CLUSTAL 2.1 multiple sequence alignment ENST00000376663.3 CAGCAACTATGAAATAATCGTAGTATGAGAGGCAGAGATCGGGGCGAGACAATGGGGATG ENST00000445879.1 ------------------------------------------------------------ ENST00000376663.3 TGGGCGCGGGAGCCCCGTTCCGGCTTAGCAGCACCTCCCAGCCCCGCAGAATAAAACCGA ENST00000445879.1 ------------------------------------------------------------ ENST00000376663.3 TCGCGCCCCCTCCGCGCGCGCCCTCCCCCGAGTGCGGAGCGGGAGGAGGCGGCGGCGGCC ENST00000445879.1 ------------------------------------------------------------ ENST00000376663.3 GAGGAGGAGGAGGAGGAGGCCCCGGAGGAGGAGGCGTTGGAGGTCGAGGCGGAGGCGGAG ENST00000445879.1 ------------------------------------------------------------ ENST00000376663.3 GAGGAGGAGGCCGAGGCGCCGGAGGAGGCCGAGGCGCCGGAGCAGGAGGAGGCCGGCCGG ENST00000445879.1 ------------------------------------------------------------ ENST00000376663.3 AGGCGGCATGAGACGAGCGTGGCGGCCGCGGCTGCTCGGGGCCGCGCTGGTTGCCCATTG ENST00000445879.1 ------------------------------------------------------------ ENST00000376663.3 ACAGCGGCGTCTGCAGCTCGCTTCAAGATGGCCGCTTGGCTCGCATTCATTTTCTGCTGA ENST00000445879.1 ------------------------------------------------------------ ENST00000376663.3 ACGACTTTTAACTTTCATTGTCTTTTCCGCCCGCTTCGATCGCCTCGCGCCGGCTGCTCT ENST00000445879.1 ------------------------------------------------------------ ENST00000376663.3 TTCCGGGATTTTTTATCAAGCAGAAATGCATCGAACAACGAGAATCAAGATCACTGAGCT ENST00000445879.1 -------------------------ATGCATTGAGCAATCGGAGTCAAAATCACTGAGCT ****** ** *** ** **** *********** ENST00000376663.3 AAATCCCCACCTGATGTGTGTGCTTTGTGGAGGGTACTTCATTGATGCCACAACCATAAT ENST00000445879.1 AAATCCCCACTTAATGTGTGTGCTTTGTGGAGGATACTTAATTGATGCCAGAACCATAAT ********** * ******************** ***** ********** ********* ENST00000376663.3 AGAATGTCTACATTCCTTCTGTAAAACGTGTATTGTTCGTTACCTGGAGACCAGCAAGTA ENST00000445879.1 AGAATATCTGCATTCCTTCTGTGAAACCTGTATTTCGTGTTACCTATAGATCAGCAAATA ***** *** ************ **** ****** ******* *** ****** ** ENST00000376663.3 TTGTCCTATTTGTGATGTCCAAGTTCACAAGACCAGACCACTACTGAATATAAGGTCAGA ENST00000445879.1 TTGTCCTTT----AATGTCCAAGTTCACAAAACCATTATGCT-CTGAATATAACATCAGA ******* * **************** **** ** ********** ***** ENST00000376663.3 TAAAACTCTCCAAGATATTGTATACAAATTAGTTCCAGGGCTTTTCAAAAATGAAATGAA ENST00000445879.1 TAAAAATCCTCAATCTATTGTATACAA-TTACTTCCAGGCCTTTTCAGAAATAAAATGA- ***** ** *** ************ *** ******* ******* **** ****** ENST00000376663.3 GAGAAGAAGGGATTTTTATGCAGCTCATCCTTCTGCTGATGCTGCCAATGGCTCTAATGA ENST00000445879.1 -----GAAGGGATCTTTATGCATCTCTTTATTCAGCTGTTGCTGCCAATGGCGCTAATGA ******** ******** *** * *** **** ************* ******* ENST00000376663.3 AGATAGAGGAGAGGTTGCAGATGAAGATAAGAGAATTATAACTGATGATGAGATAATAAG ENST00000445879.1 AAATAGAGAA---GTTGCAGATGAAGATAAGAGAATTATAACTGATGGCGAAACAATAAG * ****** * ********************************** ** * ****** ENST00000376663.3 CTTATCCATTGAATTCTTT-----GACCAGAACAGATTGGATCGGAAAGTAAACAAAGAC ENST00000445879.1 CTTATCCATTGGATTTTTTTTTTTGACCAGAACAGA----------AAGTAAACAAAGAC *********** *** *** ************ ************** ENST00000376663.3 AAAGAGAAATCTAAGGAGGAGGTGAATGATAAAAGATACTTACGATGCCCAGCAGCAATG ENST00000445879.1 AAAGAGAAGTTTAAGGAGGAGGTGAATGATAAAAGTTATTTACAATGCTCAGCCAGAATG ******** * ************************ ** **** **** **** **** ENST00000376663.3 ACTGTGATGCACTTAAGAAAGTTTCTCAGAAGTAAAATGGACATACCTAATACTTTCCAG ENST00000445879.1 ACTGTGATGAACCTAAGGAA---------------------CATATCTTATACTTCCCA- ********* ** **** ** **** ** ****** *** ENST00000376663.3 ATTGATGTCATGTATGAGGAGGAACCTTTAAAGGATTATTATACACTAATGGATATTGCC ENST00000445879.1 ATTGATGTCATGTATGAAGAGGAATCTTTAAAGGATAAATATACATTAATGGATATTACT ***************** ****** *********** * ****** *********** * ENST00000376663.3 TACATTTATACCTGGAGAAGGAATGGTCCACTTCCATTGAAATACAGAGTTCGACCTACT ENST00000445879.1 TACATTTATATGTGGATAAGAAATGGACTTCTTCCTTTAAAGTACGGTGTTTGACCTATT ********** **** *** ***** * ***** ** ** *** * *** ****** * ENST00000376663.3 TGTAAAAGAATGAAGATCAGTCACCAGAGAGATGGACTGACAAA--TGCTGGAGAACTGG ENST00000445879.1 AGTAAAAGAATGAAGCTTAGTTGCTGGAGAGATGAACTGACAAAAATGCTGGAGAACTGG ************** * *** * ******** ********* ************** ENST00000376663.3 AAAGTGACTCTGGGAGTGACAAGGCCAACAGCCCAGCAGGAGGTATTCCCTCCACCTCTT ENST00000445879.1 AATGTGACTTTGGAATTAACAAGGCCAATGGCCTAGTAGGAGTTATTTCCTCTAGCTCTT ** ****** *** * * ********** *** ** ***** **** **** * ***** ENST00000376663.3 CTTGTTTGCCTAGCCCCAGTACTCCAGTGCAGTCTCCTCATCCACAGTTTCCTCACATTT ENST00000445879.1 CTTGTTTGCCTAGCTGCACTACTCCAATCCAGTCTCCTCATCTTCACTTTCCTCACATGC ************** ** ******* * ************* ** *********** ENST00000376663.3 CCAGTACTATGAATGGAACCAGCAACAGCCCCAGCGGTAACCACCAATCTTCTTTTGCCA ENST00000445879.1 CCAGTATTATGAATGCCACCAGGAACAGTCCCACTGGTAACTATGAACCTTTCTCTGCCA ****** ******** ***** ***** **** ****** * ** *** * ***** ENST00000376663.3 ATAGACCTCGAAAATCATCAGTAAATGGGTCATCAGCAACTTC-TTCT--GGTTGATACC ENST00000445879.1 ACAGACCTAAAAAATCATCAGCAAATGGGTTATTAGAAACTTCATTCTTAGGTTGATAAC * ****** *********** ******** ** ** ****** **** ******** * ENST00000376663.3 TGAGACTGTTAAGGAAAAAAA--------------------------------------- ENST00000445879.1 TGAGACTGTTAAGGAAAAAAAAATCCAGCTCCTAATTTTTTTTTTTTTGAGACAGGGTCT ********************* ENST00000376663.3 ------------------------------------------------------------ ENST00000445879.1 TGCTCTATTGCCCAGGCTGGATCACAGTGGTGTGATCACAACTCACTGCAGCCTAGACCT ENST00000376663.3 ------------------------------------------------------------ ENST00000445879.1 CCTGGGCTCAAGCTATCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACCACAGGTGAGTG ENST00000376663.3 ----------------------------TTTTAAA------------------------- ENST00000445879.1 CCACCATGCCCAACAAATTTAAATTTTTTTTTAAATGTAGAGATGGGGGTCTCCCTATGT ******* ENST00000376663.3 ------------------------------------------------------------ ENST00000445879.1 TGCCCATGCTGGTCTCAAACTCCTGGGCTCAAGCAATCCTCCCTCCTTGTCCTCCCAAAG ENST00000376663.3 ---------------------------------------CCCCTGATTTATATAGATATC ENST00000445879.1 TGTTGAGATTACAGATGTGAGCCATAGTGCTCAGCCAAGCTCCTAATTTATATAGGTATG * *** ********** *** ENST00000376663.3 TTCATGCCATTACAGCTTTCTAGATGCTAATACATGTGACTATCGTCCAATTTGCTTTCT ENST00000445879.1 TCTATGCCATTACAGCTTTACAAACACTAATACACATGACTGTGGTCAAATTTGCTTTCT * **************** * * ******** ***** * *** ************ ENST00000376663.3 TTTGTAGTGACATTAAATTTGGCTATAAAAGATGGACTACATGTGATACTCCTATGGACG ENST00000445879.1 TTTGTAGTTACATTGAATTTGACTATAAAAGATGGACCAAGTGTGACATTCATATATACA ******** ***** ****** *************** * ***** * ** *** ** ENST00000376663.3 TTAATTGAAAAGAAAGATTGTTGTTATAAAGAATTGGTTTCTTGGAAAGCAGGCAAGACT ENST00000445879.1 TTACTTGGAAAGAAAGATTGTC-TTAAAAAGAACTGGTTTTTGTGTGGGCAGGCAATG-T *** *** ************* *** ****** ****** * * ******** * ENST00000376663.3 TTTTCTCTGTGTTAGGAAAGATGGGAAATGGTTTCTGTAACCATTGTTTGGATTTGGAAG ENST00000445879.1 TTTCTTCTGTGT------------GAAGTGTTTTCTGTAAACACTGTTTGAATGTGAAAA *** ******* *** ** ********* ** ****** ** ** ** ENST00000376663.3 TACTCTGCAGTGGACATAAGCATTGGGCCATAGTTTGTTAATCTCAACTAACGCCTACAT ENST00000445879.1 CCCTCTAAAATAGACATAAACCTTGGTCCATAGTTCGTCAATCTCCATTAACATCTGTGT **** * * ******* * **** ******** ** ****** * **** ** * ENST00000376663.3 TACATTCTCCTTGATCGTTCTTGTTATTACGCTGTTTTGTGAACCTGTAGAAAACAAGTG ENST00000445879.1 TACATGCTCTTGGATTGTTCTTGCTATTATGTTGTTTTATGAACCTGTAGACAACACATG ***** *** * *** ******* ***** * ****** ************ **** ** ENST00000376663.3 CTTTTTATCTTGAAATTCAACCAACGGAAAGAATATGCATAGAATAATGCATT--CTATG ENST00000445879.1 CTTTTTATTTTGAAATTTAAAAAATAAAAAGAATATGCATAGAATGGTGCATAGACTATA ******** ******** ** ** ****************** ***** **** ENST00000376663.3 TA---------GCCATGTCACTGTGAATAACGATTTCTTGCATATTTAGCCATTTTGATT ENST00000445879.1 CATCAAATGCTGCGATGTAACTGTGAGTAGCCATTTCTTGCATATTTAACCATTTTGAGT * ** **** ******* ** * **************** ********* * ENST00000376663.3 CCT--GTTTGATTTATACTTCTCTGTTGCTACGCAAAACCGATCAAAGAAAAGTGAACTT ENST00000445879.1 TCTTCATTTCACTT-TACTTCTCTGTTATTGCACAGAAC-AATCTTAAGAAAGTAAACAG ** *** * ** ************ * * ** *** *** * ***** *** ENST00000376663.3 CAGTTTTACAATCTGTATGCCT-AAAAGCGGGTACTACCGTTTATTTT-ACTGACTTGTT ENST00000445879.1 CAGTTTTACAATTTGTGTGCTTTAAAAGTGGGTACTATTGTTTATTTTTACTGACTTGTT ************ *** *** * ***** ******** ********* *********** ENST00000376663.3 TAAATGATTCGCTTTTGTAAGAATCAGATGGCATTATGCTTGTTGTACAATGCCATATTG ENST00000445879.1 TAAATGAATATATTTTGTAAGAATCAGATGGCATTATGCTTGCTTTACAATGCTGTATTC ******* * ****************************** * ******** **** ENST00000376663.3 GTATATGACATAACAGGAAACAGTATTGTATGATATATTTATAAATGCTATAAAGAAA-T ENST00000445879.1 GTACA-----------GAAACAGTATTGTAT-----ATTTATAAATATAATAATGAAAAT *** * *************** ********** **** **** * ENST00000376663.3 ATTGTGTTTCATGCATTCAGAAATGATTGTTAAAATTCTCCCAACTGGTTCGACCTTTGC ENST00000445879.1 ATTGTGTTTCATGTACTTAGAAATGGTT-TTCAAGTTATCCAAACTAGTTCAGACTTGGC ************* * * ******* ** ** ** ** *** **** **** *** ** ENST00000376663.3 AGATACCCATAACCTATGTT-GAGCCTTGCTTACCAGCAAAGAATATTTTTAATGTGGAT ENST00000445879.1 AGATAC------TCTGTGTTTGAACCTTGCTTATCATCATGTAACATTTTAAATGTGGAT ****** ** **** ** ********* ** ** ** ***** ********* ENST00000376663.3 ATCTAATTCTAAAGTCTGTTCCATTAGAAGCAATTGGCACATCTTTCTATACTTTATATA ENST00000445879.1 ACACAAATCTAAATTATTTTCCATTGGAAGAAATTGACAAATCATTACAATGTTGAAATA * ** ****** * * ******* **** ***** ** *** ** * ** * *** ENST00000376663.3 CTTTTCTCCAGTAATACATGTTT-ACTTTAAAG----ATTGTTGCAGTGAAGAAAAACCT ENST00000445879.1 TTT----CCAATAATACATTTTTTACTTTAAAATTTTATTACTATAATAAAGAAAATCTC ** *** ******** *** ******** *** * * * ******* * ENST00000376663.3 TTAACTGAGAAATATGGAAACCGT----------CTTAATTTT--CCATTGGCTATGATG ENST00000445879.1 TTAACCAAGGAATATAAAAATTGTGTATATCGTTCTAAATTTTGCCTGTTGGCTATGGTG ***** ** ***** *** ** ** ****** * ********* ** ENST00000376663.3 GAATTAATATTGTATTTTAAAAATGCATATTGATCACTATAATTCTAAAACAATTTTTTA ENST00000445879.1 GAATTAGT---GTGTTTTTAAAATGCCTGTCAGTAACTATAATTCTATAGCAAATTTTAA ****** * ** **** ******* * * * ************ * *** **** * ENST00000376663.3 AATAAACCAGC-AGGTTGCTAAAAGAA--GGCATTTTATCTAAAGTTATTTTAATAGGTG ENST00000445879.1 AATGAAACGTTTAAATTTTTAAATGAATCAGAATTTT---------TCTTTTAGTATGGG *** ** * * ** **** *** * ***** * ***** ** * * ENST00000376663.3 GTATAGCAGTAATTTTAAATTTAAGAGTTGCTTTTACAGTTA---ACAATGGAATATGCC ENST00000445879.1 GCATAGTAGCATTTTCTAATTTAATAGTTACTTTAACAGTTATAAACAATGGAATATACC * **** ** * *** ******* **** **** ******* ************ ** ENST00000376663.3 TTCTCTGCTATGTCTGAAAATAGAAGCTATTTATTATGAGCTTCTACAGGTATT----TT ENST00000445879.1 TTCTCTGTAATGTCTGATAATACAAATAATTTATTATGATCTTCTACATGTATTAATTTT ******* ******** **** ** *********** ******** ***** ** ENST00000376663.3 TAAATAGAGCAAGCATGTTGAATTTAAAATATGAATAACCCCACCCAACAATTTTCAGTT ENST00000445879.1 AAAATAGAGTGAGCATGTTGAACATAAAATATGAATAACTCCA----ACAATTTTCCATA ******** *********** *************** *** ********* * ENST00000376663.3 TATTTTTTGCTTTGGTCGAACTTGGTGTGTGTTCATCACCCATCAGTTATTTGTGAGGGT ENST00000445879.1 TATATTTTGCTTTGGCCAAACT--GTGTATATTTATCATCTATCAGTTACATGTGAGGCT *** *********** * **** **** * ** **** * ******** ******* * ENST00000376663.3 GTTTATTCTATATGAATATTGTTTCATGTTTGTATGGGAAAATTGTAGCTAAACATTTCA ENST00000445879.1 GTTTATTCTATATGAATATTGCTTCAGGTTTATATGGAAAATTTTTGGCTAAACATTTCA ********************* **** **** ***** *** ** * ************* ENST00000376663.3 TTGTCCCCAGTCTGCAAAAGAA-GCACAATTCTATTGCTTTGTCTTGCTTATAGTCATTA ENST00000445879.1 TTGTCCCCTCTATGTAAAAAAAAGCACAATTCTATCATTTTGTCTTGCTTATCACTATTA ******** * ** **** ** ************ ************** **** ENST00000376663.3 AATCATTACTTTTACATATATTGCTGTTACTTCTGCTTTCTTTAAAAATATAGTAAAGGA ENST00000445879.1 AATCACTACATTTGCGTAT--------------------TTTTAAAAAT----CAGA--- ***** *** *** * *** ********* * * ENST00000376663.3 TGTTTTATGAAGTCACAAGATACATATATTTTTATTTTGACCTAAATTTGTACAGTCCCA ENST00000445879.1 --------------ACTGGGAACAT---------------CCTAGGTTT----------- ** * **** **** *** ENST00000376663.3 TTGTAAGTGTTGTTTCTAATTATAGATGTAAAATGAAATTTCATTTGTAATTGGAAAAAA ENST00000445879.1 --------------------------TGCCAAA--------------------GAAGAGT ** *** *** * ENST00000376663.3 TCCAATAAA-AAGGATATTCATTTAGAAAATAGCTAAGATCTTTAATAAAAATTTGATAT ENST00000445879.1 TCCAAAAGACAAGGGTGT------AGGAG------------------------------- ***** * * **** * * ** * ENST00000376663.3 GAAAAGCACAATGTGCAGAAGTTATGGAAAACCTATAGAGGATTACAACAGGTAAACGTT ENST00000445879.1 GGAAGGTACAGTTTG-------TATCAGATGCCCATA-----TTTTATC----------- * ** * *** * ** *** * ** *** ** * * ENST00000376663.3 AAAGAGAATACATTGCTGACTTATAGTGATGTGGCTAAGAAGTACATGCTTTGTTGTAAA ENST00000445879.1 -------------TACTGGGTTTTA-----------------------CTTTCC------ * *** ** ** **** ENST00000376663.3 ATTGCTTGAAAGCCCATTGAAAGATGTATCTGTTTATTTACAGTCTTTGAAGTAAAAGTT ENST00000445879.1 ----CTTGAAGG--CACTGG----------TTCTCACTGTCACCCCTTG---TAAGGG-- ****** * ** ** * * * * ** * *** *** * ENST00000376663.3 ACCAATGTTTGCCAA ENST00000445879.1 AACAGAGTTC----- * ** ***