CLUSTAL 2.1 multiple sequence alignment ENST00000344327.3 GGGATCTTGACGGAGAGTGCGGGGGATGAAGGCGGGAGCTGAGGGCTGGAGAGTCTCTGT ENST00000503772.1 ---ATGT---------GTTC-----ATTGTGGCG----TTTGTGGCT------TTTATG- ** * ** * ** **** * **** * * ** ENST00000344327.3 TGACATAGTAACTCTTCAGCTCCGTCTCCCTTGCTCTCCGCTCTTACGCTTCGCTACCAC ENST00000503772.1 ----ATGGGAA-TATTCAAC--------CTCTAATC----CTACTACA-TTGGTGAAAAA ** * ** * **** * * * ** ** *** ** * * * ENST00000344327.3 CAGCGGCCCCGCCTGTGCCCTCTCTGCCCGGGCGCCCCAGACGCATCCTCGCGGGGTCTC ENST00000503772.1 CAAAA--------TGAAGCCTT-------------------CACA-----ACAGAGTTT- ** ** *** * ** * * ** * ENST00000344327.3 CTCGGCCTGACCTGCTCAGGTCAAGATCCTCTTTGCACCCCCTTAAGTGGTGACTTTTCC ENST00000503772.1 -TAAGACA---CTGTTCTGGGCTA-----TCTTTGGACTTTCTGAAGTGA---------- * * * *** ** ** * * ****** ** ** ***** ENST00000344327.3 CCGGGCCAGTGGGCGAGCCACTTGCGGCGGGCGTCTGCACCCCCTGCTTCACCGTCGTCC ENST00000503772.1 ---AATCAGTGG-----TCAT----------CAACTATAACCACAAATTAATTGA----- ****** ** * ** * ** * ** * * ENST00000344327.3 CCTGGGCACCGGTCTGCCCAGGTCCAGTTCGGCCGCTGACGCGAACCCTCCGCACCGGGT ENST00000503772.1 ---AAACATTGGTT-----ATGTTC----------TTTATG-GAG---TCCATAATG--- ** *** * ** * * * * ** *** * * ENST00000344327.3 CCCCGCTGGAACTGCCCACTCGGCTCCCCCGGGAGCGGGGCCCAGGCCAGTCGGGCGTTC ENST00000503772.1 -----TTACAA-TGGTCATT--GTTTTGCTAAAA-------------------------- * ** ** ** * * * * * ENST00000344327.3 CCGCCATGAGCCAGAGCCCGGCGTTCGGGCCCCGGAGGGGCAGTTCTCCCCGGGGCGCTG ENST00000503772.1 TTGCCATGATCAA---------------------------CAGTTTATTCCAGGAAATTG ******* * * ***** ** ** ** ENST00000344327.3 CCGGAGCCGCTGCGCGGCGCAACGAGAGCCAGGACTATCTGCTCATGGACTCGGAGCTGG ENST00000503772.1 ------------------------------AGGATGAC--GCTGATG----TGGAGT--G **** * *** *** **** * ENST00000344327.3 GAGAAGACGGCTGCCCGCAAGCCCCGCTGCCTTGCTACGGCTACTACCCCTGCTTCCGGG ENST00000503772.1 GAAA--------------------------TTTGCAAGGGCCAA-ACTCTCATTTTC--- ** * **** * *** * ** * ** * ENST00000344327.3 GATCTGACAACAGACTGGCTCACCGGCGGCAGACAGTTCTCCGTGAGAAGGGGAGAAGGT ENST00000503772.1 ---CTG----------------------------------CTTTGGGGAGGGGAGA---- *** * ** * ******** ENST00000344327.3 TAGCTAATCGAGGACCAGCATACATGTTTAGTGATCGCTCCACAAGCCTATCTATAGAGG ENST00000503772.1 -----------------GCAC------TTCCTGTTCCCTTCA-------ATCT------- *** ** ** ** ** ** **** ENST00000344327.3 AGGAACGCTTTTTGGATGCAGCTGAATATGGTAACATCCCAGTGGTGCGGAAGATGTTAG ENST00000503772.1 --------------GGTG---CCGGGTCCG---AGGTCCCTGT-------------TT-- * ** * * * * * **** ** ** ENST00000344327.3 AAGAATGCCACTCACTCAACGTTAACTGTGTGGATTACATGGGCCAGAATGCCCTACAGT ENST00000503772.1 -----TGTCTCTTGCTGAAGCTTAAA-GGGTGGATT-------TCTGA--GCTCTAC--- ** * ** ** ** **** * ******* * ** ** **** ENST00000344327.3 TGGCAGTGGCCAATGAGCATCTGGAAATTACAGAACTTCTTCTCAAGAAAGAAAACCTCT ENST00000503772.1 ---------CCAA---------GGTCATTAAAAAGGTT---TCCAGGAAAGA-------T **** ** **** * * ** ** ****** * ENST00000344327.3 CTCGAGTTGGGGATGCTTTGCTTCTAGCTATTAGTAAAGGTTATGTTCGGATTGTGGAAG ENST00000503772.1 GTAGAGATAAGTA-------------------AGTAAA---------------GTAGAGA * *** * * * ****** ** ** ENST00000344327.3 CAATTCTCAGTCATCCGGCTTTTGCTGAAGGCAAGAGGTTAGCAACCAGCCCTAGCCAGT ENST00000503772.1 CAAGTA--AGT-----------------AAGTA-GAGACAAGTAAGTAGAGCTA---AGT *** * *** * * * *** ** ** ** *** *** ENST00000344327.3 CTGAACTCCAGCAAGATGATTTTTATGCCTATGATGAAGATGGGACACGGTTCTCCCATG ENST00000503772.1 ATAAAC-------AGA----------------GATAGAGGTAAG---------------- * *** *** *** ** * * ENST00000344327.3 ATGTGACTCCAATCATTCTGGCTGCCCACTGCCAGGAATATGAAATTGTGCATACCCTCC ENST00000503772.1 --------------------------------TAGAGAGA-GAGAT-------------- ** * * ** ** ENST00000344327.3 TGCGGAAGGGTGCTAGGATTGAACGGCCTCATGATTATTTCTGCAAGTGCAATGACTGCA ENST00000503772.1 -----AAG-----TAG-------------------------------------------- *** *** ENST00000344327.3 ACCAGAAACAGAAGCATGACTCGTTTAGCCACTCCAGATCTAGGATTAATGCCTATAAAG ENST00000503772.1 ---AGAGAGAGAGGTAAG-------TAG-------AGA----GAGGTAA-----GTAGAG *** * *** * * * *** *** * *** ** ** ENST00000344327.3 GCCTGGCAAGTCCGGCTTACCTGTCATTGTCTAGTGAAGATCCAGTCATGACGGCTTTAG ENST00000503772.1 --------AG----------------------AGAGAAG-TAGAGAGATGAAGACT---- ** ** **** * ** **** * ** ENST00000344327.3 AACTTAGCAATGAACTGGCAGTTCTGGCCAATATTGAGAAAGAGTTCAAGAATGACTACA ENST00000503772.1 -----AGCAATATAAGGTCAGT----GCC----CTAAAGAGG--------------TACA ****** * * **** *** * * * * **** ENST00000344327.3 AAAAACTGTCAATGCAGTGCAAAGACTTTGTTGTTGGACTCCTTGATCTGTGCAGAAACA ENST00000503772.1 AAA---------------GCAAAGACT-----AACAGA------GATTT--GCAGGGACA *** ********* ** *** * **** *** ENST00000344327.3 CTGAAGAAGTCGAGGCCATTCTGAATGGGGATGTTGAAACGCTCCAGAGTGGTGATCACG ENST00000503772.1 --------GACAAGAACATTCTGAAT-----TATAGAAAT------------TAGTTATG * * ** ********** * * **** * * * * ENST00000344327.3 GTCGCCCAAATCTCAGCCGTTTAAAACTTGCCATTAAATATGAAGTAAAAAAATTTGTAG ENST00000503772.1 ---GCTCAAAGGGCAA--ATATAAAAG--------GAATAGAGAGGAGGGAGAT------ ** **** ** * ***** **** ** * * ** ENST00000344327.3 CTCATCCAAACTGCCAACAGCAACTTCTCTCCATTTGGTATGAGAATCTTTCTGGTTTAC ENST00000503772.1 -------AAG-----GATAA-AAATGCTCTTTCTTT----------TCTCTC-------C ** * * ** * **** *** *** ** * ENST00000344327.3 GACAGCAGACAATGGCGGTCAAGTTCCTTGTGGTCCTTGCTGTTGCCATTGGACTGCCCT ENST00000503772.1 AACAGAA-------------------CCTGTGG----------------------GTCCT **** * * ***** * *** ENST00000344327.3 TCCTGGCTCTCATTTACTGGTTTGCTCCATGCAGCAAGATGGGGAAGATAATGCGTGGAC ENST00000503772.1 ------------TTAACTAA---ACTTAAT-CAA-AGGGTGG--------ATGCAT---- ** *** ** ** ** * * *** **** * ENST00000344327.3 CATTCATGAAGTTTGTAGCACACGCAGCCTCCTTCACCATTTTTCTGGGACTGCTAGTCA ENST00000503772.1 ------TGGTGTCTGCAGC--------------------TTTT----------------- ** ** ** *** **** ENST00000344327.3 TGAATGCAGCTGACAGATTTGAAGGCACAAA-ACTCCTTCCTAATGAAACCAGCACAGAT ENST00000503772.1 --------GCTGAT----------GCACAAACATTCCAT--TATTAAACTCATCT----T ***** ******* * *** * ** * ** ** * * ENST00000344327.3 AATGCAAAACAGCTGTTCAGGATGAAAACATCCTGCTTCTCATGGATGGAGATGCTCATT ENST00000503772.1 AATGCCA----------CAGG----------CCT--------TAGAAAAAGATGT----- ***** * **** *** * ** ***** ENST00000344327.3 ATATCCTGGGTAATAGGCATGATATGGGCTGAATGTAAAGAAATCTGGACTCAGGGCCCC ENST00000503772.1 --------GGTCA----CATAAAAAGAGCTGGGAAAAAGGAAA----------------- *** * *** * * * **** ** **** ENST00000344327.3 AAGGAATATTTGTTTGAGTTGTGGAACATGCTTGATTTTGGTATGTTAGCAATTTTCGCA ENST00000503772.1 ----GATAATTATATGAG--GAAGAG-------GATTTGTGTATGTC------TCTCCAG *** ** * **** * ** ***** ****** * ** ENST00000344327.3 GCATCATTCA-TTGCGAGATTCATGGCATTTTGGCATGCTTCCAAAGCCCAGAGCATCAT ENST00000503772.1 GTGACAATCAGCTGC-----CTATG------TGG-GTGC--CCA----CCA-AACATC-- * ** *** *** *** *** *** *** *** * **** ENST00000344327.3 TGACGCAAATGATACTTTGAAGGACTTGACGAAAGTAACATTGGGAGACAATGTGAAATA ENST00000503772.1 -----------------CGAAGATCT-------------ATCAGGAGCCA---------- **** ** ** **** ** ENST00000344327.3 CTACAATTTGGCCAGGATAAAGTGGGACCCCTCTGATCCTCAAATAATATCTGAAGGTCT ENST00000503772.1 ------------CAGCATCTAGTGG-ACCCACCTG----TACAGTGCGAATTGAAGGTTT *** ** ***** **** *** * * * * ******* * ENST00000344327.3 TTATGCAATTGCTGTAGTTTTAAGTTTCTCTAGGATAGCTTATATTTTACCAGCAAATGA ENST00000503772.1 ----GAAA-------AGCCTCGATTTGCTTTC------CTTGTGCCTTCTCT-----TAG * ** ** * * ** ** * *** * ** * * ENST00000344327.3 AAGCTTTGGACCTCTGCAGATATCACTTGGAAGAACAGTCAAAGACATCTTCAAGTTCAT ENST00000503772.1 AAG----GGGCCTGTT----TCTCATT------ATCAGT---AG---CCTCCCAGCT-AC *** ** *** * * *** * * **** ** ** * ** * * ENST00000344327.3 GGTCATATTCATTATGGTGTTTGTGGCCTTTATGATTGGAATGTTCAATCTCTACTCCTA ENST00000503772.1 AGCCACA--------AGTTTTTG---CTTCTGTT-TCAGTAGATTTA----------CTA * ** * ** **** * * * * * * * ** * *** ENST00000344327.3 CTACATTGGTGCAAAACAAAATGAAGCCTTCACAACAGTTGAAGAGAGTTTTAAGACACT ENST00000503772.1 ATGTATGGGTG-AGGGAATGCTTGTATTTTTGCAGGAGATGAA----------------- * ** **** * * * ** ** ** **** ENST00000344327.3 GTTCTGGGCTATATTTGGACTTTCTGAAGTGAAATCAGTGGTCATCAACTATAACCACAA ENST00000503772.1 ----TGAACCGTGA--GGATGCCCTCAAG----AT--GTG---------TATGACCACGG ** * * *** ** *** ** *** *** ***** ENST00000344327.3 ATTCATTGAAAACATTGGTTACGTTCTTTATGGAGTCTATAATGTTACGATGGTCATTGT ENST00000503772.1 A---ACAGGAGAC--TGGAGGGACCC---ATGGATCCCA-------ACCATGGAC-CGGG * * * * ** *** * ***** * * ** **** * * ENST00000344327.3 TTTGCTAAATATGTTAATTGCCATGATCAACAGTTCATTCCAGGAAATTGAGGATGACGC ENST00000503772.1 TTCCCCCAGTATGA-----GCCATAAGC--CAGTT--------GAATCTGA--------- ** * * **** ***** * * ***** *** *** ENST00000344327.3 TGATGTGGAG-TGGAAATTTGCAAGGGCCAAACTCTGGTTTTCCTACTTTGAGGAGGGCA ENST00000503772.1 --ATGCGAAGATGGAA-----CAAAGACCAA----------------------------- *** * ** ***** *** * **** ENST00000344327.3 GAACACTTCCTGTACCCTTCAATCTGGTGCCGAGTCCAAAGTCCCTGTTTTATCTCTTAC ENST00000503772.1 -----------------------------------CCAGAGTCACGATG------CTTAA *** **** * * **** ENST00000344327.3 TGAAGCTTAAAAAATGGATTTCTGAGCTGTTCCAGGGCCATAAAAAAGGTTTCCAGGAAG ENST00000503772.1 TGGACC------AATGC-TTTCTGA-----CTCAGCTCC----------TCTCTA----- ** * * **** ******* *** ** * ** * ENST00000344327.3 ATGCAGAGATGAACAAGATAAATGAAGAAAAGAAACTTGGAATTTTAGGAAGTCATGAAG ENST00000503772.1 -CCC------------------TGAATATAAGAGACCCT-AAT-------AGTTAGGCAG * **** * **** ** *** *** * * ** ENST00000344327.3 ACCTTTCAAAATTATCACTTGACAAAAAACAGGTTGGGCACAATAAACAACCAAGTATAA ENST00000503772.1 GACTATCATCACCCCTATTCAGCATGAAG-AAGTT----ACAGAAGACG----------- ** *** * * * ** ** * *** *** * ** ENST00000344327.3 GGAGCTCAGAAGATTTCCATCTAAATAGTTTCAATAATCCTCCAAGACAATATCAGAAAA ENST00000503772.1 -----------GACCTTCATCC-------TTCTGCAA-CCCCTAGGA-----TTAGG--- ** * **** *** ** ** * * ** * ** ENST00000344327.3 TAATGAAAAGGCTCATTAAAAGATATGTACTGCAGGCCCAGATAGATAAGGAGAGTGATG ENST00000503772.1 ---------GGTCCTCT--------TGTA------------------AAAGGGA------ ** * * **** ** * ** ENST00000344327.3 AAGTGAACGAAGGGGAACTGAAGGAAATTAAGCAGGACATCTCAAGTCTCCGCTATGAAC ENST00000503772.1 ---------AAGGGGAGATATGTGGAA---AGCA------CTCAAA---CCAGAGTGA-C ******* * * ** **** ***** ** *** * ENST00000344327.3 TCCTTGAAGAAAAATCTCAGAATACAGAAGACCTAGCAGAACTTATTAGAGAACTTGGAG ENST00000503772.1 TCC---------AGTTT--GAATA-------------------------AGGGCT--AAG *** * * * ***** ** ** ** ENST00000344327.3 AGAAATTATCCATGGAACCAAATCAAGAGGAAACCAATAGATAATGCGAAGACTTCCTTA ENST00000503772.1 AAAA-------ATGAAGCTGGATCA--------CCAACCGGCAAT-TAAGGGCTGC---A * ** *** * * **** **** * *** * * ** * * ENST00000344327.3 GAAATTCATATTTATTTGTCCACTTGAAGCCATATTATTTTCTGATTTATTTTCTTAAGT ENST00000503772.1 CAGCCTGCAATTGCCTTGCTCAATTAAAAG-AGGTTACCTT-----TTATGCT----AGT * * *** *** ** ** ** * *** ** **** * *** ENST00000344327.3 GCCAATGGGCCCACCTTTTAAACAAGAAAACGTTAAATAACTTGGGCCATCCTATCATCT ENST00000503772.1 AATAACGATACCTTCTCTTTTACAAAAAAA-----GAGAA---GGG-------------- ** * ** ** ** **** **** * ** *** ENST00000344327.3 GGAGCCCTAGTATCTAATTTTTTTGGTGATTAAACTCCATTGTTCAGGGTAAAGGCTGTA ENST00000503772.1 -GGGCA--------------TGTTGG-GA--AAATCTGAGTGTT---GGGAGAAGCT--- * ** * **** ** *** * **** ** * * *** ENST00000344327.3 GATAATGAGGAAAATTATGCCCAGTTGTTTGGTGCTTGTTTTATAAACTGCTTTCTTGGA ENST00000503772.1 ------GAGGCAGG---------GCT------TGCATGTCTGACATA------------A **** * * * *** *** * * * * * ENST00000344327.3 TATAACTAACTCTTGTGATGATGTCATTGCCATGTAGTGTCTGCCTGAAAATGGGTCCCA ENST00000503772.1 TGTAAAAGACTCTTG-GAACATGTC--------------------------CGGGGCCCA * *** ******* ** ***** *** **** ENST00000344327.3 GCGGACAGGGGCTGACCCACGTTACTCCCCATGCGGTTTTTCCTCTGAAGTTTATTTCAG ENST00000503772.1 GGG----------------------------------------TCTGAAACC-------- * * ****** ENST00000344327.3 GTTCCTTCTTGCCTGCTCTGTGGATCCCCTGCTGGGGACTCCCAGCTCTGAAATTTGGGA ENST00000503772.1 ---CCTTGTGGCCT------------------TTGGAACACCAAGCTCTG-----TGCTA **** * **** * ** ** ** ******* ** * ENST00000344327.3 AAAAGTAGCCCATGGGCCTTTAGAATGCTTTAATCCTTTCTTTAGAATGCTGTTTAAACA ENST00000503772.1 AGGGGTGG---------------AAGGCT------------------------------- * ** * ** *** ENST00000344327.3 CCATTTACCCTACTTATCCCTCAATGCACATGATTGATACCGTTCATACAAAATGGTCTT ENST00000503772.1 ------ACCCTG-----------ATGCAC---------------CAT------------- ***** ****** *** ENST00000344327.3 ACATCTATGTAAAATTTTCTGATTCATCTATTTGAAAACATTACACTTAACAATGAAAAA ENST00000503772.1 -CATCTAAGC----------------------CCAGGGCAT---------------AAAA ****** * * *** **** ENST00000344327.3 AGTTTTTCCTCCACTGAACCCTGGAAACATGGTCCAGTTTTGTGTGTGTGCGTGTGTGTA ENST00000503772.1 ---------TCCATTGTGGCTTGGA--CAGAATCCGGG-----GCTTGTGGCTCTG---G **** ** * **** ** *** * * **** * ** ENST00000344327.3 AATGTGTACACACAGACATAAAGTACTTGCCCTAGTTTGTGGCTAATGTGGACACACAAA ENST00000503772.1 AATGTGTGTAGAC----------------------TTGGTGGCT---------------- ******* * ** ** ****** ENST00000344327.3 AGCTCTTTATGTTATAAATTTTTATTGTCACTAAAAAATTTTACTGTCTAAATAAGTACC ENST00000503772.1 ----CCTTGC--------TTCTTGCTCTC-CCAGGA---TCCATTGTATG---------- * ** ** ** * ** * * * * * *** * ENST00000344327.3 TTTTATTGGAGAAAAATCAAAACCCCAAACAAACACTGTGGTTGTTTGGTTCCATTATAG ENST00000503772.1 -----TTG------AGTTAAAA----GAAC-----------CTGCT---CTCCATTAT-- *** * * **** *** ** * ******** ENST00000344327.3 CACAATTTTGTGCCATTTCTGGGAGCATTTACAGATGAATCCCCACACTTAGCCATTGAA ENST00000503772.1 --CAA----GTAGCA-------GAGCAAGTGTGAA---ACCATCACA----GC------- *** ** ** ***** * * * * **** ** ENST00000344327.3 TGTAAAGGGGAAAAATAAGGTGAGAATTTGTAAATACTTATCTGTTATTTTCAATATGTT ENST00000503772.1 TGTAAA-------------------------------TCATGTGC-----TTAATGCAAT ****** * ** ** * *** * ENST00000344327.3 CTATCC-TTCTACCCAAATATATAAAACAGGAATTTGCATTCATGTGCATTTACCAAGAG ENST00000503772.1 GCACCCGTTCGACC-------------------TCCACGTTC--------TCACCAC--- * ** *** *** * * *** * **** ENST00000344327.3 GTTGTTGTTGTTACTTACTGATCATGTGAAGTGGTGTCTTAAACAACTAA-AAGCGATGA ENST00000503772.1 -------CTGTTTCT--CTG------------------TTGGATTACCAATAAATAACGT **** ** *** ** * ** ** ** * * ENST00000344327.3 AGGTTCATATGTTTACTCAAAGACCATTG--GCATTCAGAGG-ATGCTGGACATTAACTG ENST00000503772.1 GGGCTCCCAGA---GCTCAGGG-CCTTTGCAGCCTCCACAGACACGATGGCCCC---CTG ** ** * **** * ** *** ** * ** ** * * *** * *** ENST00000344327.3 GAACTGCTACTTCCAATTCAATAATGGGAGATTTCAAATGCAAATCTTTAACTTCATCTT ENST00000503772.1 G---TGC-----CCACTTTAAT---------TCTCAAAC---------TGTCTTTTTCTC * *** *** ** *** * ***** * *** *** ENST00000344327.3 AAAGATGAAATGGTTGCAGAAAATCTGTTTAGCTCCAACTTTGGCTTAATTTAAATCAAA ENST00000503772.1 AA---------------------TCC-TTTGACTCCGAC--AGACTTTGT---------- ** ** *** **** ** * *** * ENST00000344327.3 GAACATTTATGTAACCAGATCAGAAAATACAGCTGAAAATTTATATTCAGTGATTTTGTA ENST00000503772.1 ---CACCCCCATGACC----------------------------------TGGTGTTGGG ** * *** ** * *** ENST00000344327.3 TTTGTGGATACTACTTATGGAAAAGTTACTTGGTGATACATAAAGATCGATTTTCAAATA ENST00000503772.1 TCT---GATCACCCCAATAAGAAAACCCCATTGTCTCAGGCCAAAATC--TCCTTA---- * * *** * ** *** * * ** * ** *** * * *