CLUSTAL 2.1 multiple sequence alignment ENST00000309035.6 AAACCCCCAGTTGGTTGTCCCTGCCGTCTCGGAAGGGTTAGCACACAGCCAGGTCTGTTT ENST00000434549.1 --------------ATGGCCCTAT----------GGATAAGCACAAAGTCAAGA------ ** **** ** * ****** ** ** * ENST00000309035.6 TTGATGTATGTAATTGAA---GATTTATAAAGAA-AAGCTTCTCCTCTGCCTCATCCGCA ENST00000434549.1 --GACA---GTGATTGAACAGAATTTGTGAAGGGTGAAGGTATCCGCTTTCAGA-CCGTG ** ** ****** **** * *** * * *** ** * * *** ENST00000309035.6 GTCATTTTTTTTCCAATGCCAGTTCCCAGCAGGCATATAAATATTGGTCGTTCTCAGAGC ENST00000434549.1 AACAGGCCCTTTGCACC-CCAGCACCCCCCAGCCCC-----CAGTGG-CACTGCTGGACT ** *** ** **** *** *** * * *** * * ** ENST00000309035.6 TGGGATGCTGCTGGGTGGTACGAGGGCC--CCTGGGAGAACGCCGAGTCCCTGCGGCCTC ENST00000434549.1 GAGGCCACTGCACCGTGG--AGATGACTATCCTGAAAAA---CTTAGCCACCGTGGCCTT ** **** **** ** * * **** * * * ** * * * ***** ENST00000309035.6 TGGGGAGGAGAAGCTCCCTGACGTATGGCACAGCAGAG--GGGACTTGGTTTGAGCCAAA ENST00000434549.1 CTGTGACACGCAGTCC-----------ACACAGGAGATCCAAGAGTAGGTTTAAACGAAG * ** * ** * ***** *** ** * ***** * * ** ENST00000309035.6 CCACCG--ACCACAGGACGCTGCCCTGCCCGTGGCCGCCGAGCCCTACCTGTACCGGGAG ENST00000434549.1 CGGTAGGCACCATGAGGCACCACACCACC-----------ACCCTCA-----ACAGGGAG * * **** * * * * * ** * ** * ** ***** ENST00000309035.6 GCCGTTTATAACTCAGTGGCTGCAAGAAAGGGGTCTACTCCTGACTTCACCTTCTACGAC ENST00000434549.1 GACTTGGAGAGGTTAAAAGCCCTGAGAG-------------TGACCGTGCAGA-TA-GGC * * * * * * * ** *** **** * ** * * ENST00000309035.6 AGCAGACA-GGCAGTGATGTCTGGTCGCAGCCCCCTGCTGCCACGGGAGTACTA----CA ENST00000434549.1 AGCAGCTACGACTATGAGAAC--ATCAGGGCTGCCAGCAAGCTCAGGATCGCTGTGTGCA ***** * * * *** * ** ** ** ** * * *** ** ** ENST00000309035.6 GTGATCCGTCTGGAGCTGCTAGGGTACCCAAAGAGCCTCCCCTCTATCGGGACCCAGGAG ENST00000434549.1 GCATCCTGTCCATAGCAG-TGGAACAGATAGTCAATTCCACTTCCATCTGTACCGGAAGA * * *** *** * * * * * * * * ** *** * *** ENST00000309035.6 TCAGCCGGCCGGTCCCCAGCTACGGAGTGCTTGGCAGCAGAACGTCATG-GGATCCAATG ENST00000434549.1 ACAGGTGGCTG---------TACCAGACGCT-----GCGGGAAGCGATGCGGGTACAGAG *** *** * *** *** ** * * * *** ** * ** * ENST00000309035.6 CAAGGCCGGTCACCTGCCCTGCAGGACGCCGGTCACCTGTACCGGGATCCTGGAGGTAAA ENST00000434549.1 TATGG------AGCAGATCCGCGA------GGTCAACT----CGGGA----GGAGCCTAC * ** * * * * ** ***** ** ***** **** * ENST00000309035.6 ATGATCCCTCAGGGG--CGGCAGACACAGAGCAGGGCTGCATCTCCCGGGCGGTATGGAC ENST00000434549.1 AT-----CTTAGGGAGATGGTGGGC-CTCATC--GGCTGCAATTGCAGGG-GGCA--GGC ** ** **** ** * * * * * ******* * * *** ** * * * ENST00000309035.6 GGGAGCAGCCCGACACCAGGTATGGGGCGGAGGTGCCTGCCTACCCCCTCAGCCAGGTCT ENST00000434549.1 AGTTGCTGTTCTATCCAAGGTCTTTGGATTGAGTGTCA---TATTTTATGACCCCTACTT * ** * * * * **** * ** *** * ** * * ** * ENST00000309035.6 TCAGCGACATCAGCGAAAGACCCATTGACCCTGCCCCTGCCAGACAGGTGGCCCCGACGT ENST00000434549.1 GCAG-GAT----GGGATAGA---ATGGTTCCTGGGCCTGCAGAGGACCTACACCCTGCAG *** ** * ** *** ** * **** ***** * * *** * ENST00000309035.6 GCCTGGTTGTGGACCCCAGTTCAGCTGCTGCCCCCGAAGGCAGCA----CAG-GGGTGGC ENST00000434549.1 GATTTGTTGTA----TCAGAGACACTGC-GTCTCCTTACACTGTAATCTCAATGAACATC * * ***** *** **** * * ** * * * * ** * * ENST00000309035.6 CCCAGGGGCCCTGAATCGTGGCTACGG-GCCTGCCCGGGAAAGCATCCCATCCAAGATGG ENST00000434549.1 ACCACCACCTCT--TTGATGGTGATGGTGACTTTACTATAAAGTAGATGAGGCAAGA-GG *** * ** * *** * ** * ** * **** * * ***** ** ENST00000309035.6 CTTACGAGACTTACGAAGCTGACCTGTCCACCTTCCAGGGTCCTGGTGG-CAAGAGGACC ENST00000434549.1 CATTC----CTTGCAAATGTAGCCTGG---------GGCATCCTGTTGGATAAGAAAGC- * * * *** * ** * **** * ***** *** **** * ENST00000309035.6 GTGCTCCCTGAGTTCCTGGCCTTTCTGCGGGCGGAGGGGCTGGCAGAGGCCACGCTGGGA ENST00000434549.1 -------CTTAGCTCAGGGCCCTCA---AGGAGGGCAGGAAAGGAGAGGCAGCCCTCCAA ** ** ** **** * ** ** ** * ****** * ** * ENST00000309035.6 GCCCTACTGCAGCAGGGCTTTGACTCCCCGGCCGT---CCTGGCTACCCTGGAGGACGCG ENST00000434549.1 G---TATATGAATAGGA-----GCCCTTCAGCTGTGTTCCTGG-TCCATTGAAAGATGC- * ** * *** * * * ** ** ***** * * ** * ** ** ENST00000309035.6 GATATCAAGT-CTGTC-GCACCCAACCTGGGCCAGGCCCGTGTTCTGAGCCGCCTGGCCA ENST00000434549.1 ---ACCAAATTCTATCTGTACTC--CCCACACC-GCCTGGTATAGTGAGCAAAC--ATCA * *** * ** ** * ** * ** ** * * ** * ***** * ** ENST00000309035.6 ATAGCTGCAGGACCGAAATGCAGCTGCGGAGGCAGGACCGGGGGGGCCCGC-TGCCCCGG ENST00000434549.1 CTAGAGACAAGG----AAGGCAGCTGCCA--CCAAGATCTGCGAAGCCTTCACATCCCAG *** ** * ** ******** ** ** * * * *** * *** * ENST00000309035.6 GCGCGGTCCAGCAGCTTCAGCCACCGAAGCGAACTGCTCCATGGTGACTTGGCTTCTCTG ENST00000434549.1 A-AAGCTTAAGAAACTGT-GTGAACAAGG--AA----TTCTTTGTCACATGAGCTCCTTG * * ** * ** * * * * * ** * * * ** ** ** ** ** ENST00000309035.6 GGCGCTGCGGCTCCTCTGCAGACAGCATCCCCCCGAGCTGGAGACCCGGCTCGCCGTCCC ENST00000434549.1 GTCA--GTAATAAACCAGCAAGCAAT-TTATCTCGAGCTCAA---------TGGTGTGCA * * * * *** ** * * ****** * * ** * ENST00000309035.6 TCCAGCGCACCATCTCAGCACCTCCTGGAGACGGCAGCCACCTATTCTGCCCCTGGCGTG ENST00000434549.1 TGCAG------ATATCGGC------CAAACACGGTGG------ATCTGGCTCCAGG---A * *** ** ** ** * **** * ** ** ** ** ENST00000309035.6 GGCACCCATGCCCCACACTTCCCCTCCAACTCCGGGTACAGCTCTCCCACCCCTTGCGCC ENST00000434549.1 GG--------------ACTTC--CTGCCGCCATGGG-AGGGATC----ATCCCTGGAGGC ** ***** ** * * *** * * ** * **** * * * ENST00000309035.6 CTGACAGCGCGTCTGAGCCCCACGTACCCCCTGCAGGCAGGGGTGGCCTTGACTAACCCG ENST00000434549.1 ATTCCAGTGATTCACAATCTC-----CCCACCGC-GGCA----CACCCTT------CCCA * *** * ** * * * *** * ** **** **** *** ENST00000309035.6 GGCCCCTCAAACCCCCTTCACCCAGGCCCCAGAACAGCCTACTCCACGGCATACACGGTG ENST00000434549.1 AGCTCC------CTCTCCCAACCAGCCCATAAAACA----------TGG---GGACAAT- ** ** * * ** **** ** * **** ** ** * ENST00000309035.6 CCCATGGAGCTGCTAAAGAGGGAGCGCAACGTGGC-CGCCTCTCCGCTGCCCAGCCCTCA ENST00000434549.1 --CAAGAACACCCCAACGAGGCCAGGCG--GTGGCTCACCCCTCTAAT-TCCAGCACTT- ** * * * ** **** ** ***** * ** *** * ***** ** ENST00000309035.6 CGGCAGCCCCCAGGTCTTGCGGAAGCCAGGTGCACCCCTGGGGCCATCCACCCTGCCGCC ENST00000434549.1 TGGGAG------------GCTGAGGC-AGGCAGATCACTGAGG--AAAGAGTTCGA---- ** ** ** ** ** *** * * *** ** * * * ENST00000309035.6 GGCCAGCCAGAGCCTC----CACACGCCTCACTC-ACCGTAC-----CAGAAGGTGGCCC ENST00000434549.1 GACCAGCCTGAACAACATGGCAAAACCCTATCTCTACCAAAAACATACAAAAATTAGCCG * ****** ** * * ** * *** *** *** * ** ** * *** ENST00000309035.6 GGCGCA-CAG-GGGCACCCATCATCGTGTCCACCATGCTTGCA---CCAGAAC-CAAGTA ENST00000434549.1 GGTGTGGTAGCGGGCGCCTGTAGTC----CCAG-GTACTCGGGAGGCCAAGGCACGAGAA ** * ** **** ** * ** *** * ** * *** * * ** * ENST00000309035.6 TCCGCCCCCAGATCATGAACGGCCCCCTGCACCCCCGCCCCCTGGTGGCGCTGCTGGAC- ENST00000434549.1 TC-GCTT---GAACTTGGGAGGC-----GGA-----GGTTGCAGATAGCGCCACTGCACT ** ** ** * ** *** * * * * * * **** *** ** ENST00000309035.6 --GGCCGCGACTGCACTGTGGAGATGCCCATCCTGAAGGACCTGGCCACTGTGGCCTTCT ENST00000434549.1 CCAGCCTGGGCTACAGAG-GGAGAC-TCTGTCTCAAAAAAAAT--TAAATAACACCTC-- *** * ** ** * ***** * ** ** * * * * *** ENST00000309035.6 GTGACGCGCAGTCGACGCAGGAAAT-CCACGAGAAGGT--TCTAAACGAAGCCGTGGGCG ENST00000434549.1 --AACAAGCAAT---TCCAGAGAATGCCGAAAGATAATCATTCAAATAAACTTGAGACCA ** *** * *** *** ** *** * * *** ** * * * ENST00000309035.6 CCATGATGTACCACACCATCACCCTCACCAGGGAGGACCTGGAGAAGTTCAAGGCCCTG- ENST00000434549.1 ACAGACAGTAAAAAA---------TTAATGAAGAGAA---AAGGAATTTGATGGTCTTTT ** *** * * * * *** * *** ** * ** * * ENST00000309035.6 -AGAGTGATCGTGCGGATAGGCAGTGGCTATGACAACGTGGACATCAAGGCTGCCGGCGA ENST00000434549.1 TAAACTGATTCTGGATATATGCATCATTAATGTTGCAGTG----TTAAAACT-------A * * **** ** *** *** *** *** * ** ** * ENST00000309035.6 GCTCGGAATTGCCGTGTGCAACATCCCGTCTGCAGCCGTGGAAGAGACAGCGGACTCTA- ENST00000434549.1 GCTGGAAA-------GTTGAAGATGTCCTCTGC--TTACAGAAGAGCTGAAAGACTATGA *** * ** ** ** ** * ***** ****** **** * ENST00000309035.6 --CCATCTGCCACATCCTCAACCTGTACCGGAGGAACACGTGGCTGTACCAGGCACTGCG ENST00000434549.1 TGTTATTTGTTA-ATGACCAGC---TGCTG-------TTATTG-TATGTTAAGTTTTTCA ** ** * ** ** * * * * * * * * * * * * ENST00000309035.6 GGAAGGCACGCGGGTTCAGAGCGTGGAGCAGATCCGCGAGGTGGCCTCGGGAGCGGCCCG ENST00000434549.1 TCTGTGCA-------TCAAACCATAAAGAATA-----GAGATTTTTCCTTTATCAGTC-- *** *** * * * ** * * *** * * * * * * ENST00000309035.6 CATCCGTGGGGAGACGCTGGGCCTCATTGGCTTTGGTCGCACGGGGCAGGCGGTTGCAGT ENST00000434549.1 ---CTTTGGGCACA-GCAGGTCCTGA---ACATT--CCGCTC----TAAAATGTTACA-- * **** * * ** ** *** * * ** *** * * *** ** ENST00000309035.6 TCGAGCCAAGGCCTTTGGAT-TCAGCGTCATA--TTTTATGA-----CCCCTACTTGCAG ENST00000434549.1 -----TCAAGAGTTTCAAACATCAAAATAAAAAATGTTAGGAGGAAATCCCCATTT-TAA **** ** * *** * * * * *** ** *** * ** * ENST00000309035.6 GATGGGATCGAGCGGTCCCT--GGGCGTGCAGAGGGT--CTACACCCTGCAGGATTTGCT ENST00000434549.1 GAC----TC---TAGTCCCTTCAGGC-TACAGAGGCTGATTATCTCTT------TTTGCT ** ** ****** *** * ****** * ** * * ****** ENST00000309035.6 GTATCAGAGCGACTGCGTCTCCTTGCACTGCAATCTCAACGAACATAACCACC-ACCT-C ENST00000434549.1 A-ATAGGAAC-ATTACATT-------ACTACAAAATGGA--GACAAAATTGTTTGCCTGT ** ** * * * * * *** *** * * *** ** *** ENST00000309035.6 ATCAATGACTTTACCATAAAGCAGAT--GAGGCAGGGAGCATTCCTT--GTGAACGCAGC ENST00000434549.1 GTTA--GACGTCTGCATGCATAGGATTGGAGACAGCACAGACTCCTGTAGAGAGAACTGT * * *** * *** * *** *** *** * **** * ** * * ENST00000309035.6 CCGTGGCGGCCTGGTGGACGAGAAAGCCTTAGCA--CAAGCC---CTCAAGGAGGGCAGG ENST00000434549.1 CTTTCACATC----TGAACGGCATA--CTGAGTGGGCAAGTTGGTTTTAAGTTCAGTAAA * * * * ** *** * * ** ** **** * *** * * ENST00000309035.6 ATACGAGGGGCAGCCCTCGACGTGCATGAGTCAGAGC--CCTTCAGCTTTGC--TCAGGG ENST00000434549.1 AC-----------CTTCTGATG---ATGGGGAAAAATAGTATTAAGTTTCACAACCTGTT * * ** * *** * * * ** ** ** * * * ENST00000309035.6 TCCGTTGAAAGATGCCCCGAATCTCA-TCTGCACTCCTCACACTGCCTGGTACAGTGAGC ENST00000434549.1 TTTACTCAAATATATTT----TCTCAGTCTCAGATCCTC-TGCTATTTTATTAAGTGGAA * * *** ** ***** *** ***** ** * * **** ENST00000309035.6 AGGCGTCA-CTG---GAGATGAGGGAGGCAGCTGCCACCGAGATCCGCCGAGCCATCACA ENST00000434549.1 AGTCATTAACTAAAAGAGTTCAAGAAGATAA-TGTTGC----ATTTCCTTATATCTCAGG ** * * * ** *** * * * ** * ** * ** * * *** ENST00000309035.6 GGTCGCATCCCA-GAAAGCTTA--AGAAATTGTGTGAACAAGGAATTCTTTGTCACATCA ENST00000434549.1 GAACACTTTTTATGATAACTTGTCAGATTTTCTATGAACAA---ACCCACTTTT------ * * * * * ** * *** *** ** * ******* * * * * ENST00000309035.6 GCGCCTTGGTCAGTAATAGACCAGCAAGCAATTCATCCTGAGCTCAATGGTGCCACATAC ENST00000434549.1 -----TTAGACATTGATA-------AAGTCTTCTTTTCT---TCCCATGACATTTTATAC ** * ** * *** *** * * ** * *** **** ENST00000309035.6 AGATATCCGCCAGGCATCGTGGGTGTGGCT-------------CCAGGAGGACTTCCTGC ENST00000434549.1 AAGTACACTCCAGATGTATTAGATATGACTAATTTTAACAAATCCTATCAGATTTGTATC * ** * **** * * * * ** ** ** ** ** * ENST00000309035.6 AGCCA-TGGAAGGGATCATCCCTGGAGGCATCCCAGTGACTCACAACCTCCC-------G ENST00000434549.1 AACTAGTTACATGCTTTATTCATAG-----TCTTTGTGAATCATTGCCTTTTTGTTTAAA * * * * * * * ** * * * ** **** *** *** ENST00000309035.6 ACAGTGGCACATCCTTCCCAAGCGCCCTCTCCCAACCA-------GCCCACAAAACACGG ENST00000434549.1 AAGATGGCCTATTCT------GAGCCTTTGTATAAGTATATTCTTGTTTTTGTGACGAAA * **** ** ** * *** * ** * * ** ENST00000309035.6 GGACAA--TCGAGAGCACCCCAACGAGCAATAGCAGAGAATGCCAGAAGGTAATCACTCA ENST00000434549.1 GAAAAACTTTAAAACTGTCCCAAATAG-AAAAATAATGGCTATCAGAAG-TA--TGTTTT * * ** * * * ***** ** ** * * * * ****** ** * ENST00000309035.6 GATACACTTGGGACCAAGAGACAGTGAAAAATAGATGAACTAAGAGAAAAAGAATCGGAT ENST00000434549.1 GTTTCAGTGTGAGTTAC----CATTACTATATTTGTTTATTGTAAAGGTGGACATTTAGC * * ** * * * ** * * ** * * * * ** ENST00000309035.6 GGTCTTTGTAACTGATTCTGGACATATGCATCATTGATGTTGCAGTGTTGAAACT--ACA ENST00000434549.1 ATTCAGTGCAATTCACAATAAAAA-AT------TTTCTGTTA-AGTTCTGAAATTCAGTT ** ** ** * * * * * ** ** **** *** ***** * ENST00000309035.6 AGAGCTAGAAAACTGAAGATGTCGTCTGCTTACGGAAGCGCTGAAAG--ACTAGGATGTG ENST00000434549.1 ACATCTCACTAA-TGTAAAAGTTCTCTACTT---GAGATGTTTAAGGCAACTGCATTGTC * * ** ** ** * * ** *** *** ** * * ** * *** *** ENST00000309035.6 ATTTA-TTAACGACCAACTTCTGTTATT---GTGTGTTAAGTTTTTCAT----------- ENST00000434549.1 AATTAGCCAATTTCCAACCCTTGTTACTCCAGGGTTCTATCTGCCTAATACCATAACCAG * *** ** ***** ***** * * ** ** * * ** ENST00000309035.6 -----------CTG-----TGCATCAAATCACAAAAAGAATAAAT--AGAGCTTTTTCCT ENST00000434549.1 ACTCAAGAACACTGAAAATTACCTCATATGATAGAAAGA-TAAATTAAAAATTAAAACCT *** * * *** ** * * ***** ***** * * * *** ENST00000309035.6 T-TATCAGTCCCTTGGGCACAGCAGGTCCTGAACACCCTGCTCTACAATGTTGCATCAAG ENST00000434549.1 CACACAAGTCCATCAT---TATCAAATCATGCCATCCTTAAGATATAATAGTGAGTTAGA * ***** * * ** ** ** ** * ** *** ** * * ENST00000309035.6 --------AGTTCAAACAACAAAATAAAA-AATATTAAGAGGAAATCCCCATCCTG---T ENST00000434549.1 GCTAAGTCAATTCAAAAAACAAAGTTGCTCAACTTTTAGAG----TTTTGATTTTAATTT * ****** ****** * ** ** **** * ** * * ENST00000309035.6 GACTTGAG------TCCCTTAAGTCTACAGGGGCTGGTGACCTCT-------TTTTGCTA ENST00000434549.1 AACCCAAAGCAAAATTACCTGGCTCAAGGGAGGGAAGTGAACCTTGAAACTCTTTTGCCA ** * * * * ** * * ** **** * * ****** * ENST00000309035.6 ATAGGAAAA------TCACATTACTACAAAATGGGG--AGAAAACTGTTTGC-----CTG ENST00000434549.1 ATAACCAAACAATTGTGACATT--TACAAAGAGGTGTTGTAAAATAATTTACATCAGCCA *** *** * ***** ****** ** * **** *** * * ENST00000309035.6 T-------GGTAGACACCTGCACG-------CATAGGA------TTGAAGACAGTAC-AG ENST00000434549.1 TTTCCATAGGTTAAGAACTTTAAGTTAATTTCATGGATCTTCCTTTTTAAATAGCATTAA * *** * * ** * * *** * ** * * ** * * ENST00000309035.6 GCTGCTGTAC-----AGAGAAGCGCCTCTC-ACATCTGAACTGCATACTGAGCGGG ENST00000434549.1 ACCTTTATACTAAAAACAAAAGTATGTTTCTACGTTGTATTTTTATA-TCAGCA-- * * *** * * *** * ** ** * * * *** * ***