CLUSTAL 2.1 multiple sequence alignment ENST00000290158.3 CTCCCTCGCTCCCTCCCTGCGCGCCGCCTCTCACTCACAGCCTCCCTTCCTTCTTTCTCC ENST00000427009.1 ---ATTGACCACATTGCTG-GAGATGAGGATCATACAGA--------------------- * * * * *** * * * *** ** * ENST00000290158.3 CTCCGCCTCCCGAGCACCAGC--GCGCT-CTGAGCTGCCCCCAGGGTCCCTCCCCCGCCG ENST00000427009.1 ---------CGGAGTAGTAGCTTGTGCTGCTGGACTAA---TAGGGGACTTATAT----- * *** * *** * *** *** ** **** * * ENST00000290158.3 CCAGCAGCCCATTTGGAGGGAGGAAGTAAGGGAAG-AGGAGAGGAAGGGGAGCCGGACCG ENST00000427009.1 ---ACAG--CATTTGG--GAAGGATGTACTGAAACTAGTAGA--------AGCTAGGCCA *** ******* * **** *** * ** ** *** *** * ** ENST00000290158.3 ACTACCCAGACAGAGCCGGTGAATGGGTTTGTGGTGACCCCCGCCCCCCACCCCACCCTC ENST00000427009.1 CTGATCCA-----------TGAAT-------TGTTAACT--------------------- * *** ***** ** * ** ENST00000290158.3 CCTTCCCACCCGACCCCCAACCCCCATCCCCAGTTCGAGCCGCCGCCCGAAAGGCCGGGC ENST00000427009.1 ------------------------------------------------GAACGGCGGAG- *** *** * * ENST00000290158.3 CGTCGTCTTAGGAGGAGTCGCCGCCGCCGCCACCTCCGCCATGGAGCTGATCACCATTCT ENST00000427009.1 -ATCG----AAGACGA------------------------ACAAAGC------------- *** * ** ** * *** ENST00000290158.3 CGAGAAGACCGTGTCTCCCGATCGGCTGGAGCTGGAAGCGGCGCAGAAGTTCCTGGAGCG ENST00000427009.1 --AAAAACCCTTGCTACACG----------------GGCAACAAAAGAATTCAAGAAAC- * ** ** ** * ** ** * * * *** * * * ENST00000290158.3 TGCGGCCGTGGAGAACCTGCCCACTTTCCTTGTGGAACTGTCCAGAGTGCTGGCAAATCC ENST00000427009.1 --------TGAAGGACCAA---GCTT--------GATCTGTT---ACCACTGG------- ** ** *** *** ** **** * **** ENST00000290158.3 AGGAAACAGTCAGGTTGCCAGAGTTGCAGCTGGTCTACAAATCAAGAACTCTTTGACATC ENST00000427009.1 -GATGATAACCTG------AGGACCCCCACTGG-----AAATCTCCAATCTTTTGA---- * * * * * ** * **** ***** ** ***** ENST00000290158.3 TAAAGATCCAGATATCAAGGCACAATATCAGCAGAGGTGGCTTGCTATTGATGCTAATGC ENST00000427009.1 --AAAACCTGGA-----------AGTG-----AGGAGTG---TGC-ATGGATGCTGA--- ** * * ** * * ** *** *** ** ****** * ENST00000290158.3 TCGACGAGAAGTCAAGAACTATGTTTTGCAGACATTGGGTACAGAAACTTACCGGCCTAG ENST00000427009.1 --------------------ATGTTT----------GGGAATGAGA-------GGATGAG ****** *** * * ** ** ENST00000290158.3 TTCTGCCTCACAGTGTGTGGCTGGTATTGCTTGTGCAGAGATCCCAGTAAACCAGTGGCC ENST00000427009.1 T-----------GAGTGAGGCT-----------TGAAAACACACCA------CATTGA-- * * *** **** ** * * * *** ** ** ENST00000290158.3 AGAACTCATTCCTCAGCTGGTGGCCAATGTCACAAACCCCAACAGCACAGAGCACATGAA ENST00000427009.1 --AAATCCTGCCACAGC-AGCAGCCGCAGCCGCCGCCGCCAACAGCA------------- ** ** * ** **** * *** * * * * ********* ENST00000290158.3 GGAGTCGACATTGGAAGCCATCGGTTATATTTGCCAAGATATAGACCCAGAGCAGCTACA ENST00000427009.1 -------GCACTG-------TCAGTGA-----GCTAAG---TAAGCACTGA----CTTCG ** ** ** ** * ** *** ** * * ** ** * ENST00000290158.3 AGATAAATCCAATGAGATTCTGACTGCCATAATCCAGGGGATGAGGAAAGAAGAGCCTAG ENST00000427009.1 TAGAAAACC--ATAACATT--GGCT------ATCTTGGAAAAGAGAAAA----------- *** * ** * *** * ** *** ** * *** *** ENST00000290158.3 TAATAATGTGAAGCTAGCTGCTACGAATGCACTCCTGAACTCATTGGAGTTCACCAAAGC ENST00000427009.1 --ACAATG--GAGTTA-----------------------CTTATAAAA-------AAAGA * **** ** ** ** ** * **** ENST00000290158.3 AAACTTTGATAAAGAGTCTGAAAGGCACTTTATTATGCAGGTGGTCTGTGAAGCCACACA ENST00000427009.1 AGA----AAGAAAGAA----AAAGAAA----------------------GAA-------- * * * ***** **** * *** ENST00000290158.3 GTGTCCAGATACGAGGGTACGAGTGGCTGCTTTACAGAATCTGGTGAAGATAATGTCCTT ENST00000427009.1 ------AGAAA-GAGAGAAAGAGCG--------AAAGAA-------AAGAGAA------- *** * *** * * *** * * **** **** ** ENST00000290158.3 ATATTATCAGTACATGGAGACATATATGGGTCCTGCTCTTTTTGCAATCACAATCGAAGC ENST00000427009.1 --------AAGAAAAGAAAAAAGAAAAG----CTA-TCTCTTCCCAG------------- * * * * * * * * * * ** *** ** ** ENST00000290158.3 AATGAAAAGTGACATTGATGAGGTGGCTTTACAAGGGATAGAATTCTGGTCCAATGTCTG ENST00000427009.1 ---GAGAGGCTA-------GAAGTAGTTTTTCT-------GTCTTTTGG-CCGGTGCC-- ** * * * ** ** * *** * * ** *** ** ** * ENST00000290158.3 TGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCC ENST00000427009.1 --------GAGTGGAAT--GCC--TG--GTTTCGGGGA----GGAGGAGGGAC------- * **** * *** ** * *** * * ** * **** ENST00000290158.3 TGAGCACACCAGCAA-GTTTTAT-GCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTC ENST00000427009.1 TGGGTTCAGCTGTGGTGCTTTGTTGTAAAAGG-------CAGC--CTGG-------CCTT ** * ** * * * *** * * ** ** *** **** *** ENST00000290158.3 ACACAGACACTAACTAAACAGGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAA ENST00000427009.1 -------TGCTA-CTGAGGAGAAAGA-------------------TGGAGCC-------- *** ** * ** * ** **** ** ENST00000290158.3 GCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACAT ENST00000427009.1 ----------TGGGTCTCAAGC------CCACCTTCTCTGTA------------------ ** * **** ** ****** ** ** * ENST00000290158.3 GTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCA ENST00000427009.1 -------CCTTTGC-------CACA-----------------CGGTACTGT--------- **** **** ****** * ENST00000290158.3 GTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTT ENST00000427009.1 ---ATGCTTGCCGGCTAGA----AGGAGGGTGAGGG-----------------ATT--TT *** * ** * * * *** ** * * * ** ENST00000290158.3 ATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGAT ENST00000427009.1 TTACAGTCTG-------------AGAATGAGTG-----------------TGTGTGAG-- ***** ** ***** * ** *** *** ENST00000290158.3 ACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGAT ENST00000427009.1 -----TG----------AGGCGGTAT-------CCACATTCTCAAGTT-----CAA---- ** **** * ** * * * ** *** * *** ENST00000290158.3 GTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTG ENST00000427009.1 GTC--------------ATTACAGTTTCTTTTT------------------CCCAGA--- *** ****** *** ** ****** ENST00000290158.3 GCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGAC ENST00000427009.1 -----AAACAAG----GGGTT-----------------------------------AGAT *** * *** * *** ENST00000290158.3 GTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATA ENST00000427009.1 GTTGC--AT--------------------------------TTCATAAAACGAACCCA-A ***** ** *** * * **** ** * ENST00000290158.3 GTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGT ENST00000427009.1 GTTCTG-----TCTA----------------CTGGTG-----CAGCACAA---GAG---- **** * *** *** ** *** **** *** ENST00000290158.3 TCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCT ENST00000427009.1 ------------------ATGTAAA----AAAAAACAA----AAAAA------------- *** *** ******* ** * ENST00000290158.3 GTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCA ENST00000427009.1 ----AAAAAAC----------ACAGAGGAAAGAC--------GCTCTTTAG-----GTTT * ***** * **** *** * **** ** ** ENST00000290158.3 CATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCT-GTGC ENST00000427009.1 TGTTTTT--------TTCGTT-----TTGTTTTGTTTTTTTTTTTTTTTTACTCTAGGGA * * * ** * ** * ** * ******** * * ENST00000290158.3 AACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGT ENST00000427009.1 AACACTGACGAATGGTC-----AGAGCTCC-TATCCTGAT-CTTTTCAG----------- *** ** ***** ** * ** * *** *** **** *** ENST00000290158.3 GGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGA ENST00000427009.1 ---TAAGGCGCCTTTCCTAA-----TACTATGGTTCAACTGTGAATGTAGAAGTG-AGGG ** *** * * *** * * * * ** *** * ** * *** * * ENST00000290158.3 GGATGCCCTGATGGCAGTTAGCACACTGGTGGAAGTGTTGGGTGGTGAATTCCTCAAGTA ENST00000427009.1 GGA------------------------------------GGGGGGAGAA----------- *** *** ** *** ENST00000290158.3 CATGGAGGCCTTTAAACCCTTCCTGGGCATTGGATTAAAAAATTATGCTGAATACCAGGT ENST00000427009.1 ---AAAGA-----AAACTCT-----GGCGTTAGA---------------GAATA------ ** **** ** *** ** ** ***** ENST00000290158.3 TTGTTTGGCAGCTGTGGGCTTAGTGGGAGACTTGTGCCGTGCCCTGCAATCCAACATCAT ENST00000427009.1 ----TAGAAAAATGTAAG--------------------------TACAAT---------- * * * *** * * **** ENST00000290158.3 ACCTTTCTGTGACGAGGTGATGCAGCTGCTTCTGGAAAATTTGGGGAATGAGAACGTCCA ENST00000427009.1 -------TGTTACAAA-TAGCGCAG--ACTTC---AAAA--------ACAAAAAAGTC-A *** ** * * **** **** **** * * ** *** * ENST00000290158.3 CAGGTCTGTGAAGCCGCAGATTCTGTCAGTGTTTGGTGATATTGCCCTTGCTATTGGAGG ENST00000427009.1 CAAACC----AAACCA-AAATT---TAAATGATCAGA---------------ATTGG--- ** * ** ** * *** * * ** * * ***** ENST00000290158.3 AGAGTTTAAAAAATACTTAGAGGTTGTATTGAATACTCTTCAGCAGGCCTCCCAAGCCCA ENST00000427009.1 -CAGCACAAAGAA------------------AACGCCCT---------CTCCT------- ** *** ** ** * ** **** ENST00000290158.3 GGTGGACAAGTCAGACTATGACATGGTGGATTATCTGAATGAGCTAAGGGAAAGCTGCTT ENST00000427009.1 ----GACTTGT---ATTTTGGCA---------GTCTGAACGCCCCCAG--AAAATTAC-- *** ** * * ** ** ****** * * ** *** * * ENST00000290158.3 GGAAGCCTATACTGGAATCGTCCAGGGATTAAAGGGGGATCAGGAGAACGTACACCCGGA ENST00000427009.1 ----GCC-------------------------AAAGAGTTTAGAAAAATATACA-----A *** * * * * ** * ** **** * ENST00000290158.3 TGTGATGCTGGTACAACCCAGAGTAGAATTTATTCTGTCTTTCATTGACCACATTGCTGG ENST00000427009.1 TA-----------------AAAGTAAA---------------CA-----CACA------- * * **** * ** **** ENST00000290158.3 AGATGAGGATCACACAGATGGAGTAGTAGCTTGTGCTGCTGGACTAATAGGGGACTTATG ENST00000427009.1 ----------CATACACACAAAACAGCAAACT------TCAGA-TAAC------------ ** *** * * ** * * ** *** ENST00000290158.3 TACAGCATTTGGGAAGGATGTACTGAAATTAGTAGAAGCTAGGCCAATGATCCATGAATT ENST00000427009.1 TAC----TTTGG---------ATTGCAAACAGGATAAATTA----AATGTTCAAACAAT- *** ***** * ** ** ** * ** ** **** ** * *** ENST00000290158.3 GTTAACTGAAGGGCGGAGATCGAAGACTAACAAAGCAAAAACCCTTGCTACATGGGCAAC ENST00000427009.1 --------------------------CTGATAAAATAA---------CCATTTGGA---- ** * *** ** * * *** ENST00000290158.3 AAAAGAACTGAGGAAACTGAAGAACCAAGCTTGATCTGTTACCATTGGGATGATAACCTG ENST00000427009.1 -----AACTGGAAAAA---AAAAAT--------GTGTAGCACCTCC----------CCCG ***** *** ** ** * * *** ** * ENST00000290158.3 AGGACCCCCACTGGAAATCTCCCATCTTTTGAAAAACCTGGAAGTGAGGAGTGTGCACGG ENST00000427009.1 -----CCCCGCTTG----CTCCTGC---TCCAGCCAC---------AGAAGTGCCTCCTT **** ** * **** * * ** ** **** * ENST00000290158.3 ATGCTGAATGTTTGGGAATGAGAGGATGAGTGAGTGAGGCTTGAAAACACACCACATTGA ENST00000427009.1 CCCCTTCACCTTCGGCCAT-------TG------------TTGAAAGTTCCC-----TGA ** * ** ** ** ** ****** * * *** ENST00000290158.3 AAATCCTGCCACAGCAGCAGCCGCAGCCGCCAACAGCAGCGCTGTTAGTGAGCTAAGTAA ENST00000427009.1 GG--CCTCCC----CAGAAGCCA-----------AGCAGTGCT----------------A *** ** *** **** ***** *** * ENST00000290158.3 GCACTG-ACTTCGTAGAAAACCATAACATCGGCCATCTTGGAAAAGAGAAAAACAATGGA ENST00000427009.1 GCATCATGCTTC--------CTGTA--------CAGCTTGAAGAACTGTGAGCCAATCAA *** **** * ** ** **** * ** * * **** * ENST00000290158.3 GTTACTTATTTAAAAAAAAAGAAAGAAAGTTATCTCTTCCCAGGAGAGGCTAGAAGTAGC ENST00000427009.1 ACCTCTTTTCTTTATAAA-----------TTATCCAGTCGCAGG------TA-------- *** * * * *** ***** ** **** ** ENST00000290158.3 TTTTCTGTCTTTTGGCCAGTGCCGAGTGGAATGCCTGGTTTGGGGGAGGAGGAGGGACTG ENST00000427009.1 -TTTCT---TTATAGC-------------AATGC--------------AAGAACAGACTA ***** ** * ** ***** ** * **** ENST00000290158.3 G-GTTCAGCTGTGGTGCTTTGTTGTAAAAGGCAGCCTGGCCTTTGCTACTGAGGAGAAAG ENST00000427009.1 ATGCACAGACCAAACAAAATATTAAACCAGGCA----------------TGGAGAACCAG * *** * ** * ***** ** ** ** ENST00000290158.3 ATGGAGCCTGGGTCTCAAGCCCACCTTCGCTGTACCTTTGCCACATGGTACTGTATGCTT ENST00000427009.1 ACAGAAGATAAAT------------TCTGTAGAAAC-------CAGAGTACTGA------ * ** * * * * * * * ** ****** ENST00000290158.3 GCCAGCTAGAAGGAGGGTCAGGGATTTTTTACAGTCTGAGAATGAGTGTGTGTGAGTGAG ENST00000427009.1 ---AACCAGAAGGA----CATTG--TTCTTATA--CCAGAAATG---GTTTGCCAGAAAA * * ******* ** * ** *** * * **** ** ** ** * ENST00000290158.3 GCGGTATCCACATTTTCAACTTCAAGTCATTGCAGTTTCTTTTTCCCAGAAAACAAGGGG ENST00000427009.1 ACA--------------------AAGTC-------TTCTGTCATCCCAGGA--------- * ***** ** * ****** * ENST00000290158.3 TTAGATGTTGCATTTCATAAAACTAACCGAAGTTTTGTTTACTGATGCAGCACAAGAGAT ENST00000427009.1 -CAGATG--------------------CAAAGTTCT--TTATTGAGGTGGCCTTATA-AC ***** * ***** * *** *** * ** * * * ENST00000290158.3 GTAAAAAAAAAAAAAAAAAAAAAAAAAAAAACACACACACAGAGGAAAGACGCTCTTTAG ENST00000427009.1 CAAATCAGAACATGAATAAAATAAAAAAGAACTCAC---CAAAGACAGGGAGTCC----- ** * ** * ** **** ****** *** *** ** ** * * * * ENST00000290158.3 GTTTTGTTTTGTTTTTTTTTTTTGGTTTTGTTTTTTGTTTTTTTTACTCTAGGGAAAACA ENST00000427009.1 -------------------------------------------------------AAAAA *** * ENST00000290158.3 CTGACGAATGGTCAGAGCTCCTATCCTGATCTTTTCATCAAGGCGCCTTTCCTAATAATA ENST00000427009.1 CT--CGA--------------------GAT----TCACCAGGGCA-----------GAAA ** *** *** *** ** *** * * ENST00000290158.3 TGGTTCAACTGTGAATGTAGAAGTGGGGGGGAGGGGGGAGAAAAAGAAAACTCTGGCGTT ENST00000427009.1 AGGT--AACTG-----ACAGAAGCAGAGTGCAAAGAG-------------CTCAGGTGGT *** ***** ***** * * * * * * *** ** * * ENST00000290158.3 AGAGGATATAGAAAAATATAAGTACAATTGTTACAAATAACGCAGACTTCAAAAACAAAA ENST00000427009.1 AC--------------------CACACTTG---------------ATTCCGGAGCCAC-- * *** *** * * * * ** ENST00000290158.3 AAATCACAACCCAAACAAACCAAAATTTAAATGATCAGAATTGGCAGCACAAAGAAAACG ENST00000427009.1 ------CAACCCATTCAAGCTGA------------------------------------G ******* *** * * * ENST00000290158.3 CCCTCTCCTGACTTGTATTGTGGCAGTCTGAACGCCCCCAGAAAATTGTGCCAAAGAGTT ENST00000427009.1 CTCACTTCAGTCC----------CACTCGAGACACC--------ATTTTGTCAAA----C * * ** * * * ** ** ** ** *** ** **** ENST00000290158.3 TAGAAAAATAAATATACAATAAAAGTAAACACATACACACAAAACAGCAAACTTCAGGTA ENST00000427009.1 TAAGAAA-------TACAG--AGGG---------ACACTCTAAA-----AATT------- ** *** **** * * **** * *** ** * ENST00000290158.3 ACTATTTTGGATTGCAAACAGGATAAATTA-AATGTTCAAACAATCTGATAAAATAACCA ENST00000427009.1 -CTGCTT---ATTGGAAACAGAGCA--TTGCAATGGGGATATG-TGTGCCATAGTAACTA ** ** **** ****** * ** **** * * * ** * * **** * ENST00000290158.3 TTTGG----- ENST00000427009.1 TGTGTGTATT * **