CLUSTAL 2.1 multiple sequence alignment ENST00000373449.2 GTGAGGCGTGCGAACTGGTGGCAGTGAGAGACTTCGGCGGACATGGCTCCCAGCGTGCCA ENST00000439142.1 ------------------------------------------ATGGCTCCCAGCGTGCCA ****************** ENST00000373449.2 GCGGCAGAACCCGAGTATCCTAAAGGCATCCGGGCCGTGCTGCTGGGGCCTCCCGGGGCC ENST00000439142.1 GCGGCAGAACCCGAGTATCCTAAAGGCATCCAGGCCGTGCTGCTGGGGCCTCCCGGGGAC ******************************* ************************** * ENST00000373449.2 GGTAAAGGGACCCAGGCACCCAGATTGGCTGAAAACTTCTGTGTCTGCCATTTAGCTACT ENST00000439142.1 GGTAAAGGCACCCAGGCACCCATATTGGCTGAAAACTTCTGTGTCTGCCATTCGGCTACT ******** ************* ***************************** ****** ENST00000373449.2 GGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTAGGAAAAAAGCTGAAGGCA ENST00000439142.1 GGGGACAGGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTAGAAAAAAAGCTGAACGCA ******* *********************************** ************ *** ENST00000373449.2 ACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTGGAGCTCATTGAGAAGAAT ENST00000439142.1 ACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTGGAGCTCATTGAGAAGAAT ************************************************************ ENST00000373449.2 TTGGAGACCCCC-TTGTGCAAAAATGGTTTTCTTCTGGATGGCTTCCCTCGGACTGTGAG ENST00000439142.1 TTGGAGACCCCCCTTGTGCAAAAATGTTTTTCTTCTGGATGGCTTCCCTCGGACTGTGAG ************ ************* ********************************* ENST00000373449.2 GCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGAGAAGCTTGATTCTGTGAT ENST00000439142.1 GCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAAAGAAGCTTGATTCTGTGAT **************************************** ******************* ENST00000373449.2 TGAATTCAGCATCCCAGACTCTCTGCTGAT--CCGAAGAATCA-CAGGAAGGCTGATTCA ENST00000439142.1 TGAATTCAGCATCCCAGACTCTCTGCTGATGATTTTAGAGTCAACTGTGAGAC------- ****************************** *** *** * * ** * ENST00000373449.2 CCCCAAGAG-TGGCC--GTTCCTACCACGAGGAGTTCAACCCTCCAAAAGAGCCCATGAA ENST00000439142.1 -----AGAGCTGGCCATGTGCCAGCCA-GTAGAGAACGACATCC---ATGGGCTC-TG-- **** ***** ** ** *** * *** * ** * * * ** * ** ENST00000373449.2 AGATGACATCACCGGGGAACCCTTGATCCGTCGATCAGATGATAATGAAAAGGCCTTGAA ENST00000439142.1 ---CGAGGTCATTGATGACACC--AAT--GTCACTCAGCTGCAGCTGGAGA-----CAGA ** *** * ** ** ** *** **** ** ** * * * ENST00000373449.2 AATCCGCCTGCAAGCCTACCACACTCAAACCACCCCACTCATAGAGTACTAC----AGGA ENST00000439142.1 GATCC-------AGGCTTTCAAGGAGGAGCTGCTCTTATGAAGAAGAACCATGAAGAGGA **** ** ** ** * * * * * * ** ** * **** ENST00000373449.2 AACGGGGGATCCACTCCGCCATCGATGCATCCCAGACCCCCGATGTCGTGTTCGCAAGCA ENST00000439142.1 AGTAAAAGGCCTACA-------------AGCCCAGATTGCCAGCTCTGGGTTGACTGTGG * * * ** * ****** ** * *** * ENST00000373449.2 TCCTAGCAGCCTTCTCCAAAGCCACATCCTAGTATCAGAAGGCCAGGCGAGACTGCAACA ENST00000439142.1 TGGTAGATGCCC---------CCATATC------TCAGGACTTC-GCCAAGATCATGGCA * *** *** *** *** **** * * * * *** ** ENST00000373449.2 CTGCTCATCACCCCGCGGCGTGATCCCTGCTCTTAGGTGCTGGGCAGAGGGGAAGGGTGG ENST00000439142.1 G---ACATCTGGGCCCAATATGACG---------AGGTG----GCTCAGAAGAA------ **** * * *** ***** ** ** *** ENST00000373449.2 TCAGGGTGAGGATGGTGAGGGAGGGCTGGTGAGGGGCTCAGAGGAATACTTGGAACAACA ENST00000439142.1 -CAGA--GAGGA-GCTGGACAATAACAGGT------CTCAGCAGATTGAGGAGAGCACCA *** ***** * ** * * *** ***** ** * ** ** ** ENST00000373449.2 GCAGTG-TTATTGTAGTGTGGCAGTTTCTTTTATACATAGGTGAGAGTTTTTAAAGTGTA ENST00000439142.1 -CAGTGGTCACCACA------CAGTCC-------ACCGAGGTTGGAGCTGCTAAGGCG-- ***** * * * **** ** **** *** * *** * * ENST00000373449.2 AGGGAAAAATTAATTTTTTAAAAAACACCATGCTTGGAGGGTGGGGGTAGAAATAGACAC ENST00000439142.1 -----------------------------ATGCTCACAGAGCTG--------ACACGTAC ***** ** * * * * ** ENST00000373449.2 AATATTATTTCTAAGGAATCGGGTTTTCATTTACTCTGGACTG-GTGAAAATATTTTTTA ENST00000439142.1 AGT-CCAGTTCTTGGAGATCAA------------CCTAGACTCCATGAGAAA---TCTGA * * * **** * *** ** **** *** ** * * * ENST00000373449.2 AAGCCAGTGCTCTAAGACCTCAGCTTTTATCTCAGAACCCCATGGGTTCCAGACCAAGAG ENST00000439142.1 AGGCCAGT-----------TTGG----------AGAAC------------AGCCTGAGGG * ****** * * ***** ** * ** * ENST00000373449.2 TACAGGAAATCAAATTGTTGTCCTGTCTGTCTATAGCTTGGAACAGGGAGCTTTGATTAC ENST00000439142.1 ---AGGTAGT---------GGCCCG-----CTATGCCCTGCAG-ATGGAGC--AGCTCAA *** * * * ** * **** * ** * * ***** * * * ENST00000373449.2 TGACTCCGGTTCCAC-ACACTGTAAGATCAAAAAACCATCTCCACATTTGAAAGAGATGT ENST00000439142.1 TGG----GATCCTGCTACACC-TGGAGTCAGAG--------------CTGGCACAAACCT ** * * * * **** * *** * ** * * * * ENST00000373449.2 AAGGTGTATTCATAGGGATGGTG----GCTCAACAA-ATCAAGCAA-ACTGGA-ATCAAG ENST00000439142.1 GGG-------CAGAGGGACAGTGCCAGGCCCAGGAGTACCAGGCCCTGCTGAACATCAAG * ** ***** *** ** ** * * ** ** *** * ****** ENST00000373449.2 GGGAGGGGGAAGGGAATGAAATGGAAAGGGAGGCTGATTCCCTTCCCCTGACTTACCACT ENST00000439142.1 G--------------------TCAAGCTGGAGGCTG----CGATCGCC--ACCTACC--- * * * ******** * ** ** ** **** ENST00000373449.2 AATTTACTAGGCTACCTACTTTCATGAGTAACCTCTCACAGCTACCCAGCACATGCCACA ENST00000439142.1 ----------GCCGCCTGCT-----GGA-----------AGATGGCAAGGACTT----CA ** *** ** * ** * * ** ** * ** ENST00000373449.2 ATCCTATGCTCTTGCCTTCTTTTATCTGCACTGTGTGAAGGGACTCTTTTAAATAAATGA ENST00000439142.1 ATCT--TGGTGATACC---------CTGGACTGC----AGCAACTCCAT----------- *** ** * * ** *** **** ** **** * ENST00000373449.2 GCAAGTGTCCTAAGCTATGTCATCCAAAGATTGTCCTTTCCATTCTCAAATCCTGTGACT ENST00000439142.1 GCAAAC--------------CATCCAAAA---------------------------GACC **** ******** *** ENST00000373449.2 GGGATCACTCAACAGCACTGTGATGTATTATTTTCAATGAGGTGCCTTTCTTAACTGACC ENST00000439142.1 ---ACCACCCGCCAG-------ATAGACC--CGCCAGATAG----------TGGATGGCA * *** * *** ** * ** ** * ** * ENST00000373449.2 AAATGCTGCCTTGTTTGGCCCCTAAATCAATAAAATATGTTAAAATTTGTATCCCCTGTT ENST00000439142.1 AAGTGGTGTCTG-----------AGACCAATGA----CACCAAAATTC-----------T ** ** ** ** * * **** * ****** * ENST00000373449.2 GTGGCATTTTTTTTAGATAATCTAAGCTAGAAAAATGACATTGAATTCTGGACCTGGCTG ENST00000439142.1 GAGGCATT---------------AAGCCAGCAGAA--GCAGGGTATCCT----TTGG--- * ****** **** ** * ** ** * ** ** *** ENST00000373449.2 GAAGGAAAAGAAGCCCTTTCTTGTCGCTGGCAGCTGTGTGGTAGGGAGGTCCAAGTATGT ENST00000439142.1 ---------GGAGCCC------GAAGCCAATAA----AAAGTTCAGAGGTTAAAAAAAAT * ***** * ** * ** ***** ** * * ENST00000373449.2 GCATATGAGATAAGCCTGCAACCTCTTGACCTTCAGCTCCTATGCAGGCTTCTCTTGAGC ENST00000439142.1 --AAATAAAAAAAG-----------TTGA-----AGC----------------------- * ** * * *** **** *** ENST00000373449.2 CCAGAGACAAGGCAGCTTGGTCTAGTGGAGATAGCACTGTGCTTGGAGTTCAGGGGACCT ENST00000439142.1 --AGAAATAAATGAATTTGA---AATGAGGAAAACAATA-----------CAAAAGACCA *** * ** * *** * ** ** * ** * ** **** ENST00000373449.2 AGGACAAATCCCAGCCAGTTAGTTATTCACTGTGCTCCTGTTTCCTCAGCTGAAAAAGGA ENST00000439142.1 ATGAAA-----CAAAAAGTTGGTT-----------------TTTTTCAAAAGATAAACAA * ** * ** **** *** ** *** ** *** * ENST00000373449.2 AGTTGGTTATGCCACCTTCTTGGCCTTAATGGCATTAAATGAAATTTATAGGAAGAAGGT ENST00000439142.1 AATTGACAA----ACATT--TAGCCAGAGT------AAGGGAAA--AATGGAGAGGA--- * *** * ** ** * *** * * ** **** ** * ** * ENST00000373449.2 TTTTGCTCAG-TACCTGGCATGCAACAGACATTGGATAAATGTTAGTTGGATCCAGATAT ENST00000439142.1 -----CTCAAATACATAAAA----ACAGAGATGAAAAAGGAGACA-TTACAACT-GATAC **** *** * * ***** ** * * * * ** * * **** ENST00000373449.2 ACACAGAAAGATATCTGCTTCCTGCCAGGCTGGATAACTGTTGAATGGACACTTGTCCAT ENST00000439142.1 -CACAGAAATTCAAAGGATTATT---AG--TGGCTAAT--ATGAGCAACTACATGCCCAT ******** * * ** * ** *** *** *** ** ** **** ENST00000373449.2 AGTCTAGAAAGCCAGTGCTTCTAATCCTTAAGCCAGATCTTTGACTACCTTTTCAGTTGC ENST00000439142.1 ATATTGGAAA--------TTCTAG-----AGG--AAAT----GGATA-----------AA * * **** ***** * * * ** * ** ENST00000373449.2 TTCTTTAACACTCTTTGTTGCTTCTCTGTGTGTCCTAGTTTAAATTCATTTCCTCTCCAG ENST00000439142.1 TTCCTCGACAC------------------------------AGA--------CAACCCAC *** * **** * * * *** ENST00000373449.2 CAAAAGTGAGCT-TAAATAATTTCTCCAAACTAAAGCTCTCATGTTTTTGGAAGGGCTGC ENST00000439142.1 CAAAACTGAACCATGAAGAAAT--------CTAAAA----------TCTGAACAGAC--- ***** *** * * ** ** * ***** * ** * * * ENST00000373449.2 CTTTGCAAGTGAGGTTTCTGAGAAATGACTGTTGTTCCCAAAACAAGAGGGAGCTGGGCT ENST00000439142.1 -----CAA----------TAACAAGT---------------AACAAGA-----------T *** * * ** * ******* * ENST00000373449.2 GGAAGCACCACTATTCTTCTTTAGGCATCTTGTTACAGAGAGAGGCAGGGTCTTCACTGA ENST00000439142.1 TAAAGC------------------------TGTAATAAAAAG--------TCTCC--CAG **** *** * * * ** *** * ENST00000373449.2 CATATTAAATCCTGTTCCCTGAACCAGCCCCTCCCTCTTCTGCTCCACTTCCTCACCTGT ENST00000439142.1 CAAAGAAAAGCCTG------GAATC-----------CAATGGCTTCACTGCTGAATTTTA ** * *** **** *** * * *** **** * * * ENST00000373449.2 GCAGAGTCATTTTCAGGTGTTAGCCTTACTGATTTGCACTGATCTGTTTGTTCCCTGAGC ENST00000439142.1 GCAAA--TATTTGAAAAAGA-------ACTAAT----ATCAATCC------TACTCAAAC *** * **** * * *** ** * *** * * * * ENST00000373449.2 TTTTTAAATACCCTGTGAAAATTTTCTTTCCTCCCTTGGTCATCATGCATCTAATTGTGG ENST00000439142.1 TATTT----------TGAAAA---------------------------ATAGAGGAG-GA * *** ****** ** * * * ENST00000373449.2 GGAAATGTTTGTCAAAC-CAACCTGCAAAGCAGCATGGTGTAGTTGAGAAGAATAAAC-A ENST00000439142.1 GGGAATACTT-CCAAACTCATTCTATGAGGCA-----------------AGGATACACCA ** *** ** ***** ** ** * *** ** *** ** * ENST00000373449.2 GAGAAGACTGGGTGAGCTATTGTTTGTTTGCTTCTTTGGGCCTGGGTTTCCTCATCTAAT ENST00000439142.1 GGCAATACTATGC-AGCCATAAAA-------------AGGAATAAGATT----ATGTTAT * ** *** * *** ** ** * * ** ** * ** ENST00000373449.2 CTGCAAACCAAGAATGCAGACTAGTCCTACCACTCCCGGAAGACTGACGTTGTGCCAGGT ENST00000439142.1 TTGCAGAACATGTATGGAGTTGAAAGACATTATCCTCATCAAACTAACG------CAGGA **** * ** * *** ** * * * * * * *** *** **** ENST00000373449.2 ATTATGCAAAGGCTTCATGTAACCCTCGACTTCACGTAACCCTCACACAGCACCCTGTGG ENST00000439142.1 A-----CAAAA---------AACC-------------AAACATCACACG----------- * **** **** ** * ****** ENST00000373449.2 AGTCAGAACTGTCCTTCACTTTTATAGGTGAGGAAACCAGACTCAGAGAGGTGAAGTGGC ENST00000439142.1 --------------TTCTCAGTTATAAGTG--GGAGCTGAAC--AATGAGACCACATGG- *** * ***** *** * * * ** * *** * *** ENST00000373449.2 ATTCCTGAGGTCATGCATAAGAGGCAGTCAGGACTGAAACACAGTCTCTAACACTTATCC ENST00000439142.1 ------------ACACATAAGGGA------------AAACA---------ACACACA--- * ****** * ***** **** * ENST00000373449.2 GTCCCCTTGATCTTGTTG-CTGAAGTGATTTAATTACTTGCGTAGCTCTGCACACAGGAA ENST00000439142.1 -----CTGGGGCCTGTTGGTTGGAGGG-----------TGGGTA---TTG---AGGGGAG ** * * ***** ** ** * ** *** ** * *** ENST00000373449.2 GGGCTGCTCTGAATAAGAGCTCTTTTCCATGGACACTCAGCGCTGCCGGAACTGATTTTG ENST00000439142.1 GGA-------GAATCAGG----------AAGAATAGCTAATG--GCCG---CTGGGCTT- ** **** ** * * * * * * **** *** ** ENST00000373449.2 AAGAAGTCACTGCCGGCTCTGAGGGCCTAGGGTATGTGTCTTAGGATCTCCTGTGTGCAC ENST00000439142.1 --------ACTACC-------------TAGGTGATG-------GAATGATCTGTGCA-GC *** ** **** *** * ** ***** * ENST00000373449.2 AAAGTGTCACTGACAGAACACAGCAGGATGGAGAGCAGCCTCCTCAGAAGCCTCACAAGT ENST00000439142.1 AAA---CCACC-ATGGCACACATTTATCTGTGTAACA----------AACCTGCACATGT *** *** * * ***** ** * ** ** * **** ** ENST00000373449.2 CTTTCCTCAGATGAAGACAGAGCAACGAGTCAGAAGACAGATTTCAACAGCGACTTCACC ENST00000439142.1 ACC-CTTAAAATAAAATTTGAAGAAAAAA--AAAAGTC---TCCTAGTAAAGA----AAA * * * ** ** ** ** * * *** * * * * ** * ENST00000373449.2 ATGCGACCTTGGACAAGTTATCTCACCTCATCAGTAGAATAGGAATGATCCCTACCCCTC ENST00000439142.1 GTGTGGGCC----CAA------TGGCTTTAACACT-------GAATTCTACCAAACATTT ** * * *** * * * * ** * **** * ** * * * ENST00000373449.2 AAAGGTGCTGATGACACTAGTGACCAAGATACTCATGTGGGTTGGACTGCCCAGGACACA ENST00000439142.1 AAAG------AAGA-ACTAAT-ACCAA--TTCT------ACTCGAACTGTTC------CA **** * ** **** * ***** * ** * * **** * ** ENST00000373449.2 GCAGATGCTTAGTAAACACAGATGGAATTCAGAGGGAAAATGTAGGCATTGAAGAAAGT- ENST00000439142.1 AAAGACG----GAAAAAAGGGATTACTCTC-------AAACTCATTCTATGAGGCCAGTA *** * * *** * *** ** *** * * *** * *** ENST00000373449.2 -TGTCTTACTGACCATCCGGAACCAGGCTAAGGATCCCCTAGAAATCATAGACCTCTGAA ENST00000439142.1 TTATCCTGCTA-----CCAAAACCAGAC-AAAGACACATCAAAAA----AGG-----AAA * ** * ** ** ****** * ** ** * * *** ** ** ENST00000373449.2 ATTATATGCAGAATTCTTTATGTGTTTTCATAATTAATAATAGTCTAACATATTAAATTC ENST00000439142.1 ACTACAGGCCAA-----------GTTTTC-TGAT-------------------------- * ** * ** * ****** * ** ENST00000373449.2 TTAGCTGTGTGAGA ENST00000439142.1 --------------