CLUSTAL 2.1 multiple sequence alignment ENST00000309035.6 AAACCCCCAGTTGGTTGTCCCTGCCGTCTCGGAAGGGTT--AGCACACAGCCAGGTCTGT ENST00000454986.1 ---------GGTATACGCCCCCAC-GTCCTGAACGGCCCCGAGCACCCCACCCCCTGTGG * * * *** * *** * * ** ***** * ** * ** ENST00000309035.6 TTTTGATGTA----TGTAATTGAAGATTTATAAAGAAAAGCTTCTCCTCT--GCCTCATC ENST00000454986.1 CGTTGCTGGACCACTGCAACTGCA---CCGTG--GATATGCCCATCCTGAAAGACCTGAC *** ** * ** ** ** * * ** * ** **** * * * ENST00000309035.6 CGCAGTCATTTTTTTTCCAATGC-CAGTTCCCAGCAGGCATATAAATATTGGTCGTTCTC ENST00000454986.1 CACCGTGGCCTTCTGT--GATGCACAGTCCAC-GCAGG-----AAAT-----------CC * * ** ** * * **** **** * * ***** **** * ENST00000309035.6 AGAGCTGGGATGCTGCTGGGTGGTAC-GAGGGCCCC-TGGGAGAACGCCGAGTC-CCTGC ENST00000454986.1 A---CCAGAATGTT-TTAAATGAAGCCGTGGGCGCCATGACGTACCACAAAATCACCT-- * * * *** * * ** * * **** ** ** * * * * ** *** ENST00000309035.6 GGCCTCTGGGGAGGAGAAGCTCCCTGACGTATGGCACAGC---AGAGGGGACTTGGTTTG ENST00000454986.1 --TCTCCAGGGAGGA-------CCTGGAGAAGTTCAAGGCCCTAAGAGTGACT--GTTGC *** ******* **** * * ** ** * * **** *** ENST00000309035.6 AGCCAAACCACCGACCACAGGACGCTGCCCTGCCCGTGGCCGCCGAGCCCTACCTGTA-- ENST00000454986.1 AGATAGGC-ACTGGCCAC--GACAATG---TGG--ATGGACATCAAGGC-TGGCTGTGAG ** * * ** * **** *** ** ** *** * * ** * * **** ENST00000309035.6 -CCGGGAG-GCCGTTTATAACTCAGTGGCTG---CAAGAAAGGGGTCTACTCCTGACTTC ENST00000454986.1 CTCGGGATTGCTGTGTGCAACATCCCTTCCGAGCCGAGGAAGAA----ACAGCCGACTCC ***** ** ** * *** * * * ** *** ** * **** * ENST00000309035.6 ACCTTCTACGACAGCAGACAGGCAGTGATGTCTGG-TCGCAGCCCCCTGC--TGCCACGG ENST00000454986.1 ACCATCTGCCACATCCT-CAATCTGTACCGGAGGAACCGTGGCTGTACGAGGCGCTGCGG *** *** * *** * ** * ** * * ** ** * ** *** ENST00000309035.6 GAGTACTACAGTGATCCG---TCTGGAGCTGCTAGG-GTACCCAAAG-AGCCTCC-CCTC ENST00000454986.1 GAAGGC-ACGTGGGTACGGAGCCTGGAGCAG--AGGTGGATCCGGAGCAGCCTGCATCCC ** * ** * * ** ******* * *** * * ** ** ***** * * * ENST00000309035.6 TATCGGGACCCAGGAGTCAGCCGGCCGGTCCCCAGCTACGGAGTGCTTGGCAGCAGAACG ENST00000454986.1 TGCGAAGACGCTGG-----GCC------TCTTCGGCTTCAGTG-GCACGG-AGCAGGCAG * *** * ** *** ** * *** * * * ** ** ***** * ENST00000309035.6 TCATGGGATCCAATGCAAGGCC----GGTCACCTGCCCTGCAGGACGCCGGTCACCTGTA ENST00000454986.1 T--TGCAGTTCGAGCCAAGGCCTTCGGATTCAGTGTCTTACTTTATAATCCCTACTTGCA * ** * * * ******* * * ** * * * * ** ** * ENST00000309035.6 CCGGGATCCTGGAGGTAAAATGATCCCTCAGGGGCGGCAGACACAGAGCAGGGCTGCATC ENST00000454986.1 ---GGGT----GGGACAGAGCAGTCCCT--GGGCCTGCAGA--------GGGTCTATGCC ** * * * * * ***** *** * ***** ** ** * ENST00000309035.6 TCCCGGG-----CGGTATGGACGGGAGCAGCCCGACACCAGGTATGGGGCGGAGGTGCCT ENST00000454986.1 CTGCAGGATTTGCTGTATCAGAGTGACCACCTCTCCATGCACTGCAGTTTCAAGGAACAT * ** * **** * ** ** * * ** * * *** * * ENST00000309035.6 GCCTACCCCCTCAGCCAGGTCTTCAGCGACATCAGCGAAAGACCCATTGACCCTGCCCCT ENST00000454986.1 AACCACAACCTCACCAATGACTTTACTGTAA--AGCAGATGGGGCAGGGAGAAT-TCCTT * ** ***** * * * *** * * * *** * * ** ** * ** * ENST00000309035.6 GCCAGACAGGTGGCCC-CGACGTGCCTGGTTGTGGA-----CCCCAGTTCAGCTGCTGCC ENST00000454986.1 GTGA---ACGCAGCCCGTGGTG-GCTTGGTGGACAAGAAAGCCTTAGGACAG-----GCC * * * * **** * * ** **** * * ** ** *** *** ENST00000309035.6 CCC--GAAG-GCAGCACAGGGGTG--GCCCCAGGGGCCCTG-AATCGTGGC--TACGGGC ENST00000454986.1 CTCAAGAAGAGCAGGATAGAGGCGCAGCCCTCGACATGCAGGAATCAGAGCCCTTTGGCT * * **** **** * ** ** * **** * * * **** ** * ** ENST00000309035.6 CTGCCCGGGAAAGCATCCCATCCAAGATGGCTTACGAGACTTACGAAGCTGACCTGTCCA ENST00000454986.1 TTGCTCAGGG-----TCCGTTTAAAGATG-----CAAG------GAATTTTATCTGTATT *** * ** *** * ****** * ** *** * * **** ENST00000309035.6 CCTTCCAGGGTCCTGGTG--GCAAGAGGACCGTGCTCCC--TGAGTTCCTGGCCTTTCTG ENST00000454986.1 CCCCACACTG-CCTGGTACAGTGAGCAGGCGTCACTGGAGATGAGAGGCAGCTGCCACCG ** ** * ****** * ** * * ** **** * * * * ENST00000309035.6 CGGGCGGAGGGGCTGGCAGAGGCCACGCTGGGAGCCCT------ACTGC---AGCAGGG- ENST00000454986.1 AGATCTGTTGAGCCACCACAGGTTACATTCAGAAAGCTTAAGAAACTGTGTGAACAAGAA * * * * ** ** *** ** * ** ** **** * ** * ENST00000309035.6 --CTTTGACTCCCCGGCCGTCCTGGCTACCCTGGAGGACGCGGATATCAAGTC-TGTCGC ENST00000454986.1 TTCTTTGTCACATCAGC-GCCTTGGTCAG--TAATAGAC-CAGCAAGCAATTCATCTCGA ***** * * * ** * * *** * * *** * * * *** ** * *** ENST00000309035.6 ACCCAACCTGG-GCCAGGCCCGTGT-TCTG--AGCCGCC-TGGCCAATAGCTGCAGGACC ENST00000454986.1 GCTCAG--TGGTGCCACATACAGGTATCTGCCAGGCATCGTGGGTG-TGGCTCCAGGA-- * ** *** **** * ** **** ** * * *** * *** ***** ENST00000309035.6 GAAATGCAGCTGCGGAGGCAGGACCGGGGGGGCCCGCTGCCCCGGGCGCGGTCCAGCAGC ENST00000454986.1 GCACTCC--CTGC--AGCCA----CGGAAGGGATCAT--CCTTGGAGGCATCCCAGTGAT * * * * **** ** ** *** *** * ** ** ** **** ENST00000309035.6 TTCAGCCACCGAAGCGAACTGCTCCATGGTGACTTGGCTTCTCTGGGCGCTGCGGCTCCT ENST00000454986.1 T-----CAC-------AATCTCCCGACAGTGGTACATCCTTCCCAAGCTC-------CCT * *** ** * * * *** * * * ** * *** ENST00000309035.6 CTGCAGACAGCATCCCCCCGAGC-TGGAGACCCGGCTCGCCGTCCCTCCAGCGCACCATC ENST00000454986.1 CTCCCAAC--CAGCCCACAAAACACGGAGAC---AATCGAGAGCACCCCAACGCACAATA ** * ** ** *** * * * ****** *** * * *** ***** ** ENST00000309035.6 TCAGCACCTCCTGGAGACGGCAGCCACCTATTCTGCCCCTGGCGTGGGCACCCATGCCCC ENST00000454986.1 GCAGAGAATGCCAAAA--GGTAATCA----TTCCAATAC--ACTTGGG-ACCAAG----- *** * * * ** * ** *** * * **** *** * ENST00000309035.6 ACACTTCCCCTCCAACTCCGGGTACAGCTCTCCCACCCCTTGCGCCCTGACAGCGCGTCT ENST00000454986.1 AGAGTGAACAAATAGATG-GAATAAAATAATTTGACGGTCT---TTTTAAC--TGATTCT * * * * * * * ** * * ** * * ** * *** ENST00000309035.6 GAGCCCCACGTACCCCCTGCAGGCAGGGGTGGCCTTGACTAACCCGGGCCCCTCAAACCC ENST00000454986.1 GG-----ACATATCCATCATTGAT----GTTGCAGTG---------------TTAAAACT * ** ** ** * ** ** ** * *** * ENST00000309035.6 CCTTCACCCAGGCCCCAGAACAGCCTACTCCACGGCATACACGGTGCCCATGGAGCTGCT ENST00000454986.1 AC-------AAGAGCTAGAA-AACTGAAA--ATGTCATC-----TGCTTGTGGAAGTGCT * * * * **** * * * * * *** *** **** **** ENST00000309035.6 AAAGAGGGAGCGCAACGTGGCCGCCTCTCCGCTGCCCAGCCCTCACGGCAGCCCCCAGGT ENST00000454986.1 GAAA---GACTAGGATGTGA---TTTATTAACAACCAACTTCTGTTATTGTGTGTTGAGT ** ** * *** * * * ** * ** ** ENST00000309035.6 CTTGCGGAAGCCAGGTGCACCCCTGGGGCCATCCACCCTGCCGCCGGCCAGCCAGAGCCT ENST00000454986.1 TTTTC---ATCC--GTGCA----TGAAATCA----------CACAAAATAAACAGAGCTT ** * * ** ***** ** ** * * * ****** * ENST00000309035.6 CCACACGCCTCACTCACCGTACCAGAAGGTGGCCCGGCGCACAGGGGCACCCATCATCGT ENST00000454986.1 TTTCCTTTGTCAGTC-----------------CCTTGAGCATAGCAGGTCCTGACACCCT * *** ** ** * *** ** * ** ** * * ENST00000309035.6 GTCC-ACCATGCTTGCACCAGAA--CCAAGTATCCGCCCCCAGATCATGAACGGCCCCCT ENST00000454986.1 GTTCTAGAATA-TTGCATCAGGAGTTCAAACATCAAAATAAAAAATATTAAGAGG----- ** * * ** ***** *** * *** *** * * ** ** * ENST00000309035.6 GCACCCCCGCCCCCTGGTGGCGCTGCTGGACGGCCGCGACTGCACTGTGGAGATGCCCAT ENST00000454986.1 AAATCCTTATCCT---GTGACTCTG-------GTCCC------------------CTCAG * ** ** *** * *** * * * * ** ENST00000309035.6 CCTGAAGGACCTGGCCACTGTGGCCTTCTG-TGACGCGCAGTCGACGCAGGAAATCCACG ENST00000454986.1 TCTACAGGGGCTGGTTGCCT---CTTTTTGCTAATAGGAAGAT--TGCATTA---CTACA ** *** **** * * ** ** * * * ** *** * * ** ENST00000309035.6 AGAAGGTTCTAAACGAAGCCGTGGGCGCCATGATGTACCACACCATCACCCTCACCAGGG ENST00000454986.1 AAATGGG---GAAGCAAACTGTTTGC-CTGTGGTA-----------GACACTTGACACAT * * ** ** ** * ** ** * ** * ** ** ** ENST00000309035.6 AGGACCTGGAGA-AGTTCAAGGCCCTGAGAGTGATCGTGCGGATAGGCAGTGGCTATGAC ENST00000454986.1 AGGAT-TGAAGACAGTACAGGCTCCTG----------TACAGAGA---AGTGTCTCTCAC **** ** *** *** ** * **** * * ** * **** ** * ** ENST00000309035.6 AACGTGGACATCAAGGCTGCCGGCGAGCTCGGAATTGCCGTGTGCAACATCCCGTCTGCA ENST00000454986.1 ATCTGAAATGCCTACTGAGCAGACAAGTTGG---TTGTT-TG-GTAAAACCC--TCT--A * * * * * ** * * ** * * *** ** * ** * ** *** * ENST00000309035.6 GCCGTGGAAGAGACAGCGGACTCTACCATCTGCCACATCCTCAACCTGTAC---CGGAGG ENST00000454986.1 ATGATGAAAAAAGTGTTAAGTTTCACAAGCTGTT-TGTACTCAAA-TATATTTTCTCAGT ** ** * * ** * *** * ***** * ** * ** ENST00000309035.6 AACACGTGGCTGTACCAGGC-ACTGCGGGAAGGCACGCGGGTTCAGAGCGTGGAGCAGAT ENST00000454986.1 TTCAGATC-CTCTGCTATTTTATTGAGTGGAAAGACTTGAACTAAAAGGTTTAAGAAGAT ** * ** * * * * ** * * * ** * * * ** * ** **** ENST00000309035.6 CCGCGAGGTGGCCTCGGGAGCGGCCCGCATCCGTGGGGAGACGCTGGGCCTCAT--TGGC ENST00000454986.1 ----AATGTTGCATT--------TCCTTATGTCTCAGGAAACACT---TTTTATGGTAAC * ** ** * ** ** * *** ** ** * ** * * ENST00000309035.6 TTT---GGTCGCACG-GGGCAGGCGGTTGCAGTTCGAGCCAAGGCCTTTGGATTCAGCGT ENST00000454986.1 TTGTCAGATTGCCCATGAGCAAAC--CCACTTTTTTAG---ATGTTGATAAAGTCTTCTT ** * * ** * * *** * * ** ** * * * * ** * * ENST00000309035.6 CATATTTTATGACCCCTACTTGCAGGATGGGATCGAGCGGTCCCTGGGCGTGCAGAGGGT ENST00000454986.1 TTCTTCATGTGATACTT-CATACAAGAACACTTCAGATG--TGTTAGATGTG-ACTGATT * * *** * * * * ** ** ** * * * *** * * * ENST00000309035.6 CTAC---ACCCTGCAGGATTTGCTGTATCAGAGCGACTGCGTCTCCT-TGCACTGCAATC ENST00000454986.1 TTAACAAATCCTATTAGATT---TGTGTCA-ACTAGTTACATGTTCTATTCATAGT--CT ** * *** **** *** *** * * * * * ** * ** * ENST00000309035.6 TCAACGAACATAACCACCACCTCATCAATGACTTTACCATAAAGCAGATGAG--GCAGGG ENST00000454986.1 TTTGTGAAT-----CATTGCCTTTTTG-----TTTA----AAAG--GATGGCCTGTTTTG * *** ** *** * **** **** **** * * ENST00000309035.6 AGCATTCCTTGTGAACGCAGCCCGTGGCGGCCTGGTGGACGAGAAAGCCTTAGCACAAGC ENST00000454986.1 AGC---CTTTGTATAGGTA--CCTTCCTGTTTTTGTG-ACAAACAAGATTTTAAAATTGT *** * **** * * * ** * * * *** ** * *** ** * * ENST00000309035.6 CCTCAA--GGAGGGCA--GGATACGAGGGGCAGCCCTCGACGTGCATGAGTCAGAGCC-C ENST00000454986.1 CCTAAACAGAAAAATAATGGCTATCAGAAGTA-----TGTTTTGTTTTAGTTTGAGTTGC *** ** * * * ** ** ** * * * ** * *** *** * ENST00000309035.6 TTCAGCTTTGCTCAGGGTCCGTTGAAAGATGCCCCGAATCTCATCT-GCACTCCTCACAC ENST00000454986.1 TATTACTGTACTTA-------TTGTAAAG----CTGGA---CATTTAGCATTC-----AC * ** * ** * *** ** * * * *** * *** ** ** ENST00000309035.6 TGCCTGGTACAGTGAGCAGGCGTCACTGGAGATGAGGGAGGCAGCTGCCACCGAGATCCG ENST00000454986.1 TGCCATTTTTAGTAAA---ACGTTAATT---TTAAAAAATATAG-TGTCAT--AGACCTG **** * *** * *** * * * * * ** ** ** *** * * ENST00000309035.6 CCGAGCCATCACAGGTCGCATCCCAGAAAGCTTAAGAAATTGTGTGAACAAGGAATTCTT ENST00000454986.1 ACAA------AGAGCTCATATGCAAAA-----------------TAAATAAGGAATGCCT * * * ** ** ** * * * * ** ******* * * ENST00000309035.6 --TGTCACATCAGCGCCTTGGTCAGTAATAGACCAGCA-AGCAATTCATCCTGAGCTCA- ENST00000454986.1 ATTTTTATATTGGA---TTGCTAAATAATAACCCAATATAAAAATAGGTAAGGAGCTTAC * * * ** * *** * * ***** *** * * *** * ***** * ENST00000309035.6 ATGGTGCC---ACATACAGA-TATCCGCCAGGCATCGTGGGTGTGGCTCCAGGAGGACTT ENST00000454986.1 ACAGTCACTTAACAAAAAGAATATTCAAATGGC-TTATAAACATAT-----GAAAAGTTA * ** * *** * *** *** * *** * * * * * * ENST00000309035.6 CCTGCAGCCATGGAAGGGATCATCCCTGGAGGCATCCCAGTGACTCACAACCTCCCGACA ENST00000454986.1 CCT--AGCCTTATGAGT-----TCCTTATGGAAAT----GTAAGTTAAAAAT-----ACA *** **** * ** *** * * ** ** * * * ** *** ENST00000309035.6 GTGGCACATCCTTCCCAAGCGCCCTCTCCCAACCAGCCCACAAAACACGGGGACAATCGA ENST00000454986.1 ATGAGATGTC----------ACTTTATTCCCACGAATATAACTAAAATTAGAAAGATCAA ** * ** * * * ** ** * * ** * * * *** * ENST00000309035.6 GAGCACCCCAACGAGCAATAGCAGAGAATGCCAGAAGGTA----ATCACTCAGATACACT ENST00000454986.1 CAATATC-----AAGCATTGGT-GAGAATG--AGGAGGAACAGGAACATTCATATCCTGC * * * **** * * ******* ** *** * * ** *** ** * ENST00000309035.6 TGGGACCAAGAGACAGTGAAAAATAGATGAACTAAGAGAAAAAGAATCGGATGGTCTTTG ENST00000454986.1 TGTTAC-AAGAA-----GAAACTTGTAC-AACCACTTTGAAAACTGTTAG-TGCTTTTTT ** ** **** **** * * *** * **** * * ** * *** ENST00000309035.6 TAACTGATTCTGGACATATGCATCATTGATGTTGCAGTGTTGAAACT-ACAAGAGCTAGA ENST00000454986.1 TTTCTAACAATGCA---ATGCCTAAATC-TGTACCAATA--GAAATGGACACACACAAAC * ** * ** * **** * * * *** ** * **** *** * * ENST00000309035.6 AAACTGAAGATGT-CGTCTGCTTACGGAAGCGCTGAAAGACT----AGGA-TGTGATTTA ENST00000454986.1 ACAC-GGACACACACAACCCCAAATGAATGT-CTGAGAATCTTCACAGCAGCATTATTCA * ** * * * * * * * * * * **** * ** ** * * *** * ENST00000309035.6 TTAACGACC--AACTTCT-GTTATTGTGTGT---TAAGTTTTT---CATCTGTGCATCAA ENST00000454986.1 T-AACAACCCTAATATCCAGTAACAGAGGATGGATAAATTTTGGTGTATTCATATAATAG * *** *** ** ** ** * * * * *** **** ** * * * ENST00000309035.6 ATCAC---AAAAAGAATAAATAGAGCTTTTTCCTTTATCAGTCCCTTGGGCACAGCAGGT ENST00000454986.1 AATACTGCAAAACAATCAAAATTAGCGTATTGCT------GCTACATATA-ACAGTATGT * ** **** * *** *** * ** ** * * * **** * ** ENST00000309035.6 CCTGAACACCCTGCTCTACAATGTTGCATCA-AGAGTTCAAACAACAAAATAAAAA-ATA ENST00000454986.1 A-TGCATCTCATGAT-TATA--GCTCTTTCAGAGAAGTTAAACACAAAAGTATACATACT ** * * ** * ** * * * *** *** * ***** *** ** * * * ENST00000309035.6 TTAAGAGGA--AATCCCCATCCTGTGACTTGAGTCCCTTAAGTCTACAGGGGCTGGTGAC ENST00000454986.1 TTATGCACATCAATGGCCATA-TATGATTTCA----------TTTATATGGTATA-TGAG *** * * *** **** * *** ** * * ** * ** * *** ENST00000309035.6 CTCTTTTTGCTAATAGGAAAATCACATTACTA----CAAAATGGGGAGAAAACTGTTTGC ENST00000454986.1 CACT----------AGCAAAACTAAGTTATGATTTTCAAAGTCG---GAATGGTGGTTGC * ** ** **** * *** * **** * * *** ** **** ENST00000309035.6 CTGTGGTAGACACCTGCACGCATAG-GATTGAAGA-CAGTACA-----------GGCTGC ENST00000454986.1 TT-TGA-AGA-ATTTGGAGGGAGAGTGATTGGAGAGCTATAGAAAATGTTCCTGGGATGC * ** *** * ** * * * ** ***** *** * ** * ** *** ENST00000309035.6 TGT-ACAGAGAAGCGC---CTCTCACATCTGAACTGCATACTGAGCGGG ENST00000454986.1 TGTTACAAGGGCATTCACTTTTTCATAACTTAATTGA--GCTACACGCT *** *** * * * *** * ** ** ** ** **