CLUSTAL 2.1 multiple sequence alignment ENST00000374379.4 AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGA ENST00000453177.1 ------------------------------------------------------------ ENST00000374379.4 GCTGAAGCCGTGGCCAGCTCGACGCCGGACAGTCCAGCGAGCAGCACGGCGGGAACCGGC ENST00000453177.1 ------------------------------------------------------------ ENST00000374379.4 AGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA ENST00000453177.1 ------------------------------------------------------------ ENST00000374379.4 GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACA ENST00000453177.1 ------------------------------------------------------------ ENST00000374379.4 AAGAGCCCCTCATCGAGCTCTTCGTCAAGGCTGGCAGTGATGGTGAAAGCATAGGAAACT ENST00000453177.1 ------------------------------------------------------------ ENST00000374379.4 GCCCCTTTTCCCAGAGGCTCTTCATGATTCTTTGGCTCAAAGGAGTTGTATTTAGTGTGA ENST00000453177.1 ------------------------------------------------------------ ENST00000374379.4 CGACTGTTGACCTGAAAAGGAAGCCAGCAGACCTGCAGAACTTGGCTCCCGGGACCCACC ENST00000453177.1 ------------------------------------------------------------ ENST00000374379.4 CACCATTTATAACTTTCAACAGTGAAGTCAAAACGGATGTAAATAAGATTGAGGAATTTC ENST00000453177.1 -------CATAACTTTCAACAGTGAAGTCAAAACAGATGTAAATAAGATTGAGGAATTTC ************************** ************************* ENST00000374379.4 TTGAAGAAGTCTTATGCCCTCCCAAGTACTTAAAGCTTTCACCAAAACACCCAGAATCAA ENST00000453177.1 TTGAAGAAGTCTTAAGCCCTCCCACGTACTTAAAGCCTTCACCAAAACACCCAGAATCAA ************** ********* *********** *********************** ENST00000374379.4 ATACTGCTGGAATGGACATCTTTGCCAAATTCTCTGCATATATCAAGAATTCAAGGCCAG ENST00000453177.1 ATACTGCTGGAATGGACATCTTTGCCAAATTCTCTGCATATATCAAGAATTCAAGGCCAG ************************************************************ ENST00000374379.4 AGGCTAATGAAGCACTGGAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATC ENST00000453177.1 AGGCTAATGAAGCACTGGAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATC ************************************************************ ENST00000374379.4 TGAATTCTCCTCTCCCTGATGAAATTGATGAAAATAGTATGGAGGACATAAAGTTTTCTA ENST00000453177.1 TGAATTCTCCTCTCCCTGATGAAATTGATGAAAATAGTATGGAGGACGTTAAGTTTTCTA *********************************************** * ********** ENST00000374379.4 CACGTAAATTTCTGGATGGCAATGAAATGACATTAGCTGATTGCAACCTGCTGCCCAAAC ENST00000453177.1 AACGTAAATTTCTGGACAGCAATGAAATGACATTAGCTGATTGCAATCTGCTGTCAAAGC *************** **************************** ****** * ** * ENST00000374379.4 TGCATATTGTCAAGGTGGTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAATGA ENST00000453177.1 TGCATATTGTCAAGGTTGTGGCCAAAAAA-ATCGCAACTTTGATATTCCAAAAGAAATGA **************** ************ ****************************** ENST00000374379.4 CTGGCATCTGGAGATACCTAACTAA----TGCATACAGTAGGGACGAGTTCACCAATACC ENST00000453177.1 CTGTCATCTGGAGATACCTAACTAACTAATGCATACAGTAGGGATGAGTTCACCAGTACC *** ********************* *************** ********** **** ENST00000374379.4 TGTCCCAGTGATAAGGAGGTTGAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAG ENST00000453177.1 TGTCCCAGTGATGAGGAGGTTGAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAG ************ *********************************************** ENST00000374379.4 TAAAATCGCGTTTGTAAAAGAGATGTCTTCATGTCTTCCCCTAAGAATACGCTTTTCCTA ENST00000453177.1 TAAAATCGCGTTTCTGAAAGAGATGTGTTCATGTCTTGCTCTAAGAATTTGCTTTTCCTA ************* * ********** ********** * ******** ********** ENST00000374379.4 ACAGGCTACTCCT--TCCTGTAGAGCAGAAATTGTATTTTGCACGAACATGCAGTTATTG ENST00000453177.1 ACAGGCTACTCCTCTTCCTGTAGAGTAGAAATTGTATTTTGCATGAACATGCAATTATTG ************* ********** ***************** ********* ****** ENST00000374379.4 AAGATTAGGATCAAGGATAGACAAGGTATAGTAGTTATCTTAAAATATACACTCCTAAGC ENST00000453177.1 AAGATTAGGATCAAGCATAGACAAGGTATAGTAGTTATCTTAAGATATACACTCCTAAGC *************** *************************** **************** ENST00000374379.4 AGTATTATTTTAAAATCCTTTACCCTGGCTACCTCCCCTACCCGGGTTCCCCTCTCTTTA ENST00000453177.1 AGTATTATTTTAAAATCATTT-------------------------TATCCCTCT----- ***************** *** * ****** ENST00000374379.4 ATTTGGAGACACTCCACCACAAACTTTTCACTTTAGAGGTAGCTTGCCATCTCTCAGGAG ENST00000453177.1 ---------------------AAATGTTC------GAGGAAGG----CATGTCT------ ** * *** **** ** *** *** ENST00000374379.4 CCCTCACCATTGTGTCCATTCACTGTGTATAGATGGCAGAACTTTTGAGGTGCAATGTTT ENST00000453177.1 --------ATTGTG---ATTT------TAATGAAGACAGAATTATT-----------TTT ****** *** ** ** * ***** * ** *** ENST00000374379.4 AATTGTTAAAAATAGTAGCCACGACTTTATCAGGCAGCCCCAAACTGGTGCATAATGCAT ENST00000453177.1 CTCTGT--AGAAAGACAAATACTACTTTATCAGGGA------AGTTAGT-CA-AATG--- *** * ** * ** *********** * * * ** ** **** ENST00000374379.4 GGTACAAGAAATATTTATGTATTTTTTGGAATTTTGTAATATTTAGTAAGAGTATATGAA ENST00000453177.1 --------AAAT---------------GGAAATTGGTAA--------ATGG-----TCAA **** **** ** **** * * * ** ENST00000374379.4 AGGATTGCTACTGTATCAGAAATATTGTTTCAATTTAGTCTATCCTGGATATGTACTAAC ENST00000453177.1 AAGCTAGCTA-------GGAAAAA-----------------------GAT-----CCAAC * * * **** **** * *** * *** ENST00000374379.4 GAATATTACCACCAGAGAAGAGAGCTTTCTACAAAAGTCACTACAGATTTTGCTATATTG ENST00000453177.1 -AACAT-----------------GCTTT-----AACCCCATTGCA-----TG-------- ** ** ***** ** ** * ** ** ENST00000374379.4 CTTTGTAGATAGATTTTTACTTTTGCCTAAAAGCATTTATCCTTCATACCAATTGTAACA ENST00000453177.1 -TTTGTGGAAAGA------CCATAGCTTAAAATC------------------TTGAGAAA ***** ** *** * * ** ***** * *** * * ENST00000374379.4 TCTGACACCATGTAGAAGCTAAAAGTTTAGAGGGAGTGAGGGTTTTCTCAAGACCTTCCT ENST00000453177.1 TTTG----------GGACATAAAAGTTT-------------------TCATGGT------ * ** * * ********* *** * ENST00000374379.4 CAAGCATTTTATCTTTAGAAGAGAAACTGATGGGCACCTGATACTCTGTCTAAATACGTT ENST00000453177.1 -AGACAGTTCAT----------GGAGTATATGAAC---TGACATTATGGAAAAAT----- * ** ** ** * * *** * *** * * ** **** ENST00000374379.4 TGTTATATGTGTTTTGCCCTGTGCCATTCATTTGGAACTTTATTGCATTCTTTATT-TTA ENST00000453177.1 ------------------CTG---------------ATTTTATT------TTTACAGTTA *** * ****** **** *** ENST00000374379.4 AAAAGCTTGTTTTTACGTAATCATAGAGCTTGCTATTTGTACATCTGTTGAGCAACACTA ENST00000453177.1 ACAAATCCATTCCT--------------CTTA--ATTTAAACACCTGTTGTG-------- * ** ** * *** **** *** ****** * ENST00000374379.4 CATAACTGATTTTTAGTTGACTTAGCTATAGCAGTACAATGATTAGTAATGTAAAAATTA ENST00000453177.1 ----------TTTTACTT------------------CGATGA----------AGAGATTG ***** ** * **** * * *** ENST00000374379.4 ACACAGAAATTAACCTAAGGAATGAAGGGTGGGTTTGTCAAA--ATATCAAGTAAATTTT ENST00000453177.1 G----------AGTCT---GAATAGAAAGTCTGTTTTCCGGGGGATACTGAG-AAATTTT * ** **** * ** **** * *** ** ******* ENST00000374379.4 TGTTTCTAAAGTACATTTAATGTAGATGACCTAAAGAATGCGTTATCCATCCTATATAAA ENST00000453177.1 TGT-----------ATTCAG-------GAGTTGGAAAGCTCTCT-TCCATTCTAGTT--- *** *** * ** * * * * * ***** *** * ENST00000374379.4 AGAAAGATAAAACACAGGTCACCAATTTTCTCATTTCACCCCATTTACCTTGTATAGAGG ENST00000453177.1 -----GATAAAAC--------------TTCCCTTTT-------TTTG----ATGTAGA-- ******** *** * *** *** * **** ENST00000374379.4 ATTGTTCATTCCTTTGGGACTAAGTTATAGTTATGGTGAGTGTGTATTTACTGTAGTTTT ENST00000453177.1 --TGCAGATTTT-------CTA---TACAGTTCTG-----------------------TT ** *** *** ** **** ** ** ENST00000374379.4 GCCTGATCTCACTCATTGCACTTCCTGGAGTTAAATTTTCCAACAGCCATGTTGAGGAAT ENST00000453177.1 GTCTTCTTTTACTA---GGACT-------GTTAACTTTTGTGATA---AAATTCA--AAT * ** * * *** * *** ***** **** * * * ** * *** ENST00000374379.4 AGCACTCTGCATGTTTTTG-TTTTGTTTTTCGGGGTTTTTTTTAATTGAAGCCCTAAACC ENST00000453177.1 AAGATTTTATTTCTTGATAATTTTGGTTTTCACAATTTATCTT---TAAATCCTT----- * * * * * ** * ***** ***** *** * ** * ** ** * ENST00000374379.4 AGGAATTATTTGTGTTCTAACAGGAGGATGAACTTGCTGAAAATAAAACTTTGCTATGTA ENST00000453177.1 --GAGCAATCTGTATACAATTAAGAGA------TTTCTCA------------------CA ** ** *** * * * * *** ** ** * * ENST00000374379.4 TTTACTCTTTTTTAAAAGACAAAAGCAAAACCAGACTTTCTACGTACTACTCCAAAGACT ENST00000453177.1 TTTATTC----TTAAA-----------------------CTGAGTA-------------- **** ** ***** ** *** ENST00000374379.4 GTGATTGTGACTATAATACATTTTTGGTAATTTTTTTATACCTAATTTGTATAGGAAGTG ENST00000453177.1 --GATC--AACTCTAGGA---TTTAGGCA-------TGT---TAACTT------------ *** *** ** * *** ** * * * *** ** ENST00000374379.4 CTATTTCTCATAGGCTGTTTCTTGAAATTTTAAGTTTATTGCTTTAAAATGGCAGTGTTT ENST00000453177.1 -TACTTCT-----GTTGTGTTTTGAA-------------------------------TCT ** **** * *** * ***** * * ENST00000374379.4 CTCCCACTTTGATATGCTAACATTTAGTAAGCACTGGCTTTATGAAAGCGGCTTTTTATA ENST00000453177.1 CTCC---------------------AG--------AGTTGCATGTAGGTAGCTTTT-AT- **** ** * * *** * * ****** ** ENST00000374379.4 AGTATACTGCATTTTTTGAGCCTATCATTAATTAGCTTAGTATGAAAGATAAGAAAATCT ENST00000453177.1 -----------TTCTGTGCGCTTACAGTCAATTAG------------------AAAATAT ** * ** ** ** * ****** ***** * ENST00000374379.4 CCATGTTGTATCCATTTGGCTCAGGAAGATTCTTTGCCTTACCTTTCTTAGAACTCTTTA ENST00000453177.1 CTACAAAGTA-------GGCT-----GGGTGTGGTGGCTCA---TGCCTGTAATTC---- * * *** **** * * ** ** * * * * ** ** ENST00000374379.4 TTGCTTATCAAAAGTTTGAGTACCCGCTTGGTTTTTTTTTGGTAATTAAATATTGTATGA ENST00000453177.1 --------CAACACTTTGGGAGGCTGA-------------GGCAGGCAGAT----CACGA *** * **** * * * ** * * ** * ** ENST00000374379.4 TTTATCTGGTTCAAGGAAGATGCACTATTCAGTTATCTATTGAGAAATTATTTTGCAGTG ENST00000453177.1 -------GGTC--AGGAG--------------------ATCGAGA--CCATCTTG--GCC *** **** ** **** ** *** * ENST00000374379.4 GTTTTAGTGGGTGAAAATGTCCCATCTGCACCAGTACACAGGCAGGCATTATCATTCTTC ENST00000453177.1 AATAT----GGTGAAA---CCCTGTCTGTAC---TAAAAAGACAAAAATTAGC------- * * ******* ** **** ** ** * ** ** **** * ENST00000374379.4 ACCTACTTTTTAAATAGTGGCAACTTGGGATTCATTCTGGTGATTCTGAACCTTGCCTCA ENST00000453177.1 -------------------------TGGG---CGTGGTGGCG----TGCACCT------G **** * * *** * ** **** ENST00000374379.4 TAGCTTAAAGTATAAAAAAGATTCAAGAGCAGTGAGGTTTGTTCTTTCCAGTGAATGGTG ENST00000453177.1 TAGTCCCAGCTACTCAGGAGGCTGAGG--CAG-GAGAATCACT---------------TG *** * ** * ** * * * *** *** * * ** ENST00000374379.4 GACTGAGTGGTGCGAGGTGGAGGGCTAACAAGAGGAAAGAACTACATTCTTCAGAATACA ENST00000453177.1 AACC------TGGGAGGCAGAGGC--------------------------------TGCA ** ** **** **** * ** ENST00000374379.4 GTGATGAAAATTCATTTTGAAACTCAAATATTTTCATTTTGGATATTCTCCTGTTTTTAT ENST00000453177.1 GTGAGACAAGATCATGCCATGGCACTA-------CAGCCTGGGTG--------------- **** ** **** * * * ** *** * ENST00000374379.4 TAAACCAGTGATTACACCTGGCCATCCCTCTAAATGTTCTAGGAAGGCATGTCTATTGTG ENST00000453177.1 --AGAGAGTGA--------GACCCTGTCTCAAAA-------------------------- * ***** * ** * *** *** ENST00000374379.4 ATTTTGATGAAGACAGAATTATTTTTCTCTGTAGAAACACAGATACCACTTTATCAGGGA ENST00000453177.1 ------AAAAAAAAAAAA--------------AAAAAAAAAGAAAA-----TATCCGGAA * ** * * ** * *** * *** * **** ** * ENST00000374379.4 AGTTAGTCAAATGAAATGGAAATTGGTAAATGGACAAAAGCTAGCTAGTAAAAAGGACGA ENST00000453177.1 AGTGA---AAATGGAGAGGAAAT--------------------------AGAAA------ *** * ***** * ****** * *** ENST00000374379.4 CCCAGCAACATGCTTTAACCCCATTGTATGTTTGTGGAAAGAGCATAGTTTAACATCTTG ENST00000453177.1 ------------------------TGTATTTTT----AATGA----------ACATTTT- ***** *** ** ** **** ** ENST00000374379.4 AGAAATTTGGGACATAAAGTTTTCATGGTAGACAGTTCATGCAGTATATGAATTGCCATA ENST00000453177.1 ----------GATACAAA--TTTCAT-----------CATTTA----ATGATTCACCA-- ** * *** ****** *** * **** * *** ENST00000374379.4 ATGGAAATAATCTGATTTTATTTTTACAACTAACATCCATTCCCCTTCATTTAAACACCT ENST00000453177.1 -------------------ATTT------CTTACATTAATT-----TGAATTAAGCA--- **** ** **** *** * * **** ** ENST00000374379.4 TTTGTGTTTTACTTCAGTGAGGAGATTGGAGTCTGAATGGATCTGTTTTCCAAGAGATTC ENST00000453177.1 -------TTGAATTCA---AAGAGACAGGAGCATTCATTGATATAT------ATGGACTT ** * **** * **** **** * ** *** * * * ** * ENST00000374379.4 TGAGAAATTTTTGTATTCAGCAGTTGGAAAGCTCTCTATTCTAGTTGATAAAACTTCCCT ENST00000453177.1 TTAAAAATTCCATCCTTTATAAATAGACAAG------GTTTGGGCT-ACAAAAATTATAT * * ***** ** * * * * *** ** * * * **** ** * ENST00000374379.4 TTTTTGATGTAGATGCAGATATTCTATACAGTTCTGTTGTCTTTTACTAGGACTGTAAAC ENST00000453177.1 TTTT--ATC---ATGGAAAAATTT----CAACTC------------CTCAAGTCATAA-- **** ** *** * * *** ** ** ** *** ENST00000374379.4 TTTTGTGATAAAATTCAAATAAGATTTTATTTCTTGGTAATTTTGGCTTTCACAATTTAT ENST00000453177.1 TGTTG-AATAGAATTGGAGTAT-------TTTCTTTAGAATTT---CTTGAACAGGCAA- * *** *** **** * ** ****** ***** *** *** * ENST00000374379.4 CTTTAAATCCTTGAGCAATCTGTATACAATTAAGAGATTTCTGACATTTATTCTTACACT ENST00000453177.1 -ATTAAAGCTT------AT---TATAGAATGCAAGTATTT---ACTTTTCTCTTTG---- ***** * * ** **** *** * **** ** *** * ** ENST00000374379.4 AAATGGATCAACTCTAGGATTTAGGCATGTTAACTTCTGTTGTGTTTTGAATCTCTCCAG ENST00000453177.1 GAAT--ATCAAAACCAGTGTAT-----TGCTGACAGCTATTGTATTTTAAAAAAATGTAT *** ***** * ** * * ** * ** ** **** **** ** * * ENST00000374379.4 AGTTGCA-TGT-AGATAGCATTTATTTCTGTGCCCTTAAACCCATTTAGAAAATAACTAC ENST00000453177.1 ATTTTCACTATCATAAAGGATTC-TTTTTCCTCCCT------CAT---GAAAATAA---- * ** ** * * * * ** *** *** * **** *** ******** ENST00000374379.4 AAAGTAAAAATGTAGAGGAAATAGAAATGTATTT--TTTCATGAACATTTTGATACAAAT ENST00000453177.1 ---ATGACAACTGGGGGTAAATATATATATATATAATTTC-TGAA-GTAAAAAGAAAGAT * * ** * * ***** * ** *** * **** **** * * * * ** ENST00000374379.4 TTCATCATTTAATGATTCACCAATTTCTTGCATTAATTTGAATTTAAGCATTTAATTCAA ENST00000453177.1 CCTCCCTTCCAA------ACAAATATGAT-CAT--ATTTTATTCTA--CTTGTGAT--AA * * ** ** *** * * *** **** * * ** * * * ** ** ENST00000374379.4 AGAGAGGGGAGCATCCATTATTGATACATGTGGGCTTTTAAAAACTCCATCCTTTATAAA ENST00000453177.1 AGGCAGTGAGGCATTTGTT-TTGGGGAATGT---------------CCA--------AAA ** ** * **** ** *** **** *** *** ENST00000374379.4 TAGTCAAGGTTTGGGCCACACAAAGTATATTTTTATCATGGAAAAATTTCAACTCCTCAA ENST00000453177.1 TATCTATGATTT-------------TACTTTTCCAGC-CAAAACAATTTTG-CTTCTCTG ** * * *** ** *** * * ** ***** ** *** ENST00000374379.4 GCCGTAATGTTGAACAGAATTGGAGTATTTTCTTTATAATTTCTTGAACAGGCAAATGAA ENST00000453177.1 GC-----------AC---------GTATT--------AATC-----AATAGGCAAA---- ** ** ***** *** ** ******* ENST00000374379.4 AGCTTATTATAGAATGCATGTATTTTCTTTTATCTTTGGAACATCAGCACCAGTATATTG ENST00000453177.1 ---------------ACAT--------TTTGAACTTTTAAATATTA-------------- *** *** * **** ** ** * ENST00000374379.4 CTGGCAGCTATTGTATTAAAAAATAAAGTATATTTTCACTATCATAAAGGATTCTTTTTT ENST00000453177.1 ---------------------------------TTCCAC-ATCACA-----CTAATTTAT ** *** **** * * *** * ENST00000374379.4 CCCCCCTCATGAAAATAAACAACAACTTGGGGTAAAAGTG ENST00000453177.1 TCTAGTTCAGAAAAAT----------TTGGAGTG------ * *** ***** **** **