CLUSTAL 2.1 multiple sequence alignment ENST00000367321.3 TGAGTCCCACTCCGCACCCCACCCTCTGTCTGGTACAGCTTACCAAACCAAAGTGCCCAA ENST00000525272.1 -GAGTTGGG-----------ATTGCTTG-CAGATGAAA-TTA--AAATCAA--TGGCAAA **** * ** * * * * *** *** *** ** * ** ENST00000367321.3 AGCCGTGACA---TCCCGGCCGGCG-------GCTCGCAGGCCCCCGCCCTCCG----CA ENST00000525272.1 AGTAAAGACAAAGTTTTTGTCTGTGCTAGAAAGGATAAAGGATCAAGCAGATGGAAAATA ** **** * * * * * * *** * ** * * ENST00000367321.3 CGTCACGGCCGCCGGGTGCAGTGCCCCCTAGGGGCCCCTGGGACGAGGAGGAAGCGCCAG ENST00000525272.1 CATCTTAGTCACTGGGATCA-CGCCCACT-----CCTCTAGGAGAAGGGAAGAGCAC--A * ** * * * *** ** **** ** ** ** *** *** *** * ENST00000367321.3 GTCCTTCCCGCCGCCGCCGCCGCCGCCG-CCGCCTGCTCCCCTGGCACGCGCCCCGCC-G ENST00000525272.1 GTTATGACTGG-GCTGT-GCAGGCTCTGACCATGCATCTGCATGTCACCTCTTTTGCCTG ** * * * ** * ** * * * * ** * ** *** *** * ENST00000367321.3 CCCTCGGCAGCCGC----AGCTCCGTGTCCCC---TGAGAACCAGCCGTCCCGCGCCATG ENST00000525272.1 TATGAGGCAACCTTCCCAAGGACCGACTTTTGGAGTGGAAAGAAGGAGTCATGGGTAGTG **** ** ** *** * ** ** ** *** * * ** ENST00000367321.3 GGCACGCGTCTGCCGCTCGTCCTGCGCCAGCTCCGCCGCCCGCCCCAGCCCCCGGGCCCT ENST00000525272.1 GATATGCCCTGGTCATCC--CATGGAAGAGTTCAACC-TTCACTTGA---CTGGAGATAT * * ** * * * * ** ** ** ** * * * * * * * ENST00000367321.3 CCGCGCCGCCTCCGTGTGCCC-TGTCGCGCTAGCAGCGG-CGGCGGC----GGAGGCGGC ENST00000525272.1 CCATGCCATCACAGT-TGCCAATAATTCACCAGCTGCTGTCATCGACCCAAGGATTCTGC ** *** * * ** **** * * * *** ** * * ** * *** * ** ENST00000367321.3 --GGCGGTGGCCGGG--AGGGCCTGCTTGGACAGCGGCGGCCGCAGGATGGCCAGGCCCG ENST00000525272.1 ATGAAAATGCACAGACAAGGCTCTGTATAATCAGCTG-ATTCATTTAATGAATGGTGTCA * ** * * *** *** * **** * * *** * * ENST00000367321.3 GAGCAGCTGCAGCCCCGGCGGCCGAACGCCCGCGGCGCGGGACTCCATCGTCAGAGAAGT ENST00000525272.1 CAGAATTTTCAG-----------AAATTCTCT--------GATTACTTGACTAAAAAAAA ** * * *** ** * * ** * * * * * ** ENST00000367321.3 CATTCAGAATTCAAAAGA-AGTTCTAAGTTTATTGCAAGAAAA--AAAC----------- ENST00000525272.1 -ACTGGGAATAAATAAGACAGATCCAAGCACACTGACAGAAGAGGAAATGAGTAAATTTG * * **** * **** ** ** *** * ** **** * *** ENST00000367321.3 CCTGCCTTCAAGCCGGTTCTTGCAATTATC-CA-GGCAGG----------TGACGACAAC ENST00000525272.1 CCTGCCTCGACGCCGACCCTTCCA-CCATCGCATGGCAGAGAGTATTGAATAAAAATGAC ******* * **** *** ** *** ** ***** * * * ** ENST00000367321.3 -----TTGATGCAGGAAATCAAC-----CAGAATTTGGCTG--AGG-AGGCTGGT-CTGA ENST00000525272.1 CGATTTCAATACAAACAACTGATTTCTACAAAAAATAACCATCAGGCAGGCAAACACAGA * ** ** ** * ** ** * * *** **** * ** ENST00000367321.3 ACATCACTCACATTTGC---CTCCCTCCAG-ATAGCAGTGA--AGCCGAGATTATAG--- ENST00000525272.1 GAAAGGCTCCTCTTGGCAAACGCTGTTTGATATCGTGGTGGCCAGC-GAGATCATGGTGG * *** ** ** * * * ** * *** *** ***** ** * ENST00000367321.3 -----------ATGAA--ATCTTAAAGATCAATGAAGATA---CCAGAGTACATGGCCTT ENST00000525272.1 TGCTGGCCCTTATGAACAGCCTCTCAGAC--ATGAAGACATGGCTGGGAAGGATGGTGGT ***** ** *** ******* * * * **** * ENST00000367321.3 GCCCTTCAGAT-----CTCTGAGA-----ACTTGT--TTAGCAACAAAGTCCTCAATGCC ENST00000525272.1 GGCCATCTGATGCAGACCCTGGAATGGACACCTGTATTCATGCACGTGGGCCCTTTTGCT * ** ** *** * *** * ** *** * * ** * ** *** ENST00000367321.3 TTGA--AACCAGAAAAAGATGTGGATG--GAGTAACAGACATAAACCTGGGGA-AGCTGG ENST00000525272.1 AACATCACCCATGGCAATTCTTCAGTGTTGGCTGACAAA-ATTGCCCTGAAACTGGTTGG * * *** ** * ** * * *** * ** **** * *** ENST00000367321.3 TGCGAGGGGATGCCCA-TGAATGT--TTTGTTTCACCTGTTGCCAAAGCTGTAATTGA-- ENST00000525272.1 TGAAGAAGGATTTGTAGTGACTGAAGCTGGCTT----TGGTGCTGACATTGAAATGGAGA ** **** * *** ** * * ** ** *** * ** *** ** ENST00000367321.3 ACTTCTTGAAAAA---TCAGGTGTCAACCTAGATGGAAAGAA-GATT---TTGGTAGTGG ENST00000525272.1 AATTTTTCAACAAGTGTCAAGCTTCCAGCTTGGTGCCCAGTGTGGTTGTGTTGGTGGCAA * ** ** ** ** *** * ** * ** * ** ** * ** ***** * ENST00000367321.3 GGGCCCATGGGTCTTTGGAAGCTGCTC--------------TACAA-TGCC--TGTTCCA ENST00000525272.1 CGGTGCA-AGCTCT---GAAGATGCACAGTGGCGGGCCAAGTGTAACTGCTGGTGTTCCT ** ** * *** **** *** * * ** *** ****** ENST00000367321.3 GAGAAAAGGGTCCATGAC--AATGAGCATCCAGTGGAAAACA------CGCC--AGCTTC ENST00000525272.1 CTGAAGAAAGAACATAAAGAAAAGAACATCCAGTTGGTGGCAGATGGCTGCCGTAACCTC *** * * *** * ** ** ******** * ** *** * * ** ENST00000367321.3 AA--AGCAA--------------GCTTCACGAGGCTGACATTGTGGT----CCTAGGCTC ENST00000525272.1 TAGCAGCAAATTCAGATTGCTCAGCTCTTTGGGGTTCCCATTATGGTGACTCTGAAGGTC * ***** *** * ** * **** **** * * * ** ENST00000367321.3 ------ACCTAAGCCAGAA--GAGATTCCCCT--TACTTGGATACA-ACCAGGAACTACT ENST00000525272.1 TTCAAGATCCACACCGGTGCTGAGATTGACTTGGTGTGTGAGCTCACAAAACGGGCTGGT * * * ** * ****** * * * ** ** * * * ** * ENST00000367321.3 GTTCTCAACTGC--TCCCATG--ACTTCCTGTCAG--GGAAGGT--TGGGTGTGGCTCTC ENST00000525272.1 GCCTTTGA-TGCAGTCCCTTGCTATCACTGGTCAGTTGGTAGAAAACGGTTGCGGACTT- * * * *** **** ** * * ***** ** ** ** ** ** * ENST00000367321.3 CAAGAATACATTTTGGTGGACTCATTGAGGAAGATGATGTGATTCTCCTTGCTGCAGCTC ENST00000525272.1 --GGCTTGGGCTTTGAGAGAAGCTGCAAGTAAAAGAAGTTGATTCCATTTCCCGTA---- * * **** ** * ** ** * * ****** ** * * * ENST00000367321.3 TGCGAATTCAGAACATGGTCAGTAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGC ENST00000525272.1 TG-ATGTTCAG--CTT--CCAATTGTGGAAA-AGATAA------GAACCATGGCCCTGGC ** ***** * * ** * ****** **** **** ** * *** ENST00000367321.3 GGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCC-----CCTGTGCCAAGTGACAT ENST00000525272.1 TGT-----CTATGGAGCCAACGATATCCAGCTCTCTCCTGAGGCACAAACCAAAATAGAT ** ** ** * ** ******** * **** * ** ENST00000367321.3 TG--AGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGA ENST00000525272.1 TGTTAACACTCAACAGGGT---TTCAGAAATTTGCCCATCTGCATGGCAAGGACCCACCT ** * **** *** ** *** ** ** * * ** ****** ENST00000367321.3 TTGCTTG-CAGATGAAATTG----AAATCTATGGCAAAAGCAAAGCCAAAGTACGTTT-- ENST00000525272.1 TTCTCTGTCTCACCAACCTGCCAAAAAATTGTGCCAAGGG--ACTTCATTGTACCTCTCA ** ** * * ** ** *** * ** *** * * ** **** * * ENST00000367321.3 -----GTCCGTGCTAGAA-AGGTTAAAGGATCA--AGC-----AGATGGAA-AATACGTC ENST00000525272.1 GTGATGTCAAGGCCAGCATAGGTGCTGGGTTCATTGGCCCTTTGGTTAGAACAATGAGCA *** ** ** * **** ** *** ** * * *** *** * ENST00000367321.3 TTAGTTGCTGGGATCAC-ACCCACCCCT----------------CTTGGAGAAGGGAAGA ENST00000525272.1 TCG--TGCCAGGACTGCCACTTGGCCCTGCTTTCATGACATAGACCTTGATATGGAAACA * *** *** * ** **** * * ** * ** ** * ENST00000367321.3 GCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACA---CCTGAATGTCAACTCCT ENST00000525272.1 GAACAA--ATTAA-AGCCTTGT------TCTAAGTGAACAAGGCTTTCATAGGAATTGAT * *** * * * ***** *** * * *** * * ** ** * * ENST00000367321.3 TTGCCTGCTTGAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGG ENST00000525272.1 TCAGGTTCCTGAAACAGACTCCTCCTTGCCTTTTTGCTGCAGTTAGAGAAGAAACT--GA * * * *** *** ** * * * * ** *** * ** ** * * * ENST00000367321.3 GTGGTGGATATGCCCAGGTCATCC--CCATGGAGGAGTTCAACCTTCACTTGACTGGAGA ENST00000525272.1 ATTTTAAAAATGTCC--TTTATGCAATGTTGGAGAAATGG----TGAAATAGGTCAAGGA * * * *** ** * ** * ***** * * * * * * ** ENST00000367321.3 CATCCACGCCATCACCGCTG---CCAATAACTTGCTGGCTGCCGCCATCGACACGAGGAT ENST00000525272.1 TTTCTTCCTCATTGAAGGTGTATCCTATTCACAACAGAGTATAGTGTTCAGCAAAAGGAC ** * *** * ** ** ** * * * * ** ** **** ENST00000367321.3 TCTTCATGAAAACACGCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAA ENST00000525272.1 -CTCCACCAAGTC-TGAAAAAAAATAA---TTTACTTAA-------GTTTCAATAG---- ** ** ** * * *** * **** * * *** *** * *** ENST00000367321.3 TGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTAAAAAAACTGGGAATAAATAA ENST00000525272.1 -AGT-TTACATTATTTCTA------CTGCTTACAC--TTTAGAATGTTA--ATTTTATGG ** * * * **** * * **** * * * * ** * * * ** ENST00000367321.3 GACTGATCCGAGCACACTGACAGAAGAGGAAGTG---AGTAA-ATTTGCCCGTCTCGA-- ENST00000525272.1 GACTAA---GGG---ATTAAAAGAGTGTGAACTACAAGGTAACATTTTCCACTCTTGAGT **** * * * * * * *** *** * **** **** ** *** ** ENST00000367321.3 CATCGACCCATCTACCATCACGT----GGCAGA----GAGTATT-GGATACAAATGACCG ENST00000525272.1 TTTCTTTTTTTTTTTCCTTTTTTTTAAATTATACTTTAAGTTTTAGGGTACATGTGCACA ** * * * * * * * *** ** ** **** ** * ENST00000367321.3 ATTTCTACGAAAAATAACCATCGGGCAGG-GAAACACAGAGAAGGGCCATTACCGGCAGG ENST00000525272.1 ATGTGCAGGTTAGTTACATAT-GTATACATGCGCCACGTTGGTGTGCTGCACCCAGTAAC ** * * * * ** ** * * * *** * * ** ** * * ENST00000367321.3 -CGCAGTTTGACA-TCGCAGTGGCC---AGCGAGATCATGGCGGTGCTGGCCCTGACGGA ENST00000525272.1 TCACCATTTAACAGTAGGTATATCTCCGAACGCTATC-CCACCCCCCTTCCCCCACCCCA * * *** *** * * * * * ** *** * ** *** * * ENST00000367321.3 CAGC--CTCGCAGACATG-AAGGCACGGCTGGGAAGGATGGTG-GTGGCCAGTGACAAAA ENST00000525272.1 CAACAGTCCCCAGA-GTGTGATGTTCCCCTTCCTGTGCCCATGTGTTCTCATTGTTCAAT ** * * **** ** * * * ** * ** ** ** ** ** ENST00000367321.3 GCGGGCAGCCTGTGAC--AGCAGATGATTTGGG-GGTGACAGGTGCTTTGACAGT--TTT ENST00000525272.1 TC---CCACCTATGAGTGAGAACATGCTGTGTTTGGTTTTTGGTCCTT--GCAATCGTTT * * *** *** ** * *** * ** *** *** *** ** * *** ENST00000367321.3 GATGAAAGATGCAATAAAACCAAACCTGATGCA-GACCCTGGAAGGGACACCTGTGTTCG ENST00000525272.1 GCTGAGA-ATG--ATGGTTTCCAGCTTCATCCATGTCCCTACAAAGGACA--TGAACTCA * *** * *** ** * * * * ** ** * **** ** ***** ** ** ENST00000367321.3 TGCATGCGGGCCCTTTTGCTAACATTGCT-CACGGCAACTCTTCAGTGTTGGCTGATAAA ENST00000525272.1 T-CAT-------TTTTT------ATGGCTGCATAGTA-TTCCATGGTGTACATGTGCCAC * *** **** ** *** ** * * ** **** * ENST00000367321.3 ATTGCCCTGA---AACTGGTTGGTGAAGAAGGATTTGTAGTGAC-CGAAGCTGGCTTTGG ENST00000525272.1 ATTTTCTTAATCCATTCTATTATTGTTGGAC-ATTTGGGTTGGTTCCAAGT---CTTTGC *** * * * * ** ** * * ***** ** * *** ***** ENST00000367321.3 TGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGC-CGAGCTTCCGGCTTGGTGC ENST00000525272.1 TATTGT-----GAATAG-----TGCTACAATAA-ACGTACGTGTGCATGTGTCTTTATAG * ** **** * * ** *** * * ** * * ** * * *** * ENST00000367321.3 CCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAA ENST00000525272.1 C-AGCATGATT-TAT-AATCCTTTGGGTATATACCCAGTAATGGGATGGC--TGGGTCAA * * * ** ** * * * * *** * * * * * **** *** *** ENST00000367321.3 GTGTAACGGCTGGTGTT---CCTCTTAAGAAAGAATATACAGAGGAGAACATCCA-GCTG ENST00000525272.1 ATGGTATTTCTAGTTCTAGATCCCTGAGGAATCGCCACACTG------ACTTCCACAATG ** * ** ** * * ** * *** * ** * ** **** ** ENST00000367321.3 GTGGCAGACGGCTGCTGTAACCTCCAGAAGC--AAA----TTCAGATCACTCAGC--TCT ENST00000525272.1 GTTGAACTAGTTTACAGTC-CCACCAACAGTGTAAAAGTGTTCCTATTTCTCCACATCCT ** * * * * * ** ** *** ** *** *** ** *** * ** ENST00000367321.3 TTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTG ENST00000525272.1 CTCCAGCACCTGTTGT-----TTCCTGACTTTTTAATGATCGCCATTCTAACTG------ * * ** ***** ** * * ** * ** ** ** * *** ENST00000367321.3 ACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGAT--GCAGTCCCCTGCTATCA ENST00000525272.1 -------GTGTGAGATGGTATCTCA---TTGTGGTTTTGATTTGCATTTCTCTG--ATGG ******* * * * * * *** ****** *** * * *** ** ENST00000367321.3 CTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCG-GGCTGTGAGAGAGGCTGCGA ENST00000525272.1 CCAGT--GATGATG----AGCATTTTTTCATGTGTCTTTTGGCTGCATAAATGTCTTCTT * ** * ** ** ** ** * * ** ** ***** * * ** * ENST00000367321.3 GTAAAAGAAGCCGATTC--------CAGTTCCTGTATGATGT--TCAGGTTCCAATTGTG ENST00000525272.1 TTGAGAAGTGTCTGTTCATATCCTTCACCTCCTTTTTGACGGGGTTGTTTTTTTCTTGTA * * * * * *** ** **** * *** * * ** **** ENST00000367321.3 GACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCT ENST00000525272.1 AATTTGTTGGAGTTCATTG--TAGATTCT------------GGATATTAGCCCTTTGTCA * * * * ***** ** * * ****** * * * ENST00000367321.3 GAGGCACAAGCCA-AAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCA-TCT ENST00000525272.1 GATGAGTAGATTGCAAAAATTTTCTCCCATTCTGTAGG---TTG----CCTGCTCACTCT ** * * *** * * * ** ** *** *** *** ** *** ENST00000367321.3 GCATGGCAAAGACCCACCTTTCTCTAT-----CTCACCAACCTGACAAAAAAG-GTGTGC ENST00000525272.1 G-ATGGTAG---TCTCTTTTGCTGTGCAGAAGCTCTTTAGTTTAATTAGAACCCATTTGT * **** * * ** ** * *** * * * * ** * ** ENST00000367321.3 CAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTT ENST00000525272.1 CAAT---TTTGGCTTTTGTTGCCATTG-CTTTTGG--TGTTTTAGACATGAAGTCCTTGC *** ** ** * ** ** * * ** *** * ** * * ENST00000367321.3 AC---CCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCT----GC ENST00000525272.1 CCATGCCTATGTCCTGAATGGTAT------TGCCTAGGTTTTCTTCTAGGGTTTTTATGG * *** ** * *** * * **** * * * * ** * * ENST00000367321.3 TTTTA----TGACAT--AGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAA ENST00000525272.1 TTTTAGGTCTAACATTTAAGTCTTTA-ATCCATCTTGAATTAATT-----TTTGTGTAAG ***** * **** * **** * * * * *** * ** **** * ENST00000367321.3 GTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACA-GACTACTCTTTGCC-- ENST00000525272.1 GTG--TAAGG-----AAGGGATTCAGTTTCAGCTTTCTACATATGGCTA------GCCAG *** **** * *** * * ** * * * * *** *** ENST00000367321.3 TTTTTGCTGCA------GTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTAT-GCAAT ENST00000525272.1 TTTTCCCAGCACCATTTATTTAAAAGGGAATC--ATTTCCCCATTTCTTGTTTTTGTCAT **** * *** ** * * * ** **** * * **** * * ** ENST00000367321.3 GCTGGAGACATGGTGAAATAGGCCAAAGATTTCTT-CTTCGTTCAAGATGAAT----TCT ENST00000525272.1 GTTTGTCA-AAGATCAGACAG-TTGTAGATATGTGGCATTATTTCTGAGGGCTCTGCTCT * * * * * * * * * ** **** * * * * ** ** * * *** ENST00000367321.3 GTTCACAGTGGAGTATGG---TGTTC-GGCAAAAGGACCTCCACCAAGACTGAAAGAAAC ENST00000525272.1 GTTC-CATTGGTCTATATCTCTGTTTTGGTAGTAGTACC-----------------ATGC **** ** *** *** **** ** * ** *** * * ENST00000367321.3 TAATTTATTT-CTGTTTCTGTGGAGTTTCCATTATT-TC--------TACTGCTTACACT ENST00000525272.1 TGTTTTGGTTACTGTAGCCTTGTAGTATACTTTAAAGTCAGGTAGCGTGATGCCTCCAGC * *** ** **** * ** *** * * *** ** * *** * ** ENST00000367321.3 TTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAA---GGTA--A ENST00000525272.1 TTTGTTCTTTTGGCTTA---GGATTGA---CTTGGCAATGCAGGCTCTTTTTTGGTTCCA ** * *** *** *** * * ** * * ** ** *** * ENST00000367321.3 CAT----TTTCCACTCTCAAGTTTTCTACTTTGTCTTTGAACTGAAAATAAACATGGATC ENST00000525272.1 CATGAACTTTAAACTCTTGAGTTTTCTACTTTGTCTTTGAACAGAAAATAATCATGGACT *** *** ***** *********************** ******** ****** ENST00000367321.3 TAGAAAACCAA------------------------------------------------- ENST00000525272.1 TAGAAAACCAAACCCACACACAGAGTGGGATCAAGCCATTGCAAGCCCTGAAAGACCCTA *********** ENST00000367321.3 ------------------ ENST00000525272.1 TGATCTACTTTAGTTTTT