CLUSTAL 2.1 multiple sequence alignment ENST00000340107.4 GTCGCGGGCAGCTGGCGCCGCGCGGTCCTGCTCTGCCGGTCGCACGGACGCACCGGCGGG ENST00000457012.1 -----------------CCATGGGGCCTCCCT-----------ATGG------------- ** * ** * ** * ** ENST00000340107.4 CCGCCGGCCGGAGGGACGGGGCGGGAGCTGGGCCCGCGGACAGCGAGCCGGAGCGGGAGC ENST00000457012.1 ----------------------GGGTGTTGAGTCC-------------TGGAGTG----- *** * ** * ** **** * ENST00000340107.4 CGCGCGTAGCGAGCCGGGCTCCGGCGCTCGCCAGTCTCCCGAGCGGCGCCCGCCTCCCGC ENST00000457012.1 -------------CCAGGTTTTGG------------------------------------ ** ** * ** ENST00000340107.4 CGGTGCCCGCGCCGGGCCGTGGGGGGCAGCATGCCCGCGCGCGCTGCCTGAGGACGCCGC ENST00000457012.1 -GGTCCCTGCATCA------------CAGT------------------------------ *** ** ** * *** ENST00000340107.4 GGCCCCCGCCCCCGCCATGGGCGCCCCTGCCTGCGCCCTCGCGCTCTGCGTGGCCGTGGC ENST00000457012.1 --------------------------------------------------------TGAC ** * ENST00000340107.4 CATCGTGGCCGGCGCCTCCTCGGAGTCCTTGGGGACGGAGCAGCGCGTCGTGGGGCGAGC ENST00000457012.1 CATC---------------------TCCCTGG---------------------------- **** *** *** ENST00000340107.4 GGCAGAAGTCCCGGGCCCAGAGCCCGGCCAGCAGGAGCAGTTGGTCTTCGGCAGCGGGGA ENST00000457012.1 --CAGAGATCCCAGTGCCTGATTCTGGCCAGTAGGAATATTTACTCTTAACCAATGGGGA **** **** * ** ** * ****** **** * ** **** ** ***** ENST00000340107.4 TGCTGTGGAGCTGAGCTGTCCCCCGCCCGGGGGTGGTCCCATGGGGCCCACTGTCTGGGT ENST00000457012.1 CACCTTGGAGCTGAGCTGCCACCCACCCAGCAGTGGTCCCATGACACCCCCTGTCTGGGT * ************* * *** *** * *********** *** ********** ENST00000340107.4 CAAGGATGGCACAGGGCTGGTGCCCTCGGAGCGTGTCCTGGTGG--GGCCCCAGCGGCTG ENST00000457012.1 CAAGGTTGGGGCAGGGCTGGTGTCCT-GAACTGCATCCTGATGTTCAGCAGCGGTGGCTG ***** *** *********** *** * * * ***** ** ** * * ***** ENST00000340107.4 CAGGTGCTGAATGCCTCCCACGAGGACTCCGGGGCCTACAGCTGCCGGCAGCGGCTCACG ENST00000457012.1 CTGGTGCTCAATGCCTTCGA-GAGAACGCTGAGGCCAATAGCTGCTGGCAGCGGCTCACC * ****** ******* * * *** ** * * **** * ****** ************* ENST00000340107.4 CAG----CGCGTACTGTGCCACTTCAGTGTGCGGGTGACAGACGCTCCATCCTCGGGAGA ENST00000457012.1 CAGGTTGTGTGTACTGTGCC-CTTCTGTGTGCGAGTGACAGG------------------ *** * ********** **** ******* ******* ENST00000340107.4 TGACGAAGACGGGGAGGACGAGGCTGAGGACACAGGTGTGGACACAGGGGCCCCTTACTG ENST00000457012.1 TGAC-------------------------------------------------CCCACTG **** * **** ENST00000340107.4 GACACGGCCCGAGCGGATGGACAAGAAGCTGCTGGCCGTGCCGGCCGCCAACACCGTCCG ENST00000457012.1 GACTCAGCTCCAGCGGGTGGACAGGAACCAGCTTGTGGTGCCAGACACCAACACCATTTG *** * ** * ***** ****** *** * *** * ***** * * ******** * * ENST00000340107.4 CTTCCGCTGCCCAGCCGCTGGCAACCCCACTCCCTCCATCTCCTGGCTGAAGAACGGCAG ENST00000457012.1 CTTCTGATGCCTGACCATGGGCAACTCTACTCCCTCCAT---CTGGCTGAAGAGCCAGAA **** * **** ** ****** * *********** *********** * * ENST00000340107.4 GGAGTTCCGCGGCGAGCACCGCAT-------------------TGGAGG----------- ENST00000457012.1 GAAGTTCTGTGGAAAGCATCACACGCGAGCATCGAGGTGGGCCTGGAGGGTGGTGGGGGC * ***** * ** **** * ** ****** ENST00000340107.4 --------CATC--------------------AAGCTGCGGCATCAGCAGTGGAGCCTGG ENST00000457012.1 ATGGCTGCCATCCTCTCTCGCCCTTCCACTTGGAGCCGAGGCACCGGCAGTAGAGTCTGG **** *** * **** * ***** *** **** ENST00000340107.4 TCATGGAAAGCGTGGTGCCCTCGGACCGCGGCAACTACACCTGCGTCGTGGAGAACAAGT ENST00000457012.1 TTATGAAGAGGGCGGTGCGTTCAGACTGCTGTT-TTCCACACATGTCATGAAGAACAAGC * *** * ** * ***** ** *** ** * * *** *** ** ******** ENST00000340107.4 TTGGCAGCATCCGGCAGACGTACACGCTGGACGTGCTG---GAGCGCT-----CCCCGCA ENST00000457012.1 TCAGCAGCATCCAGCAAACTTACATGCTGGACAGGCTGTGTGTGGGCTGTGGCCTTCAGG * ********* *** ** **** ******* **** * * *** * * ENST00000340107.4 CCGGCCCATCCTGCAGGCGGGGCTGCC----GGCCAACCAGAC------GGCG-GTGCTG ENST00000457012.1 CAGGG--AGCATG-AAGTGAGGTAGCCCTAAGCCCAGCTGGGCCCTCTCAATGTGTTCTC * ** * * ** * * * ** *** * *** * * * * ** ** ENST00000340107.4 GGCAGCGACGTGGAGTTCCACTGCAAGGTGTACAGTGACGCACAGCCCCACATCCAGTG- ENST00000457012.1 CTCACCAGCG------CCTTCTGCTAGG----CAGCGAGGTGCAGCTCCATGGCAGGTGT ** * ** * **** *** *** ** * **** *** * *** ENST00000340107.4 -----GCTCAAGCACGTGGAGGTGAATGGCAGCAAGGTGGGCCCGGACGGCACACCCTAC ENST00000457012.1 ACAGCACCTTAGCACACGGAGGTGAATGTCAGCAAGGCGGGCCTGGACAGCACACCGTAC * ***** *********** ******** ***** **** ******* *** ENST00000340107.4 GTTACCGTGCTCAAGTCCTGGATCAGTGAGAGTGTGGAGGCCGACGTGCGCCTCCGCCTG ENST00000457012.1 CTCACTGTTCTCAAG------------------GTGG----------GCACCACCGT-TG * ** ** ****** **** ** ** *** ** ENST00000340107.4 GCCAATGTGTCGGAGCGGGACGGGGGCGAGTAC-CTCTGTCGAGCCACCAATTTCATAGG ENST00000457012.1 GC-------TGGGTACAGGGTGGAC---AGCACGCCCTACC---TCACTGTTCTCA-AGG ** * ** * ** ** ** ** * ** * *** * *** *** ENST00000340107.4 CGTGGCCGAGAAGGCCTTTTGGCTGAGCGTTCACGGGCCCCGAGCAGCCGAGGAGGAGCT ENST00000457012.1 TGGGCACCA------CCATTGGCTGGGC----ACAGGG--TGGACAGCACACCGTACCTC * * * * * ******* ** ** ** * **** * ENST00000340107.4 GGTGGAGGCTGACGAGGCGGGCAGTGTGTATGCAGGCATCCTCAGCTACGGGGTGGGCTT ENST00000457012.1 AGT----GTTCTCAAGGTGGGCAC------------CACCCCTGGCT---GGGTG----- ** * * * *** ***** ** ** *** ***** ENST00000340107.4 CTTCCTGTTCATCCTGGTGGTGGCGGCTGTGACGCTCTGCCGCCTGCGCAGCCCCCCCAA ENST00000457012.1 ------------CAGGGTG--GACAGC----ACGCCCTACCTC----ACTGTTCTC---- * **** * * ** **** ** ** * * * * * ENST00000340107.4 GAAAGGCCTGGGCTCCCCCACCGTGCACAAGATCTCCCGCTTCCCGCTCAAGCGACAGGT ENST00000457012.1 --AAGG--TGGGCACCACCATTG---------------GCT--------GGGC-ACAGGG **** ***** ** *** * *** ** ***** ENST00000340107.4 GTCCCTGGAGTCCAACGCGTCCATGAGCTCCAACACACCACTGGTGCGCATCGCAA--GG ENST00000457012.1 -----TGGA---CAGCACGCCCT---ACCTCACTGTTCTCAAGGTGGGCACCACCATTGG **** ** * ** ** * ** * **** *** * * * ** ENST00000340107.4 CTGTCCTCAGGGGA--GGGCCCCACGCTGGCCAATGTCTCCGAGCTCGA--GCTGCCTGC ENST00000457012.1 CTGGGTACAGGGGAATGGGC---AGGCTGG---AGGCCTC---GCTTCACTGAAGTCTTC *** ******* **** * ***** * * *** *** * * * ** * ENST00000340107.4 CGACCCCAAATGGGAGCTGTC-TCGGGCCCGGCTGACCCTGGGCAAGCCCCTTGGGGAGG ENST00000457012.1 --ACTTCACG-GGTAGATTTCATTGAAATCTACTAGCATTA--TAGAATTTTTGGAGTAA ** ** ** ** * ** * * * ** * * * **** * ENST00000340107.4 GCTGCTTCGGCCAGGTGGTCATGGCGGAGGCCATCGGCATTGACAAGGACC----GGGCC ENST00000457012.1 CCTATGAAAGACAA--AATTATGTTGGAAGGC--CGAAGCGG--GAGGATCATTTGAGTC ** * ** * *** *** * * ** * **** * * * * ENST00000340107.4 GCCAAGCCTGTCACCGTAGCCGTGAAGATGCTGAAAGACGATGCCACTGACAAGGACCTG ENST00000457012.1 --CAGGACTTTGAGACCAGCCTGGGAAACGCAGTGAAACCCCATCTCTACAAAAAATACA ** * ** * * **** * * * ** * * ** * ** ** * ENST00000340107.4 TCGGACCTGGTGTCT---GAGATGGAGATG-----ATGAAGATGATCGGGAAACACAAAA ENST00000457012.1 ACAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCAAGA-GGTCAGGAGATTGAGA- * ** * * *** *** ** ** **** * ** *** * * * ENST00000340107.4 ACATCATCAACCTGCTGGGCGCCTGCACGCAGGGCGGGCCCCTGTACGTGCTGGTGGAGT ENST00000457012.1 ---TCATC------CTGG----CTA---ACATGGTGAAACCCCATCTCTACTAAAAAAAA ***** **** ** ** ** * *** * * ** * ENST00000340107.4 ACGCGGCCAAGGGTAACCTGCGGGAGTTTCTGCGGGCGCGGCGGCCCCCGGGCCTGGACT ENST00000457012.1 A-------AAAAAAAAAAAAAAAAAAATTAGCCAGGCGTGGTGGC----GGGC------- * ** ** * ** * **** ** *** **** ENST00000340107.4 ACTCCTTCGACACCTGCAAGCCGCCCGAGGAGCAGCTCACCTTCAAGGACCTGGTGTCCT ENST00000457012.1 -----------AGCTGTAGTCC----------CAGCT----------------------- * *** * ** ***** ENST00000340107.4 GTGCCTACCAGGTGGCCCGGGGCATGGAGTACTTGGCCTCCCAGAAGTGCATCCACAGGG ENST00000457012.1 ------ACTCGGGAGGCTGAGGCA-GGAGAA--TGGC---------ATGAACCCA---GG ** ** * * * **** **** * **** ** * *** ** ENST00000340107.4 ACCTGGCTGCCCGCAATGTGCTGGTGACCGAGGACAACGTGATGAAGATCGCAGACTTCG ENST00000457012.1 A---GGCAG-----AGTTTGC-AGTGAGCCAAGATCGCGCCAC------TGCA--CTCCA * *** * * * *** **** * * ** ** * *** ** * ENST00000340107.4 GGCTGGCCCGGGAC-GTGCACAACCTCGACTACTACAAGAAGACGACCAACGGCCGGCTG ENST00000457012.1 GCCTGGGC---GACAGAGCGAGACTCCGTCT--CAAAAAAAAAAGAAAAATG---AGCTG * **** * *** * ** ** ** ** * ** ** * ** ** * **** ENST00000340107.4 CCCGTGAAGTGGATGGCGCCTGAGGC-CTTGTTTGACCGAGTCTACACTCACCAGAGTGA ENST00000457012.1 -----GGTGTGG-TGGCGGC--ATGCACCTGT-------AGTCC-CAGCTACTCAGGAGG * **** ***** * * ** * *** **** ** ** * * ENST00000340107.4 CGTCTGGTCCTTTGGGGTCCTGCTCTGGGAG--ATCTTCACGCTGGGGGGCTCCCCGTAC ENST00000457012.1 C-----------TGAGGT--------GGGAGCAATTTTC-----------CTTCTTGAAC * ** *** ***** ** *** ** * * ** ENST00000340107.4 CCCGGCATCCCTGTGGAGGAGCTCTTCAAGCTGCTGAAGGAGGGCCACCGCATGGACAAG ENST00000457012.1 CCGGGAA-----GTCGAGA----CTTCA-----------GTGAGCC--CAGATGG----- ** ** * ** *** ***** * * *** * **** ENST00000340107.4 CCCGCCAACTGCACACACGACCTGTACATGATCATGCGGGAGTGCTGGCATGCCGCGCCC ENST00000457012.1 --TGCCA-TTGCACTC-CAGCCT-------------CGGAGACAGAGACA-------CTG **** ***** * * *** *** * ** * ENST00000340107.4 TCCCAGAGGCCCACCTTCAAGCAGCTGGTGGAGGACCTGGACCGTGTCCTTACCGTGACG ENST00000457012.1 TCTCAGAAAAAAA-----AGGTA-CCAGCAGGAAACA-AAATCCTGTGC--ACTGAGTAG ** **** * * * * * * * ** * * *** * ** * * * ENST00000340107.4 TCCACCGACGAGTACCTGGACCTGTCGGCGCCTTTCGAGCAGTACTCCCCGGGTGGCCAG ENST00000457012.1 TTCTCC----AGGATATGAACTTGTTGG-----TTCATATAGAACCTGCTATG-AACCAA * * ** ** * ** ** *** ** *** ** ** * * *** ENST00000340107.4 GA--CACCCCCAGCTCCAGCTCCTC--AGGGGACGACTCCGTGTTTGCCCACGACCTGCT ENST00000457012.1 AGTCCAAAATTAGATGTGGTTTCTCCTAAAGAAT------GTGTCAATTCATAAA----- ** ** * * * *** * * * **** ** * ENST00000340107.4 GCCCCCGGCCCCACCCAGCAGTGGGGGCTCGCGGACGTGAAGGGCCACTGGTCCCCAACA ENST00000457012.1 -------------------AGTGGGAA-TCACTCCTGTGA-------CTG-TCTCTCATA ****** ** * **** *** ** * * * ENST00000340107.4 ATGTGAGGGGTCCCTAGCAGCCCACCCTGCTGCTGGTGCACAGCCACTCCCCGGCATGAG ENST00000457012.1 ATT----GGTTCAAAAACA------TTTGCTTTT------------CTCTC-----TGCA ** ** ** * ** **** * *** * ** ENST00000340107.4 ACTCAGTGCAGATGGAGAGACAGCTACACAGAGCTTTGGTCTGTGTGTGTGTGTGTGCGT ENST00000457012.1 ACTTTGTATATTTTTAAA-----TTAATTAAATCTTTTTACTATATGTGTATTTATCC-- *** ** * * * * ** * * **** ** * ***** * * * * ENST00000340107.4 GTGTGTGTGTGTGTGTGCACATC-CGCGTGTGCCTGTGTGCGTGCGCATCTTGCCTCCAG ENST00000457012.1 ---------TATTT-----CATCTCGGGTTTACCT-------TG-ATAATTTGTTCCTAA * * * **** ** ** * *** ** * *** * * ENST00000340107.4 GTGCAGAGGTACCCTGGGTGTCCCCGCTGCTGTGCAACGGTCTCCTGACTGGTGCTGCAG ENST00000457012.1 TGAAATATTTATTCTGCGTTTG-----TAGTATTCCATAGTTTCC------ACGTT---- * * ** *** ** * * * * * * ** *** * * ENST00000340107.4 CACCGAGGGGCCTTTGTTCTGGGGGGACCCAGTGCAGAATGTAAGTGGGCCCACCCGGTG ENST00000457012.1 --TTTAGG------TTTTCTGGGCAG--TCGACATGGAAGATTTATGAG-------GGTA *** * ******* * * *** * ** * *** ENST00000340107.4 GGACCCCCGTGGGG-CAGGGAGCTGGGCCCGACATGGCTCCGGCCTCTGCCTTTGCACCA ENST00000457012.1 GGGCTTTGGTGTCATCAGTGAAT---GACCAAGAGTTTTCTTTTCTTTTCTTTT----TA ** * *** *** ** * ** * * ** ** * * *** * ENST00000340107.4 CGGGACATCACAGGGTGGGCCTCGGCCCCTCCCACACCCAAAGCTGAGCCTGCAGGGAAG ENST00000457012.1 AGAGACA---------AAATCTTG----CTCTGTCATCCA-------GTCTGGAGTGCAG * **** ** * *** ** *** * *** ** * ** ENST00000340107.4 CCCCACATGTCCAGCACCTTGTGCCTGGGGTGTTAGTGGCACCGCCTCCCCACCTCCAGG ENST00000457012.1 TG--GCATG------ATCTTG-GCTCACTGTA-----ACCTCCGCCTCCCAGGTTCTAGC **** * **** ** ** * ********* ** ** ENST00000340107.4 CTTTCCCACTTCCCACCCTGCCCCTCAGAGACTGAAATTACGGGTACCTGAAGATGGGAG ENST00000457012.1 AATTCTCCTCCCTCAGCCT---CCCGAGTAGCTGGGACTACAGGTGCCTG---------- *** * * ** *** ** ** *** * *** *** **** ENST00000340107.4 CCTTTACCTTTTATGCAAAAGGTTTATTCCGGAAACTAGTGTACATTTCTATAAATAGAT ENST00000457012.1 -------CTGCCATAC------------CCGG---CTA------ATTTTT---------- ** ** * **** *** **** * ENST00000340107.4 GCTGTGTATATGGTATATATACATATATATATATAACATATATGGAAGAGGAAAAGGCTG ENST00000457012.1 -----------------TGTACTT----------------------------------TA * *** * * ENST00000340107.4 GTACAACGGAGGCCTGCGACCCTGGGGGCACAGGAGGCAGGCATGGCCCTGGGCGGGGCG ENST00000457012.1 GTA-----GAGAC----------------------------------------------- *** *** * ENST00000340107.4 TGGGGGGGCGTGGAGGGAGGCCCCAGGGGGTCTCACCCATGCAAGCAGAGGACCAGGGCC ENST00000457012.1 --------------------------GGGGTTTCACC-ATGT-------TGCCCAGG--- ***** ***** *** * ***** ENST00000340107.4 TTTTCTGGCACCGCAGTTTTGTTTTAAAACTGGACCTGTATATTTGTAAAGCTATTTATG ENST00000457012.1 ----CT--------AGTCTTG------AACT---CCTG-----------AGCT------- ** *** *** **** **** **** ENST00000340107.4 GGCCCCTGGCACTCTTGTTCCCACACCCCAACACTTCCAGCATTTAGCTGGCCACATGGC ENST00000457012.1 -----CAGGCAATC-----CACCTGCCTTGGC-CTCCCAAAGT---GCTGG--------- * **** ** * * ** * ** *** * ***** ENST00000340107.4 GGAGAGTTTTAATTTTTAACTTATTGACAACCGAGAAGGTTTATCCCGCCGATAGAGGGA ENST00000457012.1 ----------GATT------------ACAGGCGTGA-----------GCC---------A *** *** ** ** *** * ENST00000340107.4 CGGCCAAGAATGTACGTCCAGCCTGCCCCGGAGCTGGAGGATCCCCTCCAAGCCTAAAAG ENST00000457012.1 CGGT-----------GCCCAG--TGACCCAGAGTT------TTCTCT------------- *** * **** ** *** *** * * * ** ENST00000340107.4 GTTGTTAATAGTTGGAGGTGATTCCAGTGAAGATATTTTATTTCCTTTGTCCTTTTTCAG ENST00000457012.1 GTTGT----AGC-----ATGACAAATATAAGGATAGCTGATATACTTAATACTCATTT-- ***** ** *** * * **** * ** * *** * ** ** ENST00000340107.4 GAGAATTAGATTTCTATAGGATTTTTCTTTAGGAGATTTATTTTTTGGACTTCAAAGCAA ENST00000457012.1 -----TTA---TTGTGTGAG--------TCAAATGAGTTATT-----GCATCTAAAGGAA *** ** * * * * * ** ***** * * **** ** ENST00000340107.4 GCTGGTATTTTCATACAAATTCTTCTAATTGCTGTGTGTCCCAGGCAGGGAGACGGTTTC ENST00000457012.1 ACCAGTG-----AAGCA------------TGCCATTTGACTTTGG-------ATTATTTC * ** * ** *** * ** * ** * **** ENST00000340107.4 CAGGGAGGGGCCGGCCCTGTGTGCAGGTTCCGATGTTATTAGATGTTACAAGTTTATATA ENST00000457012.1 AAGACAGCA-----CACTGAGCCCACAT-CCACTGTT----------------TCATTAA ** ** * *** * ** * ** **** * ** * ENST00000340107.4 TATCTATATAT-ATAATTTATTGAGTTTTTACAAGATGTATTTGTTGTAGACTTAACACT ENST00000457012.1 TATTTAGATAGGACAGAAAAGCAAATGTTGATAAGA----------ACAAATACTACACC *** ** *** * * * * * ** * **** * * **** ENST00000340107.4 TCTTACGCAATGCTTCTAGAGTTTTATAGCCTGGACTGCTACCTTTCAAAGCTTGGAGGG ENST00000457012.1 ACTTAATAAATAAT----GAATGGTAT------GAATAATG------GAAATTTGA---- **** *** * ** * *** ** * * ** *** ENST00000340107.4 AAGCCGTGAATTCAGTTGGTTCGTTCTGTACTGTTACTGGGCCCTGAGTCTGGGCAGCTG ENST00000457012.1 ------TGAAT-CAGATGAATCA----GTACT--TATT---------------------- ***** *** ** ** ***** ** * ENST00000340107.4 TCCCTTGCTTGCCTGCAGGGCCATGGCTCAGGGTGGTCTCTTCTTGGGGCCCAGTGCATG ENST00000457012.1 -----------------------TAGTTCATA-------------------CAATGTGT- * * *** ** ** * ENST00000340107.4 GTGGCCAGAGGTGTCACCCAAACCGGCAGGTGCGATTTTGTTAACCCAGCGACGAACTTT ENST00000457012.1 -TAGTCA------TTATTCTAA---------GTGATTT---------------ATACCT- * * ** * * * ** * ***** ** * ENST00000340107.4 CCGAAAAATAAAGACACCTGGTTGCTAACCTGG ENST00000457012.1 -----------ATACACTTAAT-----AC---- * **** * * **