CLUSTAL 2.1 multiple sequence alignment ENST00000314138.6 CGGCTCAGGGCTGGCGCATTTGGTGAGGAGCTCAGACAACGAGGCCCTTAGGGTCGGCTT ENST00000492974.1 ------------------------------------------------------------ ENST00000314138.6 AGGCGGTTCCCTGACCAAGGCGCCAGAAAAGGGCCTGGCTCAAGCAAGCACGGGCGGCGT ENST00000492974.1 ------------------------------------------------------------ ENST00000314138.6 GCAGTACAGCACACCTAGCCCCGATTCTTCAACAGTTCTCGCCCTCCGAGCCTAGCACAA ENST00000492974.1 ------------------------------------------------------------ ENST00000314138.6 CGAGCCTCACCGAAACCGTACACCGCCACCAGGACACTCCGTGATGGGGGATCACCACCC ENST00000492974.1 ------------------------------------------------------------ ENST00000314138.6 TCAGAAAGAGGAAGCGACTAGCAGGCGCGCAATCCCGCGAGACCAGGAGGCCCCGCCCGA ENST00000492974.1 ------------------------------------------------------------ ENST00000314138.6 AGCCCGGCCTCTGTGACCGGAAGTGAGGCGTTTTGCCCCGCCCCCGTGGCCGATACCTCG ENST00000492974.1 ------------------------------------------------------------ ENST00000314138.6 CGAGACTTGGCGAAGGCCTTCCTTTTTCGTCTGGGCTGCCAACATGCCATCCAGACTGAG ENST00000492974.1 -----------------TTTTTTTTTTCGTCTGGGCTGCCAACATGCCATCCAGACTGAG ** ************************************** ENST00000314138.6 GAAGACCCGGAAACTTAGGGGCCACGTGAGCCACGGCCACGGCCGCATAGGCAAGCACCG ENST00000492974.1 GAAGACCCGGAAACTTAGGGGCCACGTGAGCCACCGCCACGGCCGCATAGGCAAGCACCG ********************************** ************************* ENST00000314138.6 GAAGCACCCCGGCGGCCGCGGTAATGCTGGTGGTCTGCATCACCACCGGATCAACTTCGA ENST00000492974.1 GAAGCACCCCGGCGGCCGCGGTAATGCTGGTGGTCTGCATCACCACCGGATCAACTTCGA ************************************************************ ENST00000314138.6 CAAATACCACCCAGGCTACTTTGGGAAAGTTGGTATGAAGCATTACCACTTAAAGAGGAA ENST00000492974.1 CAAATACCACCCAGGCTACTTTGGGAAAGTTGGTATGAAGCATTACCACTTAAAGAGGAA ************************************************************ ENST00000314138.6 CCAGAGCTTCTGCCCAACTGTCAACCTTGACAAATTGTGGACTTTGGTCAGTGAACAGAC ENST00000492974.1 CCAGAGCTTCTGCCCAACTGTCAACCTTGACAAATTGTGGACTTTGGTCAGTGAACAGAC ************************************************************ ENST00000314138.6 ACGGGTGAATGCTGCTAAAAACAAGACTGGGGCTGCTCCCATCATTGATGTGGTGCGATC ENST00000492974.1 ACGGGTGAATGCTGCTAAAAACAAGACTGGGGCTGCTCCCATCATTGATGTGGTGCGATC ************************************************************ ENST00000314138.6 GGGCTACTACAAAGTTCTGGGAAAGGGAAAGCTCCCAAAGCAGCCTGTCATCGTGAAGGC ENST00000492974.1 TGGCTACTACAAAGTTCTGGGAAAGGGAAAGCTCCCCAAGCAGGCTGTCACCGTGCAGGC *********************************** ****** ****** **** **** ENST00000314138.6 CAAATTCTTCAGCAGAAGAGCTGAGGAGAAGATTAAGAGTGTTGGGGGGGCCTGTGTCCT ENST00000492974.1 CAAATTCTTCAGCAGAAGAGCTGAGGAGAAGATTAAGAGTGTTGGGGGGGCCTGTGTCCT ************************************************************ ENST00000314138.6 GGTGGCTTGAAGCCACATGGAGGGAGTTTCATTAAATGCTAACTACTTTTTCCTTGTGGT ENST00000492974.1 GGTGGCTTGAAGCCGCATGGAGGGAGTTTCATTAAATGCTAACTACT------------- ************** ******************************** ENST00000314138.6 GTGAGTGTAGGTTCTTCAGTGGCACCTCTACATCCTGTGTGCATTGGGAGCCCAGGTTCT ENST00000492974.1 -TAAAAAAAAA------AAAAGAA----------------------GAAGA--------- * * * * * * * ** ENST00000314138.6 AGTACTTAGGGTATGAAGACATGGGGTCCTCTCCTGACTTCCCTCAAATATATGGTAAAC ENST00000492974.1 -------AGAAGAAGAAAA-ATGG----------------------AATAC-TGG-AAAT ** * *** * **** **** *** *** ENST00000314138.6 GTAAGACCAACAC-AGACGTTGGCCAGTTAAACATTTCTGTTTATAAAGTCAGAATAATA ENST00000492974.1 GTGAGACCAAAATGAGAAATC--CCAG---AGCATATTGGTGTG----GTGATAATGAC- ** ******* * *** * **** * *** * ** * ** * *** * ENST00000314138.6 CCTGTTGATCACTGAAAGGCCTGCATGTATTGTACTCTGAATTTTACAGTGAATGAGAGA ENST00000492974.1 CCAGCAGA-CAGGGAAAG-----CA----------------------GGTGAAGGAGAGA ** * ** ** ***** ** ***** ****** ENST00000314138.6 ATGTACCCTAATTGTTCAACAGGGCTCAAAAGGAAAGATTCCATTTTGATGGGTCACATT ENST00000492974.1 G--------------------------AGGAGGTAA---------TTGCTGTGTGAAGTC * *** ** *** ** ** * * ENST00000314138.6 CTAAAGAGGGGCAGTGTGATAGGAATGAGATGGTCCTTTAGGACTTAAGTTCTCAGCCCA ENST00000492974.1 TT------------TGCGG-AGGAAAGAGACAA-----TAGGATAT------------CA * ** * ***** **** ***** * ** ENST00000314138.6 AGGTTTTTCCACGTGGCCCCCTCATCTTTTTTTTTTTTTTAAACGGAGTCTCTCTTGCCA ENST00000492974.1 AG---------------------------------------AACGG-GTCTTCCCTG--- ** ***** **** * ** ENST00000314138.6 GGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAGCCTCCGCCTCCCAGGTTAAGCGA ENST00000492974.1 ----GGAGCATG-----AATATTTCACCTCA--------TCCATTTC------------- **** * ** ** **** *** ** ENST00000314138.6 TTCTCCTGCCTCAGCTTCCTGACTAACTGGGATTACAGGCGCCCACCACCATGCCCAGCT ENST00000492974.1 ---------------------------------TACAGG--------------------- ****** ENST00000314138.6 AATTTTTGTATTTTCAGTAGAGATGGGGTTTCACCATGTTGGCCATGCTGGTCTCTAACT ENST00000492974.1 ---------------AGTGAAGGCAGGAT------ATGT--------------------- *** ** ** * **** ENST00000314138.6 CCTAACCTCAAGTGATCTGCCCACATCGGCCTCCAAAAGTTCTGGGATTATAGTGTGAGC ENST00000492974.1 ------------------------------------AAGTTCTGA---TATAGT-TAAGT ******** ****** * ** ENST00000314138.6 CACTGCGCCCGGCCATGGCTCCTTAATCTTGATCCAAATTATTGTTACATCCAGAATGTG ENST00000492974.1 ----------GG--ATAG-------ATCCTG--------TAGTG---------GAA---G ** ** * *** ** ** ** *** * ENST00000314138.6 ATGAATCAAAATCTCGAGATGGGGGTCCAGCAATCTGAAATTTCAGTATGCCAGGGCTTT ENST00000492974.1 ATGA---AGAATTTCAAT-------TCTGATAGTCTGTATTTCCAAAATGACA------- **** * *** ** * ** * **** * ** ** *** ** ENST00000314138.6 TCTGTATGTCAAAGTGGGTTTGAAATAGTTAATTTTTCTTCTAGTCTGAAATGTATCGGG ENST00000492974.1 ------------------TTTGAGAC---TAGCTCATCAGCTAATGGGGAATG-----GG ***** * ** * ** *** * * **** ** ENST00000314138.6 AAAATTTGGAAATCCTGAAGGCTGGAAATTGAAATAAGTTTTTCTAGGATTTGTGTCTCT ENST00000492974.1 AGAAT---GAGA-----GAGTATGGAAATT------------TTGAGGA----------- * *** ** * ** ******** * **** ENST00000314138.6 TGCTATTGGAAAACTGATGGTGACCAATTCATGTTTACAAATAAGATCCTCATAGATCTC ENST00000492974.1 -AAAATTAGAAGAC--ATG-------------------AAAT--GGTCTACA-------- *** *** ** *** **** * ** ** ENST00000314138.6 GGTAAATTATAATTTGCTACAGTTTTATGGTTCTTCCTGTGATTTTGAGCTTTTTTTGAC ENST00000492974.1 ----------AATTTACTCAAATTTCATG------------------------------- ***** ** * *** *** ENST00000314138.6 CCAAAATAATACAGTCTAAAACTATAGACAAATAAGATGGCACTTAGACTCCTGGGTTTT ENST00000492974.1 -----ACAACG--------------------------------TTAG-----------TT * ** **** ** ENST00000314138.6 AGTTAGTGGAGGTTTCCTTAGTGCACTGTGGGGTCATAATAAGCCGAGAACCATGGCTGT ENST00000492974.1 GCTTATTGGAGATTTCT--------------GGCCAT--TAA------------------ *** ***** **** ** *** *** ENST00000314138.6 CTATGGGACACATCTGTCAGGACAACCTTTAGAGGATGTTGGGGATCAAATAGAAGGCAC ENST00000492974.1 ---------------------------TTTAAAG-----TGA-----AAATAGA------ **** ** ** ******* ENST00000314138.6 AGAGAAGCACTGAATTGGCTTACATAAGAATAGGCTAGAATTACAAGTAGTGAAACCTCG ENST00000492974.1 ----------TTAATTGATTATTATAAAAGCAGG------TAACAAGCC-TAAAATATAG * ***** * **** * *** * ***** * *** * * ENST00000314138.6 ATTCAGCTGGACAATTTTAAACAAATGTATCATTTGGCTTGTATCTTCTGTTGTGCTGGA ENST00000492974.1 -------TAGATGTTCATAGAATGGTGCATA--TTGTTTTGT------TATTGTTCTGGA * ** * ** * ** ** *** **** * **** ***** ENST00000314138.6 GAAGTTAGAAATAAGGGCTCTCCAGACCAGCCTGACCAACCTGGAGAAACCTTGTCTCTA ENST00000492974.1 ----CTCTTAACCGGAAATCTCAGGGCCAGATTAA--AGTTCAGA---ATCTTTTCT--- * ** * **** * **** * * * ** * *** *** ENST00000314138.6 CTAAATACACAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTTTGGA ENST00000492974.1 ------------GATTGGCT--------------------------TTAGCTTCTCTC-- *** ** **** ** * ENST00000314138.6 GGCTGAGCCAGGAGAATCTCCAGGAGGCGGAGGTTGCTGTGAGCCGAGATCGTGCCATTG ENST00000492974.1 ------------AGATTTTCTGAGA------------TGTGAT------TCCTTCTAT-- *** * ** ** ***** ** * * ** ENST00000314138.6 CACTCCAGCTTGGGCAACAAGAGTGAAACTCTGTCCACCCCCCCCAAAAAAAGTAAGGGC ENST00000492974.1 CTCCCCATCT---------AGA---------TGCCCATTGCCATC--------CCTGCGC * * *** ** *** ** *** ** * * ** ENST00000314138.6 TCTCCATTAGGGCCCATAGAGGACTTGTAATATGGAACCTGAATCCAAGGATCCCACAAT ENST00000492974.1 TATGCA----GATCTTTAG------TATAACAT----CCTCTATCC-----TCTTTACAT * * ** * * *** * *** ** *** **** ** ** ENST00000314138.6 AAGTGGTCAGTAGTTCATGATGAATTAAAAGACTCAATATTTGGTCTTCACCCAATACCT ENST00000492974.1 AAATAG-------------ATGAACAAACAAAGCAGAT---------------------- ** * * ***** ** * * ** ENST00000314138.6 GTGTGACTTTTAGTCCTAATTTCCTCATCTTTAAAATTTCAGTGAAAGTGCCTACCTGAG ENST00000492974.1 ----------------CAATTTCTCCA--TTTAAGATCCT----------CATACCTTGG ****** ** ***** ** * ***** * ENST00000314138.6 GATTGTGTAGATTAAAATGGAAACCGTGCACTTAATTTTTTGTTTTGTTTTGAGACGGAG ENST00000492974.1 GG--------------ATGGAGGG--------TAATC---------------AGAAGGAG * ***** **** *** **** ENST00000314138.6 TCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTCAGATCACTGCAAGCTCCG ENST00000492974.1 TAAAGC---------CAGGTTG------------------TTGGATGA--GAAGG----G * ** **** ** * *** * * * * * ENST00000314138.6 CCTCCTAGGTTCAGACCATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGACTACAGGCGC ENST00000492974.1 TTCTCTAGG----ACTCATTTTTCAGCT---GCTTCTT--GTCACATTGAATA------- ***** **** * * ** ***** ** * ** ** ENST00000314138.6 CCGCCACTGCGCCCGGCTA-ATTTTTTGCATTTTTAGTAGAGACAGGGTTTCACCGTGTT ENST00000492974.1 -------TGTGCAAATCTATATTTCTTTTAGTCTCAGCAAGGGTGGGGAATC-CCATGTC ** ** *** **** ** * * * ** * * *** ** ** *** ENST00000314138.6 AGCCAGGATGGTCTCGATCTCCTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTA ENST00000492974.1 CTTTAAAACAA---GAATTTTCTGAATTCCTTGCTCC--------------CTGTATCTA * * ** * **** * * ** * *** ** ENST00000314138.6 CAGGCATGAGCCACCGCGCCCGGCCCAGGCACTTAATTTTTGTGTTTGACTTAGTAACTT ENST00000492974.1 TTGGT-----------TGCTCTGC---GGCACCT-----------TCAACTCAGCATCT- ** ** * ** ***** * * *** ** * ** ENST00000314138.6 AAGTGCAAACTATTACGGGAGCAGATGGAGTCAATTGGCCTTCATGTGATTGTCAGTGGG ENST00000492974.1 --------GCT-TTCCTGAATCTG-----TTCAATTG---TTCCCATAA--GTTAATG-- ** ** * * * * * ******* *** * * ** * ** ENST00000314138.6 AAATTGGTCCAAGCAGAGGGAATACTGGTTCAGGAAACTGGTTTGGGAAGGTTAGGCAAA ENST00000492974.1 ---TTTGCTC------------------TTTA------TGATCTTAGA------------ ** * * ** * ** * * ** ENST00000314138.6 CGGGAAGTGCTATGGTGGAGAGAAAGATTACTCTGGCCGGGCTGTAAAGGACGGCTACAA ENST00000492974.1 ----------TGTGATGTTGACTTCTACTTCTTTAGTCAT-TTGC-----ACGGGT---- * ** ** ** * * ** * * * ** **** * ENST00000314138.6 TGGGAGGCTGAAGGCAGAACCAAGAAAATGGGAGTGAGTATGGAAAAGGTACGATTCAGA ENST00000492974.1 ------GCTGA------------------GACAGTCAATAT---AAAAATCTTATTCA-- ***** * *** * *** *** * ***** ENST00000314138.6 CGGCATAATGGACGGGACTTGGAGACTGAATTGTAGTGGGCCGACCACAAAATGATAAGG ENST00000492974.1 ---------------------------------TAGT-------TCTCAGTACGGTAG-- **** * ** * * ** ENST00000314138.6 CATGGAAGGAAGTAGAGTTTGGGGGGAAGGATCCCTAGTCCCTTAATGGCTACCTTCTTC ENST00000492974.1 ------------------------------------------------------------ ENST00000314138.6 CCCAGGAGTTGTTAGGCCATCCGATCCCCTGGCCTGGGAAAGAAACACTGATTTCGTTGC ENST00000492974.1 --CAGAAACAGTCAGGTTGACTGA----CTGGTCC---AAGGTAA-------------GC *** * ** *** * ** **** * ** * ** ** ENST00000314138.6 TGGCTTGTTCACTCACCAGAAGCTACAGCTACTAACAGTTCTAAAAACTGTTTCATGTGA ENST00000492974.1 TGGTTA-----------AGAAGTAGTAG-----AATAG-----------GACTCATGT-- *** * ***** ** ** ** * ****** ENST00000314138.6 TGAGGAACAGACGAAAATAGTTTTGAGCCCTAAGTCCGCCGATTCCAGTGCTTTCTTGAA ENST00000492974.1 --------------------------------------------CTAGTACT-------- * *** ** ENST00000314138.6 CCCGCATTTACTAAAATATTTTCATGACTGCCAAGCTTTGAATAGCCTGCTGTGTTCATG ENST00000492974.1 -----ATTTACC------TTCTC-TGGCTG------------------------------ ****** ** ** ** *** ENST00000314138.6 GAGGCTCATACTGGCGATCTCTAGTGGCTGGCTAAAGCTTGAATTGCAAAAGATCTAATT ENST00000492974.1 ------------GGTG-----CAGTGGCT------------------------------- ** * ******* ENST00000314138.6 TCTGGTCTAATGTATATATGCCTTAAATATAGTTGCGTTCAAACGTGGGAGCTGCAGGTG ENST00000492974.1 ----------------TATGCCTTTAACAC--CAGCGCTC-----TGGGAG--GC----- ******** ** * *** ** ****** ** ENST00000314138.6 CAACTTGATTTTATGACAAATGGCTGCCACATAATTTGCACAAGCAGTGCTCGTCAAGGG ENST00000492974.1 ---CTTGA---CAGGAGAA-------TCACTTGAG----GCCAGGAGT-----TCAAGAC ***** * ** ** *** * * * ** *** ***** ENST00000314138.6 CAGCTAAATCAGGCGAGCTTTCAATCAAAATAAATGTACTACTAAACCCTACTTAGCGGC ENST00000492974.1 CAGC-----CTGGCCAACAT---AGCAAGAT----------CTTGTCTCTAC--AG---- **** * *** * * * * *** ** ** * **** ** ENST00000314138.6 TAACTAGCCCAAGAGCAGACAGCCCACGGACGGACTGCAAGTCGGAAGCGCGGGCGGAAG ENST00000492974.1 -AAATA----AAAAAAAATTAGCCTA----------GCAA-------------------- ** ** ** * * **** * **** ENST00000314138.6 CTGTGCAGCGCCCACCTGGTGGCTCCATCGGCCGCGTTCATCAGTCAGCACGACCCGACC ENST00000492974.1 -TGT-TGGCGCCCACCTG-----------------------CAGTC-------------- *** *********** ***** ENST00000314138.6 TCAGTGGCGTCCTCACAACACAGACCGGACCTTGGGTCTTACCCCGGCACCTGAGAACCA ENST00000492974.1 CCAG-------------------------------------------------------- *** ENST00000314138.6 CTTCCGGTGAGTAGCTTCTACTTCCGGAGACGATGACTCCCCCGCGTCCCAGACCGGAAG ENST00000492974.1 -----------------CTACTT---GGGAGGCTGA---------------GGCGGGAAG ****** * ** * *** * * ***** ENST00000314138.6 AAGCCCGGCGGAGACCGGCCTCGCTCGGCCACTTCCGGCAAGGGCGGAGCCGGCCAGTGG ENST00000492974.1 A-------------------TCACTTGGGC----CCAG-GAGTTCAAGGCTG--CAGTG- * ** ** ** * ** * ** * ** * ***** ENST00000314138.6 TGCGCGAGCGCAGATAACTCCCCTGGAGAGGCGGGATGTTCAACTCCACCCCTGGTCCTT ENST00000492974.1 ------AGTAT-GATAACACCACTG---------------------CACTCCAG---CCT ** ****** ** *** *** ** * * * ENST00000314138.6 GGGCGGCCGTGGGTCCCCTTCGAAGCGGAGGAATGGCCAACCTCGCCGCACTTCGAGCCC ENST00000492974.1 GAGTGAC----------------------AGAGTGA--GACCTTGTC-----TCTAA--- * * * * ** ** **** * * ** * ENST00000314138.6 CTTTAGGGTGCGTTTAAGAACAGTGGGCGTGGCCTTTACGTAAATCTTCGAGATGGGAAC ENST00000492974.1 --TAAAACTACATTCATAAAAA------------TATAAATAAATTTTAAAAA----AAC * * * * ** * ** * * ** ***** ** * * *** ENST00000314138.6 CTCCAGAATTTGTCTCAATTGTCTAAAAGGTAATGAGCGTCAGCGACATTCAAGGGCACT ENST00000492974.1 ------AACTTATCT----TCTCTGAAA------------CAGTGGTTCCCAAAG----T ** ** *** * *** *** *** * *** * * ENST00000314138.6 TTGGGCTAAAAAAGAAAGTGCTTGTACACGGATGGAAATATTCTAGAAGAACATAAAAGG ENST00000492974.1 TT----------ATAATGTA-TTGTAATCACCTTGAG-TGTT-TATTAAAACACA----- ** * ** ** ***** * * ** * ** ** * **** * ENST00000314138.6 AATTTCCTCTTAGGAGGTTAGGGAAATGAGCACGAAGTATGTTTTGGTGCAGTTTTTTGT ENST00000492974.1 ---TTTCT-----GAGCTTC--------AGTCCCAAAGATGT--TGATTCAGTA------ ** ** *** ** ** * ** **** ** * **** ENST00000314138.6 TCAACCCAATGCGTATTTTCATATTGAGAGGCAATATAAATGGAGCGAAAGTATCTTGAG ENST00000492974.1 --GATCTAGGACG-----GCAC-CTGAGA----ATCTAAAC-----------TTCT---- * * * ** ** ***** ** **** *** ENST00000314138.6 AAAAAAAAAAAAACTACCAGAACTTGCCGTTGCTGAAAAGTAATATTTTCTCTTTCGAGA ENST00000492974.1 ----AACAAATTTCTAAATGAAGTTAATGCTGCTGG---------TTTTTTCTGTAGAAA ** *** *** *** ** * ***** **** *** * ** * ENST00000314138.6 GTTTTCATGGCCTTTTAAATTACACCCCCACCTCCACAGGCAAATAAATTTGTTTTGGAA ENST00000492974.1 ACAT--AAAGCATTTCAAGTTCTGCCCTCCC--------------AAATCT--------- * * ** *** ** ** *** * * **** * ENST00000314138.6 TGCATACCACATCATCTGGCTCTAGAAACGTATTTTGTGTAGCTCCCCTAGCAAGAATAT ENST00000492974.1 ---------CATTCTCTGGCTCCA----------------AGTCC-------AAGAATCT *** ******** * ** * ****** * ENST00000314138.6 AGGTTAAAGCGTAAATTTAATTCCTGGCTCTATTTTACATCCCAATTTTTATTTTCCTCT ENST00000492974.1 ----TA----------CTAAT-----ACTTTATGTC---TCCCAA--------------- ** **** ** *** * ****** ENST00000314138.6 CATTCCCACTTTACGTTGTTTCAAATAACCTAGTTTGTGTATCCCTGTAAGTCATTTTGG ENST00000492974.1 CAT----GCTGAGGATCTCTTTAGATG--------TGCGTGCCC-------TAATCTTGG *** ** * ** * ** ** ** ** * ** **** ENST00000314138.6 TATAAAGTAGGTTATAAGTGTACATGCGAAAAGATGTTTTTAACAAAAATGTAACTGA ENST00000492974.1 -ATGTAGTAG-TTGC---TGTATCTGCAGG--------TTAGACAGA----------- ** ***** ** **** *** ** *** *