CLUSTAL 2.1 multiple sequence alignment ENST00000305786.2 GTAGCCGCCAGCTCGGCCGCACGTCAGGGCGCGGGAGCGCGGAGCGAGTTTGGTTGCACT ENST00000458172.1 ------------------------------------------------------------ ENST00000305786.2 TACACCGGTACTTAAGCGCGGACCGGCGTGTCCTTGGACTTAGAGAGTGGGGACGTCCGG ENST00000458172.1 ------------------------------------------------------------ ENST00000305786.2 CTTCGGAGCGGGAGTGTTCGTTGTGCCAGCGACTAAAAAGAGAATTAAATATGGGTGATG ENST00000458172.1 ------------------------------------------------------GTGATG ****** ENST00000305786.2 TTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACCGTTGAAAAGG ENST00000458172.1 TTGAGAAAGGCAAGAAGATTTTTGTTCAGAAGTGTGCCCAGTGCCACACCGT-GGAAAGG *********************** ** ******* **************** * ***** ENST00000305786.2 GAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAGACAGGTCAGG ENST00000458172.1 GAGGCAAGCACAAGACTGGGCCTAATCTCCATGGTCTCTTCAGGCAGGAGACAGGTCAGG ********************** ***************** *** * ************ ENST00000305786.2 CCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGGGGAGAGGATA ENST00000458172.1 CCATTGGATTCTCTTACACAGATGCCAATAAGAACAAAGGCATCACCTGGGGGGAGGATA ** ***** *********** ********************** ****** ******* ENST00000305786.2 CACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAAATGATCTTTG ENST00000458172.1 CACTGATGGAGTATGTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAAATGATCTTTG ************** ********************************************* ENST00000305786.2 TCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAAAAAGCTACTA ENST00000458172.1 CCGGCATTAAGAA---GGCAGAAAGG-CAGACTTGATAGCTTATCTCAAAAAAGCTATTA ************ ** ******* ******* ********************** ** ENST00000305786.2 ATGAGTAATAATTGGCCACTGCCTTATTTATTACAAAACAGAAATGTCTCATGACTTTTT ENST00000458172.1 GTGGGTAACAATTTTCCACTGCCTTATTTATTAAAAAACAGAAATGTCTCCTGACTTTTT ** **** **** ****************** **************** ********* ENST00000305786.2 TATGTGTACCATCCTTTAATAGATCTCATACACCAGAATTCAGATCATGAATGACTGACA ENST00000458172.1 TGTGTGTACCATAATTTAATAGATCTCATACACCAGACTTCAGATCATGAATGACTGAGA * ********** *********************** ******************** * ENST00000305786.2 GAATATTTTGTTGGGCAGTCCTGATTTAAAACTAAGACTGGCTTGTGGTTAAATGAATAT ENST00000458172.1 GCATATTTTGTTGGACAGTCCTGATTTAAAACTAAGACTGGCTTGTGATTAAATGAATAA * ************ ******************************** *********** ENST00000305786.2 GTTCAGT--------TTTTGAATTTTAATA-GTAACTCCAATTCAGTAAATGGTATCACT ENST00000458172.1 GTTTGGTAGTTTGGTTTTTGAATTTTAATAAGTAATTTTAATTCAGTAAATGCTATCACT *** ** *************** **** * ************* ******* ENST00000305786.2 GTTTACCCCTTTTAAAGATATGATTAGACTTCGTTAGTAATGTTCAACTTTTCACAAAGA ENST00000458172.1 GTTTACCCCTTCTAAAGATATGATTAGACTTTGTTAATAATGTTCAACTTTTCACAAAGA *********** ******************* **** *********************** ENST00000305786.2 TGGTGAGTGCCATCTTAAAACTTACTGGAGATTGGTTTTATATTTAGATTTATATAACTG ENST00000458172.1 TGGTGAGTGCCATCTTAAAACTTATTGGAGAGTGGTTTTATATTTAGATTTATATAACTG ************************ ****** **************************** ENST00000305786.2 GTTATGTGAATATATTTAAATACTGGGGAAATTGCTTCACTGTCTTAGAACCAAGCAAGA ENST00000458172.1 GTTATGTGAATATATTTAAATACTGGGGAAATTCCTTCACTGTCTCAAAACCATGCAAGA ********************************* *********** * ***** ****** ENST00000305786.2 TTCACCTGTGTTTTGTGTTCATGTTCATTTGCCTCTTAAAGGCAAGGGTTGAAGATAAAT ENST00000458172.1 TTCACATATATTTTGTGTTTAT------TTGCTTCTTAAAGGCCAGGGTTGAAGATA--- ***** * * ********* ** **** ********** ************* ENST00000305786.2 AAGGTAGCAATGTCTA-----TAGTTTTGGCCTTAACTATGCCAATCTAATTATAATTCC ENST00000458172.1 -AGGTAGCAATGTTTACTTTATATTTTTGGCCTTAACTATGCCAATCTAATTAGAATTCC ************ ** ** ***************************** ****** ENST00000305786.2 CTGTATTTAAAATGGTTTCTTTTACTTATTGAAAGGCATTTTAGTGTGGTTTATGTGTAA ENST00000458172.1 CTGTATTTAAAATGGTTCCTTTTACTTATTGAATGGTATTTTAGTGTGGTTTATGTGTAA ***************** *************** ** *********************** ENST00000305786.2 TAT----TAAAGATTATTCAACACCTCTCACATCTTACAGATCTATAAGGTCACATGCTT ENST00000458172.1 TATCAAATAAAGATTATTTAACAC------------------------------------ *** *********** ***** ENST00000305786.2 TTAAAATAGTAGCAAGTTAAACTTCACTCTTGAATTCTTTACAATCTAAGTCAAACTAAG ENST00000458172.1 TTAAAAAAATAAAAAAATAAA------------ATGTGGTACA----------------- ****** * ** ** **** ** **** ENST00000305786.2 TTATAATTTAGGATTGTCTTTAAACAGCCATTCAGAAACAAAACTGTAGAACTGTGTATT ENST00000458172.1 --------------------TAAACA-CCAT--------------GGAAAACTATGCA-- ****** **** * * **** ** * ENST00000305786.2 TGATTGGGAATGGTGCTTTTGCCAACTTAAAAGGATTAAAGTAACGGAGATATACACAAA ENST00000458172.1 --------------------GCCA---TAA-------AAAGGAACG-AGAT-TACA---- **** *** **** **** **** **** ENST00000305786.2 TTTTAAAATTATGTGTGATCACAAGACTAAAGATAATTAAAAAGAAAACCACAGATCATG ENST00000458172.1 --------TCCTTTGCAGGGACATGGATGGAGCT---------GGAAGCTG----TCAT- * * ** *** * * ** * * ** * **** ENST00000305786.2 ACTTTTTGACTGTGCTTGATTTCATGACTGATGCACAAATTTTAATGATTAAAAAGTGCA ENST00000458172.1 -------------------CCTCA----------GCAAACT-------------AACACA *** **** * * ** ENST00000305786.2 GGAGCCCTAAATGTCAGTGCAGCAGCCCTAAATGTCAGTGCAGCAGTGTTAACCAGTCAT ENST00000458172.1 GGAACAGAAAA----------------CCAAA---CACTGCA----TGTT---------- *** * *** * *** ** **** **** ENST00000305786.2 GGTGCTAGATTGTTTACTTGGTTTTCTAGGACTGCCTCAACTAGAATAACACTTCACTAA ENST00000458172.1 ------------CTCACTTG--TATGTGGGA----------------------------G * ***** * * * *** ENST00000305786.2 TTGACTCTTAGTTTCTTTGCTCAGATTGAGAACTGCAGCATTTATGCCAGACATGGACAG ENST00000458172.1 TTGAC------------------GAT-GAGAAC-----------------ACATGGCCAC ***** *** ****** ****** ** ENST00000305786.2 AGGAATGCCTGTGGTCATAGTTTTGTGATGTGTAACAGTGTATAATTACATACTGAATTA ENST00000458172.1 A------------------------TGGTGGGGAACAAC--------ACACACTGGG--- * ** ** * **** *** **** ENST00000305786.2 TTTCATGCATAGTCTGTGCCATACACATTTAGAGTAGTCCTTGGAGATTTTATGGAGATG ENST00000458172.1 -----------GCCTGT-----------------------TGGGAGG----GCAGGGGTG * **** * **** * * ** ENST00000305786.2 GTGAGCACAAGGTAAGTCATAAAGAATAATGAGAAAATAAATCTATGCTGGTGCAGCTGA ENST00000458172.1 GGGG----AAGGAGAG-CATCAGGAAGAAT-----AGCTAATGGATGCTGG---GGTTAA * * **** ** *** * *** *** * *** ******* * * * ENST00000305786.2 GAACTGTATCTTTGTGGGACAGTGAGAAGACTGAGAAGATGTGAATCCATGGTCTCAAAG ENST00000458172.1 ------TACCT-----------------------------------------------AG ** ** ** ENST00000305786.2 GTGATAGGGACGATTAGATAGGTGTTTTAAGGCCTGAAAGCAATTTATAACATATGAGTC ENST00000458172.1 G-GAT-GGGATGATC-------TGT------GC-----AGCAAACCAC----CATGGCAC * *** **** *** *** ** ***** * *** * ENST00000305786.2 TTATTTTTATTTATAGAAATGTGGAAAGCTTGCTGTAATTCATATTTGAAGTCCTAGTCT ENST00000458172.1 ACATTTCCCT--------ATGTAACAAACCTGC-ACATCCTGCACATGAACCCCT----- **** * **** ** * *** * * **** *** ENST00000305786.2 GAGTTCTGGTGGGGAATTTAAAAATGCATCCTGGAAATCCTTTAAAGATTTCAGACTTTG ENST00000458172.1 -------------GAATCTAAAAGT-----------------TGAAG-----------TA **** ***** * * *** * ENST00000305786.2 AAAGGCCTTGTAGCAGAGGACTTGGTGACTGTATAAAGTTAGTGGTATTCAGGGACAGTG ENST00000458172.1 AAA-----------AGA------------TATATGAAATTATCTGTATGTA-------TG *** *** * *** ** *** **** * ** ENST00000305786.2 TAGCAAGTAGCTTACAAGGGGACAATTCTGGACTAATGAGAAAGACCTGAAGTGAAGGCT ENST00000458172.1 TA----------TGC-------------------------------------------CT ** * * ** ENST00000305786.2 AGAGAGTTGATTTTTTTTTTTTTTGGCATCCTGGAAATGATACAGGAAACATATTAAGAT ENST00000458172.1 AGA----------------------------TGTAAGT--------ATACATAT----GT *** ** ** * * ****** * ENST00000305786.2 AGATACAGAAATGTGTTCAACCTTCCATCTTGGCTAGTTGTGGCGTTTAGTTTGTTTTTT ENST00000458172.1 ATATGCATGCATATCATCA------CATTTT---TA-TTGAGGTAT--AAC--------- * ** ** ** * *** *** ** ** *** ** * * ENST00000305786.2 GAGACATGGTCACGCTGTGTCGCCAAGGCTGGAGTGCAGTGGTGCGATCTCGGCTGGCTG ENST00000458172.1 -ACATATGGTTAAGTTG---CACTAA---TCAAGTGTAT-------ATCTTGA-TGA--- * * ***** * * ** * * ** * **** * **** * ** ENST00000305786.2 CAACCTCTATTTCCCAGGCTCAAGCGATTCTCTCACTTCAGCTTCCCAAGTAGCTGGGAC ENST00000458172.1 -------TATTATACA------------------------------TAAGTA-------- **** ** ***** ENST00000305786.2 TACAGGTGTTCGCCACCATGCCCAGCTAATTTTTTTGTAGAGATGGAGTTTTGCCATGTG ENST00000458172.1 TATATG----------CATGT--AACCAAGACCTCTATAT------------------TG ** * * **** * * ** * * ** ** ENST00000305786.2 GTCCCAGGCTGGTCTCAAACTCCTGAGCTCAAGCAATCCGTCCACTTGCCTTGGCTCCCC ENST00000458172.1 GTCTATGACTGATCTCCAATT--------------------------------------- *** * *** **** ** * ENST00000305786.2 AAAGTGCTGGGATTACAGGCGTGAGCCACCAGGCCCTGCCTGGTTTTCAAATTCAGAAAT ENST00000458172.1 -AATTGTTG----TAAAGATATAAAGCATCAAGGTTCA--TGTTTTTCATAT--AGCTAT ** ** ** ** ** * * ** ** * ** ****** ** ** ** ENST00000305786.2 CTTATTATTTAACCCAGAAGTAATCAGCCCAGTAGTAACTTAGGTTTAATTTTTTTTCAG ENST00000458172.1 C--------------------AATCCCCCC------------------------------ * **** *** ENST00000305786.2 GTTTAAAATTTTTCTCATTTATTTTTTCTGAGACGGAGTTTCGCCCTTTTCGCCCAGGCT ENST00000458172.1 ----------TCTACCATTTATTGT-------AAAGAGCATAA----TTTCTCCCAG--T * * ******** * * *** * **** ***** * ENST00000305786.2 GAGTA-CAGTGGTGCAATCTCACTGCAACCTCCGCCTTCCAGTTGCAAGTGATTCTCCTG ENST00000458172.1 GAATGGCAGAGGTATG--TTTAGTGCAAAT---------------CAAGTG--------- ** * *** *** * * ***** ****** ENST00000305786.2 CCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCGCCACCACGCCTGGCTAATTTTTG ENST00000458172.1 -------------AACA--------TATATGTAT--------AGGTCTG-----TTTCTG * * ** * * * * * *** *** ** ENST00000305786.2 TATTTTTAGTGGAGATGGTGTTTCACCATGTTGGCCAGACTGGTCTTGGACTCCTGACCT ENST00000458172.1 GGCTTTT--------TGTCCTTTCATTATG--------ACGTGTCT-------------- **** ** ***** *** ** **** ENST00000305786.2 CGTGATCCACCCACCTTGGCCTCCCAAAGTTCTAGGATTACAGGTGTGAGCCACCACGTC ENST00000458172.1 ----AT------ACTT----------AAGTCC--AGACCACAG----------------- ** ** * **** * ** **** ENST00000305786.2 CGGCCAATTTTTCTCATTTCTATGCCTCCTATATTAAGGTCTGTGTTGGCACAGATGAGT ENST00000458172.1 ----------TTTTAATTATTATGGCTT-TATAGTGAG-----TCTTGA-AAACTTGGGT ** * *** **** ** **** * ** * *** * * ** ** ENST00000305786.2 AACTGCCATGTTCTAGGTCAGTTATACCCAAGCACTTCTGGTGGTTTAAAATGTGATTCT ENST00000458172.1 A-----TAAGTCCT---CCAACTTT------GTACTTCC--TTGTTTAAAA-ACTATCTT * * ** ** ** * * * ***** * ******** ** * ENST00000305786.2 GTAACTTTTTTATTTTTATTTTTTTGAGATAATTTCACTCTTGTTGCCCAGGCTGGAGTG ENST00000458172.1 G--GCTCTCCTA-----GATTTTTTGA----ATTTC--------CGTATAAATTTTAG-- * ** * ** ******** ***** * * * ** ENST00000305786.2 CAATGGCGTGATCGCTGCTCACCGCAACCTCCGCCTTCCAGGTTCAAGCGATTCTCCTGA ENST00000458172.1 ---------AATCA----TCTTGGCAATTTAC------------------ATACAC---A *** ** **** * * ** * * * ENST00000305786.2 CTCAGCCTCTCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCCAGCTTATTTTGTG ENST00000458172.1 CCCAAACTCACA------------CACACACACACACACACACACACA------------ * ** *** ** *** ** * * ** * ** ENST00000305786.2 TTTTTAGTAGAGACAGGGTTTCTCCATGCTGGACAGGCTGGTCTTGAACTCCCGACGTCA ENST00000458172.1 -------CACAGACAGTATTT--------------------------------------- * ****** *** ENST00000305786.2 GGTGATCTACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCC ENST00000458172.1 --TGACCTA------------------------GGGATTG-------------------- *** *** ****** ENST00000305786.2 TGGCCAATTATGTAATTT--TTTAAAAAGGACATTTCTATCAGGGATATATACCTTCAGA ENST00000458172.1 ------ACTATGTAACTTAATTTGGA---GACAATT--------GACATATA------AA * ******* ** *** * **** ** ** ***** * ENST00000305786.2 AATAAGGAAATAGGGGAAAAAAAGAGCACTATAAACCACATGTTTTCATTTCTAGTGCTT ENST00000458172.1 AATATTGAGAT--------------------------------------TTCCAAC---- **** ** ** *** * ENST00000305786.2 CGCTGTAAGTGGCTAGGTTGGTAGAATCAAAAACAAGGGCCAGATGTATTTAAGGGGTAT ENST00000458172.1 --------------------------TCATGAACATA------ATATATCT--------C *** **** ** *** * ENST00000305786.2 TCAGATGCCACCTACATGCTTATTTTGTCTAGAACAGTGCTGTCTAATAGAACTTTCTGT ENST00000458172.1 TC--------------TACTTATGTCGT-------------GTTTGAT-----TTCTTTT ** * ***** * ** ** * ** ** * * ENST00000305786.2 GACGATGGATATTTTGTAGACTTTTGCTGTCCAGTGTGGTAGCCACTAACCACATGTGGC ENST00000458172.1 AGCAATG---------------TTTGC-----AGTGT--------------ACA---GGT * *** ***** ***** *** ** ENST00000305786.2 TGTTAAGCCCTTGAAATATAGCTAGTGTGACTAGAAAGTATTTTATTTTAAATTTACATA ENST00000458172.1 T-TTACACCTT-------TTGTTAGTTTTATTTCTAAGTATTTGAT---AAGTTTTTAT- * *** ** * * * **** * * * ******** ** ** *** ** ENST00000305786.2 GGCACAAGTGGCTAGTGGCTACTGTAT-TGACATTCTGGGTCTAGGACTAGAACCAGTGG ENST00000458172.1 -----------------GCTATTTTAAATGATATT-------------TGAAA------A **** * ** *** *** * ** ENST00000305786.2 TCTGTAACAAAAGTACTTTCTCTTTACT--CTATTAA-ATCTAGAATTAGCCGGGCATGG ENST00000458172.1 TCTTCA---------TTTTCTAATTATTTGCTATTGGTATATAGGA--------ACATAA *** * ***** *** * ***** ** *** * *** ENST00000305786.2 TCGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTC ENST00000458172.1 ---CTAATTTTTGTA-TATTGACTTTT-------------------GTTTATTTG---TC ** ** **** * * ** * * * *** ** ENST00000305786.2 AGGCGTTTGAGACCAGCCTGGTCAACATGGCGAAACCCTGTCTCTACAAAAAACATAAAA ENST00000458172.1 ------TTAAGAC-------------AGGGCATTGCTCTGTCACCACAGG---------- ** **** * *** * ***** * *** ENST00000305786.2 ATTAGCCAGGTGTGGTGGTGGGCACCTGTAATCTCAGCTACTTGGGAGGCTGAGGCACAA ENST00000458172.1 -CTGG---AGTGCAGTGG----CACCTG-------------------GGCTCAAGCA--- * * *** **** ****** **** * *** ENST00000305786.2 GAATCACTTGAACTTGGGAGGTGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCA ENST00000458172.1 ------------------------------------------ATTCTCCCAC----CTC- *** * **** *** ENST00000305786.2 AGCCTGGGTGACGAGTGAAACTGTCTCCAAAAAAAAAAAAAAA ENST00000458172.1 ---------------------TGTCTCC--------------- *******