CLUSTAL 2.1 multiple sequence alignment ENST00000307221.4 TAACATTGTCTTTAACATAAAAGTGTACCTATTTGCAGTCACTACCTCTATCACCACCAC ENST00000446806.1 ------------------------------------------------------------ ENST00000307221.4 CAGCAGAGCCTGAGCTGAGGAAACCACGGTTCTCAATACCCAGCACACCCACTTCCAACT ENST00000446806.1 ------------------------------------------------------------ ENST00000307221.4 ATCTGTTAAAACATGGTGGATTACTATGAAGTTCTAGGACTGCAAAGATATGCTTCACCT ENST00000446806.1 ------------ATGGTGGACTACTACGAGGTGCTGGACGTGCCCCGGCAGGCCTCATCC ******** ***** ** ** ** * *** * * ** *** * ENST00000307221.4 GAGGACATTAAAAAAGCTTATCATAAAGTGGCACTTAAATGGCACCCTGATAAAAATCCA ENST00000446806.1 GAGGCCATCAAGAAGGCGTACCGCAAGCTGGCGCTCAAGTGGCACCCCGACAAAAACCCT **** *** ** ** ** ** * ** **** ** ** ******** ** ***** ** ENST00000307221.4 GAAAATAAAGAAGAAGCAGAGAGAAAATTCAAAGAAGTAGCTGAGGCATACGAGGTATTA ENST00000446806.1 GAGAACAAGGAGGAAGCGGAGAGGAGATTCAAGCAGGTGGCCGAGGCCTACGAGGTGTTG ** ** ** ** ***** ***** * ****** * ** ** ***** ******** ** ENST00000307221.4 TCAAATGATGAGAAACGGGACATTTATGATAAATATGGCACAGAAGGATTAAACGG---- ENST00000446806.1 TCGGACGCCAAGAAACGCGATATCTATGACCGCTATGGCGAGGCGGGGGCGGAGGGCGGC ** * * ******* ** ** ***** ****** * ** * ** ENST00000307221.4 -----AGGTGGAAGTCATTTTGATGATGAATGTGAGTACGGCTTCACATTCCATAAGCCA ENST00000446806.1 TGCACAGGCGGCAGGCCCTTCGAGGACCCCTTCGAGTACGTCTTCAGCTTCCGCGACCCA *** ** ** * ** ** ** * ******* ***** **** * *** ENST00000307221.4 GATGATGTTTTTAAAGAAATTTTTCATGAAAGGGATCCATTTTCTTTTCACTTCTTTGAA ENST00000446806.1 GCCGACGTCTTCAGGGAGTTCTTCGGCGGCCAGGACCCATTCTCCTTTGACCTCTTGGGA * ** ** ** * ** * ** * *** ***** ** *** ** **** * * ENST00000307221.4 GACTCGCTTGAGGACCTGTTAAATCGTCCAG-GAAGCTCCTATGGAAACAGAAACAGAGA ENST00000446806.1 AACCCGCTGGAGAATATTTTGGGGGGGTCAGAGGAACTGCTGGGGAAGCAGAAGCAGAGC ** **** *** * * ** * *** * * ** ** **** ***** ***** ENST00000307221.4 TGCAGGATACTTTTTCTCCACTGCCAGTGAATATCCAATTTTTGAGAAA---TTTTCTTC ENST00000446806.1 GTCTGCACCCCTTTTCTCTGCCTTCAGTGAATTTCCAGCTTTTGGGGGTGTTTTTTCTTC * * * * ******* * ******** **** ***** * ******** ENST00000307221.4 ATATGATACAGGATATACATCACAGGGTTCATTGGGGCATGAAGGCCTTACTTCTTTCTC ENST00000446806.1 TTTTGATACAGGATTTCGTTCCTTTGGCTCCCTGGGAAGTGGGGGCCT---TTCTTCCTT * *********** * ** ** ** **** ** ***** ***** ** ENST00000307221.4 TTCCCTGGCTTTTGATAATAGTGGGATGGACAACTACATATCTGTTACAACTTCAGACAA ENST00000446806.1 CTGCATGTCCTACGGTAGTGATGGGACAGGCAGCTTCAAGTCCATGTCGACTTCCACTGA * * ** * * * ** * ***** * ** ** ** ** * * ***** * ENST00000307221.4 AATCGTTAATGGCAGAAATATTAATACAAAGAAAATTATTGAAAGTGATCAAGAAAGAG- ENST00000446806.1 AATAGTTGATGGTAAAAAAATCACCACCAAGAGAATCATTGAGAATGGCCAAGAAAGGGT *** *** **** * *** ** * ** **** *** ***** * ** ******** * ENST00000307221.4 --AAGCTGAAGATAATGGAGAGTTGAC-----ATTTTTTCTTGTAAATAGTGTGGCCAAT ENST00000446806.1 GGAAGTGGAGGAAGATGGAGAGTTGAGTTAAAGTCCTTCATAATAAATAG------CAAA *** ** ** ************ * ** * ******* *** ENST00000307221.4 GAAGAGG-GCTTTGCA---AAAGAATGCAGCTGGAGAACACAGTCA--TTCAA---CAAC ENST00000446806.1 GAGCAGTTACTCCGCATTGACACCAAGTAATTCCAGTCCACATTTGACTTTAAGCACATC ** ** ** *** * * * * * * ** **** * ** ** ** * ENST00000307221.4 T-----ATTCACCAAATTCTCACAGCTCCAAACATGTA------TCTCAA------TATA ENST00000446806.1 TGGAGGAATAGCGGACTTTTTTTAGGATTGAAAGTGAACTTTACTTTCAGAACAGCTGTA * * * * * ** * ** ** ** * * *** * ** ENST00000307221.4 CT------TTCGTGGACA----ATGATGAGGGAGGTA--TATC-TTGGGTTACCAGCAAC ENST00000446806.1 CCCAAGAATTTATAAACACTTCATGCCAACACCTGTTCTTATCGTTGGGACTACACGGAT * ** * *** *** * ** **** ***** ** * ENST00000307221.4 AGAGATCCCCCTAT-TTTCTCAGCAGGAGTCAAAGAGG-GTG-GTAAGAGGAAAAAAAAG ENST00000446806.1 AG-GACCTCTGTTTGTCTTTCAATCGTTGTAAAATATCTGTATGCAATTTGCTATTTATT ** ** * * * * * * *** * ** *** * ** * ** * * * ENST00000307221.4 AAGCGTAAA---GAGGTGCAAAAGAAGT-----CTACCAAAAGGA---ATTGTTAAATTG ENST00000446806.1 AAACTTAAGCCTGAGGCAGACAATGATTATTTGCTAGTGGTAGGACAGAATGTTCAGTTC ** * *** **** * ** * * *** **** * **** * ** ENST00000307221.4 A-CTCTTCAAATATATAACATTT-------GAACACAATTGTGTG-----TGTTTTGGTT ENST00000446806.1 AGCACTTTGAGCAT-TACCTTTTTCCGTTGGGA---AAGTGTGAGCCAGGTGGTTTGCTC * * *** * ** ** * *** * * ** **** * ** **** * ENST00000307221.4 --AATCACA-AATTTTGTAGAT-AACACTTAATACTATA--CTAAGAGCTTT-TCAACAC ENST00000446806.1 TAAATCATTTGACTTTATTGTTTAGTGTGTAGTGGTGAAATCTACAAATAATATCAATAC ***** * *** * * * * ** * * * *** * * **** ** ENST00000307221.4 TTTTAGCAGGATT-----GTGG---------ACATTTGGTTAGTAGTTT----TTTTGAA ENST00000446806.1 TTCTGGCTTAATTTAATGATGGTTCAAAACAACATGCATTTATTATCTTAATATTTTGGA ** * ** *** *** **** *** ** ** ***** * ENST00000307221.4 -----------TGGGT---ATGTCA-------GAAAAGGATGA------GTTTGTGGTGA ENST00000446806.1 GGTCAGACATTTGAATCCCATATCACTGAGCTGAAATCGGTGGAAGCATGTTCCCTCTGA ** * ** *** **** * ** *** *** ENST00000307221.4 CAGTTGGTGCTAA---TAAGAATT---TGCCTGG---GCAGTATAGTGAGA---TCTTTT ENST00000446806.1 AGGCTGAGGACAAACCTTGGGGTTACATGGTTGGTCGGTGGTATACTAGGACTGTCTTCA * ** * ** * * ** ** *** * ***** * ** **** ENST00000307221.4 CTCTACAAAAAATTTAAAAATTA-GCCAAGTGTGGTGGTG-TGCACCTGTAGTCCCAGCT ENST00000446806.1 GCCTGAACGTGGTTCTCCAACTATGGTAGGT-TGCTGGGGATAAGCCCCCAATTCCGGCC ** * ** ** ** * * ** ** *** * * ** * * ** ** ENST00000307221.4 ACTCGGGAAGCTGGTAGAAAGACTG--CTTGAGCCTGGAAGACATAGGTTGCAGTGTAAT ENST00000446806.1 A-----GAAGCTGGCCCCTAAACTGGCCATAAAC----AAAATCTCTGCAGCACTGTGAC * ******** * **** * * * * ** * * * *** *** * ENST00000307221.4 GGGATCACG----CCA------CTGCACTCCAGCTTGGG----TGACAAAGTAAG----- ENST00000446806.1 GTGTTCATGATAGCCATGATGCCTATGCTGAAGGTTGTGAGTTTACTGGAATAAGGGCAA * * *** * *** ** ** ** *** * * * **** ENST00000307221.4 ---AC-CCTGTCTTA---AAAAAAAAAAA------AAGGAATTTGGAAAACTGCAA---- ENST00000446806.1 GGAACACCTGGCCCACCCAGGGAGGAAAACCGCTTAAGGTGTTCCTAAA-CTACAAATAA ** **** * * * * **** **** ** *** ** *** ENST00000307221.4 -----TGAGTTTTTTAC-TTTTGA----ATTTTTCTTTAGTAGA--GTT---TATAGCCT ENST00000446806.1 TAACATGAGCCATCTGTGCCTTAAGGACATGTTTCTGCTGCAGATAATTAGCCAGAGCCC **** * * ** * ** ***** * *** ** * **** ENST00000307221.4 ATTTTTCTTTTTTC--TAATTAAAACCACTA-------TACAAACTTACGAAAC-ATGCA ENST00000446806.1 ATCCCTTTGTTTCCCGTAAGGAATACTTTTAGTTAATCTATAATCTATAGAAATGATGCT ** * * *** * *** ** ** ** ** ** ** **** **** ENST00000307221.4 TAGCAT----TAGAAGACAA-GAATGTATCAAGACACACAGGTTCAGACTACACAATTAT ENST00000446806.1 TATCACAGGCTTGCTGTCAATAAATATGTGGGTAAATCTCTGTTTGGGGCTCTCAGCCCT ** ** * * * *** *** * * * * *** * * ** * ENST00000307221.4 -----TCATGAAATGGCTG-TTTTCCAATGGAGGAACAGCATTTGATGCAT-TATAACTT ENST00000446806.1 GAAGGCTGTGAGTCCCCTGATTTCCCACTCCACACTCTATATTTC-TGTGTGTGTGTCTT *** *** *** *** * * * **** ** * * * *** ENST00000307221.4 AAA-------GGTACTAC-AAATTAAAAATTAAAGTATAAAGT--ATTTTA--AGT---- ENST00000446806.1 TAATTCGTCTAGCGCTGCTGGGTTAGGGTCTCCACGACCAAGCTGGTCTTGGCAGTGGGT ** * ** * *** * * * *** * ** *** ENST00000307221.4 --TAGAAAT-----AGACTTAGCTGGGTGCAGTGGCTCACACCTGTAATCCTAGCAT-CT ENST00000446806.1 CCTGGAAATGTAAAAAAAGGATCTCCATAAGGCCACACAGAACTATCCTATTGCTATGCT * ***** * * * ** * * * ** * ** * * * ** ** ENST00000307221.4 TGGGAGGC--CCAGGCAGGAGGGTTGAAGTCAGA---ATTT-CACGACAGTCCGGGTAA- ENST00000446806.1 TGGGACATATCAAATTAGGTTGATGAAAGCCAAGTGTATCTGTAATATTTTTTGGGTGAG ***** * * *** * * *** ** ** * * * * **** * ENST00000307221.4 -CATAATGAGACCTGTCCTCTATGAAAAAACTTTTTT------AAAAATTTAGCTGGGTG ENST00000446806.1 GCACCATAA-ACACAAC----AAGAAAGTACCTTTCTGTTGGCACAGGTTATGCCCCAAA ** ** * ** * * **** ** *** * * * ** ** ENST00000307221.4 TGGTGGTACGTGCC----TGTAGG--CCTAGCTACTTAGGAGGC---TGAGGTGGGAGGA ENST00000446806.1 TGAAGACCTTTTCCATCACAAAGGGTCCCTTCTTCTAGGGTCACCTCTGAG--GAAAGGT ** * * ** *** ** ** ** ** * **** * *** ENST00000307221.4 TTGCTTGAGCCCAGGAGTTTGAGGTTGTAGGGAGCTA-TGATCTTGCCA--TTGCACTCC ENST00000446806.1 TTGCATAAG-------GCATGAGA--GCAAAAGGCAACTGAACTGGATAGGCTGAAAAA- **** * ** * **** * * ** * *** ** * * ** * ENST00000307221.4 AGCTGAGAGTGTGACCCTG-----TCTCTAAAGAAAAACTATAGAAAATTTAAAAA---- ENST00000446806.1 AATTAAGAGCAGCATGCTGGTAATTTTTTACAGAAAAATCATGG----CCTGAACACATC * * **** * *** * * ** ******* ** * * ** * ENST00000307221.4 ATTAAAAAACGGGTAACATGGTAAATTTTATGTAGTATATTTTACCACATTTTTTTTAAA ENST00000446806.1 ATTAACCAACAAAGAGTGTGATATGGGTT-TG-GATATGCTCTAGAAC-----CCTCAGA ***** *** * ** ** ** ** *** * ** ** * * * ENST00000307221.4 GGCCAGTCTTATCCTGAATTCCTCAGAGCAGT---CTGTATGG-TA-GGCCATCAGT--G ENST00000446806.1 GTCCACTCTGCATGTAATGGCACCCAAGCAATAAACAGCAGGAACATGGCAGTCAGCTGG * *** *** * * * * **** * * * * * * *** **** * ENST00000307221.4 AATCACTCCAGA------CAGGAAATTTTCTATTTTTGTTTAGAGTTTGTACAC---AAA ENST00000446806.1 CACCATCCCACAGGGGCTCATGGGGTCTGACACTGAACTCTGAAATCAACATGCTCCGAG * ** *** * ** * * * * * * * * * * * * ENST00000307221.4 ATCTACAAATACATTACTCTAAAATAGCACCTATA---GCCATTTTA-ATTTAGTCA--- ENST00000446806.1 GTGCCTGGGTAGTTGATTCTCATACAATAACCATAAAAGAAGTATCAGAATAAGACAGAC * ** * * *** * * * * * *** * * * * * * ** ** ENST00000307221.4 TGTTGGGA-----GAAAAAT-AGATGGGTTACAAATACATCAGAT-ATCGAGC--AAATG ENST00000446806.1 TGTTAAGGCTTTTGAAAAATGAGTTCAGTTTTTTGTACATCAGACGAGGGAACTTACATG **** * ******* ** * *** ********* * ** * * *** ENST00000307221.4 GTTTGAGTTAC--ATCTAGCAGC--ACTAAAACTTATTCAACTTTGGCCAAATACAAATG ENST00000446806.1 TGTGAAGATACTCACTGAGTAGTTTGCTGAG-TAGGTTTGCTTTTGGAGCAGTTCA---- * ** *** * ** ** ** * ** ***** * * ** ENST00000307221.4 CGAAATTAGAAAAAAATTATAATATCTGCTATTTTTAAAAGACAGCTATAGTCAAGAGCT ENST00000446806.1 -GGGAT--GAAAGGAGTTTCAAAG--TGGTA-----GAAAGGCATGGGCAGTTTCATTGT * ** **** * ** ** ** ** **** ** *** * ENST00000307221.4 TGTGTTTTGTATCGGTATTTGATTTTTAGTGGGCAGATGGGAGAAGGAAAGGTTATTTAT ENST00000446806.1 GGTTTTGTGTGTTGGAAATCACTACTC--TGGGTAGA--GTAGAATGAGTTGGTGTGTAT ** ** *** * ** * * * * **** *** * **** ** * * * *** ENST00000307221.4 TCTATAGAAGAGACTGCGGACA----ATT----AGTATTCAA-----AGT---------- ENST00000446806.1 -CTACACAATTGGGTACATAAATCCCATTGTTCAGTGGTCAGCAAAGAGTGGCATACCAG *** * ** * * * * * *** *** *** *** ENST00000307221.4 --TTATTTTCAGAAAATAAAATAATAAAAGCCCAGGGTATTTTAAA--------- ENST00000446806.1 TGTCACTCAGAGGTAGTGGGTCTGTAACAACTCTGGCTAGTTTTAACAGTTGAAA * * * ** * * *** * * * ** ** *** **