CLUSTAL 2.1 multiple sequence alignment ENST00000369046.4 AGTGACAATTAAAGATGGCTGCGCCCATGTAACATCACTAGCGACCGGTGACCTCTTTTT ENST00000400977.2 ------------------------------------------------------------ ENST00000369046.4 CCCCCTTGCCTGGCTCCTGTGGTGGCAGGCTGGGCACGAGGACCATGCTGGGCCGGAGCC ENST00000400977.2 --------------------------------------------ATGCTGGGCCGGACCC ************* ** ENST00000369046.4 TCCGAGAAGTTTCTGCGGCACTGAAACAAGGCCAAATTACACCAACAGAGCTCTGTCAAA ENST00000400977.2 TCTGAGAAGTTTCTGCAGCACTGAAACAAGGCCAGATTACGCCAACAGAGCTCTGTCAAA ** ************* ***************** ***** ******************* ENST00000369046.4 AATGTCTCTCTCTTATCAAGAAGACCAAGTTTCTAAATGCCTACATTACTGTGTCAGAAG ENST00000400977.2 AATGTCTCTCTCTTATCAAGAAGACCAAGTTTCTACATGCCTACATTACTGCATCAGAAG *********************************** *************** ******* ENST00000369046.4 AGGTGGCCTTAAAACAAGCTGAAGAATCAGAAAAGAGATATAAGAATGGACAGTCACTTG ENST00000400977.2 AGGTGGCCTTAAAACAAGCTGAAGAATCAGAAAAGAGATATAAGCATGAACAGTCACTTG ******************************************** *** *********** ENST00000369046.4 GGGATTTAGATGGAATTCCTATTGCAGTAAAAGACAATTTCAGCACTTCTGGCATTGAGA ENST00000400977.2 GGGATTTAGATGGAATTCCTATTGCAGTAAAAGACAACTTTAGCACATCTGGCATTGAGA ************************************* ** ***** ************* ENST00000369046.4 CAACATGTGCATCAAATATGCTGAAAGGTTATATACCACCTTATAATGCTACAGTAGTTC ENST00000400977.2 CAACATGTGCATCAAATATGCTGAAAGGTTATGTACCACCTTATAACGCTAGAGTAGTTC ******************************** ************* **** ******** ENST00000369046.4 AGAAGTTGTTGGATCAGGGAGCTCTACTAATGGGAAAAACAAATTTAGATGAGTTTGCTA ENST00000400977.2 CGAAGTTGTTGGATCAGGGAGCTCTACTAATAGGAAAAACAAATTTAGATGAGTTTGCTA ****************************** **************************** ENST00000369046.4 TGGGATCTGGGAGCACAGATGGTGTATTTGGACCAGTTAAAAACCCCTGGAGTTATTCAA ENST00000400977.2 TTGGATCTGTAAGAACAGATGGTGTGTTTGGACCAGTTAAAAACCCCTG-AGTTATTCAA * ******* ** *********** *********************** ********** ENST00000369046.4 AACAATATAGAGAAAAGAGGAAGCAGAATCCCCACAGCGAGAATGAAGATTCAGACTGGC ENST00000400977.2 AATAATATAGAGAAAAGAGGAAGCAGAATCCCCACAGCAAGAATGAAGATTCAGACTGGC ** *********************************** ********************* ENST00000369046.4 TGATAACTGGAGGAAGCTCAGGTGGGAGTGCAGCTGCTGTATCGGCGTTCACATGCTACG ENST00000400977.2 TGATAACTGGAGGAAGCTCAGGTGGGAGTGAGGCTGCTATGTCGGC-------------- ****************************** ****** * ***** ENST00000369046.4 CGGCTTTAGGATCAGATACAGGAGGATCGACCAGAAATCCTGCTGCCCACTGTGGGCTTG ENST00000400977.2 ----TTTAGGATCAGCTACAGAAGGATCGACCAGAAATCCTGCTGCTCACTGCAGGCTTG *********** ***** ************************ ***** ****** ENST00000369046.4 TTGGTTTCAAACCAAGCTATGGCTTAGTTTCCCGTCATGGTCTCATTCCCCTGGTGAATT ENST00000400977.2 TTGGTTTCAAACCAAGCTATGGTTTAGTTTCCCATCATGGTCTCATTCTCCTGGTGAACT ********************** ********** ************** ********* * ENST00000369046.4 CGATGGATGTGCCAGGAATCTTAACCAGATGTGTGGATGATGCAGCAATTGTGTTGGGTG ENST00000400977.2 TGATGGATGTGCCAGGAATCTTAACCAGATGTGTGGATGATGCAGCAATTGTGTTGAGTG ******************************************************* *** ENST00000369046.4 CACTGGCCGGACCTGACCCCAGGGACTCTACCACAGTACATGAACCTATTAATAAACCAT ENST00000400977.2 TACAGGCTGGACATGACACCAATGATTGTACCACAGTATAGGACCCTATT---AAACCAT ** *** **** **** *** ** * ********** * ** ****** ******* ENST00000369046.4 TCATGCTTCCCAGTTTGGCAGATGTGAGCAAACTATGTATAGGAATTCCAAAGGAATATC ENST00000400977.2 TTAT-----TTGGTTTGGCAGATGTGAGCAAACTATGTATAGAAATTCCAAAGGAATATC * ** ****************************** ***************** ENST00000369046.4 TTGTACCGGAATTATCAAGTGAAGTACAGTCTCTTTGGTCCAAAGCTGCTGACCTCTTTG ENST00000400977.2 TTGTGCCAGAATTATTAAGTGAAGTACAGTCTTTTTGGTCCAAAGCTGCTGACCTCCTTG **** ** ******* **************** *********************** *** ENST00000369046.4 AGTCTGAGGGGGCCAAAGTAATTGAAGTATCCCTTCCTCACACCAGTTATTCAATTGTCT ENST00000400977.2 AGTCTGAAGGGGCCAAAGTAATTGAAGTATCCATTCCTCACACCAGTTATTCAATTGTCT ******* ************************ *************************** ENST00000369046.4 GCTACCATGTATTGTGCACATCAGAAGTGGCATCGAATATGGCAAGATTTGATGGGCTAC ENST00000400977.2 GCTATCATGTATCGTGCACATCAGGAGTGGCATTAAATATGGCAAGACTTGATGGGCTAC **** ******* *********** ******** ************ ************ ENST00000369046.4 AATATGGTCACAGATGTGACATTGATGTGTCCACT--------------------GAAGC ENST00000400977.2 AATGTAGTCACAGATGTGACACTGATGTGTCCACTCAGTGTGTCCACCCATGGTTGAAGC *** * *************** ************* ***** ENST00000369046.4 CATGTATGCTGCAACCAGACGAGAAGGGTTTAATGATGTGGTGAGAGGAAGAATTCTCTC ENST00000400977.2 CATGTATGCGTCAACTAGACAAGAAGCGTTCAATGATGTGGTGAGAGGAAGAATTCTCTC ********* **** **** ***** *** ***************************** ENST00000369046.4 AGGAAACTTTTTCTTATTAAAAGAAAACTATGAAAATTATTTTGTCAAAGCACAGAAA-G ENST00000400977.2 AGGAAACTTTTTCTTATTAAAAGAAAACTGGGAAAATTATTTCATCAAAGCACAGAAAAG ***************************** *********** ************** * ENST00000369046.4 TGAGACGCCTCATTGCTAATGACTTTGTAAATGCTTTTAACTCTGGAGTAGATGTCTTGC ENST00000400977.2 TGCGACGTCTCATTGCTAATGACTTTGCAAATGCTTTTAACTCTGGAGCAGACGTCTTCC ** **** ******************* ******************** *** ***** * ENST00000369046.4 TAACTCCCACCACCTTGAGTGAGGCAGTACCATACTTGGAGTTCATCAAAGAGGACAACA ENST00000400977.2 TAACTCCCACCATCTTAAGTGAGGCAGTACCATATTCGGAGTTCATCAAAGTAGACAACA ************ *** ***************** * ************** ******* ENST00000369046.4 GAACCCGAAGTGCCCAGGATGATATTTTTACACAAGCTGTAAATATGGCAGGATTGCCAG ENST00000400977.2 GAACACGAAGTTCCCAGAATGATATTTTTACACAAGCTGTAAATATGGCAGGATTGCCAG **** ****** ***** ****************************************** ENST00000369046.4 CAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATTG ENST00000400977.2 CAGTGAGTATCCCTGCTGCACTCTCAAACCAAGGGTTGCCAGTAGGACTGCAGTTTTTTG *************** ************************* ************** *** ENST00000369046.4 GACGTGCGTTTTGTGACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTAC ENST00000400977.2 AACATGCATTTTGTGACCAGCAGCTTCTTACAGTAGCCAAGTGGTTTGAAAAACAAGTAC ** *** ******************************** ******************* ENST00000369046.4 AGTTTCCTGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAATG ENST00000400977.2 AGTTTCCTGTTATTCAACTTCAGGAATTCATGGATGATTGTTCATCAATGATC---ACTC ********************** *** ***************** ** * * * * ENST00000369046.4 AAAAGTTAGCCTCTGTCTCTCTAAAACAGTAAACATATCTTACAAATTAAAATGACTTTT ENST00000400977.2 AGTAG--GGCACATCACTCAGTAGGGCAG-GAAGAAAT-TTCTGGATTCTTCTCATTCT- * ** ** * *** ** *** ** * ** ** *** * * * * ENST00000369046.4 AGGCTGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGAGCGG ENST00000400977.2 -ACCTGAGAGCAGAGGAAGACCTCTAGAAGCTGAGC----TCAAATTCCCCCTCTGCTTA *** * **** ** ** ** ** * *** * * ** * ENST00000369046.4 ATCATGAGGTCAGAAGATCTAGAACAGCCTGGTC-AACATGGTGAAACCCCGTCTCTACT ENST00000400977.2 ACCGT-AGCTCGCCATTTTC-------TTTGCTCTAACATGA-------CTGT-TCCAT- * * * ** ** * * ** ** ****** * ** ** * ENST00000369046.4 AAAAATACAAAAATTAGCCAGGCTTAGTGGCGGGCATCTGTAGTCCCAGCTACTCAGGAG ENST00000400977.2 -ATGACACAAGGAATATC----TTCCAAAGCAGTTTCCT-----CCCAGAGTCCTGAAAG * * **** * ** * * ** * ** ***** * ** ENST00000369046.4 GCTGAGGCAGGAGAAT-CACTTGAACCCTGGAGGTGGAGGTTGCA-----GTGAGCCGAG ENST00000400977.2 G--AAACTAGGAAAATGTAAATGTCCTCTGCTTCTGGCTTTCCCATATCTACCAGGTAGA * * **** *** * ** * *** *** * ** ** ENST00000369046.4 ATCATGCCACTGCACTGCACTCCAGCCTGGGTGACAAAGCAAGACTGTGTCTCAAAATAA ENST00000400977.2 AGCGTGATGCAAGATT-CTCACCACCCCATGT-------CTTCTCTCCTTCCCAAAAT-- * * ** * * * * * *** ** ** * ** ** ****** ENST00000369046.4 ATAAATAAAATAAAATAAAATGACGTACAGAGATTCTATATTCTAGAGAGTCAAATGGTC ENST00000400977.2 -TCATCAGGACTCAAGGGGGAGATTTTCACTTCTTTTCCTCTCTGGA-------ATGCTC * * * * ** ** * ** ** * *** ** *** ** ENST00000369046.4 TTGCTCAATTCTTGTAATTAGGTTCTTGTTAATACAGTCA--TTCCATG---GAATTACT ENST00000400977.2 TTCTGCCA--CTTGTCTTTC--TTCTTCTCAGGGCAACAAAACTTCATGCCCAGGTTAAT ** * * ***** ** ***** * * ** * * **** *** * ENST00000369046.4 TTTTAAAATTCCTGTGACAATTAA--TAATAAATAACGTGTCAGCATTTAGTAAGCATCC ENST00000400977.2 TGCAGAAAACGGTGTCCCCTCTATGCTACAGAAGAATCTCTAAG-ACCTAGT-----TCG * *** *** * ** ** ** ** * * ** * **** ** ENST00000369046.4 ACTAAG-TG---TACAATACTTCTACAATAACACAAGATACCTG--------TTCCTCAA ENST00000400977.2 ACTAAGCTGGCTTTTAATACACTAAAAAGGCCAAAGAAGTTTTGAAAAGCCCTTTCTAAT ****** ** * ***** * ** ** * * ** ** ** * ENST00000369046.4 AGACAATGCATTCTGCCATAATGTTCATTAAAGAGTTTACAGTAAAAATAAGATTAGGGA ENST00000400977.2 TGGCAAGTCCTGGTTTCACAAAACT-ATTAAA----TTA----AAAAAAAAAACTA---A * *** * * * ** ** * ****** *** ***** ** * ** * ENST00000369046.4 TAAACTTCTCAAAAATTGTACATCTGTGTAACTAAAGCACTAACAAAAACATGAATAGTC ENST00000400977.2 AAGATTTTTTAAAA----TAATTCC---TACTCTGGGCAT---CAAAAGC-TAGATAGTT * * ** * **** ** ** ** *** ***** * * ***** ENST00000369046.4 CTTCTAGAGGTAACTTGGATAGCCTAGGCAGGCAACTTATCATGTGGTGAAGGCCGCCTC ENST00000400977.2 TTCAT--------TTTGCATT--------------CCTATTATA----GAAACCCTATTC * * *** ** * *** ** *** ** ** ENST00000369046.4 AGGGGTTGTTAAAAATGCACAGAAACAATTGAGTGCGATTATTGGCTTCTGAGCGCTGAG ENST00000400977.2 ----CTCCTT-----------GAGGCAAATGGATGC---TTCTGGC-----AGCA-TGGG * ** ** *** ** *** * **** *** ** * ENST00000369046.4 CAGAGCAGGTGGAAGAGGAACTTTGAGCACAGGAGGAAA----TGCAACCAGTCAGGGCC ENST00000400977.2 AAGGG-AGACACCAGAAAAA-----AATTCATGAGGAAAACACTCCAATAAATT---GCA ** * ** *** ** * ** ******* * *** * * ** ENST00000369046.4 CAGAATCATGCAAATCTCAGGGGTATGCCTCTCTGGGGAGGAGCTCCACTTGCAGGGACT ENST00000400977.2 AAGAAT-----AAATTCCCAGCACAGTGCTCTC--------AACACTCTTTTCTTGAGTA ***** **** * * * ***** * * * ** * * ENST00000369046.4 CCTTTTATTTCCCTAAGAAAGAGCTGAAATGACTGAGAACTTTCCTTTCCTCCTTAGAGT ENST00000400977.2 TCTAGTATGTGCCAGACTCCAGGCAGAAGCTA-TGAGGCCAGTG--TGGCTCACTCGGGT ** *** * ** * ** *** * **** * * * *** * * ** ENST00000369046.4 TACAATTTTACTTCTGCTATTCCGGAGCCCA--TGCCTAGAAGC--CAGAACAACTCCAT ENST00000400977.2 GTGAG---------TGGTGT---GGAGCACAGATACGTAGCTGGTGCAGAAGAGTTCAGT * ** * * ***** ** * * *** * ***** * ** * ENST00000369046.4 GTTACACTGAGTTCATGCTCCTATTTACTGATCACAAATGAGCTCATTAATGTCATCGAA ENST00000400977.2 -TGGTAATCAGCTC-TGCCCAGGATTTCAGA----GAATTGGCTCTGAAGTATGAATGAA * * * ** ** *** * ** * ** *** **** * * * * *** ENST00000369046.4 ACATTTATTGTAACCTAACAGACCATCACAGATTGGAAA-----CTTGGTAGATAGCAGA ENST00000400977.2 G------TTG-GAC---ACAGA--GTCAAGGGGAGGAAGGAAGTCCAGGCAAA-AG--GA *** ** ***** *** * **** * ** * * ** ** ENST00000369046.4 GCATGGTATTAGTGAAAAAGGTTCAAAATACACAAGTAACATACACTCTGAAAAACA--- ENST00000400977.2 GTGCTGTGT-----ACAAAGACACAGAG---ACGTGAAATATCTGCCCCATTCAACGGAT * ** * * **** ** * ** * ** ** * * *** ENST00000369046.4 TGCAGATAATTTGCTGATGAAGCA--GAAGAGGGGATGCGCATGGCAAGAACTTGCCTTA ENST00000400977.2 TTCAAATAGCCTAAT-ATGACTCAATGTAGAGAGGTTGGGGA--GCAAACAC----CATA * ** *** * * **** ** * **** ** ** * * **** ** * ** ENST00000369046.4 CCCCAGATTCTCTATATCTCATGGTTTCCTTTTCCTCTTGACTGTCTTTACGAGTGTTTT ENST00000400977.2 GCATAAATGATTTTCATAGCATGA--------AAAGGAAGACTGTGATCA-GCTTGTGTT * * ** * * ** **** ****** * * * *** ** ENST00000369046.4 TTATTTGGGACCCTCGAGCC-CAG---AGATATTAATGGATATCTGTATTCAATATTTGA ENST00000400977.2 TAAGAAAGATCACTCTAGCTTCAGTATGGATAG-AGTGGAGA---GGGTTGAGAGT---- * * * * *** *** *** **** * **** * * ** * * ENST00000369046.4 CAAAATCTAATGGAAACCATCCATTTACTCATGATAAGGCTTCATCACTGGATTTCTGTG ENST00000400977.2 -AGAGGCCA--GGAAACTAGCTAATAACA-GTAACAA----TAATAAC--AATTGCC--- * * * * ****** * * * * ** * * ** * ** ** *** * ENST00000369046.4 TCTTCACTAGAACACCATTGTCATCTCATATTGATCAGGTAT---TTTAATCT----AGC ENST00000400977.2 ----------AACACAGTGCTCCCTGCGT---GA-CAGGTATATATTTAATCCTCACAAC ***** * ** * * ** ******* ******* * * ENST00000369046.4 ACTTACATATTGTT-GATAAATGAAAGCTGAATTGTTACTTAATAAATTCACTTTGTTTA ENST00000400977.2 AATAACAACCCATGAGGTAGGTGCAATTAGTGTCCTCCTTTAACAGGAG-ACTGAGGCTG * * *** * * ** ** ** * * * **** * *** * * ENST00000369046.4 GTAAAAAAAAATTGTTTTCTAAATATGACGTTCATGAAG--AGAAAATAAT-GAGTCAGA ENST00000400977.2 ---AGAGAGGCTTGCCTTCCTAACAT--CCATCATACAGCCAGCAAATGGCAGAGCCAGA * * * *** *** ** ** * **** ** ** **** *** **** ENST00000369046.4 AT-CATCTGCAGAACCACTGGAATGTTTCATCGTCACCTGTTAGTTTTCATAAACAGTTT ENST00000400977.2 AAATGAATGCAGG-CAGCCTGACTCCTGCAT--TCACATTCTGGCTCT--------GCTC * ***** * * ** * * *** **** * * * * * * * ENST00000369046.4 TCTGTCCTCTCTGAGAT-CCTCCCGCTCCCAAATACT-CAACCTGATTAACTTCAC-ATA ENST00000400977.2 TTTGCTGGCTGTATGATGCCTGCAGAGCTCAGGCTTTGCAGC--AATCCAGGTCAGGATA * ** ** * *** *** * * * ** * ** * ** * *** *** ENST00000369046.4 AAAGT--CTTA----TGTGCCAGGCTTAGTAATATT---CCTAT---AGATTTTGACTCT ENST00000400977.2 ATGGTGACCAAGGATTGTGGTAAGCAGAATAAAGCCTCGCCTACCAAAGATGTCCACTCC * ** * * **** * ** * *** **** **** * **** ENST00000369046.4 G-AATCCCTGAAAGAGGAAGAAATCCATGAGAGAAAATTGCATTA--CTTTATAGCAAGA ENST00000400977.2 CTAATTCCCA----------GCACCTGTG-------ACTACATTAGGCTGCATGGCAAAA *** ** * * ** * * ***** ** ** **** * ENST00000369046.4 GGAAACCGTTTTAAGTTTTTTAATTGCTCAGACACCACAAC--ATCCTAGATGGAGGAAA ENST00000400977.2 GGGGA-----TTAAGGTTGCAGATGG---AAAC-TTTTAACTCACCTTAAAATATGGAGA ** * ***** ** ** * * ** *** * * ** * *** * ENST00000369046.4 CCATTTTAGTTGAAGGAGCAAATATGATGTCAAAAGCAAGTAAATAAACAAACCGTTGCC ENST00000400977.2 CTGTTCT-------GGACCATCTGGGTGGCCTAAAG--------TAATCAAAGGGT--CC * ** * *** ** * * * * **** *** **** ** ** ENST00000369046.4 CCAATCTGTTTTTATGTAATGAATTTAAAAAAAAAGAGAGAGAGAGAGAGATGGGCTCTC ENST00000400977.2 TTAAGAG-----TGGAAAAGGGAGGCAGAAAAAAAGGATCAGAGAAAGAAATGTGATC-- ** * ** * * * ******** ***** *** *** * ** ENST00000369046.4 CCTGTGTTGCCCAGGCTAGTCTCAAACTCCTGGGCTCAAGTGATCTGCCTCCCTCAGCCT ENST00000400977.2 ---ATGAAAGCCAGGC----------------------AGAGAGCTGT-------AACAT ** ****** ** ** *** * * * ENST00000369046.4 CCCAAAGTGCTGAGATTAAAGACGTGAGCCACCACACCTGGCCGAAATAATAATATTCAA ENST00000400977.2 TGCTGGATGTGGAGATAGGGGAAG-GGGCCAC------------AAGT------------ * ** ***** ** * * ***** ** * ENST00000369046.4 TATTATATATTCAATGATATTATTCAGTATTCAATATTATTTCAAATAATATTAAATCTC ENST00000400977.2 -----------CAAGGA------------------------------------------- *** ** ENST00000369046.4 TTGTTCCTGTATCTCTACATGAGCTGCACTAATAATTTGAATCTGGAAATTAAAAAGTGA ENST00000400977.2 ------------CTGCAGATGGCCT----------TTGAAAACTGGAAA--AGGCAAAGA ** * *** ** ** ** ******* * * ** ENST00000369046.4 AACATTTACCGTTCTCATATACTGATACCCAACTACCATGAAATGATACCTAATTTGTTT ENST00000400977.2 AGCAG-----ATTCTC-TCTCCTAA-GCCT--CCAGAAAGAAATGCAGCCCTACCAAGTC * ** ***** * * ** * ** * * * ****** ** * * ENST00000369046.4 TTCTTTTCTCTTCATTTTTACTCTTAATCTAGTAGGTCTCATTTTGCCAAGTCACTGTCT ENST00000400977.2 ---------CTTCATT-------TTAGCCCAATGAGATCCATAT---CAG---ACT-TCT ******* *** * * * * *** * ** *** *** ENST00000369046.4 GGGAATTTAAGTGGCAAATACTTTCTTTGTCTCAGCTAATTAAACTCTAAAATTATTAGC ENST00000400977.2 ---AGCCTACA---CAACTA-----------TAAGATAAT---ACATTTGTATTGTTT-- * ** *** ** * ** **** ** * *** ** ENST00000369046.4 AACAGAA ENST00000400977.2 -------