CLUSTAL 2.1 multiple sequence alignment ENST00000377494.1 GTTGCTAATGGTGTCATGCACCCACCGGC-CACCCTTGGCGCGAGCGCCCCCCTCTGGAC ENST00000513659.1 ----CAACAAACTTCACAATTCCAAAGATATGGAATCAACCTAAGTGCCCATC----GAC * * *** *** * * * ** **** * *** ENST00000377494.1 ACCCTGCTCCGTGCGCGCTCACAGTTCG-CCTGTGCGGGGCCGGGGC---CAGGGTCAGG ENST00000513659.1 A----GATGAGTGAATAAAGAAAATGTGATCTATATATCACATGGATATACACGGCCACA * * * *** * * * * ** * * ** ** ** ** ENST00000377494.1 AGCCGGGGATAGGGAGGA----AGAGGGCCTGTGGACAAG----CTGAGC-CGGGACCCC ENST00000513659.1 TCTC----ACAGGAAAAATTCCAGATCATCCATGGGAACTTCCCCTTACCTCAGCGCCTT * * *** * * *** * *** * ** * * * * ** ENST00000377494.1 TGGGACCTTTG-CGGAGGTGGCCTGGGAGCGCTCAGTTCCCAGGCTCAGGCTTCCCGCTG ENST00000513659.1 TGGGGACTTTGACCAAAA----CTAGGAAGGCTGCATCAGTAGGGAAAAGATGCTTTC-- **** ***** * * ** *** *** * *** * * * * * ENST00000377494.1 ACGCCTCCTG-GCCGCAGCGGGCTCCCCCCGCCCCAGGAATGTTCCTC--TCCCATCCAG ENST00000513659.1 -CTTTTCCTGTGCTTCAGC------TCCTTGC--TGGGAGTCTACATGGGTTTTGTACA- * ***** ** **** ** ** *** * * * * * * ** ENST00000377494.1 TCCGCCTCCCCTAGGGCAGGCCCCCTGGGGGCTGCCGCAGCCCCGCCTCGCCTTCCTGGG ENST00000513659.1 -CAGTTTCCAGGAGGGCAA--CTCCTAGAG--TGCAGTAGCCT-GC--TGCC-------A * * *** ****** * *** * * *** * **** ** *** ENST00000377494.1 CTCCCGGGAGGGGGCGAGGCGGGCAGGACGCCTGGGTTCTCTCCCCCCACCTCCCATAC- ENST00000513659.1 CT-----------GCGAAGC---CCTGAT-CCTGGG-----------CATCT---ATAAG ** **** ** * ** ****** ** ** *** ENST00000377494.1 CAGGGAGAAATTCCTCCGAGGTCCCCTCAG-GCTCTGGGTTCCCAAAATAACCCTGCGGG ENST00000513659.1 CAGGG-------CCTCAACTGCCAAGCCAGTGGTATGAGCTGCCA-------CCAGCAGT ***** **** * * *** * * ** * * *** ** ** * ENST00000377494.1 GGAAGGGAGGCTGTGGAGGGAGGGAAGCGGGAGGGGCGCAGAGCCGAGCTGCGGGGTGCT ENST00000513659.1 GCAAGGATTGCC-TGTA------------------------AGTTGAGCACCAG-----T * **** ** ** * ** **** * * * ENST00000377494.1 GCAGGTGCCTCTGGGGAGAGGGCGCGAGGAGAAGGCGCCCTGCGGGGGGCTGGGCGCCAG ENST00000513659.1 GCAGGCCCC---------AGAGTGTGGG----------CCTGGAGGAGTCTCCACGTCA- ***** ** ** * * * * **** ** * ** ** ** ENST00000377494.1 CCAGTCCTGGGATCTTGGTTCGTCCCCATCCTCGTGAAGCCCCTCGGCCTTCCCGCGACT ENST00000513659.1 ----CCCTCACAC----ACTCATACCCACCATCATCCCACCT-TCAGCTTCTCCCTGCCC *** * ** * **** * ** * ** ** ** * ** * * ENST00000377494.1 C-CGAGGGTGGGCCGGAAGCCTCTCTGCGGGTCC---GTTTCCCAACTGGCGGGTTGCAC ENST00000513659.1 TGCCATGGCAAACGAGA---CTCCCAGCC--TCCAGAGATTCATGAG-GAGGAGATGCA- * * ** * ** *** * ** *** * *** * * * * **** ENST00000377494.1 CATCCCGGGCCAGACCGTTTAACCCCGGGAGTGGCCGCGGGGGACAACTCCGCCCCTGTC ENST00000513659.1 ------------GATGGTG-------AAGGATGGG-GTGTTTGACAACTG----CTTGT- ** ** * *** * * ******* * *** ENST00000377494.1 CAGCAGGGGGCGTGCCCGCCCC---GCCCCGTTTCTGCCCGCGGGGCCGCTCCCCCGCCC ENST00000513659.1 -AATTGATGCTATGATTGGATCAAGGACTCATTCCTGCCTTGGAGAAAAGACTTGAACCA * * * ** * * * * * ** ***** * * * ** ENST00000377494.1 GCGACTCCGCAGACTCCCGCTCTGCCTCTCCCGGGACAGG-GGTTCGGTCCGAGCCCGGT ENST00000513659.1 GAG----CAGGGAGCCTGGGGGTGCT------GGGACAGAAGGTTGGGGCTGAG---GGC * * * ** * * *** ******* **** ** * *** ** ENST00000377494.1 GGGAGGCTCCCGGAGCGCAGCCTGGGCCCAGCCCACCCCGCGCCGGCGGCCATGGCAGGC ENST00000513659.1 AGAATGT-----GATGGTGGCATG----CAGCTAA----GGGCAG--GGCCAGGGCAGGC * * * ** * ** ** **** * * ** * ***** ******* ENST00000377494.1 ACCCTGGACCTGGACAAGGGCTGCACGGTGGAGGAGCTGCTCCGCGGGTGCATCGAAGCC ENST00000513659.1 GTCC----------CTAAGGTTGTAC-------CAACT--TTTGTGAAT--ATTTGTATT ** * * ** ** ** * ** * * * * ** ENST00000377494.1 TTCGATGACTCCGGGAAGGTGCGGGACC-CGCAGCTGGTGCGCATGTTCCTCATG-ATGC ENST00000513659.1 TTC-----CTCATGGAATAAAAAGGCTCATGTAATTAATCTCCATATATAT-ATACATTT *** *** **** ** * * * * * *** * * ** ** ENST00000377494.1 ACCCCTG-GTACATCCCCTCCTCTCAGCTGGCGGCCAAGCTGCTC-CACATCTACCAACA ENST00000513659.1 ATATATGTGTATATA---TACATTTATATATATATAAATGTATACACACACACACACACA * ** *** ** * * * * * ** * * **** ** *** ENST00000377494.1 ATCCCGGAAGGACAACTCCAATTCCCTGCAGGTGAAAACGTGCCACCTGGTCAGGTACTG ENST00000513659.1 CACACAGAAAGAGAGTAGTATATACATACACA-GCATACATGC-----------ATA-TA * * *** ** * * * * * ** * * ** *** ** * ENST00000377494.1 GATCTCCGCCTTCCCAGCGGAGTTTGACTTGAACCCGGAGTTGGCTGAGCAGATCAAGGA ENST00000513659.1 TATTCCCTTTTTTCTGG--GAGTTT---TTCCACTCATT-TCCATTCACCAAAGCAATGC ** ** ** * * ****** ** ** * * * * ** * *** * ENST00000377494.1 GCTGAAGGCTCTGCTAGACCAAGAAGGGAACCGACGGCAC-AGCAG---CCTAATC-GAC ENST00000513659.1 -CTTTGTGCCATG-TACGTGAAGAAAT-ATTCGTCTGCTCTAGCAAAGACCTCATCTGGC ** ** ** ** ***** * ** * ** * **** *** *** * * ENST00000377494.1 ATAGACAGCGTCCCTACCTACAAGTGGAAGCGGCAGGTGACTCAGCGGAACCCTGTGGGA ENST00000513659.1 ACAGA----------AGCTGTCAG-GGAAACAAC----TACTTGGTTGAATT-TGCAGGA * *** * ** ** **** * * *** * *** ** *** ENST00000377494.1 CAGAAAAAGCGCAA-------GATGTCCCTG--TTGTTTGACCACCTGGAGCCCATGGAG ENST00000513659.1 GGGAAAAGGGGAGACTTCTTTGAGATCCCTGGTTTTTTTAATGA---AGACTTTATATGG ***** * * * ** ****** ** *** * * ** ** * ENST00000377494.1 CTGGC-----GGAGCATCTCACCTACTTGGAGTATCGCTCCTTCTGCAAGATCC-TGTTT ENST00000513659.1 CTTACCCTGTGAGAAATGTTAAATTTCTGGACAATC-CTTGGCTAACCAGATCTGTATAT ** * * ** * * * **** *** ** * ***** * * * ENST00000377494.1 CAGGACTATCACAGTTTCGTGACTCATGGCTGCACTGTGGACAACCCCGTCCTGGAGCGG ENST00000513659.1 TAGTACGTTCCAAGTT-----GTTCA--GCAGAACAGCAGACAAAT---TACT------- ** ** ** **** *** ** * ** * ***** * ** ENST00000377494.1 TTCATCTCCCTCTTCAACAGCGTCTCACAGTGGGTGCAGCTCATGATCCTCAGCAAACCC ENST00000513659.1 TTTATTTTTAATTTCAATA-CTCTTTGCTTTAGAAACAATTT-TG--------------- ** ** * ***** * * * * * * ** * ** ENST00000377494.1 ACAGCCCCGCAGCGGGCCCTGGTCATCACACACTTTGTCCACGTGGCGGAGAAGCTGCTA ENST00000513659.1 ------CTGTGGCACTTCCTAGTCTGTG---ACTCTGTCT------TGAAAAGG--GCTG * * ** *** *** *** **** * * * * *** ENST00000377494.1 CAGCTGCAGA--ACTTCAACACGCTGATGGCAGTGGTCGGGGGCCTGAGCCACAGCTCCA ENST00000513659.1 GAACT-CAGGCTGCGTAGACATACATATTTCATTTATCTGGTCTTCAACTTAAA----CA * ** *** * * *** * ** ** * ** ** * * * ** ENST00000377494.1 TCTCCCGCCTCAAGGAGACCCACAGCCACGTTAGCCCTGAGACCATCAAGCTCTGGGAGG ENST00000513659.1 TTCACCTCTTTATAAAAACTT----CTCTGTAATTCTGAAGGTAATTCCCCTTT------ * ** * * * * ** * ** * * ** ** ** * ENST00000377494.1 GTCTCACGGAACT-AGTGACGGC-GACAGGCAACTATGGCAACTACCGGCGTCGGCTGGC ENST00000513659.1 TTTTGATGGAGTTCAAAAATTGCTGACTTGCACTGTTGGGAAAT-----CATCA-CTGAC * * * *** * * * ** *** *** *** ** * * ** *** * ENST00000377494.1 AGCCTGTGTGGGCTTCCGCTTCCCGATCCTGGGTGTGCACCTCAAGGACCTGGTGGCCCT ENST00000513659.1 ------TGTGA--TTTCATTTTCCATACTTTCATATTTACATCCA---CCTGCTTTTTCT **** ** * ** ** * * * * ** ** * **** * ** ENST00000377494.1 G--CAGCTGGCACTGCCTGACTGGCTGGACCCAGCC--CGGACCCGGCTCAACGGGGCCA ENST00000513659.1 GTTCAG-TGGGA--GAC-AAGCAGTTGGAGCCAACCTTCTGAGCTTCTTCAAAAAGGCTA * *** *** * * * * * **** *** ** * ** * **** *** * ENST00000377494.1 A-GATGAAG------CAGCTCTTTAGC-ATCCTGGAGGAGCTGGCCAT-GGTGACCAGCC ENST00000513659.1 TCAACAAAATATTCACAATTTGTTGATTATCACTGAGAGATTGATTGTCAGATACTGTTT * ** ** * ** *** *** ** * * ** ENST00000377494.1 TGCGG--CCACCAGTACAGGCCAACCCCGACCTGCTGAGCCTGCTCACGGTGTCTCTGGA ENST00000513659.1 CACAAACCCATCT-TCTTTTATACTTTCGAGATTATCTACCT-CTTTCATTCTCTTTTGT * *** * * * *** * * *** ** * * *** * * ENST00000377494.1 TCAGTATCAGACGGAGGATGAGCTGTAC-CAGCTGTCCCTGCAGC--GGGAGCCGCGCTC ENST00000513659.1 CTTATTCTGGGC--AGGGTCTCCTGGCCTCAGCC-TCACT-CAGCTCAGAGGCCACGAGC * * * *** * *** * **** ** ** **** * *** ** * ENST00000377494.1 CAAGTCCTCGCCAACCAGCCCCACGAGTTGCACCCCACCACCCCGGCCCCC----GGTAC ENST00000513659.1 --ACCCTTTGGCCCCGGGCTCCGT---CTGGAGCCCGCTGCTCCAGACCTCCTTAGGTTC * * * * * * ** ** ** * *** * * ** * ** * *** * ENST00000377494.1 TGGAGGAGTGGACCTCGG---CTGCCAAACCCAAGCTGGATCAGGCCCTCGTGGTGGAGC ENST00000513659.1 CGCCGCGGCACAGCTAGGATCCTGACGGACTCT--CTAGGTC---TCTGCCAGGCACCAG * * * * ** ** *** * ** * ** * ** * * ** ENST00000377494.1 ACATCGAGAAGATGGTGG---AGTCTGTGTTCCGGAACTTTGACGTCGATGGGGATGGCC ENST00000513659.1 ACACCAAAAGCATGCTGATGTAGTCTCAATTGATTTGTTTTTAAATTGGTAATTAAACCT *** * * * *** ** ***** ** *** * * * * * * ENST00000377494.1 ACATCTCACAGGAAGAATTCCAGATCATCCGTGGGAACTTCCCTTACCTCAGCGCCTTTG ENST00000513659.1 CCACCTTTATTGAA-------AGATCATT--TGGAAGATTTTGTT--CTCA-------TA ** ** *** ******* *** * ** ** **** * ENST00000377494.1 GGGACCTCGACCAGAACCAGGATGGCTGCATCAGCAGGGAGGAGATGGTTTCC-----TA ENST00000513659.1 -----CTCGGTCAG--TTA--ATAAACATATGATTTGTCAAAAGATAGATTTTAGAAACA **** *** * ** ** * * * **** * ** * ENST00000377494.1 TTTCCTGCGCTCCAGCTCTGTGTTGGGGGGGCGCATGGGCT-TCGTACACAACTTCCAGG ENST00000513659.1 TTTTATGAATTCAAAAAATTTG--AGGGAAATATTTGGGTTGTTTTAGA-AGCTCTGTCA *** ** ** * * ** *** **** * * ** * * ** ENST00000377494.1 AGA-GCAACTCCTTGCGCCCCGTCGCCT--GCCGCCACTGCAAAGCCCTGATCCTGGGCA ENST00000513659.1 AGATGTAGTT--TTA-ATCAAGAAACTTATGTCAAAAGTTTAAGAATC-AAGCCTTAATA *** * * * ** * * * * * * * * ** * * *** * ENST00000377494.1 TC-TACAAGCAGG-GCCTCAAATGCCGAGCCTG-TGGAGTGAACTGCCACAAGCAGTGCA ENST00000513659.1 TTATTCTTGCAGATGTCCTTGGTA--AAATCTGCTGGTGGGGATAATTAAAA----TACA * * * **** * * * * *** *** * * * * ** * ** ENST00000377494.1 AGGATCGCCTGTCAGTTGAGTGTCGGCGCAGGGCCCAGAGTGTGAGCCTGGAGGGGTCTG ENST00000513659.1 C--ATTGTATATACTTTGTATTTCCTTTTTGG-CCTTTTTTTTTTTTTTAATGGAGTCTA ** * * * *** * ** ** ** * * * ** **** ENST00000377494.1 CACCCTCACCCTCACCCATGCAC-AGCCACCATCACCGCGCCTTCAGCTTCTCTCTGCCC ENST00000513659.1 -ACTGTCACCCAGGCTGGAGTGCTAGAGTGCAGTGGCACAATCTTGGCTCACCACAACCT ** ****** * * * ** ** * * * *** * * ** ENST00000377494.1 CGCCCTGGCAGGCG-AGGC---TCCAGGCCTCCAGCAGAGATCCGTGAGGAGGAGGTACA ENST00000513659.1 CTGCCTTCCAGATGGAAGCAATTCTCGTGCCTCAGC-----CTCCTGAGTAGCTGGGACT * *** *** * * ** ** * * **** * **** ** ** ** ENST00000377494.1 GACGGTGGAGGATGGGGTGTTTGAC--ATCCACTTGTA-----ATAGATGCTGTGGTTGG ENST00000513659.1 ACAGGTGTGCCCCACCACGCCTGGCTAATTTTTTTGTATTTTTATTAAAGATGGGGTTTC **** * ** * ** ***** ** * * ** **** ENST00000377494.1 ATCAAG--GACTCATTCCTGCCTTGGAGAAAATACTTCAACCAGAGCAGGGAGCCTGGGG ENST00000513659.1 ACCATGTTGGC-CAGGCTGGTCTTGAACTCCTGACCTCAGGT-GATCTCTCTACCTTGGC * ** * * * ** * * **** * ** *** ** * *** ** ENST00000377494.1 GTGTCGGGGCAGGAGGCTGGGGATGGGGGTGGGATATGAGGGTGGCATGCAGCTGAGGGC ENST00000513659.1 CTCCCAAAGT-----GCTGGGATTACAGGT-----ATGAG---------CCCCTGTG--- * * * ****** * *** ***** * *** * ENST00000377494.1 AGGGCCAGGGCTGGTGTCCCTAAGGTTGTACAGACTCTTGTGAATATTTGTATTTTCCAG ENST00000513659.1 ----CCCAGCCCAGTGT---GGAGCTTCTATTCACTCC--------TTTCTATGTACC-- ** * * **** ** ** ** **** *** *** * ** ENST00000377494.1 ATGGAATAAAAAGGCCCGTGTAATTAACCTTCA ENST00000513659.1 ------------------TGTGGTT---CTG-- *** ** **