CLUSTAL 2.1 multiple sequence alignment ENST00000342657.3 ------AGACCAGAAACG---GAAGAG----AGC-GCGGGGGATG-TGTTTGGCGTGGGG ENST00000515379.1 ATGTCTAAGTCAGAGTCTCCTGAAGAGCCCGAACAGCTGAGGAAGCTCTTCATTGGAGGG * **** * ****** * * ** * *** * * ** * *** ENST00000342657.3 CGCACTGTT----CAGTTGCTC----TCCTGGATGGC--TTTATGTCTCCGCGGTGT-TT ENST00000515379.1 CTGAGCTTTGAAACAACTGATGAGAGCCTTGAGGAGCCATTTTGAGCAATGGGGAATGCT * * ** ** ** * * ** ** *** * * ** * * ENST00000342657.3 CCTAGA--GTCTCGGCGT------TTCTACCTCTTCGCACCC-------TTT---CCTGC ENST00000515379.1 CACGGACTGTGTGGTCATGAGAGATCCAAACACCAAGCACCCCAGGGGCTTTGGGTTTGT * ** ** * * * * * * * * * ****** *** ** ENST00000342657.3 CACCCTTTGTCCCCTGGAAGCC-CGGAGACATCAGCGGCTGCAATTTTGCTACTCGCTGC ENST00000515379.1 CACATATGCTACTGTGGAGGAGGTGGATGCAGCCATGAATGCAAG---GCCACACAAGGT *** * * * **** * *** ** * * ***** ** ** * * ENST00000342657.3 TCGGCGTGGAACTGTCAGGACAAAAAATAATATCCAAAGATA---TTTTGGCA--CTAAC ENST00000515379.1 GGATGGAAGAGTTGTGGAACCAAAGAGAGCTGTCTCGAGAGAAGATTCTGAAAGACCAGG * ** *** **** * * ** *** * ** ** * * * ENST00000342657.3 GGCGC---TATCTGTAGCAAGAAAGTTGAGCAGTGTGAACTGTTGA-GACTTCCAAGGAG ENST00000515379.1 TGCCCACTTAACTGTGAAAAAGATATTTGTTGGTG-GCATTAAAGAAGACACTGAAGAAC ** * ** **** ** * ** *** * * * ** *** *** * ENST00000342657.3 ACTTC-----AGACAACCAAGA-CAGTGTAAAGGAA---AACAGA--GAAA--AAGACTT ENST00000515379.1 ATCACCTAAGAGATGATTTTGAACAGTATGGAAAAATTGAAGTGATTGAAATCATGACTG * * *** * ** **** * * ** ** ** **** * **** ENST00000342657.3 GTT-AGACATTATTAAGGGCACGAAAGTTG-------AA---TTGAGCACAGTAAATGTA ENST00000515379.1 ACCGAGGCAGTGGCAAGAAAAGGGGCTTTGCCTTTGTAAATTTTGACGACCATGACTCCA ** ** * *** * * *** ** **** ** * * * * ENST00000342657.3 CAAACAACAAAGCCACCCAACAGAAGTTCACT-TAAA-AGCTACAACTG---------GC ENST00000515379.1 TGGATAAGATTGTCATTCAGAAATACCATACTGTGAATGGCCACAACTGTGAAGTTAGGA * ** * * ** ** * * *** * ** ** ******* * ENST00000342657.3 GGGCCTCA-------AAGAGCTTTAGGACA-TGCT--------CCAAAGAAGA-GAAATG ENST00000515379.1 AAGCCCCGTCACAGCAAGAGAT---GGATAGTGCTTCATCCAGCCAAAGAGGTCGAAGTG *** * ***** * *** * **** ******* * *** ** ENST00000342657.3 AGCCCCTGAGTCCTGAGTTG-----GTGGCAGCTGCATCTGCTGCTCTG----TTTTGAC ENST00000515379.1 -GTTCTGGAAACTTTGGTGGTGGTCGTGGAGGTGGTTTCGGTGGGAATGACAACTTTGGT * * ** * * ** * **** * * ** * * ** **** ENST00000342657.3 AAGCAAACAAGCCAGAACTGCTCAGGCAGCTCCG-TAGCA-TGAGGAAGAGTCAGGGGCA ENST00000515379.1 CATGGAGGAAACTTCAGTGGTTGTGGTGGCTTTGGTGGCAGTCATGGTG-GTGGTGGATA * * ** * * * * ** *** * * *** * * * * ** ** * ENST00000342657.3 CAGAGAGA-TGGAGAGAGACCTAGTTAGTTT--CAATAACAAAA----TATCAGATATGA ENST00000515379.1 TGGTGGCAGTGGGGATGGCTATAATGGATTTGGTAATGATGGAAGCGATTTTGGAGGTGG * * * *** ** * ** * *** *** * ** * * ** ** ENST00000342657.3 ---AAATTGCCA-GATGT--------GCTACAGCTAGAATT--AATATAAGGCC----AG ENST00000515379.1 TGGAAGCTACAATGATTTTGGCAATTACAACAATCAGTCTTCAAATTTTGGACCCATGAA ** * * * *** * * *** ** ** *** * * ** * ENST00000342657.3 AGCATCAGATTCAGTTTGACCAAGGCTATGACAATTATCCTGGCCTGGAGAAGACTGCT- ENST00000515379.1 GGGAGGAAATTTTGGA-GGCAGAAGCTCTGGCCCTTATGGTGG--TGGAGGCCAATACTT * * * *** * * * * *** ** * **** *** ***** * * ** ENST00000342657.3 -----GATCTTAGAAACAGGAAAAATATA----TTCAGGGGGAAGAGAT----------- ENST00000515379.1 TGCAAAACCACAAAACCAAGGTGGCTATGGCGGTTCCAGTAGCAGCGGTAGCTATGGCAG * * * ** ** * *** *** * * ** * * ENST00000342657.3 --GTAATAGATTTCACATTATGG--CAGTTACTAA-AGAAGCACGTGAACAGACACATCA ENST00000515379.1 TGGCAGAAGATTTTA-ATTAGGAAACAAAGCTTAGCAGGAGCGGAGAGCCAGAGAAGTGA * * ****** * **** * ** ** ** *** **** * * * ENST00000342657.3 CCTTCA--CTTTGGGATATGG--AATTTGATAAG-CAGTTAGCCACAG----AATATGAA ENST00000515379.1 CAGGGAAGCTACAGGTTACAACAGATTTGTGAACTCAGCCAAGCACAGTGGTGGCAGGGC * * ** ** ** ***** ** *** * ***** * * ENST00000342657.3 CAACCCCTTGAGAATGAGA------TTGAAGAACTGATCCAGG-----GGACAAAAGA-- ENST00000515379.1 CTAGCTGCTACAAAGAAGACATGTTTTAGACAAAT-ACTCATGTGTATGGGCAAAAAACT * * * * ** *** ** * ** * * ** * ** ***** * ENST00000342657.3 -GGGGA--------------AACTG------AG--------AGTTCCCAATTAATAATGA ENST00000515379.1 CGAGGACTGTATTTGTGACTAATTGTATAACAGGTTATTTTAGTTTCTGTTCTGTGG-AA * *** ** ** ** **** * * * * ENST00000342657.3 AGC----AGCTTCATATCTAAGATCTCTGGTG--GACTTTTTCTGCCCGTGGACGCCGCT ENST00000515379.1 AGTGTAAAGCATTCCAACAAAGGGTTTTAATGTAGATTTTTTTTTTGCACCTATGCTGTT ** *** * * * *** * * ** ** ***** * * * ** * * ENST00000342657.3 GA----------AGAAGC---ATCGTTA--------AAGTCTCTCTTCACCTTGCCGTCA ENST00000515379.1 GATTGCTAATGTAATAGTCTGATCGTGATGCTGAATAAATGTCTTTTCTTTTTAATGTGC ** * ** ***** * ** * *** *** ** ** ENST00000342657.3 TGTCTAA-GTCAGCGT-CTCCAAAA----------GAG---CCCGAACAGC-TGAGG--- ENST00000515379.1 TGTGTAAAGTTAGTCTACTCTGAAGCCATCTTGGTAAATTTCCCCAACAGTGTGAAGTTA *** *** ** ** * *** ** * *** ***** *** * ENST00000342657.3 -AAGCTCTTCAT-----TGGAGGGTTGAGCTTTGAA-------ACAAC-TGATGAGAGCC ENST00000515379.1 GAATTCCTTCAGGGTGATGCCAGGTTCTATTTGGAATTTATATACAACCTGCTTGGAGG- ** ***** ** **** ** *** ***** ** * *** ENST00000342657.3 TGAGGAGCCATT---TTGAGCAA---TGGGGAACGCTCACAGACTGT----GTGGTAATG ENST00000515379.1 -GAGAAGCCATTGTCTTCAGAAACCTTGGTGTAGTTGAACTGATAGTTACCGTTGTGACC *** ******* ** ** ** *** * * ** ** ** ** ** * ENST00000342657.3 AGAGATCCA-----AACACCAAGCGCTCCAG--GGGCTTTGGGTTT----GTCACATATG ENST00000515379.1 TGAAGTTCACCATTAAAAGGGATTACCCAAGCAAAATCATGGAATTATTGGTTATAAAAG ** * ** ** * * * * ** *** ** ** * * * * ENST00000342657.3 CCACTGTGGAGGAGGTGGATGCAG-----CTA---TGAATA-CAACGCCACACAAGGT-- ENST00000515379.1 TGATTGTTGGCACATCCTATGCAATATATCTAAATTGAATAATGGTACTAGATAAAATTA * *** * ***** *** ****** * * * ** * ENST00000342657.3 -GGATGGAAGAG----TTGTGGAAC---CAAAGAGAGCTGTCTCCAGAGAA------GAT ENST00000515379.1 TAGATGGGAATGAAGCTTGTGTATCATCCATTATCATGTGTAATCAATAAATGATTTAAT ***** * * ***** * * ** * *** ** ** ** ENST00000342657.3 TCTC-----AAAGACCAGGTGCCCACTTAACTGTGAAAAAGA-TATTTG----TTGGTGG ENST00000515379.1 TCTCTTGAAAAAAACAAGGAAGGAGATT--TTAGAACAAATACTATTTAAAGCTTATTTG **** *** ** *** ** * * *** * ***** ** * * ENST00000342657.3 CATTAAAGAAGA---CACTGAAGAACATCACCTAAGAGATT-ATTTTGAACAGTATGGAA ENST00000515379.1 CATTAAACAAGATTACATACAAAAATCTGTCTTAAAATCTTTACTTTTAAAGTTATATAT ******* **** ** ** ** * * *** * ** * *** ** *** * ENST00000342657.3 AA-ATTGAAGTAA----TTGAAATCATGAC-----TGACCGAGGCAG---------TGG- ENST00000515379.1 ACTGTTACAGAAAGATGTCCAAGATATAGTGCCCTTGATAAAGGCAGGATACAAAATGGA * ** ** ** * ** ** *** ****** *** ENST00000342657.3 ----------------------CAAGAAAAG--------GGGCTT-------TGCCTTTG ENST00000515379.1 TTGTTCATTTTCATAGAATATATAAATAAAATAATACGTAGGCCTCAATTAATGACTTTA ** *** *** * ** **** ENST00000342657.3 TAACCTT--TGACGACCATG--ACTCCGTGGATAAG-ATTGTCATTCA----------GA ENST00000515379.1 AATTGTTCCTGAAGATCTTGCCATTAAGTGAAAAAGTATTTTCATTCATTTTAATGGAGA * ** *** ** * ** * * *** * *** *** ******* ** ENST00000342657.3 AATACCAT----ACTGTG-----------AAGGG--CCA--CAACTGTGA-AGTTAGAAA ENST00000515379.1 AAAATTATGATCACAGTGTATTCCATCCCAAGACATCCAAACAATTCTTACAAATAGAAA ** * ** ** *** *** *** *** * * * * ****** ENST00000342657.3 AGCC----CTGCCAAAGCAAGA----------GATGGCTAGTGCTTCA------------ ENST00000515379.1 AATCAGAACAATGAAAACAAAATGGTGTAAGTAATAAAAAGTGTTTGAAGGTAAATAAAT * * * *** *** * ** **** ** * ENST00000342657.3 ----TCCAGCCAAAGAG----GTCGAAGGGGTTCTG------------------GAAACT ENST00000515379.1 ACACTTTGAACATAAAGTGTAGTAAATGAAACTGTGTCATATTCACCAAAAGAAGAAGCT * ** * ** ** * * * ** *** ** ENST00000342657.3 T----TGGTGGTGGTCGT-GGAGATGG----TTTC----------GGTGGGAATG-ACAA ENST00000515379.1 TCCTATTATGATGGAAGAAGGAAGTGGAGTTTTTCTTTGGAAGAGGGTGGAGAAGCAGAT * * ** *** * *** *** **** ***** * * * * ENST00000342657.3 CTTTGGTCGTGGAG--GAAACT-TCAGTGG--TCGTGGTGGCTTTG-------GTGGC-- ENST00000515379.1 CATTAATTTTTAAGCGGCAGCTCTTTGTGGGTTCATGGTTATCTTACACTCAAACAGCTC * ** * * ** * * ** * **** ** **** ** ** ENST00000342657.3 ------AGCTGTGG--TGGTGGTGGATATGGTGG----CAGT---------GGGGATGGC ENST00000515379.1 ACAACCAACTGGAGAGTGGTAGCCACTATTGTAAAAAACAGTTTGAAATTTGGAGATAGA * *** * **** * *** ** **** ** *** * ENST00000342657.3 TATAATGGATTTGGTAATGATGGAAGCAATTT--TGGAGGTGGTGGAAGCTACAATGATT ENST00000515379.1 TA-GATAGATATAGATATAAAACACAAAACTTAACAGTGGGGTTGTCAGACATGG-GATT ** ** *** * * ** * * ** ** * ** * ** ** * **** ENST00000342657.3 -TTGGCAA---TTACA------ACAATCAGTCTTC--AAATTTTGGACCCATGAAGGGAG ENST00000515379.1 ATTAGCCACTTTTACTTTCTATACTATATATCTTATAAAATTTAAGATTTACAATGAGCA ** ** * **** ** ** **** ****** ** * * * * ENST00000342657.3 GAAATTTT--------GGAGGCAGAAGCT----------CTGGCCCCTATGGCG-GTGG- ENST00000515379.1 TGTATTTTTGTTCGCAGAAAATAAAAGCTGAAGAAAAAATTGTTTGTTGTAACATGTAAC ***** * * * ***** ** * * * ** ENST00000342657.3 --AGGCCAATACTTT--------GCAAAACCA-CA-----AAACCAA--GG--TGGCTAT ENST00000515379.1 CAAAGCTGATACTCTTGTTATATATAAAGCTAATATATATAAACTGACAGGACTGGCTAT * ** ***** * *** * * * **** * ** ******* ENST00000342657.3 GGCGTTTCCAGCAGCAGCAGTAGCTATGG----CAGTGGCAGA----------AGATTTT ENST00000515379.1 ATAATTTGTGG-AGCCCCATAATTTCTGGAGCCCAGTGCAAAATGAAAGGTGGAAATTTT *** * *** ** * * *** ***** * * * ***** ENST00000342657.3 AATTAGGAAAC----AAAGCTTAGCAGGAGAGGAGAGCCAGAGAAGTGACAGGGAAGCTA ENST00000515379.1 TGTCCTAAAATTGTTAACAATTCTAAGATGGCGACAGC-AGAGCATTA--AACCAAGTTC * *** ** ** ** * ** *** **** * * * *** * ENST00000342657.3 CAGGTTACAACAGATTTGTGAACTCAGC-CAAGCACAGTGGTGGCAGGGCCT---AGCT- ENST00000515379.1 GAGGCCCTTGTAAGTGTG-GGACCCAGTGTGAATACACAGGTA-CGGGCCCATGAAACTA *** * * ** * ** *** * *** *** * ** ** * ** ENST00000342657.3 GCTACAAAGAA-GACATGTTTTAGACAAATACTCATGTGTA---TGGGCAAAAAACTCGA ENST00000515379.1 GCTCTGAAAATTGATACGGAAAACACAAAGGCTTTAGTATACAATGGAAAAAGGATATGA *** ** * ** * * * ***** ** ** ** *** *** * ** ENST00000342657.3 GGACTGTATTTGTGACTAATTGTATAACAGGTTATTTTAGTTTCTGTTC-TGTGGAAAGT ENST00000515379.1 AAAGACAATTTATAA-------TACAGGAAGTTAAAATGATTAGTAAACATATAAAATGT * **** * * ** * * **** * ** * * * * ** ** ENST00000342657.3 GTAAAGC--------ATTCCAACAAAGTGTTTTAATGTAGATTTTTTTTTTTGCACCCAT ENST00000515379.1 TCAAACTCACCAGTTATCATAGAAATGCAAATTAAAATAACATGCCATTTCTTC-CCTAT *** ** * ** * **** ** * *** * * ** ** ENST00000342657.3 GCTGTTGATTGCTAAATGTAATAGTCTGATTG-TGACGCTGAATAAATGTCTCT------ ENST00000515379.1 CAAATTGA-----AAACAATATATTTTAAATGATAACACCTAATGTTGGCCTGGAGGGTA **** *** *** * * * ** * ** * *** * ** ENST00000342657.3 - ENST00000515379.1 A