CLUSTAL 2.1 multiple sequence alignment ENST00000296702.5 ACGTCGGGTCGGCGGGTGGATGAACGCGGCCCTCTGTAATGGCGGAGCGTGGCGGGGACG ENST00000447458.1 ---------CTGAGGGTTGTT-------------------------------CGGGTAC- * * **** * * **** ** ENST00000296702.5 GGGGCGAGAGTGAACGATTCAACCCGGGGGAGCTCAGGATGGCCCAACAGCAGGCCTTGA ENST00000447458.1 ----------------ATTCTTCACATGTG---TCA---TGGTTTGATAG-AGGACT--- **** * * * * *** *** * ** *** ** ENST00000296702.5 GGTTCCGAGGTCCGGCTCCCCCACCAAATGCAGTGATGCGAGGCCCACCACCTCTGATGC ENST00000447458.1 ---------------------CATCAAA------------AAGATCACCAC------TGG ** **** * * ****** ** ENST00000296702.5 GACCTCCTCCACCTTTTGGTATGATGCGAGGCCCTCCTCCACCACCACGGCCGCCCTTTG ENST00000447458.1 GAAT--CTAGATCTTT-GTTGGAGAGGGAAG------------AGAAAGA---------- ** ** * **** * * * ** * * * * ENST00000296702.5 GACGTCCTCCTTTTGATCCTAATATGC-CGCCAATGCCTCCTCCAGGAGGGATACCTCCA ENST00000447458.1 GAAG-------------CTTAATGAGCACATTGAAGCACTTACCAGAAAGAAGA------ ** * * **** ** * * ** **** * * * * ENST00000296702.5 CCTATGGGCCCTCCACACCTCCAGAGACCACCTTTCATGCCTCCTCCCATGAGTTCCATG ENST00000447458.1 -----GGG---------------AAGACT------------------------------- *** **** ENST00000296702.5 CCTCCTCCTCCGGGTATGATGTTTCCACCAGGAATGCCTCCTGTGACTGCTCCTGGTACT ENST00000447458.1 --------TCTGGAT---------------GAAA---CCTCTGTGA---------GTACC ** ** * * ** * ****** **** ENST00000296702.5 CCAGCACTACCTCCTACGGAGGAGATATGGGTTGAAAATAAAACTCCAGATGGGAAGGTT ENST00000447458.1 TTAACAT------CCACGTGGAAGAAGTAAAAAAAAAATAAGATTCTGGGTGG---AGTT * ** * *** * *** * ******* * ** * *** *** ENST00000296702.5 TATTATTATAATGCTCGGACACGTGAATCTGCATGGACCAAGCCAGATGGAGTTAAGGTT ENST00000447458.1 C--TCCTCCAATG-----ACAGGAAAA---------AACAA---AGATAATTTGAAGAAT * * **** *** * ** * *** **** * *** * ENST00000296702.5 ATTCAGCAATCAGAACTGACACCTATGCTTGCAGCCCAGGCACAGGTTCAGGCTCAGGCC ENST00000447458.1 AT------GTCAGA---GACAAATATA-TTACAACCAAAGT-TGACTTCAGG-----GCA ** ***** **** *** ** ** ** * * ****** ** ENST00000296702.5 CAGGCGCAGGCTCAGGCCCAGGCGCAGGCTCAGGCCCAGGCACAAGCTCAGGCCCAGGCT ENST00000447458.1 CTTTTGAAGG----AGACCAAATATA---TAA----CAAACA-GAGCTAAG----AAGCT * * *** * *** * * * ** ** **** ** * *** ENST00000296702.5 CAGGCTCAGGCCCAGGCCCAGGCCCAGGCCCAGGCCCAGGCCCAAGCCCAAGCCCAGGCC ENST00000447458.1 -AATCTAAGAATCTGACCAACACCTGAA---AGATGTAGAC--------AA---CA---- * ** ** * * ** * ** ** ** * ** ** ENST00000296702.5 CAGGCTCAGGCTCAGGCACAAGCTCAGGCCCAGGCCCAGGCTCAGGTCCAGGCCCAGGTC ENST00000447458.1 -----TTTTGCAGAATGATAAA-TAGTATCCAGTACTGAACT---GT----GCCTGAGGA * ** * * ** * **** * ** ** *** * ENST00000296702.5 CAGGCACAAGTGCAAGCACAAGCAGTTGGAGCTTCCACCCCTACGACCAGTAGCCCAGCA ENST00000447458.1 AAGGCATAAAC-TGAATGTGGAT-GTTG--------------ATGACCTGGA-------- ***** ** * **** * **** * * ENST00000296702.5 CCTGCAGTATCCACTTCAACATCATCATCCACCCCTTCCTCTACCACTTCTACCACAACA ENST00000447458.1 -CTG-----------------TCAGGGTCCACCTCTACCTCC------------------ *** *** ****** ** **** ENST00000296702.5 ACTGCTACTTCAGTTGCGCAGACAGTATCAACACCCACAACACAAGATCAGACCCCAAGT ENST00000447458.1 ----------CAG----------AGCCTCGGAGCCCACAAGACAAAAT-AATTCTCAA-- *** ** ** ******* **** ** * * *** ENST00000296702.5 TCTGCTGTTTCAGTTGCCACGCCTACAGTTAGTGTTTCAACTCCTGCTCCTACAGCCACA ENST00000447458.1 --TACTGTTCCA-TTG----GGGTA-ATCTACTAATTTAACA--TGCTTC---------- * ***** ** *** * ** * ** * ** *** **** * ENST00000296702.5 CCTGTGCAAACCGTTCCCCAGCCGCACCCTCAGACGTTACCTCCTGCTGTTCCTCATTCA ENST00000447458.1 CCTG---------------AGCCA-ATTTTCAGG----------------TTTTTATGTA **** **** * **** * * ** * ENST00000296702.5 GTACCTCAGCCAACAACAGCAATACCTGCTTTTCCACCAGTAATGGTACCTCCGTTTCGT ENST00000447458.1 G-----------ATA--AGTATTAGCTGACCTATTGCAA--AATGAT------------- * * * ** * ** *** * * * **** * ENST00000296702.5 GTTCCCCTTCCTGGCATGCCAATTCCACTTCCAGGTGTAGCAATGATGCAAATAGTCAGC ENST00000447458.1 ----------CTGACA----AA---------CAGGAGAAGCATT--TGTGA--------- *** ** ** **** * **** * ** * ENST00000296702.5 TGCCCGTATGTAAAGACAGTCGCTACCACCAAGACCGGTGTATTGCCAGGAATGGCCCCT ENST00000447458.1 ----CGTTTCTGAACAGAG-----------AACACT------TTG---GAAATA--TTTT *** * * ** * ** ** ** *** * *** * ENST00000296702.5 CCTATCGTACCCATGATACATCCCCAGGTTGCTATTGCAGCTTCACCTGCTACCTTAGCT ENST00000447458.1 TCT-TTGT----ATGACAT-------GATTGATA---------CAC--------TCAAAT ** * ** **** * * *** ** *** * * * ENST00000296702.5 GGAGCAACAGCAGTTTCTGAATGGACTGAATATAAAACAGCAGATGGGAAGACATATTAT ENST00000447458.1 ACAG-----GCTATCTCT------AGTAAATCTAAAA--------------------TCT ** ** * *** * * *** ***** * * ENST00000296702.5 TATAATAATAGAACATTAGAATCAACCTGGGAAAAACCCCAAGAACTAAAGGAAAAAGAA ENST00000447458.1 T---------GAA-ACTAAAATCATCCT-----------------TTTATGGGTATAGAA * *** * ** ***** *** * * ** * **** ENST00000296702.5 AAGTTAGAAGAGAAGATTAAAGAGCCAATTAAAGAACCCTCTGAAGAGCCTCTGCCAATG ENST00000447458.1 --GTCAG------------------TGATTTAATAATGCTCT-------TCCTAACAGTG ** ** *** ** ** **** ** ** ** ENST00000296702.5 GAGACGGAGGAGGAGGATCCTAAAGAAGAGCCTATAAAGGAGATAAAGGAGGAGCCCAAA ENST00000447458.1 GTG-TGCATAGAAAGGTTTTCATCAAAGAGCATATGTGGTTTGCATTTGCAAGATGCAAA * * * * *** * * ****** *** * * * **** ENST00000296702.5 GAAGAGGAGATGACTGAAGAAGAAAAGGCTGCCCAGAAGGCAAAGCCAGTTGCTACTGCT ENST00000447458.1 T---AGCAGACTCC-----AAGAAAA-----CCTA------------AGTTGCT------ ** *** * ******* ** * ******* ENST00000296702.5 CCTATTCCTGGTACTCCATGGTGTGTCGTTTGGACTGGTGATGAGCGGGTCTTCTTTTAT ENST00000447458.1 ----TTTTTGGTTCTTTGT------TTGTTTG-----------------TTTTGTTTTGT ** **** ** * * ***** * ** **** * ENST00000296702.5 AATCCCACCACTCGTCTTTCTATGTGGGACCGACCTGATGATCTGATTGGCAGGGCAGAT ENST00000447458.1 ----------------TTTTTA-GCAGGTAAGGCCAGGTGCAGTGGCTTAT---GCTGAG *** ** * ** * ** * ** ** * ** ** ENST00000296702.5 GTTGACAAAATTATTCAGGAGCCCCCTCATAAAAAAGGAATGGAGGAATTGAAGAAACTA ENST00000447458.1 GT-GGGAGGATTGCTT--GAGCCC-------------------AGGAGTTTGAGAA---- ** * * *** * ****** **** ** **** ENST00000296702.5 AGGCACCCAACTCCGACAATGCTGTCGATCCAAAAGTGGCAATTCTCTATGAGTGCAATT ENST00000447458.1 -------CAGCCTGGGCAATATAGTGGGACC-----CTGC----CTCTACAAA-ACA-TT ** * * **** ** * ** ** ***** * ** ** ENST00000296702.5 AAAGAGGAACAAGAATTAATGGAAGAAATTAATGAAGATGAGCCTGTTAAAGCAAAAAAA ENST00000447458.1 AAA---------AAATTAGCTGCGCAAGGTGAC----ATGTGCCTGT------------- *** ***** * ** * * *** ****** ENST00000296702.5 CGGAAGAGAGACGATAATAAAGACATTGACTCAGAGAAAGAAGCTGCCATGGAAGCTGAA ENST00000447458.1 ------------------AATTCCAGCTACTCAG-----GAGGCTGAGATGGGA----AG ** ** ****** ** **** **** * * ENST00000296702.5 ATTAAAGCTGCCCGAGAAAGGGCCATTGTCCCTCTGGAGGCTCGAATGAAGCAGTTCAAG ENST00000447458.1 ATTGCATTTATCCCAGGAGG--------------TTGAGGCTGCACTGAG-----CCATG *** * * ** ** * * * ****** * *** ** * ENST00000296702.5 GACATGCTGCTAGAGAGAGGGGTGTCTGCTTTTTCAACGTGGGAGAAGGAGTTGCACAAG ENST00000447458.1 AACATGCCACTGCA-----------------CTTCAGCCTGGGAACAGAG------CAAG ****** ** * **** * ***** ** **** ENST00000296702.5 ATAGTTTTTGATCCCCGGTACTTACTTCTCAATCCTAAAGAGAGAAAACAGGTGTTTGAT ENST00000447458.1 -----------TCCC----------TCCTTCACCCCA----------------------- **** * ** * ** * ENST00000296702.5 CAGTATGTAAAGACCAGGGCAGAGGAAGAACGCAGGGAAAAGAAAAATAAAATAATGCAA ENST00000447458.1 -------------CCA---------------------AAAAAAAAAGGAAAACACTG--- *** **** **** **** * ** ENST00000296702.5 GCCAAGGAAGATTTCAAAAAAATGATGGAAGAAGCAAAATTTAATCCAA-GAGCA-ACTT ENST00000447458.1 -------ACAATTT---AATAATC-TGTCAGAGGCAAAAATTACTTTAATGGACATGCTT * **** ** *** ** *** ****** *** * ** * ** *** ENST00000296702.5 TTAGTGAATTTGCAGCCAAGCATGCTAAAGATTCAAGATTCAAAGCAATTGAAAAGATGA ENST00000447458.1 TTA-----CCTTCATCT-------CTAAAGA-------------ACAATTTAA------- *** * ** * ******* ***** ** ENST00000296702.5 AAGACCGAGAAGCCTTGTTTAATGAGTTTGTGGCCGCTGCTAGGAAGAAAGAGAAAGAAG ENST00000447458.1 -------------TTTGTTCA-----CTTACA-----TGCT------------------- ***** * ** **** ENST00000296702.5 ATTCGAAGACCAGAGGTGAGAAGATTAAATCGGATTTCTTTGAACTATTATCTAATCATC ENST00000447458.1 -TT-----AC--------------TTA--TC----CCCTCTAAATTATAG---------- ** ** *** ** ** * ** *** ENST00000296702.5 ACTTGGACAGTCAGTCTCGATGGAGCAAAGTAAAAGACAAAGTAGAAAGTGATCCACGTT ENST00000447458.1 ---------GCCAATCTTGTTGGT-TAACATAAGGGAT--------------------TT * ** *** * *** ** *** ** ** ENST00000296702.5 ACAAAGCAGTAGATAGTTCATCAATGAGAGAAGACCTTTTCAAACAGTACATTGAAAAAA ENST00000447458.1 ATTTAGCAGT------TTC-----------------TTCTCGGGTA------TGGAGCCA * ****** *** ** ** * ** * * ENST00000296702.5 TAGCCAAGAATTTAGACTCAGAAAAAGAAAAGGAGCTTGAAAGGCAAGCCCGCATTGAGG ENST00000447458.1 TGGTCA-----TTA-----------------------------------------TGAAG * * ** *** *** * ENST00000296702.5 CAAGCCTTCGAGAACGAGAAAGGGAGGTTCAAAAGGCCCGTTCAGAACAAACAAAAGAAA ENST00000447458.1 TTGGTCT----GAA--------------TCCAACTGCCAGT------------------- * ** *** ** ** *** ** ENST00000296702.5 TAGATCGAGAGAGAGAGCAGCACAAACGAGAAGAAGCTATCCAGAATTTCAAAGCTCTTC ENST00000447458.1 --GATTTTTATGGAGG--------AATGAAAAAA-------CAAAA---CAAAACT---- *** * *** ** ** ** * ** ** **** ** ENST00000296702.5 TGTCTGACATGGTACGTTCTTCAGATGTGTCATGGTCTGATACTCGTAGGACCCTCCGAA ENST00000447458.1 TG-CTGATGAAACACACTTT----ATTCATCATG------------------------AA ** **** ** * * ** ***** ** ENST00000296702.5 AAGATCACCGCTGGGAATCTGGATCCTTATTGGAAAGAGAGGAGAAAGAGAAGCTTTTTA ENST00000447458.1 GCAATCTTTGTCAGTACTCTGGATT--------------AGAAAACAAATTACTTTCTGG *** * * * ******* ** * * * * * ** * ENST00000296702.5 ATGAACACATTGAAGCACTTACCAAAAAAAAGAGAGAGCACTTTAGGCAACTTCTGGATG ENST00000447458.1 ATG---------------TTTCCTGAAAA-----------CTGT-----ACTTCTGTTTG *** ** ** **** ** * ******* ** ENST00000296702.5 AAACTTCTGCAATTACCTTAACATCCACGTGGAAAGAAGTAAAAAAAATCATTAAGGAAG ENST00000447458.1 AACGTT----AA--ACTTTAGTTCCTA---------AAGT-----------TTAAG---- ** ** ** ** *** * * **** ***** ENST00000296702.5 ATCCTCGATGTATTAAGTTCTCCTCCAGTGACAGGAAAAAACAAAGAGAATTTGAAGAAT ENST00000447458.1 -------ATGT----------------------------------------TTGAA---- **** ***** ENST00000296702.5 ATATCAGAGACAAATATATCACAGCCAAAGCTGACTTCAGGACGCTTTTGAAAGAGACCA ENST00000447458.1 -TGTCAG---------------------------TTT----ATGTATTTGAACCATAATA * **** ** * * ****** * * * ENST00000296702.5 AATTTATAACATATAGATCCAAAAAATTAATCCAAGAATCAGATCAGCACCTGAAAGATG ENST00000447458.1 AATTGATAATTT-TATATTTAAAAAATT----TAAGTA-CAGA--AGC-TTTGTA----G **** **** * ** ** ******** *** * **** *** ** * * ENST00000296702.5 TAGAAAAAATTTTACAGAATGACAAACGGTATCTAGTACTGGACTGTGTGCCAGAGGAGA ENST00000447458.1 CAAAAAAAA------AAAAAAAAAGACCAAATCTA------------------------- * ****** * ** * * ** ***** ENST00000296702.5 GGCGTAAACTGATTGTGGCATATGTTGATGACCTGGATCGCCGGGGTCCACCCCCACCTC ENST00000447458.1 ---------------------------------TGAATCATTGA----------CACTCC ** *** * *** * ENST00000296702.5 CCACAGCATCGGAGCCCACGAGACGATCAACAAAATAATTCTAAATACTC-TTCCATAGG ENST00000447458.1 TGAAAGGGTAGAGG-----GAAA-----AACAAA-CAACTTGGAAAACACATTTCA---G * ** * * * ** * ****** ** * ** ** * ** ** * ENST00000296702.5 GGCATCTATTCAA-AATGCTTGCATGAGCCAATTTTCAGGTTTTTACATATATGTGCATT ENST00000447458.1 GATATC-ATCCAGGAAAACTTCC-----CCAACC---------TTGC-TAGAGAGACAAC * *** ** ** ** *** * **** ** * ** * ** ENST00000296702.5 AGTCAACCTATTGCGAAACCATCTGACAAACAGAAGGAGAAGCATTTGTGAACAGTTTCT ENST00000447458.1 AGAGAAC----TGCAAGATTA-----CACACAA---GAAAATCATCCC------------ ** *** *** * * * ** *** ** ** *** ENST00000296702.5 GAACAGAACACTTTGGAAATATTTATGCTTTTCTTTGTGTGGCATGACTGACATACATAC ENST00000447458.1 ---CAAGACACTT----AATCACCA-GATTTTC---------CAAGATTAAAATG----- ** ****** *** * * ***** ** ** * * ** ENST00000296702.5 TCAAATATAGGCTGTCTCTAGTAAATCTTAAAATCTTGAAGCTAAAATTCATCCTTTTAT ENST00000447458.1 --AAAGGAAGAATG------GTAAATGT-----------AGCTAGA-------------- *** ** ** ****** * ***** * ENST00000296702.5 GAGGTGTGGAAGTCAGTGACTTGGTGACGTTCTTCCTAGCAGTGTTAATACATGCAAGAA ENST00000447458.1 GAGA----AAGGTCA-------------------------AGT-----CACCTACAA-AG *** * **** *** ** * *** * ENST00000296702.5 GTAAGAGCATTTGTGGCTTGAACTTGCCAGATGCAAATACCACAGACTCCAAGAAAACCC ENST00000447458.1 GAAACACCATCAGT---------TTAACAG---CAGATGTCTCAG-CT----GAAATCCT * ** * *** ** ** *** ** ** * *** ** **** ** ENST00000296702.5 GAGTTGGGGTTTGTTTTGTTTTGATTTTTTTTTTTTAAAGCGGGTAAAAGAGAAAACACT ENST00000447458.1 G----------------------------------CAA----GGCAGAAGAGA------- * ** ** * ****** ENST00000296702.5 GAAAATTGAATTCTTATCTTCCAGAGGCTACAATTATTATAATGGACAATACTTTTACCT ENST00000447458.1 -------------------TTTGGAGCCCA----TATT--------CAACATTC------ * *** * * **** *** * * ENST00000296702.5 TTGTCTCTAAAGATCAGATTAGTTTTATTTGTTCACTTACGTGCTTTGATTATCCCCTCT ENST00000447458.1 ------CTAAAGA--AAAAAAATCTT-------CAACCAAGAATTTC--TTATCCAGCC- ******* * * * * ** ** * * ** ****** * ENST00000296702.5 GAATTATAGACCGAGTCTTGTTGTTTAGCCTAAGAGAAGATTTATGTAGTAATTTCTTCT ENST00000447458.1 -------AAACTAAGTTT----------CCTAAGTGGAGG---AGATA-TAAGATCCTTT * ** *** * ****** * ** * ** *** ** * * ENST00000296702.5 CAGGTATGGAACCACGGTCATAACTAACATGTTGGCCAGAATAGAACCACTGGTTAAACA ENST00000447458.1 CAGATAAGCAA-----------------ATGTTGA-------GGGA-----GGTT----- *** ** * ** ****** * * **** ENST00000296702.5 TATTTTATTCACCATTAAGTGATCTTTATCAATATTCTGGATTAGACAACAAATTACCTT ENST00000447458.1 -------TTTACCACCAGAC----------------CTGCCTTA--CAAGAGAT---CTC ** **** * *** *** *** * ** ** ENST00000296702.5 TCTGGGTGTTTCTTGTAAACTATACTCCTGTTTGAATGTTAAACTTTGTTGCTAAAGTTT ENST00000447458.1 TTTG--------TTATCAA----AGTTCCATTT-AGCAAGATACTTT-----------TT * ** ** * ** * * * *** * * ***** ** ENST00000296702.5 AATTTTAAGATGTTTGAATGTTCAGTTTATGTATTTGAACTACAATAAACCAACCCTTTT ENST00000447458.1 ACCCTTGAAA-------ATACTAGGTTTCT-CATTTG--CTA-AATGCAATGACCCTTT- * ** * * ** * **** * ***** *** *** * ******* ENST00000296702.5 TATATATCTGTATTGTATATGATTATTGTTACTTAATTTTTAAGAGCTTATTTTAACCTG ENST00000447458.1 ---------------------AGTCTTCT--CTTCAT-----AAATCTTGTTTT------ * * ** * *** ** * * *** **** ENST00000296702.5 TTTTTAAAAGCAGCAAATAGAATTTCCCACAAAGTAAGTTGACTCTAAATCTTAAGTATT ENST00000447458.1 -TTTCA-------TAAAT-----------CAAGGGAGGGAGATGCC------TAAATATT *** * **** *** * * * ** * *** **** ENST00000296702.5 ACCTAGTTTTTAAAGGTTTGAATATAATAATGCAGTATTTGCAGTATAAAAAGGAAGGAA ENST00000447458.1 -------CTTTAATGGT---------------CACCTCTCCCACTATCACA--------- ***** *** ** * ** *** * * ENST00000296702.5 TTTGTAGAGAATCATTTTGGTGCTCAAGTCTCTTAGCAGTGCCTTATTGCCTCATAGCAA ENST00000447458.1 TTT--------TTCTCTCTGTCATCCACTTTGATATTAGT-TCAAATAGCCCTGTA---- *** * * * ** ** * * * ** *** * ** *** ** ENST00000296702.5 GAAGATGCTGGGGTTTTTTTTGTTTTTGTCCTTTGTATTAATGTATGATGGTTTGCGCCT ENST00000447458.1 ----ATGTTG---TTCCTTCTGT-----TGATTTA-ATCAATACATA--GGTTTAGG--- *** ** ** ** *** * *** ** *** ** ***** * ENST00000296702.5 TTTTGGCATTCTTTCAACATGTCGTGTACATCACACCATGAATCAGTTCCTAATTGATAT ENST00000447458.1 ----GACATTTTCT------------------------TTAATGAGGT-----TTGACCT * **** * * * *** ** * **** * ENST00000296702.5 ATCTAGCTTTACCTCCCGAGTTAAAAAAAAATCTTTTTATTTTATGCCTTCATAGGTTGC ENST00000447458.1 ACT---CTTTAGCT---GAGTTACAAA------TTTCT---------CTTC--------- * ***** ** ****** *** *** * **** ENST00000296702.5 TCGTTTCAGAGTGCCACATAAATAAAATGTTTAACAAAA ENST00000447458.1 ------------------------------TTGACAAGG ** ****