCCCAAAGTGTTGGGATT ENST00000422490.1 -TGGCTCC---CTCTTAACCTC----------TACCTGGTGCTGCCA---TGCAGAGAAT *** * *** * ***** * *** * ** *** ** * ** * ENST00000243673.2 ACAGGCGTGAGCCACCCCGCCCGGCCCTTTTTTTTCATTTATACTTTTTCATTTAGATTG ENST00000422490.1 TCAT-CTCAAGCCACAATG---GCCTCTGCTTCTTCTTCCACTGGCTGGCAATTAGCAGC ** * ****** * * * ** ** *** * * * ** **** ENST00000243673.2 TAATGAT-TAACAGAAACAGGGGTACCTTTCCCAGGGGTGTCCACCAGAAGAGTTGAAGA ENST00000422490.1 TCCTGCTACAACCCCTACATCCACTTCTGGCTCAGCAATAACTTCTGGATT-GTTCAGAA * ** * *** *** ** * *** * * * ** *** * * ENST00000243673.2 AGAGGTGA--GAAGATCCCAAGGTGAAGCCTGTCACCACGCAGACAGAACTGCCCCCTAT ENST00000422490.1 AGTTATCATGGAAATTCAGAAGATG----CTGCTA--AAGAAATCAG--CTGCCTAAGAG ** * * *** ** *** ** *** * * * * *** ***** * ENST00000243673.2 TGTAGACAGTGGTGGGAAGGGCCTGGCTCACATGCCC--CTCCTTAG--AGGCAGCCTCA ENST00000422490.1 GGGAG-CACTGCTGACTCAGCTCTGTCTCACCCACTCACCACCTTGCCTGGGTAGATTCC * ** ** ** ** * *** ***** * * * **** ** ** ** ENST00000243673.2 AGATGAACCAGGGAATC-AAACTC----AACCAGGAGGCAT------GATTCCTTCTCTC ENST00000422490.1 AAAC---CCAGAGTGCCCAAATTCCCACAATTCAAAGATATTGATGAGCTACCCAGTCCC * * **** * * *** ** ** ** ** * * ** ** * ENST00000243673.2 CTGCAATTGCACAAAAACAAGTGGTGGTGAAACATTGTTCTGTTTTCACAAGAGATGAGG ENST00000422490.1 CCTCCATTC--------CAAGAGGTGG-AAATCTTCTTTCTCTATTCACAAGTGCCTAGA * * *** **** ***** ** * * **** * ******** * ** ENST00000243673.2 GAGCAGGCTTTCCAATATGCTGGAAGTAATTGTGCTTAGACACCTCATCCTCCCAAGCTG ENST00000422490.1 CTTTAAGCTGCCCA-------GACGGCAAT-ACGTT------CTCCATCCT--CAAAATC * *** *** * * *** * * * ****** *** * ENST00000243673.2 TCTAGAAAGGCCATTTCGCTGTGTTGTCTAAATAATGAGGGTTTTTTCACACCATTTCTC ENST00000422490.1 CCTAAGATAGA---------GTGGGACCAAAATAAATAGGATTCATTCA-----TTTCTC *** * * *** * ****** *** ** **** ****** ENST00000243673.2 AAAAGGAGATTCGCTGTCAACATCATTTTGGTGGTTCAGGTGTAACTTTCACTTACAGAA ENST00000422490.1 A-------------TGGCA---------TGGGGGC-CAGGTGAA-----------CAGAA * ** ** *** ** ****** * ***** ENST00000243673.2 ACTTATGCATCCTTAAGAGATCTCAATTCTTAAGGGTCTAACTTGCCAGAGAAATCTCAT ENST00000422490.1 G-----GGGTACTTGAAGGACT----------GGGG----ACATGT----GAACCCCCAT * * *** * ** *** ** ** *** * *** ENST00000243673.2 TCCAGGG--ACTGATTGTTTTTATCACCTTCTGTCTGGTCCTGAGTGACTCACTGTGTCA ENST00000422490.1 ATTTGTGTCACTCAGT-CTTTCATTTCCTTCTCTCTTCTTTT------TTTATTTTTTT- * * *** * * *** ** ****** *** * * * * * * * ENST00000243673.2 CCCAGAAAAGAGACCTGTCAGGCAGAATCGAGCTTAATTCACCTGCTCTAAACAATTGTT ENST00000422490.1 -------------CCTGTTCGGTT--TTCTTCCTTTATTCTCT--CTCCCAACGAT---- ***** ** ** *** **** * *** *** ** ENST00000243673.2 ACTGACACACTGCTTTTAGGTTTTCTT-CTAGCACCAGATAAACTCTGAAATCAAAGCAT ENST00000422490.1 ---AAGGTGAAGGTATTAGATTTTCAGGCT--CATCAGAGATCTTTCTCCATCA------ * * * **** ***** ** ** **** * * **** ENST00000243673.2 GGATATGAGCTCAGTAGGAAACTAAGGTTTGAGGGAGAAAGAGTTTGTCACTTAGACCTC ENST00000422490.1 ---------CTCAAAGGAAAGCTTTATTCTGACCTGTGAGGGGAT--------AGATCTC **** * ** ** * *** * * * * *** *** ENST00000243673.2 TTGGCTGTTAACTGAAACTGAACTTGCTCACATCATCTGCTTCCCTGTAATGAACTATGA ENST00000422490.1 CTGAACTCTATCT----CTGATTCTGGTCAC--CA-----TTCCCT-------------- ** ** ** **** ** **** ** ****** ENST00000243673.2 GGGTTCTTTATCCTAGTTTCTATTTATGAAGATGGTTGAAAATTTTCAAGACACAAGATT ENST00000422490.1 ----TCTCTATCCT------TATGT-----GCCAGTTGG------CCATGACAC------ *** ****** *** * * **** ** ***** ENST00000243673.2 TTGAAAACTCACTGAATTATGGGCAAAACCATGACTTTCATTGGGCAGACAGAGTCTTCT ENST00000422490.1 TTGACATCTGAT---ATCAC-----AAACGTTGTCT---------CAGGAAGTG------ **** * ** * ** * **** ** ** *** ** * ENST00000243673.2 AAGCCCACAGGGATCCCCAGATGGATTTTTCAGGACAAATGGCTCATGTGCCTGTACTTA ENST00000422490.1 -------CAAGGTACCCTAGA--AATTCT-----------GATTTATAT---TTCATTTA ** ** *** *** *** * * * ** * * * *** ENST00000243673.2 TTGTCTCTGTGGTGTGTCAAGAAGTAGCTAATGGTTTCATCTGAAAGCTGCCATAGAAAT ENST00000422490.1 ----------GATG-ATTGAGA----TCTAATTTGTCTATC---ATATTCCCAGGGAAAT * ** * *** ***** * *** * * *** ***** ENST00000243673.2 TCTGTGAACCAGAATGAGACAAGGCAGCAGGCATACAGAAGGTTTGTCCTGCTCTGGGAA ENST00000422490.1 -------GCCAGGAGGGGA---------AGGTATA------GTTT--------CTGAAA- **** * * ** *** *** **** *** * ENST00000243673.2 GCATGGAGGATGTTGTACTTCACTCCTCTCTGAGGGTGTCTAGGAATACAGAAGCTCCTT ENST00000422490.1 ------------TTGTATT-------------GGGTTATCCGGGAA-------------- ***** * ** * ** **** ENST00000243673.2 GACTTACATCTCAATAAACCCATCGTAAGTCCAAAATATTGGAAGTTGAAAATGCATTGA ENST00000422490.1 ---------CTCAAT--GCTTCTCATAAGTGTAA-------GTAGTTG-----GTCGTAA ****** * ** ***** ** * ***** * * * ENST00000243673.2 ATACACCCAACCTACTGAACATCGTAGCTTAGCCAAGCCTACCTTAAATGCTCTGAGAAC ENST00000422490.1 CTATCTCC-------------TTGTGGCAGAGTGAG----------AAT-----GAGAA- ** ** * ** ** ** * *** ***** ENST00000243673.2 ACTTATATTAGCCTACAGCTGGGAAAAATCATTTAACACAAAGCCTATCTTCTAATGAAG ENST00000422490.1 ACTTACA----CATGCAG-----AGGAGTT-----GCACCGTGGTTATTTTCC---CAAA ***** * * * *** * * * *** * *** *** ** ENST00000243673.2 TATGGAATATCTCATGTAATTTATTGAATACTGTACTGAAGGTGAAAACCAGAATGGTTG ENST00000422490.1 T-TGATATA---CA-ATAATTTGCTGATAGCTCTCCT--------------------TTG * ** *** ** ****** *** ** * ** *** ENST00000243673.2 TATGGATATGCGAAGTATGGTTTCTACTGAATGTGTATTGCTTTCCCATCATCATAAAAT ENST00000422490.1 AATGCA-ATGAAAATTGAGGT----GCCGAATTT-------------AGCACTACAAAAT *** * *** ** * *** * **** * * ** * ***** ENST00000243673.2 TTTTAAAAATC-CTAAGTTGAATCATTGTTAGTCCGGGACCTTCAGTACTGCCAAGTCCC ENST00000422490.1 CCAAAATATTCTCCATGTTTCCTCACTCT---------ACATTTAGCATCA--------- ** * ** * * *** *** * * ** ** ** * ENST00000243673.2 AGAGAAAACCCTTTTACTCTGGGGAGAACCCACTGATGGCTCATTAGATCTGTCCCTTCC ENST00000422490.1 --------------TACTTT----------CTCTTGTA------TAAATTTGTGC----- **** * * ** * ** ** *** * ENST00000243673.2 CCGAGGTCCGTGTGTGACTTTGAGCAAAAAGTGACTTCTTTTTGTGAATGTAAAATTTGT ENST00000422490.1 ----------TGTCTAGTTTTGCCT----------TTCTTTTTCTGGAAAGAGAG----- *** * **** ******** ** * * * ENST00000243673.2 GAAACTTGAGTTTTTCCAATGTGCTGTAAAGTGTTTTATTGTAAATTGCTCATC--TCAA ENST00000422490.1 GAGACAT----------AATGTGCTTGCTGCTGTTTTATTGTTCCCATCTCTTTAGTCTA ** ** * ******** *********** *** * ** * ENST00000243673.2 TAAAATTTACTTCAGGTTTGTGGACT----GTG- ENST00000422490.1 TGAGA---ATTTCAACTCAGTGGGAAAGAAGTAA * * * * **** * **** **