CLUSTAL 2.1 multiple sequence alignment ENST00000377843.2 CCTTTCCCAGAGTGCTCTGCGCCGTGAAGAAGCGGCTCCCGGGGACTGGGGGCATTTTGT ENST00000504105.1 ---------------------------------------CAAGGGCTAAAGGC------- * ** ** *** ENST00000377843.2 GTTGGCTGGAGCTGGAGTAACAAGATGGCGTCGTCCGCGGAGTGACAGGGGTCCCTCTGG ENST00000504105.1 ------TGCAAC-AAAGAAACAAAAT---------TATAAAAAGAT-------------- ** * * ** ***** ** * ** ENST00000377843.2 GCCGGAGCCGGCGGCAGTGGTGGCAGCGGTATCGCCGCCCTAGCTCACCGCGCCCCTTTT ENST00000504105.1 -----------------TAGTGAAAACAAGAT----------GTTCACTAC-----TGTT * *** * * ** * **** * * ** ENST00000377843.2 CCAGCCCGCGACGTCGCCGCGCAAGCGAGGCAGCGGCGGCCGCCGAGAAACAAGTGGCCC ENST00000504105.1 GCAGTTT----------TATGTAAG--GGGTTTC-----CTGC--AGAATT---TATCAC *** * *** ** * * ** **** * * * ENST00000377843.2 AGCCTGGTAACCGCCGAGAAGCCCTTCACAAACTGCGGCCTGGCAAAAAGAAACCTGACT ENST00000504105.1 ATACTT-CAAC--TCAGATAGC--------AACTATAGCT-------------CCCATCT * ** *** * *** **** ** ** ** ENST00000377843.2 GAGCGGCGGTGATCAGGTTCCCCTCTGCTGATTCTGGGCCCCGAACC-CCGGTAAAGGCC ENST00000504105.1 GAA--GCAGCTA-----TTCCGCATTCTT--TTCAGGACCGTGAACCATCAATA--TGAC ** ** * * **** * * * *** ** ** ***** * ** * * ENST00000377843.2 TCCGTGTTCCGTTTCCTGCCGCCCTCCTCCGTAGCCTTGCCTAGTGTAGGAGCCCCGAGG ENST00000504105.1 TACACATTTGATT-------------------------GGACAATGTAAAAGC----AGA * * ** ** * * **** *** ** ENST00000377843.2 CCTCCGTCCTCTTCCCAGAGGTGTCGGGGCTTGGCCCCAGCCTCCATCTTCGTCTCTCAG ENST00000504105.1 ------------------AAGTAGCACAGCAAG----CAGCCTC----------TTCCAG * ** * ** * ******* * *** ENST00000377843.2 GATGGCGAGTAGCAGCGGCTCCAAGGCTGAATTCATTGTCGGAGGGAAATATAAACTGGT ENST00000504105.1 --TGGGCAGGGTCAGCAGGCCCAA----------ACTCCCACAGGCAAGCA--AACTGAT *** ** **** * **** * * * *** ** * ***** * ENST00000377843.2 ACGGAAGATCGGGTCTGGCTCCTTCGGGGACATCTATTTGGCGATCAACATCACCAACGG ENST00000504105.1 A----AAAGCAAGAGTAA---CATGAAAGGTTTCTA----------AGCATGA-----AT * * * * * * * * * **** * *** * ENST00000377843.2 CGAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAG-GCATCCCCAGTTGCTGTACG ENST00000504105.1 TGAGGAA----CAGAAGAAGCAGAG---CAGACGATCAGAGCAGCATTGGTTTCTCTCCA ****** *** * *** **** * *** *** * *** ** * * ENST00000377843.2 AGAGCAAGCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATG ENST00000504105.1 AA---------TCTAGAATTTTT--------AGTTCATAT-----GTACAC-------TA * * ** *** ** *** ** * ** * ENST00000377843.2 GTCAGGAAAAAGACTACAATGTACTAGTCATGGATCTTCTGGGACCTAGCCTCGAAGACC ENST00000504105.1 GCCAG-------------------TGGTTATGGACAGTGTTG-ATGTA------AAGAAC * *** * ** ***** * * * * ** **** * ENST00000377843.2 TCTTCAATTTCTGTTCAAGAAGGTTCACAATGAA-AACTGTACTTATGTTAGCTGACCAG ENST00000504105.1 TT---AATTTCAGTATAAACGGACTC----TGAGCAGCATTGGTGATGTTG--TATCC-- * ****** ** ** * ** *** * * * * ***** * ** ENST00000377843.2 ATGATCAGTAGA-ATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACC ENST00000504105.1 -TGAGTTGTAGCCACTGTAACTGTGACTATTAA----CTGAGAGAGTGAAACATGGTGTC *** **** * ** * **** ** ** * * * * ** **** * ENST00000377843.2 AGATAACTTCCTAATGGGTATTGGGCGTCACTGTAATAAGTTATTCCTTATTGATTTTGG ENST00000504105.1 TGGT---TTTCTACTGCATTTT---TTCAAGTGGAA-AAGTTA------ACTAAAT---G * * ** *** ** * ** * ** ** ****** * * * * * ENST00000377843.2 TTTGGCCAAAAAGTACAGAGACAACAGGACAAGGCAACACATACCATACAGAGAAGATAA ENST00000504105.1 GTTGAC--------ACACACAAATTGGGGGAATTTAAAAAAT----TAAAAAGTAGAAAA *** * *** * * * ** ** ** * ** ** * ** *** ** ENST00000377843.2 AAACCTCACTGGCACTGCCCGATATGCTAGCATCAATGCACATCTTGGTATTGAGCAGAG ENST00000504105.1 ----------GGCACT----------CTGGAATCC-TCTGCATTCTGGAAGTGAG-AGAA ****** ** * *** * *** *** * **** *** ENST00000377843.2 TCGCCGAGATGACATGGAATCATTAGGATATGTTTTGATGTATTTTAATAGAACCAGCCT ENST00000504105.1 -----GAGGTGACACTT--TCAAAAAGACAGACT---ATATAG---AAGAAAACTTCACT *** ***** *** * ** * * ** ** ** * *** ** ENST00000377843.2 GCCATGGCAAGGGCTAAAGGCTGCAACAAAGAAACAAAAATATGAAAAGATTAGTGAAAA ENST00000504105.1 GGAATGG----AGCAAAGAGGTG----AAAGACCCAAG-----GCAAAGACTAG--GAGG * **** ** ** * ** ***** *** * ***** *** * ENST00000377843.2 GAAGATGTCCACGCCTGTTGAAGTTTTATGTAAGGGGTTTCCTGCAGAATTTGCGATGTA ENST00000504105.1 GAGTCTGACCTCACTTTCTGACA------GCAGCTAGCCACTAGTAAACTCTG------- ** ** ** * * * *** * * * * * * * * ** ENST00000377843.2 CTTAAACTATTGTCGTGGGCTACGCTTTGAGGAAGCCCCAGATTACATGTATCTGAGGCA ENST00000504105.1 -----ACTCTTGCCGTT-----TTCTTTCTGGA----CCAG----------TATAGGGCA *** *** *** **** *** **** * * **** ENST00000377843.2 GCTATTCCGCATTCTTTTCAGGACCCTGAACCATCAATATGACTACACATTTGATTGGAC ENST00000504105.1 ---ATCTTGAATA--TCACAGTAGTATAAAATATTTATTCACCCTAATACTAAATTAC-T ** * ** * *** * * ** ** ** * * * * *** ENST00000377843.2 AATGTTAAAGCAGAAAGCAGCACAGCAGGCAGCCTCTTCCAGTGGGCAGGGTCAGCAGGC ENST00000504105.1 AAAGTATAGGTGAAATGCAGTGT---------CTTATTTTTGTTTGTATGT---GTGTGT ** ** * * ** **** * * ** ** * * * * * ENST00000377843.2 CCAAACCCCCACAG---GCAAGCAAACTGACAAAACCAAGAGTAACATGAAAGGTTTCTA ENST00000504105.1 CTTG-TTTTCACAATTTGCAGTCAGA---GCAAAACCATAATTAAC-TGGAATTCTACTG * **** *** ** * ******** * **** ** ** * ** ENST00000377843.2 AGCATGAATTGAG--GAACAGAA---GAAGC-AGAGCAGATGATC-GGAGCAGCAT--TT ENST00000504105.1 ATCAGAAAATAGGTTATACAGAAACTGAGGTGAGGGAAAATGCTTTGAAGAAGGAAAATG * ** ** * * ****** ** * ** * * *** * * ** ** * * ENST00000377843.2 GTTTCTCCCCAAATCTAGAAATTTTAGTTCATATGTACACTAGCCAGT-GGTTGTGGACA ENST00000504105.1 GATTGCTAAAAAATTAAGCAG----AGTTTG-AGGTACAGAAGACAACCAGTTGAAAATG * ** **** ** * **** * ***** ** ** **** * ENST00000377843.2 ACCATTTACTTGGTGTAAAGAACTTAATTTCAGTATAAACTGACTCTGGGCAGCATTGGT ENST00000504105.1 TCCAATGGGCCTCTGAAAACAGC---ACTCTAGAGT---TTGGGAGAGGTCACCATTGGC *** * ** *** * * * * ** * ** ** ** ****** ENST00000377843.2 GATGCTGTATCCTGAGTTGTAGCCTCTGTAATTGTGAATATTA--ACTGAGATAGTGAAA ENST00000504105.1 AATGATATA----GAA----AGCATCT---ACTG-AAACATTATAATTAAAGCCACGAAA *** * ** ** *** *** * ** ** **** * * * **** ENST00000377843.2 CATGGTGTCCGGTTTTCTATTGCATTTTTTCAAGTGGAAAAGTTAACTAAATGGTTGACA ENST00000504105.1 GTAGATGGC---------ATTGC-------CAA--GGAAGAATGTGTAAAAAGA------ * ** * ***** *** **** * * *** * ENST00000377843.2 CACAAAAATTGGTGGAGAAATTGTGCATATGCCAATTTTTTGTTAAAACCTTTTGTTTTG ENST00000504105.1 -ACAAAA-------GAGA----GTGTA-----------TTAGT-----CCTTTT------ ****** **** *** * ** ** ****** ENST00000377843.2 AACTATACTGCTTTGAGATCTCATTTCAGAAGAACGGCATGAACAGTCTTCAGCCACAGT ENST00000504105.1 --TCATACTGCTATGAAGAAATACCTGAGA--------CTGAGTAATTTATAGAGAAAA- ******** *** * * *** *** * * * ** * * ENST00000377843.2 TGTGATGGTTGTTAAATGCTCACAATTGTGCATTCTTAGGGTTTTTCCATCCCTGGGGTT ENST00000504105.1 --AGAGGTTTAATGGA--CTCACAGTTCCACATAGCTGGGGAGGCTTCACTATCATGGT- ** * ** * * ****** ** *** * *** * ** *** ENST00000377843.2 TGCAAGTTGTTCACTTAAAACATTCTTAAAATGGTTGGCTTCTTGTCTGCAAGCCAGCTG ENST00000504105.1 -GGAAGGTG-------AAGG-------AGAAGGAAAGGCATGT--------------CTT * *** ** ** * ** * *** * * ** ENST00000377843.2 ATATGGTAGCAACCAAAGATTCCAGTGTTTGAGCATATG-AAAGACTCTGCCTGCTTAAT ENST00000504105.1 ACATGGCAGCAGGCAAGA------------GAGGGTATGCAGGGGATCTGCCC-----AT * **** **** *** *** **** * * ****** ** ENST00000377843.2 TGTGCTAGAAATAACAGCATCTAAAGTGAAG-----ACT----TAAGAAAAACTTAGTGA ENST00000504105.1 TATA----AAACCACCAAATCTCAAGAGATTTATTCACTATCATGAGAACAGCATAGAAA * * *** ** **** *** ** *** * **** * * *** * ENST00000377843.2 CTACTAGATTATCCTTAGGACTCTGCATTAACTCT-ATAATGTTCTTGGTATTAAAAAAA ENST00000504105.1 AAACC----CACCCCTATGATTCA--ATTACCTCCCACCAAGTCCCTCCCA-------GG ** * ** ** ** ** **** *** * * ** * * * ENST00000377843.2 AAGCATATTTGTCACAGAAATTTAGTTAACATCTTACAACTGAACATGTATGTATGTTGC ENST00000504105.1 ACACATGGGGATTATGGAAGCT-------------ACAATTCAAGATGAG--------AT * *** * * *** * **** * ** *** ENST00000377843.2 TTAGATAAATGTAATCACTGTAAACATCTATATGATCTGGGATTTTGTTTTTATTTTGAA ENST00000504105.1 TTAGGTAGGGACA--CAG-GCAAAC-----CAT-ATCAGAGAGCTTGGTAC-ATTTTTAA **** ** * ** * **** ** *** * ** *** * ***** ** ENST00000377843.2 ATGGGAGCTTTTTTGTTTACAAGTTCATTAAAAACTAAAAACTGTTTCTGTAAGGAAATG ENST00000504105.1 ---GGA----------TTTCAAAC-------AGACAGAAAA---------------AAAG *** ** *** * ** **** ** * ENST00000377843.2 AGATTTTTTTTAAACAACAAAAAATGCCTTGCTGACTCACTATTAAATAAAAAT-CTCCC ENST00000504105.1 AGGTCTGATTTAAGGGACGGAAA---------TCATCCACTACTATGTAGCAGCACTACT ** * * ***** ** *** * * ***** ** ** * ** * ENST00000377843.2 CAATTTTTTGATAGACTACTTCAAGCCATTTGTTACATGGTATTCCTTTGCAAGT-CAAT ENST00000504105.1 TGGCCTCTCAGGAGCATATTTC---CCTTTCATT-CATTTTTCTCTTTTATTCTTGCTGT * * ** ** *** ** ** ** *** * ** *** * * * ENST00000377843.2 TTAGGTTTCG---TGTTATAACTTTTCCTCTTT-TTTTAAGAAAAATGAAAAAAGTAATT ENST00000504105.1 CTCAATCCCAATTTATTCTATTTTGCCCACTTCACTCTGGGAAGGGTGAGCTA------- * * * * ** ** ** ** *** * * *** *** * ENST00000377843.2 CTTTTGTCTGAAGGGGAAAGGC---ATTCTTTCATTTTTTTCTTTTTTTTTTTTTTTTTT ENST00000504105.1 CTCCCAGCTCCAGGGGTAAATCCTAATTTACCTAAGCTGATCATTGTGCTCCATTCATCT ** ** ***** ** * *** * * ** ** * * ** * * ENST00000377843.2 TATGACTTGCAGGCACA-ATATCTAGTACTGCAACTGCCAGAACTTGGTATTGTAGCTGC ENST00000504105.1 TGTCATAGATTGGCATATATATCT----CTATATATAATATATGTGTGTAT-ATATTTG- * * * **** * ****** ** * * * * * **** ** ** ENST00000377843.2 TGCCCGCTGACTAGCAGCTGGACTGATTTTGAATAAAAATGAAAGCATTAAAGGGTTTCC ENST00000504105.1 TATATGTTATATA-TAATTGCGTATATGTTTA-TACACACACACACACACACACACACAC * * * ** * ** ** ** * ** * * * ** * * ENST00000377843.2 CTACAAAACATTTTTCTTTAAAATACTTTT---GAAA--TGGCTATAAGCAGTTGACTTT ENST00000504105.1 ACACACAGTAGTTCTGGCCCATGCATTGTGAGGGAAAACCTGCTGTAGA-----GACTT- *** * * ** * * * * * **** *** ** ***** ENST00000377843.2 CACCCTTGGAGAGCATCACACTGTGTGAGGTTCAGTGATTGTTGACCCTCCCCAGCCCCT ENST00000504105.1 ----CTGGGAAAGAGTTTCGCTGC-TGAGA---AATGAA-GTTCCCCTTCTTCTAGCCTT ** *** ** * * *** **** * *** *** ** ** * ** * ENST00000377843.2 CCTGCTTCTTTAAGTTATCTGTGTGCGTGCGCTTCCTCTCAATCTTCTTTGCACGCTCAT ENST00000504105.1 TGTTCCTCTTGGAACT--------GCA---GCAGCC-----ATCCTGTATTGAAGAAAAC * * **** * * ** ** ** *** * * * * * * ENST00000377843.2 TTCTTTTTCTCTGACCCATGAGAAAGGAAAACTTACTGATGA--TAATTTTTAAATAGTG ENST00000504105.1 TA-----TCTCAGG---ATGGCAGAGTAGAAAATGGAAAGGACCTGGGTCCTCAATCACA * **** * *** * ** * ** * * ** * * * *** ENST00000377843.2 TAATTTATTCATTTATAGCATGTC---AGGATAAATTAAA--AGAACATTTGTCTGGAAA ENST00000504105.1 TCATTAAATTGTTGATGAGTTATCCTTGAGACAAAATAGTTCAGGAC-TATG---GAAGA * *** * * ** ** * ** ** *** ** ** ** * ** * * * ENST00000377843.2 TG-CTGCCGGGAGCCTATTGTGTAAATGTAGGTATTTTGTAAAATAACCTTGAAATTG- ENST00000504105.1 TAACTTCTC----CTCAGTGTTTAAAT-CAG---TCTAGTAAGG--ATTTT----CTGC * ** * * * *** ***** ** * * **** * ** **