CLUSTAL 2.1 multiple sequence alignment ENST00000375436.4 CGCACATGTGTTTCTGTTTTGTGTTGTAGCATTTGTTCTGGAAGCTCGTATTTACATTTT ENST00000418112.1 ------------------------------------------------------------ ENST00000375436.4 AAGTGTATCTGGTGAGTGGGCTGGAGCCCTCGTCTGGGCCGGAAAAAAAAAAGCCCTCCG ENST00000418112.1 ------------------------------------------------------------ ENST00000375436.4 ATCCGTCTTTTAGTTGCTTCTCTTCCTTTTTTCTCTCCGGTTTCTCATCACTCCAACCAG ENST00000418112.1 ------------------------------------------------------------ ENST00000375436.4 CCGCGACCATGCCCAGGAAGAAGGCGGCGGCGGCGGCCTGGGAGGAGCCGAGCTCGGGCA ENST00000418112.1 ----------GCCCAGGATGAAGACTG-GGCAGTAGCCTGGGAAGAACCGGGCTTCGGTA ******** **** * * *** * ******** ** *** *** ** * ENST00000375436.4 ACGGCACTGCCCGCGCCGGGCCCAGGAAACGCGGCGGCCCG-----GCGGGCAGGAAGCG ENST00000418112.1 ACCACAGGGGCCCCAGGCGGCCCGGGAAGCGTGGAGGTCCCAGCGTGCGGGCAGAAAGCC ** ** * ** * ***** **** ** ** ** ** ******** **** ENST00000375436.4 CGAGCGGCCCGAGCGCTGCAGTAGCAGCAGCGGCGGCGGCAGCAGCGGCGACGAGGACGG ENST00000418112.1 CAAGAGGCC-GAGCGCTGTGGCAGC----------------------------------- * ** **** ******** * *** ENST00000375436.4 CCTGGAGCTCGACGGGGCCCCCGGCGGGGGCAAGCGCGCGGCGCGGCCGGCGACA---GC ENST00000418112.1 --------TCCATGGGGCCCT-GGCGGAGGCAAGGGCACAGCGTGGCTGGCTGCATATGT ** * ******* ***** ****** ** * *** *** *** ** * ENST00000375436.4 AGGCAAGGCGGGCGGCGCGGCCGTGGTCATCACCGAACCCGAGCACACCAAGGAGCGCGT ENST00000418112.1 GAACAAGGTGAGCGGCGGGGCCGCGGTCGTCGCGGAGTCTGAGCACACCAAGGAGCGCAT ***** * ****** ***** **** ** * ** * ****************** * ENST00000375436.4 CAAACTTGAAGGGTCAAAGTGCAAAGGG-CAGCTTTTGATTTTTGGGGCAACCAACTGGG ENST00000418112.1 CAGACTTCAAGGGTCGAAGTGCAAAGGGGCAGTTTTTGATTTCGGGGTCAACCAACTAGG ** **** ******* ************ *** ********* *** ********* ** ENST00000375436.4 ACTTGATTGGTCGAAAAGAAGTGCCTAAACAGCAAGCTGCTTACCGCAATCTCGGTCAGA ENST00000418112.1 ACTCGATGGGTGGAAAAGAAGTGCCTAAACAGCAAGCTGCTTACCTCAATCTCGGTCAGA *** *** *** ********************************* ************** ENST00000375436.4 ATTTGTGGGGGCCCCACAGATATGGGTGCCTGGCGGGGGTCCGGGTGCGGACAGTGGTCT ENST00000418112.1 ATTTGTGGGGGCCCCATAGATGTGGGTGCCTGGCGGGG-TCCTGGTGCGGACAGCGGTCT **************** **** **************** *** *********** ***** ENST00000375436.4 CGGGCTCGTGTGCTGCACACAGCCTCCTCATCACCACGGAAGGGAAGCTGTGGAGCTGGG ENST00000418112.1 CGGGTTTGCGCACTGCGCACAGTATCCTCATCACGACACGATGGAAGCTGCGGAGCTGGG **** * * * **** ***** ********** ** * ******** ********* ENST00000375436.4 GTCGAAATGAGAAGGGGCAGCTGGGACATGGTGACACCAAGAGAGTAGAAGCCCCTAGAC ENST00000418112.1 GTCAAAATAAGAAGGCGCAGCTGGGACCTGGTGACACCAAGAGAATGGAAGCCCCCAGAC *** **** ****** *********** **************** * ******** **** ENST00000375436.4 TCATCGAGGGTCTTAGCCACGAAGTGATTGTGTCTGCAGCATGTGGGCGGAACCACACCT ENST00000418112.1 TCATTGCGGGTCTCTGCCGGGAAGTGAGTATGTAGGCAGCCTGTGGGCGGAACCTCACCT **** * ****** *** ******* * *** ***** ************* ***** ENST00000375436.4 TGGCCTTGACGGAAACGGGCTCCGTGTTTGCGTTTGGGGAAAACAAGATGGGGCAGCTGG ENST00000418112.1 TGGCCTTGACGGAAACGGGCTCTGCGTTTGCCTTTGGGGAGAACAAGATGGGGCAGCTGA ********************** * ****** ******** ****************** ENST00000375436.4 GCCTTGGCAACCAGACAGACGCTGTTCCCAGCCCCGCGCAGATAATGTACAACGGCCAGC ENST00000418112.1 GCCTCAGCAACCACGCAGGAGC-ATCCCCAGCACCGCACAGATCATGGACAACGGGCAGC **** ******* *** ** * ****** **** ***** *** ******* **** ENST00000375436.4 CAATTACCAAAATGGCCTGTGGGGCTGAATTCAGTATGATAATGGACTGCAAAGGAAACC ENST00000418112.1 CAATTACTAGAATGGCCAGTGGAAATGAATTCCGT---ATAATGGGCGACAAAGGAGACC ******* * ******* **** ******* ** ******* * ******* *** ENST00000375436.4 TCTATTCCTTTGGGTGCCCTGAATATGGTCAGCTGGGACACAACTCAGATGGGAAGTTCA ENST00000418112.1 TCTGTTCCTTCGTGTGCCCTCAATGTGGTCAGCTGGGAC--------------------- *** ****** * ******* *** ************** ENST00000375436.4 TCGCCCGGGCACAGCGGATAGAGTACGACTGTGAACTAGTTC------CCCGGCGAGTGG ENST00000418112.1 ----CCAGGCACAGTGAATAGT-TAAGGCTGTGAGCTGGTGCTGGTGCCACGATGAGTGG ** ******* * **** ** * ****** ** ** * * ** ****** ENST00000375436.4 CC-ATCTTCATTGAGAAGACGAAAGATGGACAGATTCTGCCTGTACCAAACGTGGTTGT- ENST00000418112.1 CCCACCTTCACTGAGA--ATGAAAGATGGGTAGATTCTGCCTGTACCAAAGGTGGTTGTG ** * ***** ***** * ********* ******************* ******** ENST00000375436.4 ------------------------ACG--------AGACGTGGCCTGTGGCGCTAACCAC ENST00000418112.1 GGGTCAAGAACCCACCAGCCAATAACGGTTGTGTAAGACGTGACCTGTAATGCTAACCAC *** ******* ***** ********* ENST00000375436.4 ACGCTGGTCCTGGACTCCCAGAAGCGAGTCTTCTCCTGGGGCTTTGGTGGCTATGGCCGG ENST00000418112.1 ACATTGATTCTGGACTCCAAGAAATGAGTCTTCTCCTGGGGCTTTGGTGGCTATGGTTGA ** ** * ********* **** ******************************* * ENST00000375436.4 CTGGGCCACGCAGAGCAGAAGGATGAGATGGTCCCCCGCCTGGTGAAGCTG---TTTGAC ENST00000418112.1 CTGGGCCACTCAGAGCAGAAGGATGAGATGGTCCCC-GCTTGGTGAGGTTGGAGTCTGAC ********* ************************** ** ****** * ** * **** ENST00000375436.4 TTCCCTGGGCGTGGGGCTTCCCAGATCTATGCTGGTTACACCTGCTCCTTTGCTGTCAGT ENST00000418112.1 TTCCTTGGGTGTGGGGCATCCCAGATCCATGTTGGTTACACCTGGTCCTTTGCTGTCTGT **** **** ******* ********* *** ************ ************ ** ENST00000375436.4 GAAGTGGGTGGTCTGTTTTTCTGGGGGGCCACCAACACCTCCCGTGAATCTACCATGTAC ENST00000418112.1 GAAGTTGGTAGTCTCTTTTTCTGGGGGAGC-CCAATATCTCCCATGAATCTTCCATGTAC ***** *** **** ************ * **** * ***** ******* ******** ENST00000375436.4 CCAAAAGCAGTGCAGGACCTCTGCGGCTGGAGAATCCGGAGCCTGGCTTGTGGGAAGAGC ENST00000418112.1 CTGAAAGCAGTGCAGGACCTCTGCGGCTGCAGAATCCAGAGCCTGGCTTGTGGGAAGAGC * ************************** ******* ********************** ENST00000375436.4 AGCATCATTGTGGCCGCCGATGAGAGCACCATCAGCTGGGGTCCGTCACCGACCTTTGGG ENST00000418112.1 AGCAACATTGTGGCCGCCAATGAGAACACCATCAGCTGAGGGCCATAACCAACCTTTAGG **** ************* ****** ************ ** ** * *** ****** ** ENST00000375436.4 GAACTGGGCTACGGGGACCACAAGCCCAAGTCTTCCACTGCAGCCCAGGAGGTAAAGACT ENST00000418112.1 TAATTGGGATACAGGGACCATGAGCCCAAGTCTTCCACTGCAGCCCAAGAGGTGAAGACT ** **** *** ******* ************************* ***** ****** ENST00000375436.4 CTGGATGGCATTTTCTCAGAGCAGGTCGCCATGGGCTACTCACACTCCTTGGTGATAGCA ENST00000418112.1 CTGAATGGCATCTTTTCAAAGCAGGTCTCCATAGGCTACTCACACTCCTTGGTGATAGTG *** ******* ** *** ******** **** ************************* ENST00000375436.4 AGAGATGAAAGTGAGACTGAGAAAGAGAAGATCAAGAAACTGCCAGAATACAACCCCCG- ENST00000418112.1 CGAGATGAAAGTGAGACCAGGAAAGAGAAGATCAAGAAACTGCTAGAGC-CGGTTGCGGT **************** *********************** *** * * * ENST00000375436.4 AACCCTCTGATGCTCCCGGAGACTCCTCCGACTCCACACCTCTCGCGGCAGCTG--TCAT ENST00000418112.1 GGCTCACTTGTAATCCC---AACACTTTGGG----AGGCC----GAGGCAGGCGGATCAT * * ** * **** ** * * * * ** * ***** * **** ENST00000375436.4 TT----CCATGTGCACTGGGACGGGA--AGTCAA-ACGAGGAA------TTT-----AAA ENST00000418112.1 CTGAGGTCAGGGGTTC-GAGACCAGCCTGGCTAACATGGTGAAACCCCGTTTCTACTAAA * ** * * * * *** * * ** * * *** *** *** ENST00000375436.4 AAAGCAAA-----AGTTGACC--GAAGGTGCATTTTTGT---TTAGACT--CCCTGAGGT ENST00000418112.1 AATACAAACAAATAGCTGGGCATGGTGGCACATGCCTGTAATCCCAGCTAATCGGGAGGC ** **** ** ** * * ** *** *** ** * **** ENST00000375436.4 TCCGTTTTACACAT-GATCCAACGTTAACTACCTTTTTTTCTGTATGCTTTCCAAAGTCC ENST00000418112.1 TGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCAGTGAGC----CGAGATCA * * ** * * *** ** * ** ** * * ** ENST00000375436.4 TTTTTTTTCCCTTAATGTTGAATTAAAATACTTGCTCATAGTTGATTTACCATTCCTACA ENST00000418112.1 CGCCATTGCACTCCAGTTTGGGC---AACA-------AGAGTGAAACTCCAACTCAAAAA ** * ** * *** ** * * *** * * * * ** * * ENST00000375436.4 AAAGAGGCAGAAACTTTGAGCAAT--CTAGGTTTTTTTTTTTTTTAAGTTTTTTCTTTCT ENST00000418112.1 AAAGAAAAAAGAAAAGAAAGAAACTGCTAGAATACAACCCCT---GAACCCTTTGATGCT ***** * ** ** ** **** * * * *** * ** ENST00000375436.4 TCCTCTCCTGAATACACTCCCCAAAACACCCCTTTCC----AGTTACAATTAGCATCGTG ENST00000418112.1 ------CCTGGGGACTCCTGCAACTCCACCCGTCTCCCAGAAGCTGTCATTTCCTGTGCA **** ** * * * ***** * *** ** * *** * * ENST00000375436.4 ATCCAAGCAGATGCCACATGGAAGAGGAATCGCCATTTACTCAGAAAAAATGTCCCTTAC ENST00000418112.1 GTGGGAGGTGAAGTCAAACA----AGGAAT-----TTTA-------AAAA--------GC * ** ** * ** * ****** **** **** * ENST00000375436.4 AGGAACCGGCAGCAGCTAGGCAGTCACCGGCCCGCCTCCATCCAAAATCACGCTCGCGTG ENST00000418112.1 AAAAGTTAGCCAAAGTT--GCATT--TTTGTTAGACTCC--CTGAGGTTCCATTT----- * * ** ** * *** * * * **** * * * * * ENST00000375436.4 CTTCGGAAGCATCCGG-GTCACT---CCTTCTCCGCTTTTTCTTGCAGATGGGCCTAGGC ENST00000418112.1 -TTACAAGGGATCCAATGTTAATTATCCTTTTCTGCATACTTTTAAAA------------ ** * * **** ** * * **** ** ** * * ** * ENST00000375436.4 CGGTGTCGGTTCTGTTTCTCCCCTTGGCTGCCTGTA-----CGCCCACAGCCTTCTGGC- ENST00000418112.1 ----GTCTGTTTT-TTTCTCTTCATGTTTAATTAAAATATTTGCTCATA----TTTGGAA *** *** * ****** * ** * * * ** ** * * *** ENST00000375436.4 ----TGCGA--CATTATAGAATCG-----GCCGTGTCC---CCCCTGGTGGGGGATTGGG ENST00000418112.1 AAAATATGAATTGTTATAAAATAGTGGAAAAGATATCCAGACTCCCAGTGAGG-ACTGTG * ** ***** *** * * *** * ** *** ** * ** * ENST00000375436.4 GATC----TGTGTTTAGCC---ATTTAT---ATCTACTTTAGCTGTTAAAGAGGTCCAAA ENST00000418112.1 TTTCCCATTATGCTTCACCCAAATTAACTCAGTCAATTCTAACTTTCAGGAGTATTCACT ** * ** ** ** *** * ** * * ** ** * * * ** ENST00000375436.4 TGAAAATCAGGTGATTGTGGAACCATGGGGACTTGGGGGTGGGGCAGAGGTGGGAACA-T ENST00000418112.1 TG----TTATGCCCCACTTCCAC-ATAGCGATTTTTCCAT----CAG-GATGTTATTAGT ** * * * * ** ** * ** ** * *** * ** * * * ENST00000375436.4 TTGTATCAGTTGAGT--CAGCTTGG--TGGCTCCCTGTGGAGCCAG-GGCTGAGCCTTGT ENST00000418112.1 TCCTAGTAATAGAAATGCAATTCAGACTAGTTTAA-GCAGAAATAGTGAATTCACTTTGT * ** * * ** ** * * * * * * ** ** * * * **** ENST00000375436.4 CACGCGCACTCGCCAATTAAGAGATGGACCAGCCAGCAGTCAAGTGCATTCTCCAGTCCT ENST00000418112.1 CACA-GAACTGGA-AACAAAGAAGTG-------CAGGGGTAAAGTG---GCTGTAA---- *** * *** * ** **** ** *** ** ***** ** * ENST00000375436.4 TGCAAGAAGGATCAGCCCTTTCTGTGCCAGCCTCGATCGCCTTGTGCTTTGGTCTCTT-- ENST00000418112.1 -GCAGCTAGAACTAG--------------GGCTCAA--GCAGTGTGTTTACAACTTGTGA *** ** * ** * *** * ** **** ** ** * ENST00000375436.4 -TTTCTCCCCCCCGCCTGGATC--CTGCCTCGCGCGGGCCGTCCTGTTGCTGAGACTCGG ENST00000418112.1 CTGTTTTCACCCCGT-TGGACTAGCTGTCTCCAGACAGCAGGCATGAAAGCAGG---CAA * * * * ***** **** *** *** * ** * * ** * * ENST00000375436.4 GGTACCGTTCTGCTGACCCAGCTCCCTTTAGTCACGTTTGCTTGGCTCTGGTACCAAATA ENST00000418112.1 GATAGCTCTCAG------CAACACTCT-------CCTTCACTCAGATTAGGAACC---CA * ** * ** * ** * * ** * ** ** * * ** *** * ENST00000375436.4 GTTGGGATTACCGAAGAGTCCCCTTCCTTGCGTGTCAGCACGGATGCTGTGACTGCCACC ENST00000418112.1 GAAGAGAGT----GAGAGTCT------TTG-GTAATAGCTC---TGTCAAGGAAGTAA-- * * ** * ****** *** ** *** * ** * * * ENST00000375436.4 TGCGTCCTCGTCAAGTGCCCGAGCTCGCCGCCGTGTGTGCTGCGCTGAGTGAGTTATGAG ENST00000418112.1 ----TCCTGGG-AAGAACTCTGACTGGCCAACATGCATCATGC-TGGAACCAATGGTGAT **** * *** * * ** *** * ** * *** ** * * *** ENST00000375436.4 GTGCCTTTCCCGGAACCCTCCTCTCGCCTGGACCCAAGAGAGGCGACAGCTGTGGCTGGG ENST00000418112.1 G-GCCT-----GGGGC-------------AGACTGAATGGAAG-GGC--CTGAGACATAA * **** ** * *** ** ** * * * *** * * ENST00000375436.4 GCTCTTGGTT-TCCAGAGGGTCTGGACTGGTTTGGGTGCTTTAAAATAGATATTTAGTTC ENST00000418112.1 ACTCATCCCTGTGCAGAGAA---GAAGCAA---GAGAGGAATGAGAGAGA---------C *** * * * ***** * * * * * * * * *** * ENST00000375436.4 AGTGGTGCTTATGGGGGAGATGGGA---CTAGAACTTAAGTGTGAGACTTGGGTGGATGG ENST00000418112.1 AGTGG-------GAGGGGGATGGAAAGGCAAGAGGGTAGGAGCGAG---TGGAACAAGAG ***** * *** ***** * * *** ** * * *** *** * * ENST00000375436.4 GAAAGTTAA--ATATTGGTCTCTTCAAGTTTTTTTTTTCTTTTGCTTTGTTACCACTTGT ENST00000418112.1 CAGCACTAAGGAGAAAGGAATCATAAGGAACTACAATCCTGC--CTCAATCACCAGAAAT * *** * * ** ** * * * * * ** ** * **** * ENST00000375436.4 -CACTGTCTCCATGTTAAAATGCCAAAAATGATGTAGTTGTTGTTGCTTTTTTCCCTATT ENST00000418112.1 ACGTTGCCCC------AAGAAGC---AGGCAAAATAAGAGATGT---------------- * ** * * ** * ** * * ** * *** ENST00000375436.4 TTCCACCCCAGTCGCTCCTTACCGTGACTCCTGCCCTTGGAGGGCATGTAGCAGTGTCTG ENST00000418112.1 -----CTGCA----------ACAGGGACTTTC--------AGGGCGTGGAG--ATAAATA * ** ** * **** ***** ** ** * * ENST00000375436.4 TCCTGCCAGTCCCAAGGCCCTGTGGGAGGAGACTGGCCTGCATCTCTCTAAGACTT-AGT ENST00000418112.1 A------AATTTAAAAGCTATT-----GGAACCCCCCCCAGAACACATTAAGCCCTGAGT * * ** ** * *** * ** * * * **** * * *** ENST00000375436.4 CTGACGCCACGCGCATCTCTTGTTCTGTGTTCAATCAGTAGTCCAGGGGAGAAGCTTCTG ENST00000418112.1 GAGATGTGAC--------TATGATCTG---------AGTCACACATGGTTACAACTTCTG ** * ** ** **** *** ** ** * ****** ENST00000375436.4 CTACTTCAGAGCTTTGCTAAACTAACCTAATTTGTCCAAATCACCCCAAAAC--CACCAT ENST00000418112.1 TT--CTCAGA-------TAGATTAACTCACTTTCTT---ATTTTTCTTGTTCTGCACAAT * ***** ** * **** * *** * ** * * *** ** ENST00000375436.4 CTCTGACGTAAGCTT--CCATGCGACAGCCTGATCCGTTTCCCTGGACAGGTCTCTTTCC ENST00000418112.1 GACTAGAGTGAATTCAACTACACCACAGATAAAT--GCCTCCT-------GCCTTCTTCA ** ** * * * * * **** ** * *** * ** *** ENST00000375436.4 TGGAATGCAGCCCAGGCACCTGTGCTCCTGGCACCCTTGAGGTCTCTCCTTTGAGCCGTG ENST00000418112.1 TT-AATG--GCCCTGGT-CATAGATTCACTTCCCCTTTGCTGCCTCAC-TTTG---CTTA * **** **** ** * * ** * ** *** * *** * **** * * ENST00000375436.4 GTCACCGAGAGGGTTGAGGACGCAGCACCCGAGGTCCCAGCCTTTGCAGGAGCCTCCCTG ENST00000418112.1 G--ACC-AGATGACAAAAAACGCATGACT----ATTACACCCTCTGTGAAA--------- * *** *** * * ***** ** * ** *** ** * ENST00000375436.4 GGCTTAGCTGGACTTAGATCTTCGGTGGCCTCATGTAAACGTGGCAGCCAGCCTCTTCTA ENST00000418112.1 -----AG-TG---TTAAATGTCCCCTTCCCAAAAGGAAACACTGC------------CTA ** ** *** ** * * * ** * * **** ** *** ENST00000375436.4 GAACCCTAGCCCAGGGACTGGAGCAGGAAAGGGACCTTCAAAGTGAAGACTGCCTTG-TC ENST00000418112.1 TAACC--AATCAAATTGCTGTAACTATGCACCAACCTT--GTGTAAATAGTGTTGTAATC **** * * * *** * * * ***** ** ** * ** * ** ENST00000375436.4 CCGCAGCTCCTTCTGGCTTAGATTGAA-AAATGGGCTTCCTAATGGGTTAAATCCTTTAA ENST00000418112.1 CCACTAAAATCTCTGTCTCTGTCTAAATAAATGAAATC---------TTAACTTCCCTAC ** * **** ** * * ** ***** * **** * * ** ENST00000375436.4 AACAAGGAGTTGTGGGGGAAGGGTGTCGTGCACTCCTAGAGAAA-GGTACACAGTTGCCC ENST00000418112.1 TTCAA-------------AATGCTGAC-TCCATTCCTTTGGAGTTGGT-----GTT-TCT *** ** * ** * * ** **** ** *** *** * ENST00000375436.4 GGTTGGGAATGTGCTTGGCGCTGACCCTGCGGGCATCTGACTGGTCTTCCAGCTCAGGAA ENST00000418112.1 GG--------GTGGTCCGTCCTCACTGTTTGAGC--TTGAATAAACTCTC--TTTA--AA ** *** * * ** ** * * ** *** * ** * * * ** ENST00000375436.4 AAAGAATTTGAAAGAGGCTTAGCGTGAAGGGGAATCAAAGAGGAGGTTGTGATTTGGTCG ENST00000418112.1 TTAGATTCTGAA-----CCTTTTG---------ATTA---------TTTTAGGTTGACAG *** * **** * * * ** * ** * *** * ENST00000375436.4 AAGGTGCCTGGTTTAGTGCTGTAATT-GTCTTATTATTTTTTTTATATATATATTTCTTG ENST00000418112.1 GAGTT--TTGG---AGTACTAGGTTTTAGCTTCCTGCTTCCCTCACTT-CAGATTCCC-- ** * *** *** ** ** *** * ** * * * * *** * ENST00000375436.4 GAGTAAACATTTTAAATAAACAACAACATTGTCTACTGTC ENST00000418112.1 AAAAAAATGATATAG-TAGAAATCTCCATCAGC-ACTG-- * *** * ** ** * * * *** * ****