CLUSTAL 2.1 multiple sequence alignment ENST00000253815.2 GCTTCGCAGCGTCACGCCCTCCGGGGCCGTGGCGGCGACGGCGGTGCGTAGCTTACTCAC ENST00000440519.1 --------ATGTAAC------TGAAGCAG----ATTAATAA-GGAATTTAGGTTTTTT-- ** ** * ** * * ** *** ** * ENST00000253815.2 AGGGGCGGCCCGTATCCCTCCGCCGCCG-GCGCGGCTCGGCCCTC---CCTCCCCTGGCC ENST00000440519.1 -------GTCCTTGGCCCTCTAGCACAGTGTTCTGTTGGATGTGATAGCTTTCATTGGCA * ** * ***** * * * * * * * * * * * **** ENST00000253815.2 CGC--CAATCCCCGCGCCTCC---CGACCTGCCCCTCGGTCGGGCCCACCCCGTGCTCCG ENST00000440519.1 GGCTACAATTATAGGACCTCATTACAGCCTGTATCAAGGT-GGGTGTGTTCT---TCTTG ** **** * **** * **** * *** *** * * ENST00000253815.2 ACGGCCCCACCCCGGCGGCGCAGCCCGCCCGCCCGCGCGTCCCTCGGTC-CACCTGCAGC ENST00000440519.1 ACAGTTCATTTTCA----TTCAGACTACTCCTTCAAACCACCTAAGGTTGCATTTATTAC ** * * * *** * * * * * ** *** ** * * ENST00000253815.2 AGGGAGGAAGACAGGCAATCCCTCCGGCTGTCCGACCAAGAGAGGCCGGCCGAGCCCGAG ENST00000440519.1 AAGAATTTAT-CATCCAAACATTTAAGTAATGAGACCATTGGTC-TCAGT--ATTCTAAG * * * * ** *** * * * * ***** * * * * * ** ENST00000253815.2 GCT----TGGGCTTTTGCTTT----CTGGCGGAGGGATCT--GCGGCGGTTTAGGAGGCG ENST00000440519.1 ATCACTGTGGTCTTCTGCTTTAACATTTTTGAAGTTATTTTTACATCAATTTGTT----- *** *** ****** * * ** ** * * * *** ENST00000253815.2 GCGCTGATCCTGGGAGGAAGAGGCAGCTACGGCGGCGGCGGCGGTGGCGGCTAGGGCGGC ENST00000440519.1 -CACTG-TTATGTGATCCAAATCCAGAAACCCCC----TAGTGCTAGAGATT---GCAAG * *** * ** ** * * *** ** * * * * * * * ** ENST00000253815.2 GGCGAATAAAGGGGCCGCCGCCGGGTGATGCGGTGACCGCTGCGGCAGGCCCAGGAGCTG ENST00000440519.1 GACCTATAAAA----------CAGACAAAATAATAAC------AGAATGTTTTGGA---- * * ***** * * * * ** * * * *** ENST00000253815.2 AGTGGGCCCCGGCCCTCAGCCCGTCCCGCCGGACCCGCTTTCCTCAACTCTCCATCTTCT ENST00000440519.1 AATAGACTGAGA-----AGTACATCATACAA----TGCTTCCTTAAAGTCAGAAT----- * * * * * ** * ** * **** * * ** ** ** ENST00000253815.2 CCTGCCGACCGAGATCGCCGAGGCGGCCTCAGGCTCCCTAGCCCCTTCCCCGTCCCTTCC ENST00000440519.1 ------AACCTGCATTAT---AACTGTAATAAACTTTATTGTTCCTACTTTGATTTTCTT *** ** * * * ** * * *** * * * ENST00000253815.2 CCGCCCCCGTCCCCGCCCCGGGGGCCGCCGCCACCCGCCTCCCACCATGGCTCTGAAGAG ENST00000440519.1 ATGCAGCTGCTCCC-------------CTATCA--TACCTC-----ATCGTTTTAATTAT ** * * *** * ** **** ** * * * * * ENST00000253815.2 AATCCACAAGCTCCCTCCACAAAACCGCCTGAGCTCGGGCTGACAGAGGAAGCCGTTTTG ENST00000440519.1 --TTTTTAGTCTCCCTCCATTCAGTCACATG--CT-----TATCAGAGAA---------- * * ********* * * * ** ** * ***** * ENST00000253815.2 CCCGATCCACAAGTATATCCTGAGTTCACTTACCTCTTGGGTGGCAGCACACATCGGTCC ENST00000440519.1 ----------------TTCTTAAGTTC--TTACAGCTTTGG--ACAATA----------- ** * ***** **** *** ** ** * ENST00000253815.2 ACCCTGCTTGTCCAGAAACTGTTAAG-AGTTGGAAGTTCAGAAGAAAAAAAAAAGGAATT ENST00000440519.1 ACT----TCTTTTAGAAACTATAAACTAGTTACAAG---GGAAAAGTTACTCAAG--ATT ** * * ******* * ** **** *** *** * * *** *** ENST00000253815.2 GAATGATCTGGCACGGGACCCTCCAGCACAGTGTTCAGCAGGTCCTGTTGGAGATGATAT ENST00000440519.1 CAGAAATTTGAAAA----------AATGGAATAT---GTGTATTATGT---GACCAATGT * ** ** * * * * * * * *** ** * ENST00000253815.2 GTTCCATTGGCAAGCTACAATAATGGGGCCAAATGACAGTCCCTATCAGGGTGGAGTATT ENST00000440519.1 CTTCACTTTAC---CT-TAGTA-TGAGACTAAA--ACGATTCCT------------CACT *** ** * ** * ** ** * * *** ** * *** * * ENST00000253815.2 TTTCTTGACAATTCATTTCCCAACAGATTACCCCTTCAAACCACCTAAGGTTGCATTTAC ENST00000440519.1 GCTCT-AACA------TGCTGAAGAAATCATCT------GCGGGGGAGGGAGACAGATAC *** *** * * ** * ** * * * * ** ** *** ENST00000253815.2 AACAAGAATTTATCATCCA-AATATTAACAGTAATGGCAGCATTTGTCTTGATATTCTAC ENST00000440519.1 ------------TCAGCTATAATATCAA-AGAAA--GCAGCATT---------ACTC--- *** * * ***** ** ** ** ******** * ** ENST00000253815.2 GATCACAGTGGTCTCCAGCACTAACTATTTCAAAAGTACTCTTGTCCATCTGTTCTCTG- ENST00000440519.1 ------AGCAGTATCCATC------CATGTTTAAA---CTTTTCACCGTTAGAAATTTGA ** ** **** * ** * *** ** ** ** * * * ** ENST00000253815.2 --TTGTGTGAT---CCCAATCCAGATGATCCTTTAGTGCCTGAG--ATTGC--TCGGATC ENST00000440519.1 GGTTGCGTGGTATACTTTATGCTCATAACCATT--GTGGCTGGAGAATTGGCATTGAATT *** *** * * ** * ** * * ** *** *** **** * * ** ENST00000253815.2 TACAAAACAGATAGAGAAAAGTACAACAGAATAGCTCGGGAATGGACTCAGAAGTATGCG ENST00000440519.1 TACAACATCAGCAGA----------ACAGAAAATGT----GATGTATTT-----TATGC- ***** * *** ****** * * *** * * ***** ENST00000253815.2 ATGTAATTAAAGAAATTATTGGATAAC-CTCTACAAATAAAGATAGGGGAACTCTGAAAG ENST00000440519.1 ATGTCAATAAAGTAATGACCTGTTCTTGTTCTACAGA---AAATAGAAGAA----AAAAG **** * ***** *** * * * ****** * * **** *** **** ENST00000253815.2 AG--AAAGTCCTTTTGATTTCCATTTGACTGCTTTCTATGAGCCCA-CGCCT-CATCTTC ENST00000440519.1 TTCCAAAGTTTCTATG--TTTAATTGTTCTGGTGAACA-GAGATTATCTTCTACATATTT ***** * ** ** *** *** * * *** * * ** *** ** ENST00000253815.2 CCCTGTGCACATGTTTACCTGATACAGCAGTGCTGCGTGTT-GTACATACTTGGAACAAC ENST00000440519.1 TCCAGGGCAC----TTATTTCA-ACAGGAAT--CAAATATTAGCCCCCACT-GGAACTTC ** * **** *** * * **** * * * ** * * *** ***** * ENST00000253815.2 AAACTAGAAATACTGTACTTCTGTACCAACATTGCCTCCTAGCAGAGAAGTGTGTGTGTG ENST00000440519.1 AAAC-ATGAATGCT-TATTTAAGCCCCAATGTA--CTTTTAATAGGAA--------TATA **** * *** ** ** ** * **** * ** ** ** * * * ENST00000253815.2 ACAAGCCAGTTCTACAGGCATTACCTAGGTGTGAGACTAAAAGCTTTTCTTATTGACTTA ENST00000440519.1 AAAGG---------CAAATATTAT-TAAACACAGGA--AAA------TCATA-------A * * * ** **** ** ** *** ** ** * ENST00000253815.2 AATTTGGATAACAGCAAGGTGTGAGGGGGGTGGTGGGTATGGTGTGTGCTTGGATGGGAA ENST00000440519.1 GGTCTAGAT----GCATG-TGTTTAGAGACTCGTGG---TAATGT-TGCTTTATTCTGA- * * *** *** * *** * * * **** * *** ***** * ** ENST00000253815.2 AGAAAAGGCTCCACT-CACCTATAGGAGATTAT---TTTTAAGTGGAATCCATTTAAACT ENST00000440519.1 -------GTTTTACTGCAGATCTGAAAGGTGATCTATTGTGGAAAAAAAACACAAAAAAC * * *** ** * * ** * ** ** * ** ** *** ENST00000253815.2 CAAAACAGTTA-TGAAAAG--CAAGG---TGAAGAACATGAAGCTGTGTCTGTATTCATT ENST00000440519.1 CTGTACCTTTAGTGGAAAGATCAATGACATGAAGTCAATAAACCCATGTTCTCATTTGTA * ** *** ** **** *** * ***** ** ** * *** *** * ENST00000253815.2 TTATTCCGAAGGAGCTACGTCTTAGGTGAAAGTTATGACCAACCAGATTAAACTCTACCC ENST00000440519.1 TCATACCCCATGACTTGTGCCTTTGG-GTAAGTTAC-----------TTAATTTGCACCT * ** ** * ** * * *** ** * ****** **** * *** ENST00000253815.2 ACATCCTGCATTTTAAGGTCTAAGTTTAACTGGTCAACATTTAAATGGATTGGAGCTATT ENST00000440519.1 -CAGTTTCCAGATCAA---TAAAATATAGTTG-TTGACATGCTATT---TT----CTAAC ** * ** * ** ** * ** ** * **** * * ** *** ENST00000253815.2 A-GTACATCAAGTGTGATGGGCTTTGTTCCCAACTCTTTTACATCTCCCTACCCCTTCAA ENST00000440519.1 ACATACATCCAGTT-------CTTTGTC-----CTGTGGTGGG-------AAAATGTGAA * ****** *** ****** ** * * * * ** ENST00000253815.2 CCTTTGGCCT-TTCAGCCCTTCTTTCTCTCTTCCATATTCTTTGGTTTGTATGTGGTTTC ENST00000440519.1 CTTTTGACAAATCCAGGTTTTAATCCTGATT---ATATTCCTTATCACCAAT-------C * **** * * *** ** * ** * ****** ** ** * ENST00000253815.2 TCAGTTAATACATAGCTAATAGCTCTTATTTTTCTTATGTTTTTAACCGCTTAGGTCTAT ENST00000440519.1 ACATTAGACCAATGATTAATATCTTTTATT---CTCA-GTTTCT-----------TCTCT ** * * ** ***** ** ***** ** * **** * *** * ENST00000253815.2 TTGGATGTAAGGGTGAAAAT-TCATTTGATGGAAATACTTGTGTATATTTAAAGACCCAA ENST00000440519.1 CT--ATAAAATGGGAATAATATTATCTGA--------CTTCTAGA-ATTGTAGAGTTTAA * ** ** ** * *** * ** *** *** * * *** * ** ENST00000253815.2 TTGCTCCTCTGGAGCTTGTACTTTCAAGAATGATTAATCTGTGTAATAAACTGGTTACTA ENST00000440519.1 TT----------AGGTAATATATGTAA-----AGTAA---ATGGCATAAATTAGGCACTA ** ** * ** * ** * *** ** ***** * * **** ENST00000253815.2 CA-GTCATTACATATAATTT-TGTGTGAATAGGCTTTTTCATTTTTAAGAAGTT------ ENST00000440519.1 TATATTTGTATACATAATATACACATATATA---TTTGTTATCTTTATGTTGTTACTCTT * * ** * ***** * * *** *** * ** **** * *** ENST00000253815.2 TGTCTAG----CTGAGATTAGTGGTGGATTTTCTCCCACTTCTGAAATGTTCAT--TTAT ENST00000440519.1 TTTCTATAATTCTAAGAT-AGATATACTTTTTCTTGAAATGATGTGATAGTCACAGCCAT * **** ** **** ** * ****** * * ** ** *** ** ENST00000253815.2 ACTGGTTG-CATTTTAAGATCATGAAACAATTCC--AGTTACATTGTAAAAAGGA--TAT ENST00000440519.1 A-TAACTGTCACTTTTATACTAT---ACTATTCTTTAGTTAAATAATGAAGATGAAACAC * * ** ** *** * * ** ** **** ***** ** * ** * ** * ENST00000253815.2 CTTACGAGTAATTTTATTGAACAAGTTAGAGGCATAAGCTTAAGAGCATTTCCATGAAAC ENST00000440519.1 CTAGCAACTGGGGATATTTTTCAAGTTA-----ATAA-----------TTTCTACGGACC ** * * * **** ******* **** **** * * * * ENST00000253815.2 AA---CACATGCAGCATTCCAGGAACTTGATTGTTAAATTCAATAAGAAATTTGCTTTAT ENST00000440519.1 TAGGTCAGAGAAATCTTTCT--CAGCTGAGCTAATAAA---AGCAAGGAATTAGTCTCAC * ** * * * *** * ** * **** * *** **** * * * ENST00000253815.2 TAATGAAACTAAGCTGCATTTCATCAAAACCTTGTGACATTCCCTTGGTACATAGGACAT ENST00000440519.1 TCAT------AGGTGGGAATTGAACAA-------TGAGA--------ACACAT-GGACAC * ** * * * * ** * *** *** * **** ***** ENST00000253815.2 AAAACACAGAGGCATTGCTATTTGGTAAGTTAAGCTTCTGTGATTGTAATTATAAAAGAG ENST00000440519.1 AGGA-AGGGGAACATCACACTCTGGGTACTG----TTGTGGGGTTGGGG----GAGGGAG * * * * *** * * *** * * ** ** * *** * *** ENST00000253815.2 CAACATTGACCAAACCTGGGAAACAAGAGCACAGTCTTGTTTGGAGAGTCTACATAATTA ENST00000440519.1 GGGGGTTAGCA----TTGGGAGATATA--CCTAATGCTAGATGACGAGT-TA-GTGGTTG ** * ***** * * * * * * ** **** ** * ** ENST00000253815.2 CTTTGCACTAACATTTGCAGGATGTTCACACAATT--TTAAATTGTAC--TGT----ATG ENST00000440519.1 CAGCGCACCAGCATG-GCAC-ATGTATACATATGTAACTAACCTGCACATTGTGCACATG * **** * *** *** **** *** * * *** ** ** *** *** ENST00000253815.2 TGGCTT----TTTGAAGTCTTCCCTTGACCCTAGTAAAATATAGCTTGAAACTTGTAAAC ENST00000440519.1 TACCCTAAAACTTAAAGTATGATAATAATA--AATAAAA-ATAAATAAATAAAAGCAAGG * * * ** **** * * * * ***** *** * * * * ** ENST00000253815.2 AACTGTGTTTGCCAG-AAACA--TCATT-CA-TGTGAACTAGGCAAGTTACCTTTTTTCC ENST00000440519.1 AATTGACT---CCAGTAAACAGTTCATTGCAGCATTAA-TAG--AAATTAATTGACTGCC ** ** * **** ***** ***** ** * ** *** ** *** * * ** ENST00000253815.2 CCCCTTCTTTTCCTAATTGTAAACTAGGCCAACCTGAAAGCCATGGCTGATGCTCTAGCC ENST00000440519.1 AGGCTTCTCT--------GCACAC----CCAA----AATACCATCACCAATATCAT-GCT ***** * * * ** **** ** **** * ** * ** ENST00000253815.2 ATCAGGTTCTTTCAAATGCATCTTTACACTCTTGCA--CAAAAGTTAAGGAATAAATGTC ENST00000440519.1 ATGGATTACAATGACAAGCACTATAAGGTATTGGTAAGTACAATCTGAGGA--------C ** * * * * * *** * * * * * * ** * **** * ENST00000253815.2 CACTGCTTTTGGTTTT ENST00000440519.1 CA-TGCA--------- ** ***