CLUSTAL 2.1 multiple sequence alignment ENST00000357599.3 AACTCCTCCCCCACCGCCCCCTCCCTCCTTCTGCTCCCGCGGTCTCCTCCTCCCTGCTCT ENST00000506236.1 ---------------------------------------CAG------------TGC--- * * *** ENST00000357599.3 CTCCGAGCGCCGGGTCGGGAGCTAGTTGGAGCGCGGGGGTTGGTGCCAGAGCCCAGCTCC ENST00000506236.1 -----AGCACTG--------------TGGA---------------CCAGAGCCTGG---- *** * * **** ******** * ENST00000357599.3 GCCGAGCCGGGCGGGTCGGCAGCGCATCCAGCGGCTGCTGGGAGCCCGAGCGCAGCGGGC ENST00000506236.1 -----------------------ACATT--------------AATCTGA----------- *** * * ** ENST00000357599.3 GCGGGCCCGGGTGGGGACTGCACCGGAGCGCTGAGAGCTGGAGGCCGTTCCTGCGCGGCC ENST00000506236.1 -------TGAAGAGGGACT-------------------TGCAGGATGTTC---------- * ****** ** *** **** ENST00000357599.3 GCCCCATTCCCAGACCGGCCGCCAGCCCATCTGGTTAGCTCCCGCCGCTCCGCGCCGCCC ENST00000506236.1 -----------AGA---------AGTTCAT------------------------------ *** ** *** ENST00000357599.3 GGGAGTCGGGAGCCGCGGGGAACCGGGCACCTGCACCCGCCTCTGGGAGTGAGTGGTTCC ENST00000506236.1 -----------------------------------------TCTGA---TGCGTG----- **** ** *** ENST00000357599.3 AGCTGGTGCCTGGCCTGTGTCTCTTGGATGCCCTGTGGCTTCAGTCCGTCTCCTGTTGCC ENST00000506236.1 AGGTGGTGC--AGCCAGTG-------AATAC-----------AGTGC-CCTCCT------ ** ****** *** *** ** * *** * ***** ENST00000357599.3 CACCACCTCGTCCCTGGGCCGCCTGATACCCCAGCCCAACAGCTAAGGTGTGGATGGACA ENST00000506236.1 -------TCAT-----------------------------------------GAAAGACA ** * ** **** ENST00000357599.3 GTAGGGGGCTGGCTTCTCTCA-CTGGTCAGGGGTCTTCTCCCCTGTCTGCCTCCCGGAGC ENST00000506236.1 ATAG-----TCACATTTCCCATCTGGCCATTGATATTGTGC--------------AGAGC *** * * * ** ** **** ** * * ** * * **** ENST00000357599.3 TAGGACTGCAGAGGGGCCTATCATGGTGCTTGCAGGCCCCCTGGCTGTCTCGCTGTTGCT ENST00000506236.1 AGAGAC-------------------ATGCTTGT--------------CCACACCGT--CC *** ****** * * * ** * ENST00000357599.3 GCCCAGCCTCACACTGCTGGTGTCCCACCTCTCCAGCTCCCAGGATGTCTCCAGTGAGCC ENST00000506236.1 GTTTGGCCACA-AGTG--GGAGTTCTGCC-CTC---ATCCGAGGA-GTCTTC-------- * *** ** * ** ** ** * ** *** *** **** **** * ENST00000357599.3 CAGCAGTGAGCAGCAGCTGTGCGCCCTTAGCAAGCACCCCACCGTGGCCTTTGAAGACCT ENST00000506236.1 ----------TACCATCT-------TTTGAT----------TTGGGGCTTTTGA----TT * ** ** ** * *** ***** * ENST00000357599.3 GCAGCCGTGGGTCTCTAACTTCACCTACCCTGGAGCCCGGGATTTCTCCCAGCTGGCTTT ENST00000506236.1 CTAA--ATGAGC----AATTTCAGTTTC----AAGCT---------TTTCATCTGCC--- * ** * ** **** * * *** * ** *** * ENST00000357599.3 GGACCCCTCCGGG-AACCAGCTCATCGTGGGAGCCAGGAACTACCTCTTCAGACTCAGCC ENST00000506236.1 --ACCTCTCCTTGCAACCAGC--------AAAACCCACAA-TACTC------ACTCATCT *** **** * ******* * ** ** *** ***** * ENST00000357599.3 TTGCCAATGTCTCTCTTCTTCAGGCCACAGAGTGGGCCTCCAGTGAGGACACGCGCCGCT ENST00000506236.1 TTGTCA-------TCTTCT-------------------------------ATGCA----T *** ** ****** * ** * ENST00000357599.3 CCTGCCAAAGCAAAGGGAAGACTGAGGAGGAGTGTCAGAACTACGTGCGAGTCCTGATCG ENST00000506236.1 CTTGTTTA--CA---------------------GTTTGAATT------------------ * ** * ** ** *** * ENST00000357599.3 TCGCCGGCCGGAAGGTGTTCATGTGTGGAACCAATGCCTTTTCCCCCATGTGCACCAGCA ENST00000506236.1 -----------------TTTAT---------------CTTTTCTC--AT----------- ** ** ****** * ** ENST00000357599.3 GACAGGTGGGGAACCTCAGCCGGACT---ATTGAGAAGATCAATGGTGTGGCCCGCTGCC ENST00000506236.1 ------------ACTTTGGTCATATTTTAATTGGAAAGA-CAATA--------------C ** * * * * * **** **** **** * ENST00000357599.3 CCTATGACCCACGCCACAACTCCACAGCTGTCATCTCCTCCCAGGGGGAGCTCTATGCAG ENST00000506236.1 TTTGTG-CCCTCACCATTGCTTCTTAACTTT--------------------TCAAAATAG * ** *** * *** ** * * ** * ** * ** ENST00000357599.3 CCACGGTCATCGACTTCTCAGGTCGGGACCCTGCCATCTACCGCAGCCTGGGCAGTGGGC ENST00000506236.1 CCAT----------TTCCCAG--CAAAACC-----ATTTA-----GTTTAAGTAAT---- *** *** *** * *** ** ** * * * * * ENST00000357599.3 CACCGCTTCGCACTGCCCAATATAACTCCAAGTGGCTTAATGAGCCAAACTTCGTGGCAG ENST00000506236.1 ----------------TTAAGATAATAC--------------AGC---ACTT-------- ** **** * *** **** ENST00000357599.3 CCTATGATATTGGGCTGTTTGCATACTTCTTCCTGCGGGAGAACGCAGTGGAGCACGACT ENST00000506236.1 ----TGATATTGTGCTTT---------------------AAAAAAAAATC--------CT ******** *** * * ** * * ** ENST00000357599.3 GTGGACGCACCGTGTACTCTCGCGTGGCCCGCGTGTGCAAGAATGACGTGGGGGGCCGAT ENST00000506236.1 GTAATCATATGGTA-ATTTCTGATTGGTTCA-------AAGA--------------CAAT ** * * ** * * * *** * **** * ** ENST00000357599.3 TCCTGCTGGAGGACACATGGACCACATTCATGAAGGCCCGGCTCAACTGCTCCCGCCCGG ENST00000506236.1 ACTTTTTTGTA---TCATGG------TCCATGGAA-------TCAACTTATCCCTTAAGG * * * * ***** * **** * ****** **** ** ENST00000357599.3 GCGAGGTCCCCTTCTACTATAACGAGCTGCAGAGTGCCTTCCACTTGCCGGAGCAGGACC ENST00000506236.1 ACAA--------------ATAAC-------AGAATGTCTT-------------------- * * ***** *** ** *** ENST00000357599.3 TCATCTATGGAGTTTTCACAACCAACGTAAACAGCATCGCGGCTTCTGCTGTCTGCGCCT ENST00000506236.1 ------ATGGAA-------AATCTA-GGGGACAG------GGCT--------------CA ***** ** * * * **** **** * ENST00000357599.3 TCAACCTCAGTGCTATCTCCCAGGCTTTCAATGGCCCATTTCGCTACCAGGAGAACCCCA ENST00000506236.1 TCAA-------GTTAT------GACATTTA--GACCTGTTCAATTTCCAGAGTAACT--- **** * *** * * ** * * ** ** * **** *** ENST00000357599.3 GGGCTGCCTGGCTCCCCATAGCCAACCCCATCCCCAATTTCCAGTGTGGCACCCTGCCTG ENST00000506236.1 ------------------TAG---------------------AGTGTGGCA--------G *** ********* * ENST00000357599.3 AGACCGGTCCCAACGAGAACCTGACGGAGCGCAGCCTGCAGGACGCGCAGCGCCTCTTCC ENST00000506236.1 GGG--AGTTCCA----------------------------------------CCTCTTCT * ** *** ******* ENST00000357599.3 TGATGAGCGAGGCCGTGCAGCCGGTGACAC-CCGAGCCCTGTGTCACCCAGGACAGCGTG ENST00000506236.1 TTGT-------------TAATTGCTCATATGCTGAG------GATACTGAAGACTG---- * * * * * * * * *** * ** * *** * ENST00000357599.3 CGCTTCTCACACCTCGTGGTGGACCTGGTGCAGGCTAAAGACACGCTCTACCATGTACTC ENST00000506236.1 -GCTTC--------------------------------AGGGATGCCCTTTCA---ATTT ***** ** * ** ** ** * * ENST00000357599.3 TACATTGGCACCGAGTCGGGCACCATCCTGAAGGCGCTGTCCACGGCGAGCCGCAGCCTC ENST00000506236.1 TGCA----CACTT-GTCCAGCCTTTTCCTG-------TGTTCA-----------GTCCTC * ** *** *** ** ***** *** ** **** ENST00000357599.3 CACGGCTGCTACCTGGAGGAGCTGCACGTGCTGCCCCCCGGGCGCCGCGAGCCCCTGCGC ENST00000506236.1 T-----------------------CACAT-CGGCCTCCC---------------TTG--- *** * * *** *** ** ENST00000357599.3 AGCCTGCGCATCCTGCACAGCGCCCGCGCGCTCTTCGTGGGGCTGAGAGACGGCGTCCTG ENST00000506236.1 -GCCTGGG--------ATTGCGTCCACACCCTCCCTAT---------------------- ***** * * *** ** * * *** * ENST00000357599.3 CGGGTCCCACTGGAGAGGTGCGCCGCCTACCGCAGCCAGGGGGCATGCCTGGGGGCCCGG ENST00000506236.1 ----TCCCACCAG----------TTCTTTCTGCAGCAA----ACA--------------- ****** * * * * ***** * ** ENST00000357599.3 GACCCGTACTGTGGCTGGGACGGGAAGCAGCAACGTTGCAGCACACTCGAGGACAGCTCC ENST00000506236.1 -ACCCATTC-----------------------ACTCTTC----CATTTCAG------TTT **** * * ** * * ** * ** * ENST00000357599.3 AACATGAGCCTCTGGACCCAGAACATCACCGCCTGTCCTGTGCGGAATGTGACACGGGAT ENST00000506236.1 AACG-GACACTTT---CTCAGAAAA-----------------CAAAA------AAAAAAT *** ** ** * * ***** * * ** * ** ENST00000357599.3 GGGGGCTTCGGCCCATGGTCACCATGGCAACCATGTGAGCACTTGGATGGGGACAACTCA ENST00000506236.1 -------------CATTTTTATCCTAATAAT-ATGT---TTCTTTGA----AAAAACTCA *** * * * * ** **** *** ** * ****** ENST00000357599.3 GGCTCTTGCCTGT-GTCGAGCTCGATCCTGTGATTCCCCTCGACCCCGCTGTGGGGGCCT ENST00000506236.1 ----CTT---TGTAGTTGTAC---ATT-TATTACTTGCTTTGTTCTATTCATAAAG---- *** *** ** * * ** * * * * * * * * * * ENST00000357599.3 TGACTGCCTGGGGCCAGCCATCCACATCGCCAACTGCTCCAGGAATGGGGCGTGGACCCC ENST00000506236.1 ---TTGCT--------GCTATCTAC---------------------------TGAAACT- *** ** *** ** ** * * ENST00000357599.3 GTGGTCATCGTGGGCGCTGTGCAGCACGTCCTGTGGCATCGGCTTCCAGGTCCGCCAGCG ENST00000506236.1 ----TTACTAT-----TTGTGTAGTTCATTG-GAGGCACCGG-----------------G * * * **** ** * * * **** *** * ENST00000357599.3 AAGTTGCAGCAACCCTGCTCCCCGCCACGGGGGCCGCATCTGCGTGGGCAAGAGCCGGGA ENST00000506236.1 GAGT-----------------------------------------------AAACTGG-- *** * * ** ENST00000357599.3 GGAACGGTTCTGTAATGAGAACACGCCTTGCCCGGTGCCCATCTTCTGGGCTTCCTGGGG ENST00000506236.1 ---------------TGAGCACGCA--------GG----CATCTCCTGG-CCTCTTGGGG **** ** * ** ***** **** * ** ***** ENST00000357599.3 CTCCTGGAGCAAGTGCAGCAGCAACTGTGGAGGGGGCATGCAGTCGCGGCGTCGGGCCTG ENST00000506236.1 CT-----------TACA-------TTCTAGTGGGGACA-GCAG----------------- ** * ** * * * **** ** **** ENST00000357599.3 CGAGAACGGCAACTCCTGCCTGGGCTGCGGCGTGGAGTTCAAGACGTGCAACCCCGAGGG ENST00000506236.1 --AAAATA--AAC----------------------------AGAC---CAGCC------- * ** *** **** ** ** ENST00000357599.3 CTGCCCCGAAGTGCGGCGCAACACCCCCTGGACGCCGTGGCTGCCCGTGAACGTGACGCA ENST00000506236.1 ---------AGTG----------------AGATGCCA-----------GAAAATGATGGC **** ** *** *** *** * ENST00000357599.3 GGGCGGGGCACGGCAGGAGCAGCGGTTCCGCTTCACCTGCCGCGCGCCCCTTGCAGACCC ENST00000506236.1 GAACAGA-CACAGTGGAAGCAG-------------------------------------- * * * *** * * ***** ENST00000357599.3 GCACGGCCTGCAGTTCGGCAGGAGAAGGACCGAGACGAGGACCTGTCCCGCGGACGGCTC ENST00000506236.1 ACATGGC-TGCAGGT-GCCAGG-------------------------------------C ** *** ***** * * **** * ENST00000357599.3 CGGCTCCTGCGACACCGACGCCCTGGTGGAGGTCCTCCTGCGCAGCGGGAGCACCTCCCC ENST00000506236.1 AGGCTCCTGT-------ACTCTCTGAT---------------CAGCATCAG----TCTCT ******** ** * *** * **** ** ** * ENST00000357599.3 GCACACGGTGAGCGGGGGCTGGGCCGCCTGGGGCCCGTGGTCGTCCTGCTCCCGGGACTG ENST00000506236.1 GC---CAGGAGGTGATGATTAAGCTGAGTGCAGACTGAG-------------CAGGAG-- ** * * * * * * ** * ** * * * * * *** ENST00000357599.3 CGAGCTGGGCTTCCGCGTCCGCAAGAGAACGTGCACTAACCCGGAGCCCCGCAACGGGGG ENST00000506236.1 -GAGTCAG--CCCTGCATCCATGAGGGAA-GTG-GCCAA-------------AACA---- *** * * ** *** ** *** *** * ** *** ENST00000357599.3 CCTGCCCTGCGTGGGCGATGCTGCCGAGTACCAGGACTGCAACCCCCAGGCTTGCCCAGT ENST00000506236.1 -CTTCCCT-CATGGG-AATGT-----------GGGACT---------AG------CCAGC ** **** * **** *** ***** ** **** ENST00000357599.3 TCGGGGTGCTTGGTCCTGCTGGACCTCATGGTCTCCATGCTCAGCTTCCTGTGGTGGGGG ENST00000506236.1 TGAAGG----------------------------CCATGC-------------------- * ** ****** ENST00000357599.3 TCACTATCAACGCACCCGTTCCTGCACCAGCCCCGCACCCTCCCCAGGTGAGGACATCTG ENST00000506236.1 -CACTG-------------------AGCAGTC-------------AAGTAAGAA------ **** * *** * * ** ** * ENST00000357599.3 TCTCGGGCTGCACACGGAGGAGGCACTATGTGCCACACAGGCCTGCCCAGAAGGCTGGTC ENST00000506236.1 -------------------GAGG-----------ACAGAGGT-------GAACACCGGT- **** *** *** *** * *** ENST00000357599.3 GCCCTGGTCTGAGTGGAGTAAGTGCACTGACGACGGAGCCCAGAGCCGAAGCCGGCACTG ENST00000506236.1 -------------TGGGGCA-----------GATGGAGGCCACAGCTG------------ *** * * ** **** *** *** * ENST00000357599.3 TGAGGAGCTCCTCCCAGGGTCCAGCGCCTGTGCTGGAAACAGCAGCCAGAGCCGCCCCTG ENST00000506236.1 ---------CCTCTCAGGG-CCAGC--CTGTG--GGAG----------GAG--------- **** ***** ***** ***** *** *** ENST00000357599.3 CCCCTACAGCGAGATTCCCGTCATCCTGCCAGCCTCCAGCATGGAGGAGGCCACCGACTG ENST00000506236.1 -------------------------------------------GAGGAGGG--------- ******* ENST00000357599.3 TGCAGGGTTCAATCTCATCCACTTGGTGGCCACGGGCATCTCCTGCTTCTTGGGCTCTGG ENST00000506236.1 -GCATGGGCCAAAGTCA-------GGCGGACACAG-------CTGCTA--GGAGC----A *** ** *** *** ** ** *** * ***** * ** ENST00000357599.3 GCTCCTGACCCTAGCAGTGTACCTGTCTTGCCAGCACTGCCAGCGTCAGTCCCAGGAGTC ENST00000506236.1 GCTCCT----CCAGAAGTG----------------ATTG--AG-GTAAG----GGATGTG ****** * ** **** * ** ** ** ** * ** ENST00000357599.3 CACACTGGTCCATCCTGCCACCCCCAACCATTTGCACTACAAGGGCGGAGGCACCCCGAA ENST00000506236.1 GAGGATGGA------TGCCAC--------ATCTG------GAGGGC-------------- * *** ****** ** ** ***** ENST00000357599.3 GAATGAAAAGTACACACCCATGGAATTCAAGACCCTGAACAAGAATAACTTGATCCCTGA ENST00000506236.1 --ATGGGAGGT----------------CAAG--------CAAGAA-------ATTTTTGT *** * ** **** ****** ** ** ENST00000357599.3 TGACAGAGCCAACTTCTACCCATTGCAGCAGACCAATGTGTACACGACTACTTACTACCC ENST00000506236.1 TTGC--------TTTTTGTTTGTTTTA--AGA---------------------------- * * ** * ** * *** ENST00000357599.3 AAGCCCCCTGAACAAACACAGCTTCCGGCCCGAGGCCTCACCTGGACAACGGTGCTTCCC ENST00000506236.1 ---------GGAGAAA----------------AGGAATTACC-----------ATTTCCT * * *** *** * *** **** ENST00000357599.3 CAACAGCTGATACCGCCGTCCTGGGGACTTGGGCTTCTTGCCTTCATAAGGCACAGAGCA ENST00000506236.1 T----GTCTATATTGC--TC------ACT-------CCTGC-------AGGCA------- * *** ** ** *** * *** ***** ENST00000357599.3 GATGGAGATGGGACAGTGGAGCCAGTTTGGTTTTCTCCCTCTGCACTAGGCCAAGAACTT ENST00000506236.1 -----------------GGAA-----------TTCTATCTCTTTTCT--GCCA-----TT *** **** **** ** **** ** ENST00000357599.3 GCTGCCTTGCCTGTGGGGGGTCCCATCCGGCTTCAGAGAGCTCTGGCTGGCATTGACCAT ENST00000506236.1 TTTATCCT-------TAAGGTCCC--------CCAGAATGC-----CTGGCATGGA---- * * * ****** **** ** ******* ** ENST00000357599.3 GGGGGAAAGGGCTGGTTT-CAGGCTGACATATGGCCGCAGGTCCAGTTCAGCCCAGGTCT ENST00000506236.1 ----------GCAGGTTTGCAGAGTGA-ATA------------------AACTAGAACTT ** ***** *** *** *** * * * ENST00000357599.3 CTCATGGTTATCTTCCAACCCACTGTCACGCTGACACTATGCTGCCATGCCTGGGCTGTG ENST00000506236.1 TCCATAAGTGT-TCCTAGTTTTTCATCACAA---------------ATGTTTAGGCTAAT *** * * * * * **** *** * **** ENST00000357599.3 GACCTACTGGGCATTTGAGGAATTGGAGAATGGAGATGGCAAGAGGGCAGGCTTTTAAGT ENST00000506236.1 G--CTAC----------AGAGATTAGAG-----------CCA-----TATCCTTGTAATT * **** ** *** *** * * * *** *** * ENST00000357599.3 TTGGGTTGGAGACAACTTCCTGTGGCCCCCACAAGCTGAGTCTGGCCTTCTCCAGCTGGC ENST00000506236.1 CTAGG----AGGCA-------GTGG----------------------------------- * ** ** ** **** ENST00000357599.3 CCCAAAAAAGGCCTTTGCTACATCCTGATTATCTCTGAAAGTAATCAATCAAGTGGCTCC ENST00000506236.1 --------AGGTTTT-----CATC---AATACCT----AAATAGGCTGGGGAGTG----- *** ** **** * ** ** ** ** * **** ENST00000357599.3 AGTAGCTCTGGATTTTCTGCCAGGGCTGGGCCATTGTGGTGCTGCCCCAGTATGACATGG ENST00000506236.1 AGGAG----AGAT--------GGTGTTGGGGCG--ACGGGGCTGCCCC----TGA----- ** ** *** * * **** * ** ******** *** ENST00000357599.3 GACCAAGGCCAGCGCAGGTTATCCACCTCTGCCTGGAAGTCTATACTCTACCCAGGGCAT ENST00000506236.1 -------------GCAGGT-------------CTG------------------------- ****** *** ENST00000357599.3 CCCTCTGGTCAGAGGCAGTGAGT-ACTG-GGAACTGGAGGCTGACCTGTGCTTAGAAGTC ENST00000506236.1 ----------------AGTGAGTCACTGCAGAACT-----TCAACTTA-GC--AAGATTT ******* **** ***** ** * ** * * * ENST00000357599.3 CTTTAATCTGGGCTGGTACAGGCCTCAGCCTTGCCCTCAATGCACGAAAGGTGGCCCAGG ENST00000506236.1 CTTACATCC--------ATAGGCTTCTGACC--CTTTCCAT-----AACAGTGGCC---A *** *** * **** ** * * * ** ** ** ****** ENST00000357599.3 AGAGAGGATCAATGCCATAGGAGGCAGAAGTCTGGCCTCTGTGCCTCTATGGAGACTATC ENST00000506236.1 CGAGAAGGT-----------GAAGT----GCGTGTCCATTATGTTTATAATGAGTTGGTT **** * * ** * * ** ** * ** * ** *** * ENST00000357599.3 TTCCAG-TTGCTGCTCAACAGAGTTGTTGGCTGAGACCTGCTTGGGAGTCTCTGCTGGCC ENST00000506236.1 TTGGAGGTTTCTGAT------AATTTCTTAC-GAAA-----TTGGAA------------- ** ** ** *** * * ** * * ** * **** * ENST00000357599.3 CTTCATCTGTTCAGGAACACACACACACACACACTCACACACGCACACACAATCACAATT ENST00000506236.1 -TTCATTAATTTTAGAAGAGTCG-----ACTCATTC-------------TATTCATGA-- ***** ** *** * * ** ** ** * *** * ENST00000357599.3 TGCTACAGCAACAAAAAAGACATTGGGCTGTGGCATTATTAATTAAAGATGATATCCAGT ENST00000506236.1 ------AG-----AATGGAACACT---------TATTACTAA--GAACAGAACA-CTTGT ** ** *** * **** *** ** * * * * ** ENST00000357599.3 CTC ENST00000506236.1 TT- *