CLUSTAL 2.1 multiple sequence alignment ENST00000326277.3 GGCGCTGCGAAGTGGAGGCGCTGCGAGCGGAGCCGCGCGGAGGGCGCGACCGGCTGGTCC ENST00000454116.1 GGC------AAGAGGAAG-GCTGAGAA-----------GGATGAGGTG------------ *** *** *** * **** ** *** * * * ENST00000326277.3 GGGCAGCGTGGGTTTGCCGCCTTCGGGGCTCCAGTCCGCGCGCCAGGGCTCGAGCAGTAC ENST00000454116.1 -------GTGAATT--CCAGCTTC----TTCCTGACCCTGAGCC----------CA---- *** ** ** **** *** * ** * *** ** ENST00000326277.3 CGCGGGCCCCTCAGGTGGGCCTCGGCTCGGGACGCCGGGAGT-CGGGACCGCCAG-TCGG ENST00000454116.1 ------CCCCCAAGGTGGCCCTCAACCTTTAAGAGTGGGAGAGCAAAATTGATGGCTTCG **** ****** **** * * ***** * * * * * * ENST00000326277.3 GGCGCCGGGACCATGGCGCTGCGCGCCC-GGGCGCT--GTACGACTTCAGGTCGGAGAAC ENST00000454116.1 AGTGCTTC-ACCAAGAAGATAGAAACACAGGGCACTCAGCTCAACTTC---TC----AGC * ** **** * * * * * **** ** * * ***** ** * * ENST00000326277.3 CCAGGAGAGATCTCGCTGCGAGAGCACGAGGTGCTGAGCCTGTGCAGCGAGCAGGA-CAT ENST00000454116.1 CAATGAG-----TTGACATGCAAGCAGATTATGGTGA---TGGGTTTTAAGAAGGAGCAT * * *** * * * **** ** *** ** * ** **** *** ENST00000326277.3 CGAGGGCTGGCTCGAGGGGGTCAACAGCCGCGGCGACCGCGGCCTCTTCCCGGCCTCCTA ENST00000454116.1 CAGAAGGTGGC-------------CAGTT-------CTTCAGCCTCAGCCAGGTCT---- * * **** *** * * ***** ** ** ** ENST00000326277.3 TGTGCAGGTGATCCGCGCCCCCGAGCCTGGCCCGGCGGGAGACGGCGGCCCGGGCGCC-C ENST00000454116.1 --TGGAGCTGGGCCAGGCCATC--ACTTCACC-----AGAGATG---CCTTCAACACCGT ** ** ** ** *** * * * ** **** * * * ** ENST00000326277.3 CGGCCCGCTACGCCAATGTGCCC-CCCGGGGGCTTCGAGCCCCTGCCTGTCGCGCCCCCC ENST00000454116.1 TGGTGAGCTCTGCCAATCAGCCCATCCAGGAACT--GGACCCA-----GTCATG------ ** *** ****** **** ** ** ** * *** *** * ENST00000326277.3 GCCTCCTTCAAGCCGCCGCCTGACGCCTTCCAGGCGCTGCTGCAGCCACAGCAGG-CGCC ENST00000454116.1 ---------------------GACCTGTT---AGTGCTGTCTCAGGGACACCAGGTCAAC *** ** * **** *** *** **** * * ENST00000326277.3 GCCTCCGAGCACCTTCCAGCCGCCCGGCGCGGG-CTTCCCG----TACGGCGGG--GGCG ENST00000454116.1 ATC-CCGGACATCATCCACATACACAAGGAAGCTCTTACCAAAGTCATGGAGAGCAGGCA * *** ** * **** * * * * *** ** * ** * * *** ENST00000326277.3 CCCTGCAGCCGTCGCCTCAGCAGCTCTACGGCGGCT-ACCAGGCCAG--CCAAGGCAGCG ENST00000454116.1 ACATGTGGCAGAAGGGAAGACAGAGGTGCAGAGGCTGATGATGTCAGAATCACAGGAACA * ** ** * * *** * * * **** * * * *** ** * * * ENST00000326277.3 ATGATGACTGGGACGACGAG--TGGGA--CGACAGCTCCA--------CGGTGGCGGAC- ENST00000454116.1 GGATTTCTTTGGACACTGTGGCTGAAATTCACCACTTCCATCCAATTCCGGTGAGAAACA * * **** * * ** * * ** **** ***** ** ENST00000326277.3 -GAGC---CGGGCGC-----TCTGGGCAGCGGAGCATACCCGGACCTCGACGGCTCGTCT ENST00000454116.1 TGGACTCACAGATGCAGGATTTCTTGCAACAAGAGATACTATTTTTTCAAAAGGTCACCC * * * * ** * *** * **** ** * * ** * ENST00000326277.3 -----TCGGCGGGTGTGGGCGCAGCCGGCCGCTACCGCCTGTCCACGCGCTCCGACCTGT ENST00000454116.1 AGGAATTGATAG-TGTTGA-ATGACTAGATACT--CGATTGTGCAC-TGTTTC---CAGT * * * *** * * * ** ** *** *** * * * * ** ENST00000326277.3 CCCTGGGTTCCCGCGGCGGCTCGGTCCCCCCGCAGCACCACCCGTCGGGGCCCAAGAGCT ENST00000454116.1 TCAAGGATGCTTTCTACAGCAGAAT--------AATAACACTAG-------CAAAGAGCT * ** * * * * ** * * * *** * * ******* ENST00000326277.3 CG-GCCAC-CGTGAGCCGCAACCTCA--ATCGCTTC-TCCACCTTCGTCAAGTCCGGCGG ENST00000454116.1 AGTGCCAGGTATTGGCGGTAGTACAAGGATGGCTTTGTTCTCAATTG--AAACTCAGCTG * **** * ** * * * ** **** * * * * * ** * ** * ENST00000326277.3 GG-AGGCCTTCGTGCTGGGGGAGGCGTCAGGCTTCGTGA-AGGACGGGGACAAGCTGTGC ENST00000454116.1 AATATAGAATTGTGT---AGGAAACAGTTAATATGGCGATAGAATAGAAACA-------- * * *** *** * * * ** ** * * *** ENST00000326277.3 GTGGTGCTGGGGCCCTATGGCCCCGAGTGGCAGGAGAACCCCTACCCGTTCCAGTGCACC ENST00000454116.1 GTAGCAAACATGACCTA-AACC----ATGCTATGA--ATTCCTACAC-TACCATTGTAAC ** * * **** ** ** * ** * ***** * * *** ** * * ENST00000326277.3 ATC------GACGACCCCACCAAGCAGACCAAGTTCAAGGGCATGAAGAGCTACATCTCC ENST00000454116.1 TTTTGGAAGAATGATACCACTTACTTTATTGCTTTTTGAAGTATGAATATTTTCAT---G * * ** **** * * ** * ***** * * *** ENST00000326277.3 TACAAGCTGGTGCCCACGCACAC---GCAG-GTGCCGGTGCATCGGCGCTACAAGCACTT ENST00000454116.1 TATATGCTGTAGACCTCAAACCCTGTGAAGAGTCTCAAAGAAGCTG-GCTGGATAAAGCC ** * **** * ** * ** * * ** ** * * * * * *** * * ENST00000326277.3 CGACTGGCTGTACGCGCG-CCTGGCGG--AGAAGTTCCCGGTCATCTCCGTGCCCCACCT ENST00000454116.1 TGAGTGACTTCTCATGAGACCTGGTCATTGAAAACTCTATGTCACCTCCCTACTCTGCAT ** ** ** * * * ***** ** ** **** **** * * * * * ENST00000326277.3 GCCCGAGAAGCAGGCCACCGGCCGCTTCGAGGAGG---ACTTCATCTCTAAGC-GCAGGA ENST00000454116.1 GTTTT---------CCTCTTGCCGTGT-GAGACAACTCACTCTTTCTTTGCCTTGCACAA * ** * **** * *** *** *** * *** * ENST00000326277.3 AGGGCCTGATCTGGTGGATGAACCACATGGCCAGCCACCCAGTGCTGGCGCAGTGCGACG ENST00000454116.1 AG------AT----TGAAAGATTTCTGAGGCCTACCA---------GAAGCAG----AAG ** ** ** * ** **** *** * **** * * ENST00000326277.3 TCTTCCAGCACTTCCTGACGTGCCCCAGCAGCACC----GACGAGAAAGCCTG------G ENST00000454116.1 CCCT---GTGCTTCCTGTC-CACCCT-GCAGAACCATGAGCCAATTAAACCTCTTTTTCA * * * ******* * *** **** *** * * * ** *** ENST00000326277.3 AAGCAGGGCA---AGAGGAAGGCCGAGAAGGACGAGATGGTGGGCGCCAACTTCTTCCTG ENST00000454116.1 TAATGAATCATACAGAAAATGGCAAATGAGGACTGGAGCATTGCTATAAAGATA--CCTG * ** *** * *** * ***** ** * * ** * **** ENST00000326277.3 ACCCTTAGCACGCCCCCCGCCGCTGCCCTTGACCTGCAGGAGGTGGAGAGCAAGATCGAC ENST00000454116.1 AA----AATGTG------GAAGCAGCTTTGGAACT--AGGTAATGGACAG-AGGTTGGAA * * * * ** ** * ** ** *** **** ** * * * ** ENST00000326277.3 G-GCTTCAAGTGCTTCACCAAGAAGATGGACGACAGCGCGCTG--CAGCTCAACCACACG ENST00000454116.1 GAGTTTGGAGGGCTCAA--AAGAAGACAGATGAGAAAGTTTGGACCATCTTAGAGAC-TG * * ** ** *** * ******* ** ** * * * ** ** * ** * ENST00000326277.3 GCCAACGAGTTCGCGCGCAAGCAGGTGACCGGC-TTCAAAAAGGAGTATCAGAAGGTG-- ENST00000454116.1 GTTAAATGGTT-------------GTGACCAAAATCCTGACAGAAACAT-GGACAGTGAA * ** *** ****** * * * ** * ** ** *** ENST00000326277.3 GGCCAGTCCTTCCGCGGCCTCAGCCAGGCCTTTGAG-----CTGGACCAGCAGGCCTTCT ENST00000454116.1 GGCTAGGC-TGAGGAGGTCTCAGATAGAAATAAGAAGCTTTCTGGA---AAATGTCTTCC *** ** * * * ** ***** ** * ** ***** * * **** ENST00000326277.3 CGGTGGGCCTGAACCAGGCTATCGCCTTCACCGGAGATGCCTATGACGCCATTGGCGAGC ENST00000454116.1 TTTTGGATATGGA--AAGCT------TACAC----AATGCCTGTACCACCCCTG-----T *** ** * * *** * *** ****** * * ** ** ENST00000326277.3 TCTTCGCGGAGCAGCCCAGGCAGGACCTGGATCCCGTCATGGACCTATTAGCGCTGTATC ENST00000454116.1 ACCTTA-GAAGCAGT--------------GATCTTG-CAT---TTTATT---------TC * * * ***** **** * *** **** ** ENST00000326277.3 AGGGGCATCTGGCTAACTTCCCGGACATCATCCACG-TTCAGAAAGGTAAAGCCTGGCCC ENST00000454116.1 AGAGGCTTATAGGCAAA---AGAGGCTGCAGCCTTGACTCAGATGAG---ACTTTGGACT ** *** * * * ** * * ** ** * ***** * * *** * ENST00000326277.3 TTAGAGCAGGTGATATGGAGTGTATTGTGCAGGCTGAAAGGGGCGACTTTGACAGCAGTA ENST00000454116.1 TT-------GTAACAT----TGTGTTA---ATGCTGAAATGAG-----TTAAGACTCATG ** ** * ** *** ** * ******* * * ** * * * ENST00000326277.3 CCACTGTGGGTTTCAGAATCATATTCTACAG-GTGAGGAAGCGAGCAGAGACGTGGACGC ENST00000454116.1 CTGGGAAGG----CATGATTGTATTTTGCAATGTGAAAAGGACAAGAGATTCGTGGG-GT * ** ** ** **** * ** **** * * * *** ***** * ENST00000326277.3 CTGGGTCTTTTCCCTAGAGTGTAAGTTGGATTG-CTCGACAGGCAGCTTCCTCCTCGAGT ENST00000454116.1 CAGGGAC----------AGAATAATATGGTTTGTCTCTATA-------TCCCTATCAA-- * *** * ** *** *** *** *** * * *** ** * ENST00000326277.3 ATCTTGCATTAGGGAATGAGTACTCTTTCTCGAAGGTTCAAAGAGTACCTTTGATGACAG ENST00000454116.1 AACCCGTGT---GGAATTA-TACTCCCT----AACGTTAGAGGTGGGGCCTAGGTGGAA- * * * * ***** * ***** * ** *** * * * * * * ** * ENST00000326277.3 TGCTATCATTTTAGAGTTTGAATAGTTGAGTAATGAGCTGCTCAAATCTGTAATCTTGAG ENST00000454116.1 ------------AAAGATTTAGTCATAAAATGGTG--CAGGT-AGATCC----TCC---- * ** ** * * * * * ** * * * * *** ** ENST00000326277.3 ACGAGGGTAGAATTAGAAGGGGACCTAAACCATGTTAGGTATCTGTTTGAACACTGCACT ENST00000454116.1 ACGA-------ATGA----------TAAAGCAC------CATCCCCTTGA-TGCTGTCCT **** ** * **** ** *** **** *** ** ENST00000326277.3 GTCACTTAGTG-GTGAGTTTCAAAAAGTGAGGAAATAATGGAGAAGAACGGATGTCTGTA ENST00000454116.1 CCTGAT-AGTGAGTGAGTTTTCA--TGTGATCTGGTTGTTTAACAGG--------CTGTG * **** ******** * **** * * * ** **** ENST00000326277.3 AATAGAAATCTGCTTTCACCCTTCCACACCTCTCAATCTCTGCTTTGGTAGAGGAATTAA ENST00000454116.1 GA---ACCTCTTTCCTCACTCTGTC-TTCCTCCTACTC-CTGCCATAGGAGACAGCT--- * * *** **** ** * **** * ** **** * * *** * ENST00000326277.3 GATCAATTCTCTGAGTTTAAGAAATTCCTGCAAAGAATTCTTGCCTGCAACCTTTACGAA ENST00000454116.1 GATTG-TCCCTTGGCCTTCTGGTATAATTA-GGAGGCTCCCTGACT----CCTCCCAGAA *** * * ** ** * ** * ** * * ** ** *** *** ENST00000326277.3 GTGAAGTAATTTCAGGAAAAGCGTACTCATTTTG-AGTTTG-AAATCTATTAATGTACTG ENST00000454116.1 ACAAAA----------GACACTATGCTTCCTTCACAGCCTGCAGAACCCTGAGT-CAATG ** * * * ** ** ** ** * * * * * * * ** ENST00000326277.3 AAATTGAGAACGTTGTTTAGGAAAATTGTTTAGGGAAACTACATAGAATGAATATAATCT ENST00000454116.1 AAA-------CCTCTTTTA---------TTTAGGATAA-TACAGAAAAT---TAGAA-CT *** * * **** ****** ** **** * *** ** ** ** ENST00000326277.3 GAGTATTGGATCTGAGAGCAGCGTTGCTGGTATCCCAGTGAGTTAGCTGTCC-AACTATC ENST00000454116.1 GCAGAGAGGAGCTGTGA--AATGTCTTCAAGGCCTTTTTCCATT---TGTCTTGGCCATT * * *** *** ** * ** * * ** **** * ** ENST00000326277.3 AGAGTTCATGAGTTATTAATAGTTGTTAGTGTCTCTGACCTTTGCTAAAGCACCAGAATT ENST00000454116.1 AGCA--CAGGGCTTCTTTATA--TGCAAATTTCTGAAGTCTTCTTGAATGTTCC----CC ** ** * ** ** *** ** * * *** *** ** * ** ENST00000326277.3 TGCAAATTAAAAAAATATATAGCAGTAGTGCTTGTCTTAACATTTCTTA-CTAATGTGCA ENST00000454116.1 CTTAAATCGG-----------------GT-TTTGTGTTATTACTACATAGCCAACCTGC- **** ** **** *** * * * ** * ** *** ENST00000326277.3 TTCTCATATA-ATGCCTTGATTGAGAGAATGGGGAGGTGTGGGAGTTAGGGAGGCAGTCT ENST00000454116.1 ----TATAGAGATACCTGAA---AAAGTAGAAGCAGGTTCAGAAGT--GGGTAACAAAC- *** * ** *** * * ** * * **** * *** *** ** * ENST00000326277.3 TGCCTGTGAAAGTCCAGTGTAGGGGCGGCTGGGCAGGGAAACCTACTCCTGAGCAGGGAA ENST00000454116.1 --------AAAGATTGG--GAGGGTTTGCAGGGATTGGAAAA-------TGA-CAAAAAG **** * **** ** *** ***** *** ** * ENST00000326277.3 ACCTACTGTCCCTGTTTCCTCAGCGGGTCTGGCCTTTACTGGTGAAGTGCTCACTGCCTT ENST00000454116.1 AT--------------------GAGGGCCTGG----TGGGAGTGATTTAATCACGGA--- * * *** **** * **** * **** * ENST00000326277.3 TCTGGTGGGCCAGTCCGTTTATGAGCAACCCTGATCTCTGGCATGTCTTTTCTTGTATTG ENST00000454116.1 --TGGGAGGCGGGT-------------------------GGGGTG---------GAAGGA *** *** ** ** ** * * ENST00000326277.3 AACTGAAGTTTGCCTCCCTTGATTGTCTTTCTGTTCCCTGGGACCGCCTTCAGACATTTG ENST00000454116.1 AAAAGAGGT------------------------------GGG--------CAGG-GTGGG ** ** ** *** *** * * ENST00000326277.3 GAGACAGCAGTCTCGCTTCCTTCCTCTCTGCTTCTCTCCTTCCCCTTCCAAATGCGTGAC ENST00000454116.1 GAGG-AGTAGGCTGG---------TGTAGGGTGGT--------------GGAAGGGTGG- *** ** ** ** * * * * * * * * *** ENST00000326277.3 TGGTCTTCTGACTCCTATGGGGGAAGGGGCTTGCTGGGAGAATGATCAAACGTTTTCAGT ENST00000454116.1 -GGTGTAGTGG-----GAGTGGGGAGTCGCCTGCTG----------CAGAGGC--ACAGC *** * ** * *** ** ** ***** ** * * *** ENST00000326277.3 CTTGTTG-CTGCCGCTGAAAGGG-AGTAC-CCTG-GACATCAGTACTAATTTTAGTAGAC ENST00000454116.1 CTCATGGACAACCTCTACTAGGGCAGTGCACCTGTGGCTT---TGCAAGTTTTAGCCCCC ** * * * ** ** **** *** * **** * * * * * * ****** * ENST00000326277.3 AGTAGTAACTTTCTTGGCAATTTGCGATTTGTAAATGCAGTCTAATATTGAATTCGTTTT ENST00000454116.1 A-CGGCTGCTCTCATGG-ACTGGGCTACTGTTGAGTGCC-TGTAGCTTT---TCCACAGT * * ** ** *** * * ** * * * * *** * ** ** * * * ENST00000326277.3 TTG--TGCAATCATATTGCTGTTGGCCTGTATTAAACCTGTATTTACATT ENST00000454116.1 GGGGGTGCAA-------GCTGTTGG-------TGGGTCTATGAAT----- * ***** ******** * ** * *