CLUSTAL 2.1 multiple sequence alignment ENST00000374865.4 AGGCCCGTGGATCTCATCGAAGATGGCGGCGCGATCTGTGTCGGGCATTACCAGAAGAGT ENST00000431951.1 ------------------------------------------------------------ ENST00000374865.4 CTTCATGTGGACAGTCTCAGGGACACCATGTAGAGAATTTTGGTCTCGATTCAGAAAAGA ENST00000431951.1 -------------------------------------TTTTGGTCTCGATCGAGGAAAGA ************* ** ***** ENST00000374865.4 GAAAGAGCCAGTGGTTGTTGAGACAGTAGAAGAG---AAAAAGGAACCTATCCTAGTGTG ENST00000431951.1 TAAAGAGCCAGTGGTAGCTGAGGTGGCAGAAGAGGTGAAAAAGGAA--TACTCTGGCATG ************** * **** * ******* ********* ** ** * ** ENST00000374865.4 TCC-ACCTTTACGAAGCCGAGCATACACACCACCTGAAGATCTCCAGAG--TCGTTTGGA ENST00000431951.1 CCCTACCCTTACAAAGCCAAACATACTTATCACCTGAAGATCTCCAGAGAGTCGTTTTGA ** *** **** ***** * ***** * ******************* ****** ** ENST00000374865.4 ATCTTACGTTAAAGAAGTTTTTGGTTCATCTCTTCCTAGTAATTGGCAAGACATCTCCCT ENST00000431951.1 ACCT---GGTAAAGAGGTTTT-GGTTCATTTCTTCCCGGTAATTGAGAGGACAGATCCCT * ** * ****** ***** ******* ****** ******* * **** ***** ENST00000374865.4 GGAAGATAGTCGTCTAAAGTTCAATCTTCTGGCTCATTTAGCTGATGACTTGGGTCATGT ENST00000431951.1 GGAAGATGGTAATCTGAAGTTCAGTCT--CGGC-----------ATGGCC---AT--TGT ******* ** *** ******* *** *** *** * * *** ENST00000374865.4 AGTCCCTAACTCCAGACTCCACCAGATGTGCAGGGTTAGAGATGTTCTTGATTTCTATAA ENST00000431951.1 AGTCCCTAACTCCAGGCTTCACGAGCTGTGCAGCGTTAGAGATGTTCTTGATTTCTATAA *************** ** *** ** ******* ************************** ENST00000374865.4 TGTCCCTATTCAAGATAGATCTAAATTTGATGAACTCAGTGCCAGTAATCTGCCCCCCAA ENST00000431951.1 AGTCGCTGTTCACAACAGATGTAAATTTGATGAACTTGATGCCAATAATCTGCCTCTCAA *** ** **** * **** *************** ***** ********* * *** ENST00000374865.4 TTTGAAAATCACTTGGAGTTACTAAGCAATTCGGAAGAGAAACACATTGAAATCACTGTC ENST00000431951.1 TTTGAAAACCACCTGAAGTTACTGAGCAATTCAGAAGAGAAATACTTTAAAATAACT-TT ******** *** ** ******* ******** ********* ** ** **** *** * ENST00000374865.4 TTTCCCTGAGCAAGGGGGCTGCTCATTAGATCTTTTGATACTTTACCATGTGAAATACTA ENST00000431951.1 TATCCCTGAGCAAGGGAGATGCTTATTAGACTTTTTGATACTTTACCATGTAAAATGCTA * ************** * **** ****** ******************* **** *** ENST00000374865.4 CCAGAACTGTTCTCTAAACCCACTTTTTCTGTAGAGGAATGTATCATCTTTTTTTTTCTC ENST00000431951.1 TCAGAACTGCCCA-TAAACCTACTTTTTCTGTAGAATTGTGCATCATCCTTTTT--TCTC ******** * ****** ************** ** ****** ***** **** ENST00000374865.4 ATATTACAAATGGACA---AATAACGGA-CTTTCTATTTTCATATTTGCTGAAACCATTT ENST00000431951.1 ATATCGTGAATCAATAGAGAATAACAGAATTTTCTGTGGTCATGTTTGCCAAAACCATTT **** *** * * ****** ** ***** * **** ***** ********* ENST00000374865.4 TTT----AAATGAAATTAGGTCATTA----TTTATGAAAAGTTT-----TGAGAGGGCAC ENST00000431951.1 TTTTAAAAAATGGAACCAAGTCATTAATAACTTAGGAAAATCTTCTTCTTGAGAGGATAC *** ***** ** * ******* *** ***** ** ******* ** ENST00000374865.4 TGT---CAACTTGGGTTTAAGACAGGAGGACATTGCAAGTTCACACCTTTCATAAGCATA ENST00000431951.1 TGTAATTAACTTGGATTTAAGAAACGAGGACACTGCAGGTTCAGACCCTTCATACGCATA *** ******* ******* * ******* **** ***** *** ****** ***** ENST00000374865.4 AAGTAGT---TGCAAGAAAGTATTTTCATCCTGTTAGGATTC--ATATCTAAGATAGAGT ENST00000431951.1 AAGTAGTGGTTGCAAGAAAATGGTTTAATCCTGTTAAGACTCTGAAATCTAAGATAAAAT ******* ********* * *** ********* ** ** * ********** * * ENST00000374865.4 TATG---CATTGCACATACACAAATAA----ACTTTTATTAGAT-AGATACCTATAAAAG ENST00000431951.1 TATTATTTATAGCACACATAAAAATAAGGAAAATTATATTAGGTTAGATATTTATAAAAG *** ** ***** * * ****** * ** ****** * ***** ******** ENST00000374865.4 AAACATAAAAGT--ATGTTGTGTATTACTGACAGTTCTAGATTAATTTCTTTTAGAATTA ENST00000431951.1 AAACATAAAAGTCTGTGTTGTACATTACTGTCCAATCTGGATTAATTTCTTTTGGAATTA ************ ****** ******* * *** ************** ****** ENST00000374865.4 AAGTAGATTTGTTAAAGTGTATTGTGTGTTGTAAATTTTTTAAGTGAAATTTGCTTGCGC ENST00000431951.1 AAGTAGATTTATTAAGGTGAAAAAAGTG-----AACATCCT----GAAA---------GC ********** **** *** * *** ** * * **** ** ENST00000374865.4 TCTGCCTTGCCATTTCTTTCCAGTAAGTATAATTTTGAAAAAATTAGAATATATGCCAAA ENST00000431951.1 CCCGC--TGATATT-------AATAA-TATTATTACGAAAACG----------------A * ** ** *** * *** *** *** ***** * ENST00000374865.4 TATTGAGTGCTGTGACTCTTCCTCATAAGAGATGTGCCAGATTCTATGTCTAATTGCATA ENST00000431951.1 TGTTGGA-------------------GAAAGAT-TATGAGGTTATATAAC------CATA * *** * **** * ** ** *** * **** ENST00000374865.4 TTCTCTTCAGAGGAGATGATGCTTATTTTAAACCTTTTTCTCTATAACTTTTAAAAAGTG ENST00000431951.1 TTTTTT-----GTAAAT-ATTTCTGTGCCAATACATTAGCACTATAGAT------GACTT ** * * * * ** ** * * ** * ** * ***** * * * ENST00000374865.4 GTGCTGAGTATTCACTAGAGTGGCAAGTCTTTGTGCTTTAATGCACTCAATTTGTG--GA ENST00000431951.1 GTACAGA-TTTCTAC-AAAATAATAA-----------TTATTGC---TAATTTGAGAAGA ** * ** * * ** * * * ** *** *** ****** * ** ENST00000374865.4 AATTACTTAAATAGCAGGTTATCAGATGGTTCTGAATGACAAAGGTGTTAAATTTGGGAT ENST00000431951.1 AATTA---AAATTCTGTGTAGTC------TTCTAAAC------TCTTTTAAAACTGTAAT ***** **** ** ** **** ** * ***** ** ** ENST00000374865.4 TTTTTTTTCAAGCTTTAGATATGGCTGGAGAGTAATGAGACAGAAGGAATGTCTTATATT ENST00000431951.1 CTCTT----AAACTTTA-------------AGTAA----------------------ATT * ** ** ***** ***** *** ENST00000374865.4 GTTCTGACTGCTGACAATTCCTAAAGAAAAGTGATAGAAGGGTTTTTAACAAAATA-AGT ENST00000431951.1 A--------------AATCTCCAGTTAAAAAC----------TTTCCAGCAAAGTACAGA *** * * **** *** * **** ** ** ENST00000374865.4 TGCATTTATTCTCTTTCCCAGGGTTACTCCTTTGAAGAGGGCAAAATTCAGTTGGGAATA ENST00000431951.1 TGCAGATGACTTATTGCTGAA------TCCT--AACAAAGTTAAAAT--AGCTAACTATA **** * * ** * * **** * * * ***** ** * *** ENST00000374865.4 T--AAATTCTGGAATCTTCATGAAGAAAATTAGTTAACAGTATAGACATGCCCTACAAAT ENST00000431951.1 TGTAAATTCCAAA-----CAATAAGAAATCTGGCCAG----AT-GAGGTGGCTCACTCCT * ****** * ** ****** * * * ** ** ** * ** * ENST00000374865.4 ATCATCCACAGGCACTTCATTCAAGAACTTCAGGTGTCAGAGTGCCTGGAGCTCTGGAGC ENST00000431951.1 GCAATCC--TAACACTTTG----GAAGGCGAAGGAGGGAGGATCGCTTGAGCCCAGGAGT **** ***** * *** * ** * ** **** * **** ENST00000374865.4 TTAGACATTAGAGTTGATTCCTTG-GGGATTGGTTCCAGGACACCTACTTGGATACCAAA ENST00000431951.1 TCAGA-GCTAGAGTG---CCCTAGTGGGAT---------GATAGCTTCT----------- * *** ****** *** * ***** ** * ** ** ENST00000374865.4 GTCCACAGATGCCCAAGCCCCTTTTATAAAATGATGTAGTATTTGCATATTATGTATGCA ENST00000431951.1 ATCCATAG-TGATCCAGCCT--------GAACGACAGAGTG------------------- **** ** ** * **** ** ** *** ENST00000374865.4 CATCCTCCCATATACTTTAAATCATCTTTAGATTACTTATACTGAATAGAATGTAAATAG ENST00000431951.1 -----------AGACCTTG-----TCTCTAAA-----------AAATAAA---TAAGTAA * ** ** *** ** * **** * *** ** ENST00000374865.4 TATTTACAATTGTGAATACAATGTATTTAGTTATGTAAATATGTAAATTTTAAAGTTATG ENST00000431951.1 GA----CAACTAT---TTGAATTTATTTTATGAGCTGAATAT-TATCTTGACATGTTTGG * *** * * * *** ***** * * * ***** ** ** * *** * ENST00000374865.4 TAAATATGTAGCTATGTAAATAGCTATAAAATAATATTTACAATTGTGAATAGTATGTAA ENST00000431951.1 TAAGAGTAT---TAGGGAAA-AACTGTAGTCCAATGTAACTCATAGAACATAG-ATGAAA *** * * ** * *** * ** ** *** * ** * **** *** ** ENST00000374865.4 ATAGTTGTGAACATAACTATTGTGAATAATATGTTATATGTTATAGTTGTGAATGTAAAT ENST00000431951.1 ACATCTTCAAATACGA-------GAACCCTA-GTC--------CAGTGATATATTTAAAA * * * ** * * *** ** ** *** * ** **** ENST00000374865.4 AGTATTCACAATTGTGAATACAATGTAAATAGCTTTCACAATTGTGAATACAATGTAAGT ENST00000431951.1 AG-----ACAAT-------ACAACCAAAGTAGATTCATC--CTAGGAATTCAAGTTTGGT ** ***** **** ** *** ** * * **** *** * ** ENST00000374865.4 AGCTATGTAAATAGTGAATACAATGTAAATAGCTATGTAAATAGTTGTTATGCTGATTAG ENST00000431951.1 --TTA---ACATGCTAAAATCAATATATGTAG---TATAA--------TACATTAAC--- ** * ** * ** **** ** *** * *** ** * * ENST00000374865.4 GGAATAATGAGAAGGAAAAAAAGTATACATATT-CAGTACAGATGCAGTCATCTTTTTTT ENST00000431951.1 ---------AGAAGGAAGAAAAAGGAACATATGACTGAATAGATACAGAAATG------- ******** **** ****** * * * **** *** ** ENST00000374865.4 CCCCTCGAACATTTTTGATCCACAATTGGTTGAATCCACAGATGGGGAACACACAGTCTT ENST00000431951.1 ------GGA----TTTGAT----AAATGA--AAGTTTA-AAAAGGAAAATA-----TTTT * * ****** ** ** * * * * * ** ** * * ** ENST00000374865.4 GGTAAATTTAACCAACAAGGAGGGTAAACGCATCCCAACAGGGAAGGTAAACTGCACATC ENST00000431951.1 AGTAAAGTCAA--AATTGGAAGG--AAAT--TTCTCAACTTGATAAAGGAATTTTGCAA- ***** * ** ** * *** *** ** **** * * ** * ** ENST00000374865.4 CATCAGTACCTCTAGAGGGCATCACTGGTTTATAGCTCAATACAGTGACTATATCAGAAT ENST00000431951.1 ----AGTAC-TACAGTGAAAATAA---------AATTAAATG--GTAAA-ATGTTGCAA- ***** * ** * ** * * * *** ** * ** * ** ENST00000374865.4 AATGGCCTTTAGTTTTCCTGA--AAGATTAAATTAGGCTTGCTGTTGTTGAATGAGATAA ENST00000431951.1 ----GCTTTC--TCTCTCTGATTAGGAGTAAGGCAAGGATGCT--TGTT---TGTAGTCA ** ** * * **** * ** *** * * **** **** ** * * ENST00000374865.4 TCAAACATATGATGTAATTTTAAAGGGTTTACATACAGAAGGCCTGCTGTATGTCCTGCT ENST00000431951.1 GCAAAGATG----GCAA----AAAGAATTAAAAATAATAAGAACTAG------------- **** ** * ** **** ** * * * *** ** ENST00000374865.4 TCTGCTGTGTAAAAGATTCAGCATGGAATCATTGGAATTTTATGTACAGGATTTCATTAT ENST00000431951.1 ----------AAAAGAA-----ATAAAATCATCA-----TTATTCAAA----TATATTAT ****** ** ****** **** * * * ***** ENST00000374865.4 CTCATTTTCTATACAATTTTTCCTTCTGATCCAGAGACACGGAAAAACAAAGGGCAAGAT ENST00000431951.1 GTTTTTATATGTATAAACTC-CAAAATAATCTATAAATA----AGAATGAAG---AAGT- * ** * * ** ** * * * *** * * * * * ** *** *** ENST00000374865.4 GGAAATAAGGGATGAGAAGGTCTATGTGGAAAAACAGTTACAACTGGAGTGGTAACTGCA ENST00000431951.1 -GAGTTACTGGATG--------TATATTCAAAA-----TGCAA---GAGT--TAATTGTA ** ** ***** *** * **** * *** **** *** ** * ENST00000374865.4 AAAACCAAGCAGCTTCATGTGATCGTTAGGACAGAAGAAATTTCTCCTTTGTAGCCTAGA ENST00000431951.1 T-----------TTTTGTGTGCCAGCAAAAACA-ATGAAACTT-------------TAA- ** **** * * *** * **** ** ** ENST00000374865.4 GCAATATTCTCAAAATTTAATGCGCATGTTAATCATTTGGGGATCTTTTATTCATTTTTT ENST00000431951.1 --AATATTC----AATTTA-----CA----AATCACATCAAGATGT-------------- ******* ****** ** ***** * *** * ENST00000374865.4 CATGTGGGGATCTTTTAAAAATGCAAATTCTGATTTGGTAAGTCTGGAGTAGGTCCTGAG ENST00000431951.1 ---------ATCT-----------AAAACCTAAT--GGTAAATCT--AATAG-------- **** *** ** ** ***** *** * *** ENST00000374865.4 CTTCTGCATGCTTCAAAAGCTGATTATGTTTTGAGAACATGGATCTAGATGCTGGTATTG ENST00000431951.1 ---------------AAA------------TTGAA-----------------------TG *** **** ** ENST00000374865.4 AGGTGGGAGACAAGTACTGCCACCTGAAACAACAGTCTTGGTAAATTTAGCCGACGAGGG ENST00000431951.1 AGATG---------TATTACTAT---------------------ATTCAGCC-------- ** ** ** * * * *** **** ENST00000374865.4 TAAACACATCCTAACAGGGAAGGTAAACTGTACGTCCATCAGTACCACTAGAGGGCATCA ENST00000431951.1 --------------------------ACTCTGTGTCT-----TACGATTGGAAATGTTAA *** * *** *** * * ** * * ENST00000374865.4 CTGGTTTATAGTTCAATACAGTGAATATATCAGAATAATGGCCTTTAGTTTTCCTGAAAG ENST00000431951.1 TTTATTTA-AATTCAA---GGTAATTAT-------TAATA------AGT-------AAGC * **** * ***** ** * *** **** *** ** ENST00000374865.4 ATTAAATTAGGCTTGCTAACTTGTTTAATGAGATAATCAGACATATGATGTAATTTTAAA ENST00000431951.1 ACT---TTCTACT-GCCACTTTGTTAAGTGATTT--TCAG----------TTGTTTCAAA * * ** ** ** * ***** * *** * **** * *** *** ENST00000374865.4 GGGTTTACATTTTTAAAAATTTAATGATTGCTACATAAAAAGGGTATCAGTTAACTAATT ENST00000431951.1 G-------ATT-------ATTTATT--TTGTTA-------------------------TT * *** ***** * *** ** ** ENST00000374865.4 TTACTTAGATGGAACTTCTGTAAGCTTAGTAGGTATGCTTAAATAAAGCCTGCTAATAAA ENST00000431951.1 TCACT---------CTTC------CTTGCT--GTCTTCCT---------TTG-TGGTGAA * *** **** *** * ** * * * ** * * ** ENST00000374865.4 ATAGAGATTCAGACTCAATAGAATGGTTTTACATATGTAATATATGTTTTAAACTGCATA ENST00000431951.1 GTA------------------AGTGATTTT-----------------CTTG--------- ** * ** **** ** ENST00000374865.4 AAATAAACTCCTCCCTCCTTTC ENST00000431951.1 ----------------------