CLUSTAL 2.1 multiple sequence alignment ENST00000377205.1 GAGAGTGCGACCGAGATGTTCCACTCGCTGGCGTCCGGGCCGCTGGTGATCTCCGGTAGC ENST00000435192.1 ------------------------------------------------------------ ENST00000377205.1 ACTCGGGCCGGCGGACAGTGAGGGCGCGACAACAAGGGAGGTGTCACAGTTTTCCATTTA ENST00000435192.1 ------------------------------------------------------------ ENST00000377205.1 GATCAACAACTTCAAGTTCTTACCATGGAAAATTCCGAGAAGACTGAAGTGGTTCTCCTT ENST00000435192.1 ------------------------ATGGAAAATTCAGAGAAGTCTGAAGTGGTTCTCCTT *********** ****** ***************** ENST00000377205.1 GCTTGTGGTTCATTCAATCCCATCACCAACATGCACCTCAGGTTGTTTGAGCTGGCCAAG ENST00000435192.1 GCTTGTGGTTCTTTTAATCCTATCACCAACATGCACCTCAGGTTGTTTGAGCTGGCCAAG *********** ** ***** *************************************** ENST00000377205.1 GACTACATGAATGGAACAGGAAGGTACACAGTTGTCAAAGGCATCATCTCTCCTGTTGGT ENST00000435192.1 GACTACA--AGTGGAACAGGAAGATACAGAGTTGTCAAAGACATAATCTCTCCTGTTGGC ******* * ************ **** *********** *** ************** ENST00000377205.1 GATGCCTACAAGAAGAAAGGACTCATTCCTGCCTATCACCGGGTCATCATGGCAGAACTT ENST00000435192.1 AATACC----AGGAGAATGGACTCATTCCTGCCCGTCACTGGGTCATCAGGTCAAAACTT ** ** ** **** *************** **** ********* * ** ***** ENST00000377205.1 GCTACCAAGAATTCTAAATGGGTGGAAGTTGATACATGGGAAAGTCTTCAGAAGGAGTGG ENST00000435192.1 CCCACCAAGAATGCCAAATGGGTGGAAGTTGATACATAA-AAAGTCTTCAAAAGGAGCAG * ********* * ********************** ********** ****** * ENST00000377205.1 AAAGAGACTCTGAAGGTGCTAAGACACCATCAAGAGAAATTGGAGGCTAGTGACTGTGAT ENST00000435192.1 ATAGAAACTGTTAAGGTGCTTATACACCATCAGGAGAAACTGGAGGCTAGTAACTGTGAT * *** *** * ******** * ********* ****** *********** ******** ENST00000377205.1 CACCAGCAGAACTCACCTACTCTAGAAAGGCCTGGAAGGAAGAGGAAGTGGACTGAA--- ENST00000435192.1 AACCAGCAGAACTTGCGTACGCTAGAAAGGCCTGGACAAAAGAGGAAGTGGACTGAACAA ************ * *** *************** ****************** ENST00000377205.1 ACACAAGATTCTAGTCAAAAGAAATCCCTAGAGCCAAAAACAAAAGCTGTGCCAAAGGTC ENST00000435192.1 AGACAGGATTCTAGTTGAAAGAAATCCCTGGAGTCCAAAACAAAAGGTACAACAAAGGTC * *** ********* ************ *** * ********** * ******** ENST00000377205.1 AAGCTGCTGTGTGGGGCAGATTTATTGGAGTCCTTTGCTGTTCCCAATTTGTGGAAGAGT ENST00000435192.1 AAGCTGTTGTGTGGGACAGATT-ATTGGAGTCCTTTGGTATTCCCAATTTGTGGAAGGCA ****** ******** ****** ************** * ***************** ENST00000377205.1 GAAGACATCACCCAAATCGTGGCCAACTATGGGCTCATATGTGTTACTCGGGCTGGAAAT ENST00000435192.1 GAAGACATCACCCAGATTGTGGCAGACTATGAGTTCACATGTAT-ACTCAGGCTGGAAAT ************** ** ***** ****** * *** **** * **** ********** ENST00000377205.1 GATGCTCAGAAGTTTATCTATGAATCGGATGTGCTGTGGAAACACCGGAGCAACATTCAC ENST00000435192.1 GATGCTCAGAAATTCATCCAT-AATCTGACGTGCTGTGAAAACACTGGAGCATCATTCAC *********** ** *** ** **** ** ******** ****** ****** ******* ENST00000377205.1 GTGGTGAATGAATGGATCGCTAATGACATCTCATCCACAAAAATCCGGAGAGCCCTCAGA ENST00000435192.1 ATAGTGAATGAATGGATCACTAATGATATCTCATCTACAACAATCTGGAGAGCCCTCAGA * *************** ******* ******** **** **** ************** ENST00000377205.1 AGGGGCCAGAGCATTCGCTACTTGGTACCAGATCTTGTCCAAGAATACATTGAAAAGCAT ENST00000435192.1 AGGGGACAGAGCATTCGCTACTTGTTATGAGAACTTGTCCAAGAATAAATCAAAAAGCAT ***** ****************** ** *** ************** ** ******** ENST00000377205.1 AATTTGTAC---------AGC-----------TCTGAGAGTGAAGACAGGAATGCTGGGG ENST00000435192.1 AATTTGTAATTATCGAAAAGCATAATCTGTCTTCTGAGGGTGAAGACAGGAATGCTGGGA ******** *** ****** ******************** ENST00000377205.1 TCATCCTGGCCCCTTTGCAGAGAAACACTGCAGAAGCTAAGACATAGGAATTCTACAGCA ENST00000435192.1 TCATTCTGGCCCCTTTG-AGAGAAACACTGCAGAAGCTAAGGCAAAGGAAT-CTACGGCA **** ************ *********************** ** ****** **** *** ENST00000377205.1 TGATATTTCAGACTTCCCATTTGGGGATCTGAAACAATCTGGGAGTTAATAACTGGGGAA ENST00000435192.1 TGATGATTTGGACTTCCCTGTTGGGGATTTGAAACAATCTGGGTGTGAGTAACTGGGGAA **** ** ******** ******** ************** ** * *********** ENST00000377205.1 AGAAGTTGTGATC-TGTTGCCTAAACTAAAGCTTAAAAGTTTAGTAAAAATCGTCTGGGC ENST00000435192.1 ATAAATTGTGATCCTGTTGCATAAACTAAAGCTTAAAAGTTTAGTAAAAATC-------- * ** ******** ****** ******************************* ENST00000377205.1 ACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACGGGG ENST00000435192.1 --AGTGG--TAAGTTAGAAA---CAGGGTTTTCTTTTCTT--------TTTATCAGAAAT ***** * * * ** *** *** * * **** ENST00000377205.1 TCAAGAGATCGAGACCATCCTGGCCAATATGGTGAAACCCCATCTCTACTAAAAATACAA ENST00000435192.1 TGCTAAGATTAATGTTTTCCT------TATGTT----CTTCTTTTTT--TAAGAATGTAC * **** * **** **** * * * * * * *** *** * ENST00000377205.1 AAATTAGCTGTGTGTGGTGGCACGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAG ENST00000435192.1 AAAT---CTCTTTAT------------CTTTAA----AACAA-----GAGATTTAG-CAG **** ** * * * ** ** * * * *** * ** *** ENST00000377205.1 GAGAATCACTTGACCCCAGGTGGTGGAGGTTGCAGTGAGCCAAGATTGCACCATTGCACT ENST00000435192.1 CA----CACTAAAACC-----AGAAGAATTTTCAGTGAAACTAG-TTACAA-ATAAGA-- * **** * ** * ** ** ****** * ** ** ** ** * ENST00000377205.1 CCAGCCTGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAATTTAGTAAAAATCA ENST00000435192.1 --AGTCAAAAAGTACATCCTAGCTCTACCACATAAAAGAAGCAAAGTGTG--AAAAGCAA ** * * * * **** * ** **** ** *** * * **** * ENST00000377205.1 ATGGTAAGCTAAAATAAGTTTTTGTTTGTTTATTTGTTTTTGAGATGGAGTCTCTACTAA ENST00000435192.1 ACATTCACTTAAAAT---TCTAACTTTGGTTAT---------GAAGGGAATTGACATT-- * * * ****** * * **** **** * *** * * * ENST00000377205.1 AAATACAAAAAATTAGCCAGGCATGGTGCCGCATAA-CTATAATCCCAGCTACTTGGGAG ENST00000435192.1 ------------TTATCCATGATTGTTGCTGGGTAATCTGCAG--CCAG------GGTAG *** *** * ** *** * *** ** * **** ** ** ENST00000377205.1 GCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCACAGGTTCCAGTGAGCCAAGGTTGTG ENST00000435192.1 ACAAAGGAAGGA--ATT-CTTACAGT-GGTGATCTTA---TAAAATGAACCATTGACAAA * *** **** ** *** * ** * * * * *** *** * ENST00000377205.1 CCA-CTGCACTCCAGCCTGGGCAAAAAAGCAAAACTCCATCTCAAAGAGAAAAAAAAAAA ENST00000435192.1 TCATCTTCACTTATGCC---------AAATAAAGGTTGTGCACATGCATGGCAGAAACA- ** ** **** *** ** *** * * ** * * *** * ENST00000377205.1 AGACCGGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCTAAGTGGGTGG ENST00000435192.1 -----------------TTGCACCAATAGTT--AGTTCTCTGTGGTACACATCAGAATTG * **** ** * ** ** ** * * * * * * ENST00000377205.1 ATCACGTGAGGTCAAGAGTTCAAGACCAGCCTGGCCAATATGGTGAAACCCCATCTCTAC ENST00000435192.1 CTGAC-TAAACTTTGG----CAAGACCTACCTGCC--------TGGAGCTCCACCTTT-- * ** * * * * ******* **** * ** * * *** ** * ENST00000377205.1 TAAGAATACAAAAAATTAG--CTGAGC------ATGGTGGTGGGCTCCTGTAG-TCCCAG ENST00000435192.1 ---GGAGGTAGGGAGTGAGGTCCAAGCCCTCACATGTT--TAGAAAGATGCAGGTACCAG * * * * * ** * *** *** * * * ** ** * **** ENST00000377205.1 CTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTAAG ENST00000435192.1 CTACTCGGGAGGCTGGGGCAGGAGAATCGTTTGAACCTGGGAGGCGGAAGTTGCAGTGAG ***** ********* ************* *************** ** ******** ** ENST00000377205.1 CCAAGATCGTGCCATTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATCTCAAAAAAA ENST00000435192.1 CTAAGATTGCGCCAGTGCACACTAGCCTGG-CGACAGAGCAACACTCTATCTCAGAAAAA * ***** * **** ***** * ******* ******** * **** ****** ***** ENST00000377205.1 AAAAAAAGCCTGACAGCTAGCAGGTTTCAGGATCCATCTGCCAAGTTAGTGAAAGGCTGG ENST00000435192.1 AAAAAAAA---GAGAGAGAG-----------------------AGACAAAGAAAGATT-- ******* ** ** ** ** * ***** * ENST00000377205.1 AGCCTCAAATCATACAGATGAGGGTCATTTTCTCCTCCTTAGCTTCTTGGAGTTTAAGAG ENST00000435192.1 --------------CAGGTA--------TTTCTGAT-----GCCCCCCAGAGAT----AG *** * ***** * ** * *** * ** ENST00000377205.1 TTGAAGGAGTCCTGAAAAGTAATGATAGAGCAAGATGAAGCTATCAGAACTGAATTTGGA ENST00000435192.1 CTGCTG----CCTTACACTTTATAA---------------CCATTC-------ACTTAGC ** * *** * * * ** * * ** * ** * ENST00000377205.1 CTTCCTCTGGGAAACTACAC-CTAGTTCATCTGAAGTGTCACGTAAACTGCAGAAAGTTT ENST00000435192.1 CTTGTTATGG---ATCATGCTCTAGCCC---TG----GCCA------------------T *** * *** * * * **** * ** * ** * ENST00000377205.1 CCAATGCTGGAAACTTCTCTCATACTATCGTGCCTTCCTACTCAGAAGTGCCTGTGCCCT ENST00000435192.1 CCAC---------CCTCTCTT-TATCTTCAGGAACAACT--TGAGAGATGAC---ACCAT *** * ***** ** ** * ** * *** ** * ** * ENST00000377205.1 GCTCAGCTGTGACTACTGACCTCAGGACCTCACTGGACAAGGCATGTGGGGACCCTTGCA ENST00000435192.1 GCT--ACCTTGA--ATCGAG---AGAACC-------ACAGGGAACGAGGGGTCTCATGCA *** * *** * ** ** *** *** ** * * **** * * **** ENST00000377205.1 GGAGCCCTGGTAAGGGTACAATGATCCTATTGTTTTTTGTTTTTGAGATGGAGTCTCACT ENST00000435192.1 AGGATTTTA-TAAG----------TCTGAATGCTCTTAGCCTTTAT--TGGTAGCTTAAT * * **** ** * ** * ** * *** *** ** * * ENST00000377205.1 CTGTCTCCCAGGCTGGAGTGCAGTGGTGCGATCTCCGCTCACTGCAACCTCCGCCTCCCG ENST00000435192.1 CAAAAGACCTGAGTGAGGCATAGTGGCGCATGCTCTG-TAATCCCA---TCTGCTTTGGA * ** * ** * ***** ** *** * * * ** ** ** * ENST00000377205.1 GGTTCAAGCAATTCTCCTGCCTCAGCCTGCTGAGTAGCTGGGATTACAGGCACCCACTAC ENST00000435192.1 GGCAGGAACAGGAGGAAAGCTTGAGCCT----AGGAGTTTGAA--ACCAGC-CTGGGCAA ** * ** ** * ***** ** ** * * * ** ** * * ENST00000377205.1 CATGTCCGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATGTTAGACAGGCTG ENST00000435192.1 AATAGTGAG--AAC---ATGTCTTTAAAAATCCTGGAGTTTC-TGAAG--AGCCCTGCTG ** * ** * * **** * *** ***** * * ** * **** ENST00000377205.1 GTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTTCCAAAGTGCTGGGATTA ENST00000435192.1 TTTCTG--TTCCAGCCCACTGTGAATCTGCCATTTGTGAGTTT---AAGC----AGAAAA * ** *** * ** * * ******* * ** *** ** * ENST00000377205.1 CAGGCATGAGCCACTGCACCCAGCCTGATCCTATTGTTGCACTATTTATGGAGCAACAAC ENST00000435192.1 AGGGTCTGTTTTCCTATACTTTTTCTCTTCTTTTTTTT---TTTTGTATGACG------- ** ** ** ** ** ** * ** ** * * **** * ENST00000377205.1 TTTGTACAAAGAACAAGCTTTGTACAGAGAACAAGCTTGGCTTTTTCTCCCAACGCCGAG ENST00000435192.1 TTTAACCAAAG---TAGTATTCT-CA---AATAGTCATAGCTTTATGTTAAAACAC-AAG *** ***** ** ** * ** ** * * * ***** * * *** * ** ENST00000377205.1 GATGCTGT-TGATGCTGCCACGTAATAGCATAATTTTGGGTGTCCTCAAGGACAGAACTT ENST00000435192.1 CTTGTTACATGGT-TTGCTAC-TGAT--TAAAATTTTG--------------TGGAAGTT ** * ** * *** ** * ** * ******* *** ** ENST00000377205.1 CCACT--TTGAATAATGGAAGTTAGAACAATGAA----TTTCACAGGGGAATAAATATTA ENST00000435192.1 TTACCAGTTGG-TAA-GGAAGA-AGATCAGTAAAAGCTTTTTGTAG----ATTAGTTTTA ** *** *** ***** *** ** * ** *** ** ** * * *** ENST00000377205.1 ATGACTGACGTGAAGAAAATATGCCATTGTTTATTCCCTCCTGCATCATTTCCATAATTT ENST00000435192.1 GGGTTTG---TGAAAATAAT-------------------CCTACG--------ATAG--- * ** **** * *** *** * *** ENST00000377205.1 GCTTTTGTACTGTCAATTTAGAGGAAATGTGTGATGCTGGTGTTTTGTTTGGCCTGTTTG ENST00000435192.1 ------AAACCG--GACTAAAGTTAAATTTCTAATGAAGATAGGATATTTG-CCTTTTTG ** * * * * **** * * *** * * * **** *** **** ENST00000377205.1 TTTGATGCTGGGGGTTTTATGTGTTGTACCCTTTACC-CCTTACATTGTGTAATTTGAAA ENST00000435192.1 C------------AATTTCTATTTTATACT-TACACCATCCTAGAT-GAAGAGTTTGTAA *** * * ** *** * *** * ** ** * * **** ** ENST00000377205.1 GTGGCAAACAAACCTGCAGTAAAAGTCCTTGATTGGCATCTTCATTCGGATGATGGAGAG ENST00000435192.1 CTGCTGAAGAAA---------AAAATACTTA---GAAATGTACAATTGTATAGTC-AGAG ** ** *** *** * *** * ** * ** * * ** * **** ENST00000377205.1 CCTTTGTGGTAGTGTTTGCTTATGTGAACAGCAGGCCTTTCAGATAAGAGAAGTGGCTTT ENST00000435192.1 CT---------GAATCT----------ATAG-------TTTAAAAAAGGGAAATG----- * * * * * ** ** * * *** *** ** ENST00000377205.1 TCCTTGGTGATGAAGGGGTAGAGATTGAGCCA-TGGGGATGGTTTAGGTTAAAGAATGCT ENST00000435192.1 ---TTA--AATAAAG---------TTAAGTAAATGTATGTGTTACAGTTCCCAACTTACT ** ** *** ** ** * ** ** * ** * * * ** ENST00000377205.1 TTTTTTTG-GCCATCATGAGGATCTAACAACAGAGTAGAAGGAAGGATGCCCTAGGTCAG ENST00000435192.1 CCTGCTAAAGCCATCAGCCAACTCT--CAA-AGAG----AGGGAGGGTGC---AA---AG * * ******* *** *** **** *** *** *** * ** ENST00000377205.1 CATGCAGGGTGGTGGGAGGGCTTTCATCTTCCTTACCCAAGCCTCTCTTTTCACTTTTCT ENST00000435192.1 CCTGACATGTAGCAGG-----TTTCAG------TATCCA----------TCCACC----- * ** ** * ** ***** ** *** * *** ENST00000377205.1 AGAAGTCCAGAAGTTGTTATATGATGAAATAGCCTCCTTTAACGTTTATTTCTGGGTGCC ENST00000435192.1 --AAGT---GAA----TGAAAGGTTGGAATG-------TCAAATCCTA----TGGATG-- **** *** * * * * ** *** * ** ** *** ** ENST00000377205.1 AACGGAGGCCCATTCCTCTAACATTCTCATAATTTTTCTCAAAGGCCTATGATCTAAACA ENST00000435192.1 -----AGAGTCATTTTTCT----CTTCCTTAGCTTT---CTGGAGTTTATGAGTTGAA-- ** **** *** * * ** *** * * ***** * ** ENST00000377205.1 TTTCACCACGGCATCCACTCAGCTGTGAGGCTGCGTACACAGTCTCCACCTCTGAAATCT ENST00000435192.1 ----------GCA-------AGGGGCCAGGCT---------------------------- *** ** * ***** ENST00000377205.1 GAACTTCGTTTACCAGTGGTGCTGTTTGAACTTCATAATGTCAGCACTTCCTGAACACTT ENST00000435192.1 -------------CAGTGGC-----TCACACCT-GTAATCCCAGCACTT----------- ****** * ** * **** ******** ENST00000377205.1 ACTGTGTGCTTGGCTTGTGCTCCTGAGTGCCTTATATCATAAGGAAACGGCAAAATCAGG ENST00000435192.1 ----------TGGC-----------AG-GCC---------AAGGCA--GGCAGA-TCA-- **** ** *** **** * **** * *** ENST00000377205.1 GGACTGGTATAAATGGTGAGCTGAGCTTGAATCTAAGCTTTGTCTTCAGAGCCAGTACCC ENST00000435192.1 ---CT-----------TGAGGTGAG---------GAG-------TTCAAGACCAG----C ** **** **** ** **** **** * ENST00000377205.1 CTAATCTCTCTTTCTGTAAAATATTACTTTTCAAAGAATGAAGTTGTAGCCAAATCTTGA ENST00000435192.1 CTGGCC---------------------------AAGA---------TAGTGAAATC---- ** * **** *** ***** ENST00000377205.1 AATTTTTCATTTACCCTAAGTGAGGACAAATAAAGCTTTCAACAACA ENST00000435192.1 -------------CCCTC----------------------------- ****