CLUSTAL 2.1 multiple sequence alignment ENST00000253686.2 AGCGTCTCCTGTGCGTCTGCGCGGGAAGTGGAACCTGGCTCTGGGGAGAAGCCGCGTGAG ENST00000543493.1 ------------------------------------------------------------ ENST00000253686.2 ATCCGCGCGGGTGCTAGCTAGTCCTTTCTCGTCGCTGCTCGGCTCGCGGCCCGTGGGGTC ENST00000543493.1 ------------------------------------------------------------ ENST00000253686.2 GGCCCCGCCACCGTTGCCGCCATGCCCATGAAGGGCCGCTTCCCCATCCGCCGCACCCTG ENST00000543493.1 GAC-----------TGCCACCA--CCTATGAAGGGGCCCTTACCCTTC----------TG * * **** *** ** ******** * *** *** ** ** ENST00000253686.2 CAATATCTGAGCCAGGGGAACGTGGT---GTTCAAGGACTCCGTGAAGGTCATGACAGTG ENST00000543493.1 CAATACCCAGACCAGGGTGATGTAGTAGTGTTCAGGGACTTGGTGAAGGTCATAAGAGTG ***** * ****** * ** ** ***** ***** *********** * **** ENST00000253686.2 AATTACAACACGCATGGGGAGCTGGGCGAGGGCGCCAGGAAGTTTGTGTTTTTCAACATA ENST00000543493.1 AATTATAACACACATGGGGAGCTGGGTGACAGTGGCAGGAAATTTGTATTTTTCAACATA ***** ***** ************** ** * * ****** ***** ************ ENST00000253686.2 CCTCAGATTCAATACAAAAACCCTTGGGTGCAGATCATGATGTTTAAGAACATGACGCCG ENST00000543493.1 CCTCAAATCCA-CA-AAAAACCCTTGGATGCAGATCATGATGTTTAAGAACACAATACCA ***** ** ** * ************ ************************ * ** ENST00000253686.2 TCACCCTTCCTGCGATTCTACTTAGATTCTGGGGAGCAGGTCCTGGTGGATGTGGAGACC ENST00000543493.1 TTACCCTTCCTACAATTCTATTTATATTATGAAGAGCAGGTCCTGGTGGATATAGAAATC * ********* * ****** *** *** ** ****************** * ** * * ENST00000253686.2 AAGAGCAATAAGGAGATCATGGAGCACATCAGAAAAATCTTGGGGAAGAATGAGGAAACC ENST00000543493.1 AAGATGAATAAGGAGATTATGGAACACATCAAAAAAATCGTGGGGAAGAATGAGGA---- **** *********** ***** ******* ******* **************** ENST00000253686.2 CTCAGGGAAGAGGAGGAGGAGAAAAAGCAGCTTTCTCACCCAGCCAACTTCGGCCCTCGA ENST00000543493.1 CACAAGAAAGGAGAGCAGGAGAAAAAGCAGCTCTCTCACCCAGCTCATTTTGGCCTTC-A * ** * *** *** **************** *********** * ** **** ** * ENST00000253686.2 AAGTACTGCCTGCGGGAGTGCATCTGTGAAGTGGAAGGGCAGGTGCCCTGCCCCAGCCTG ENST00000543493.1 AAGTAGTTCTGATGGGAATCTACCTGTGAAGTTAAAGGGCAGGTGCCCTATCCAGGCCTA ***** * * **** * * ********* *************** ** **** ENST00000253686.2 GTGCCATTACCCAAGGAGATGAGGGGGAAGTACAAAGCCGCTCTGAAAGCCGATGCCCAG ENST00000543493.1 ATGGCATTA-----GGAGACGACAGGGAAGTACAAAGCAACACTGAAAGCCAGTGCCTAG ** ***** ***** ** ************** * ********* **** ** ENST00000253686.2 GACTAAGGCCCACGGTCACTGTGGGCTGGGGTGATGGTGTCTGACCAGTGGGGAGATTGG ENST00000543493.1 CAGTAAGGTCCAAGGACACTATGGGCTAGGGTAAT----------------------TGA * ***** *** ** **** ****** **** ** ** ENST00000253686.2 AATGGGATTACTTTGGCC-CAGGGAAGCCCCTGGTTCTGTCCCTGGAGACTCTGGAAATC ENST00000543493.1 TATGGGGTTACCTTGGTCACAGAAAAGCCCCTGGTTCTG--------GAC---------- ***** **** **** * *** *************** *** ENST00000253686.2 CTTTTGCATTAAAAGGACTTTACACACCTGTGTAAAAGGATGTGGGAGAGGAGGGTCTGA ENST00000543493.1 -------------AGG------------TGTG---------GTGG-----------CTCA *** **** **** ** * ENST00000253686.2 AGCTGAGCTGCTAAATGAATATCCCTGCTCTGCTGGTCAATAAAACGCTTCCTAATAGCA ENST00000543493.1 CGC----CTG-TAA-------TCCC-------------------------------AGCA ** *** *** **** **** ENST00000253686.2 GCTTGGCGTGTATCTGGTCCTAGTGAAGAGGAAGGCCTGTGTAGCAGAAAGGCTTTGGGC ENST00000543493.1 CTTTGG-------------------GAGGCCGAGGCCAGTG------GATAACTTGAGGT **** ** ***** *** * *** ** ENST00000253686.2 CTGAGAGGTTAAGGCCACAGCCTGTTGACACCTGTTTTGGTCCTGCGACCCTTTACTGGT ENST00000543493.1 CAG-GAGTTCAAGACC--AGCCTGG------CCAATGTGGT-----GACCCC------GT * * *** * *** ** ****** * * **** ***** ** ENST00000253686.2 CTCCGCTGGCTTTGAATCTTCCTCTGGGCTCTACTCTGGAGAACATAAGGGCTGCTGTGG ENST00000543493.1 CTCTACTA-------------------------------AAAATACAAAAA--------- *** ** * ** * ** ENST00000253686.2 TTGAGTCTGGCTAGCACTGTCTGTGGTTGGCAGTGTGTACACCCCTCCGTTCAGTTCCTT ENST00000543493.1 TTAGGCATGG-------------TGGTGGGCA-CCTGTA-ATCC-------TAACTACTT ** * *** **** **** **** * ** * * *** ENST00000253686.2 GGGGGTATTTTTCAGAAATCCAAAGGCAACCCTTCGTGCAGTGCTCACTTTTTTAAGTAC ENST00000543493.1 GGGAGGCT-------GAGGCCGGAG--AAC-----------TGCT--------TGAACCC *** * * * ** ** *** **** * * * ENST00000253686.2 AGTTGATTACCCTTGCCTGCTGGGGGGCCTAGCCATGGGCCAGAGATGGAGGAGCCCCAG ENST00000543493.1 GGAGAATTGCTT------------GAACCCGG----------GAGGTGGAG--GTTACAG * *** * * ** * *** ***** * *** ENST00000253686.2 TGGCTGACAGGCCAGCCTCACTCAGGCACGTACCTGCTGACCAGTCAGCCACTGCCAACC ENST00000543493.1 TG-----------AGC-------AGAGAT-----TGT----------GCCATTGC--ACT ** *** ** * ** **** *** ** ENST00000253686.2 CATGGCCCAGCCACTGTGTGCATTAGCAGGGAGGTTTGTAGGCCATGGAGGAAATGAGGA ENST00000543493.1 C------CAGC--CTGGGTGACAGAGCAAGACTGTCT------CA-AAAAGAAAGAAAAA * **** *** *** **** * ** * ** * **** * * ENST00000253686.2 GACACCACCTAGTGGAGACATTGGGGCCCTGCTGGGGGGATGGTGTCTATAGCTGGCTCT ENST00000543493.1 GATGACGACTC-TGGAAATGT-----CTTTGCA---------------ATAAAAGGGTCC ** * ** **** * * * *** *** ** ** ENST00000253686.2 GCTGGCTCCCTCAGGCCCTGCTTACCAAGCTCTGGAGGAGGGAGTGCTGCATTACTGAGC ENST00000543493.1 CCCCCCCACTTTACACATTATGTAAAATGACACAGGGGAAAGAGTA-TATAAAACTGAGC * * * * * * * ** * * * *** **** * * ******* ENST00000253686.2 ACCTTCCTTGTTCTTTCCTCATAGGACACTGATGTTACTGTCACTTTAGTTATGCTAAAG ENST00000543493.1 ----------------------------------------------------TGCTAAA- ******* ENST00000253686.2 TGGAGGTTTCAGCCTCCAGAAGACAGCAGAGCCTTCTAGGGTCACCTTAAGAATAGGTTT ENST00000543493.1 TGAATATCCCTGTTCCATCAGGTCAACAAAATGCTT---------CTTAA---------T ** * * * * * * * ** ** * * ***** * ENST00000253686.2 AGCTAGGCTGGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGATGTGG ENST00000543493.1 GGCCAGGCAAGGTG-----GCTCACGCCCGTAATCCTGGGACTTTAGGAGGCCAAGGTGG ** **** **** ***** *** ******* * ***** ****** * **** ENST00000253686.2 GCGGATAGTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACATGGCAAGACCTTGTCTC ENST00000543493.1 GAAGATCACTGAGGTTAGGAGTTTGAGACCAGCCTGGTCTCTACTAAAAAA--------- * *** **** ******* ************* * * ** * ENST00000253686.2 TACAAAAAGTACAAAAATTAGATGGGTGTGGTGTTTCGCGTCTGTAGTCCCAGCTATTTG ENST00000543493.1 AAAAGCAAAAACAAAAATTAGCTAGGCATGGTGGTGCCTGCCTGTAATCCCAGCTACTCA * * ** *********** * ** ***** * * * ***** ********* * ENST00000253686.2 GGAAGCTGAGGTGGGAGGATC--TCGAGCCTGCGAGATCAAGGCTGCA----GTGAATCA ENST00000543493.1 GGAAGCTGAGCCACCAGAATCACTTGAACCTGGGAGGCGGAGGTTGCATGCAATGAGCCA ********** ** *** * ** **** *** *** **** *** ** ENST00000253686.2 TGATCGTGCGCTACTGCACTCCAGCCTGGGCCACAGAGCAAGACT--GTCTCAAGAAAAA ENST00000543493.1 AGATCGTGC-CT-CTGCACTCCAGCCTGGGCACTAAAGCGAGACTCCATCTCAAAAAAAA ******** ** ****************** * *** ***** ****** ***** ENST00000253686.2 AAATTTTTTAAATAAGTTTAATTATAAAGTGAAGGACCAGTTGGACCACGGACCCCTAGA ENST00000543493.1 TAA------AAATAAATTTAA-------------------------------------AA ** ****** ***** * ENST00000253686.2 AACTCAGCCAAGGAGACCTGACTTTATCTGAGACAGGAAGGCAGTGGTTAAAAGAATTAA ENST00000543493.1 AATT----------------------------------------------------TTAA ** * **** ENST00000253686.2 AAAAGGACAGTGGTGCTTGACAGAGCAGGACTGAAGTTTTCATTCCTCTACCTGCTGGGG ENST00000543493.1 AAA-----------GCTT------------------------------------------ *** **** ENST00000253686.2 CCTTGGTCAAGTCCTAAAAGCTTTCCAGGTCTGTAACTGGTTTTGTCTGTAAAATGGGGA ENST00000543493.1 -CTTAATCA-------------TTCCA-----------------------AAAAT----A *** *** ***** ***** * ENST00000253686.2 AAAGGTTACCTTTTCTGCCACATGAAGTAGCTGGCTGGTGAAATGATGTCATACTACGAT ENST00000543493.1 AAAA---------------ACA------------------AAGTGACGT----------- *** *** ** *** ** ENST00000253686.2 GTGTTTCATTAACTGTTGGAGATTATCACATTAAATTGAGCAGATTTGGATCTTTTACAT ENST00000543493.1 ---------------------------------------ACAGATT-------------- ****** ENST00000253686.2 TTGATGCTCAAGTTTGATTCTGTACCAGATCTGGGTTTGGGGTGATGGCTTGTCGGGGGT ENST00000543493.1 --------CAAG---------GCA----ATCCG--------------------------- **** * * *** * ENST00000253686.2 GGGAGGGGAAGGTGGGCAGAGACTGATGTATAATGGACAGGTGTTCCTTGAGTGACAGAC ENST00000543493.1 ----------------------------TATAA-------GAGTTCC------------- ***** * ***** ENST00000253686.2 TTACAAAGGGAGTGTTTAATTGAAATCTAGCATCTTGTCTCTCTGCTATCAGCATTTTGG ENST00000543493.1 -----AAGAGCATATTTTATAGAAAT---------------------------------- *** * * *** ** ***** ENST00000253686.2 CTGGGTGGAAAAAGCTCTCCTCCACAGAGAGCCCTCCCATGTCTGCTGGTTTCAGTTCCC ENST00000543493.1 ------AGAAAAA----------ACAAA-------------------------------- ****** *** * ENST00000253686.2 CACCCAACTGACTGAAGTCTTGACCTTGATACCACCTGCCTGGGCGTTCTACTTGGCTGC ENST00000543493.1 ----------ACT----------------------------------------------- *** ENST00000253686.2 AAGGGCTCTTCAGAAAGCACCTAGTTCCTTTTGGCTTTCATCTGCAGTGTAGGTCTCCAT ENST00000543493.1 -----------AGAA---------------------TTTACATGGAAT------------ **** ** * ** * * ENST00000253686.2 AGCTAGTGACACACAAAGCCTTATGAGAGTATTCCTTCCCTCTAGGGCCCAAAGAGGCTG ENST00000543493.1 ---------CACAAAAGGCCCT-------------------------------------- **** ** *** * ENST00000253686.2 CTAACCAGCAGGAATGTCCTGAACCAAAAGGAGTGGTGACCATTCTCTAGACAGAATAAA ENST00000543493.1 -----------GAAT------AGCCAAAA------------------------------- **** * ****** ENST00000253686.2 TGTCTGGTCCCTAATGGGACAGATAACTAGGGTTTGAGTTCAGGCTTGACACAGGAGCAA ENST00000543493.1 ------------------------------------------------------------ ENST00000253686.2 TGGGCAGTGAGGTGGACAGCCCAGACCCTGAAAGGACGTGTGGAGACAGCAGCAGTCCTG ENST00000543493.1 ----------------CAATCCAGA----GAAAG-------------AGCAA-------- ** ***** ***** **** ENST00000253686.2 TGGTGCAGTTACTGCCTGTGTGGCCAGCTTCACAGGCAGCAGATAATTTGTGGAAATAAA ENST00000543493.1 -------------------------AGCT----------------------GGA------ **** *** ENST00000253686.2 CATTATTTTCTTTTTTTGTTCCCTGTAGGCTACTTGATCCTGGATAGTTTCTCTTTAAAC ENST00000543493.1 -----------------------TGTA--CCAC-------------------------AC **** * ** ** ENST00000253686.2 CTTTGTCTTTCCCTATTTTGTTTAGTAGTGATGAAAGATGGGTTTAAAATATACAGAAAT ENST00000543493.1 --------TTCC-----------------------AGAT---TTCAAAATATATTTTAAT **** **** ** ******** *** ENST00000253686.2 GGGAGAAAATTAATTAGAGAAAATGTGAGGATTTTATAATTGATAACATGTTCTTAATTT ENST00000543493.1 ------------ATTACAG----TGTGAAAACAGTATGGT-------------------- **** ** ***** * *** * ENST00000253686.2 TACTTGCACAAGCAGTGTTCACAGCCTTATTCTGAAGTGACCACTTTTCTTCTCTTTGAG ENST00000543493.1 -ACTAGCAAAAG--------ACAGACATAT------------------------------ *** *** *** **** * *** ENST00000253686.2 GCACTACCTGGCAGCACCATCTAAACCTGTATCATCTGCTGTGGTCCCAGTTACTCAGGA ENST00000543493.1 -------------------------------------------ATCCTAGCTACTTGGGA *** ** **** *** ENST00000253686.2 GGCTGAGGCAGGAGGATCACTTGAGCCCAGGAGGTTGAGGCTGGAGTGAGCCATGACTGT ENST00000543493.1 GGCAGAGGCAGAAGGATTCTTTGAGTCCAGGCGTTTGTAGTTGCTGTGAACTATGATGGT *** ******* ***** ***** ***** * *** * ** **** * **** ** ENST00000253686.2 ACCACTGCATTCCAGCCTGGGTGACGGAGTGAGGCCCTATCTGCCTGCCAGTGAGTTCTG ENST00000543493.1 GCCACTGCACTTGAGTCTGGACAACAGAGTGAGACCCTCTCTCTTT-----TAAGA---- ******** * ** **** ** ******* **** *** * * ** ENST00000253686.2 TCATGCATCAGACTT-TGGACCTCAGAATTTTCACCTGGAACATGAGAGGTCAGATGACA ENST00000543493.1 --------CAGACATATAAACC----AAT--------GGAACA---------AAATAGAA ***** * * *** *** ****** * ** * ENST00000253686.2 TAATGAATATGTTCTAACTTCTGAAACTTTTGGAGCTTGTTTTTGCCCTTGATAGCACGT ENST00000543493.1 TT-TGAAAAT----CAACTCCTGTA-----TACAGTCAACT---GATCTT--CAACAAGG * **** ** **** *** * * ** * * *** * ** * ENST00000253686.2 ATCCTTAGAGAATAAGCTTGCCAATTTAAGGCCTGTCTGTAATGGCATCTGAATGTTCCA ENST00000543493.1 GTACTAAGAATACA-------CAATGGGGAAC--------AATA--ATCT-----CTCCA * ** *** * * **** * *** **** **** ENST00000253686.2 GCAGCCTAACTGTGCTCTGCTCCAGAAACATGTGTGTGGCTTCCCTACCTCCACACCAAG ENST00000543493.1 A-----TAATGGTGC--TGGT---AAAAC-------TGGAT-----ATCTACGTGCAAAA *** **** ** * **** *** * * ** * * ** ENST00000253686.2 GAGCTGCCTTGCTGGGTGGATGTAAAGACTGTCCTGCCAGGGTTTCCCACTAAAGGTATT ENST00000543493.1 GAA---------------AACG---AGACCCTT--------ATCTTACACAAAA------ ** * * **** * * * *** *** ENST00000253686.2 AATAAGTCCAGTGGACCACAGAGGGCCCAATCCCTCTTGGCCGCTAAGGCTAAGGTAGGA ENST00000543493.1 -ATCAACTCAATGTATTAAAGA-------------CTTTATATGTAAGTCT--------- ** * ** ** * * *** *** **** ** ENST00000253686.2 GCCAGAGAGCTGTAGAGACAGGACCACCAGGATGCTTCATGTCCATAACACAAGAGAGCG ENST00000543493.1 -CCAAA---CTG------CAAAACTAGAAGAA--------------AACATAGGAGAA-- *** * *** ** ** * ** * **** * **** ENST00000253686.2 CTGCATTGTTTGGGGGCCAGGCATTACTACTATCATGAAGAAAAATGAAGAGCAGGATGC ENST00000543493.1 ------------------AAGCTT----------------------------CAAGATGC * ** * ** ***** ENST00000253686.2 ATGTTAGTCTTTAATTCACTTTTAATAGTATAAACCTCATTTAGGTAGTAGTATTAAGCC ENST00000543493.1 ----TGGTCTTTGA---------AAT------GATTTCATT--GATA-TCACGAAAAGCT * ****** * *** * ***** * ** * **** ENST00000253686.2 ACAACAATAATGCCACATTGAAACAGCATTTAATAAAATGCATAAAGCTAATTCATGCAC ENST00000543493.1 ACATTAGTGGGGCTACATTGAA-------TTAA----------GAAGCT---TC-TGCAC *** * * ** ******** **** ***** ** ***** ENST00000253686.2 TGCAA--TACTCTATATACAAACACAACAATGCAAATTCTTCTTCAAGA-CTGAAGACAT ENST00000543493.1 CATAAAGTAAGCAATCAACAGA-GCAGAAAGGCAA---CCTCTGGAATAGCTAAAGA--- ** ** * ** *** * ** ** **** * *** ** * ** **** ENST00000253686.2 TGATTAGATATAAAATTCAGTTTAAAAAGAACATGCTATTTTTTAAATGCCATCACATAA ENST00000543493.1 --ATGGGAGA--AAAT---ATTTGCAAA-------CCATTT----------ATCTGATAA ** ** * **** *** *** * **** *** **** ENST00000253686.2 ACAAAGTGATTTCACAGGGAGAAGAAAGCTGTATAAAGCTGCAGCTTTCAACAGGTTTTA ENST00000543493.1 G-GGGTTAATTTCTAACATATAAAAAAACT--------------CCTCTAA-----TTCA * ***** * * ** *** ** * * ** ** * ENST00000253686.2 AACCTGGCATTAAAATGTAATGGCAAAACCAATATTTTCTATATTGTGAAGGGCAAAGG- ENST00000543493.1 A---TAGCAA-AAAACTTAATAACTTGATTAG--------AAAATG----GGGTAAAGAC * * *** **** **** * * * * * ** *** **** ENST00000253686.2 TTACAGAAACGGTCCCAAGAAAATCTAACACCCAAATTTTCCTTTGATAGATAGATGCCT ENST00000543493.1 TTGAATAGACTTCTCCAAATA-----------CAAA--------TGGTTAACAGGTG--T ** * * ** **** * **** ** * * ** ** * ENST00000253686.2 TTAAAAGGGCTGGTAATGC-AGTTACATTCTAACAGAGAAGTCCAAACTACAGGTAAAAA ENST00000543493.1 ATGAAAAAACAAACATCACTAATCATA-------AGGGAAATGCAAATCA-------AAA * *** * * * * * * * ** *** * **** * *** ENST00000253686.2 CTACGGCTTGTACTGTGAAAAATGTGCAGCTTTTCAGTTATAAAACTAGTTGAACACTGG ENST00000543493.1 CCACA---------ATGAGATAT---CA-CCTCACACCTGTTAGAATGGCTA-------- * ** *** * ** ** * * ** * * * * * * * ENST00000253686.2 TTTACAAGATAATCCGTAGAACAGAGAGACTGTAGAAAAATATTCCAGCACTTGA-GTTG ENST00000543493.1 -TTACAAAAAAAT----------GAAAGACAGCA----AGTGTT--GG----TGACATTG ****** * *** ** **** * * * * ** * *** *** ENST00000253686.2 TGTGTGGCAGCAGCATTTGAGTCCATGAATGCTATGGTCATTAAAATAATTGATTATACT ENST00000543493.1 TG-------GAAAAACTGGAACCC-----TGCTAC----------ACAACTGAT------ ** * * * * ** ** ***** * ** **** ENST00000253686.2 TTCCTAAAGAAAAGCCATTTTTTAATGCAAAGTCTACTACTTCCAAATGTTATTCCAAAC ENST00000543493.1 -------GGAAATGCAAAAT---GGTGTATAG-CCACTAT----AGA---------AAAT **** ** * * ** * ** * **** * * *** ENST00000253686.2 ATTAAATTTTAACAGTCTATCAATCAATAAATGTTGAACATTTTT ENST00000543493.1 AGTAAGAT------GTTTCT---TCAAAAAA--TTAAAAA----- * *** * ** * * **** *** ** ** *