CLUSTAL 2.1 multiple sequence alignment ENST00000407793.2 TGCGCAGCGGCGGGGGTTGTTCCGGCTGCCTTTCACTGAGGGGACCCGCCAGTTTCTAAC ENST00000457993.1 -----ATTGGAGGAAA--------GATG------AGTGAGAG----CATCAACTTCT--- * ** ** * ** * **** * * ** **** ENST00000407793.2 TCAGTGGCGTTTGCCCTGATTCCCGGGGCCTGGCTTTCAGCGTAGCAATTCTGCCGGCGA ENST00000457993.1 ---------------CTGACAACCTAGGCCAG------TGTGTGGTGAT---GCC----- **** ** **** * * ** * ** *** ENST00000407793.2 AGAAGGTGAGCGCAGTGCTGTGTGGCAGCAGAGCTCCTTAGGACGAGGAGCAGCGGGACG ENST00000457993.1 ---AGGCATGCCC----TTCCCTAGCATCAGGTCTCC---------AGAGCTGCAGAA-G *** ** * * * *** *** **** **** ** * * * ENST00000407793.2 AGGAAGGGCAGACTGGTGAAATCGCAAACTGGGCGTCTGTTCCGGCGCC---GGACCCCT ENST00000457993.1 ACGACGGCCGACTTGG----ATCACACTCTTGCAGGGCCATCAGGCACCAAAGGGATTCT * ** ** * *** *** ** ** * * ** *** ** ** ** ENST00000407793.2 ATTTGCAAAG-GTCCATGG-CTAATGAAACACAGAAGGTTGGTGCCATCCATTTTCCTTT ENST00000457993.1 GCCAGCATAGTGCTCCTGGACCAGTGATACAC------CCGGCACC------------CT *** ** * * *** * * *** **** ** ** * ENST00000407793.2 TCCCTTCACACCCTATTCCATCCAGGA----AGACTTCATGG----CAGAGCTGTACCGG ENST00000457993.1 GTCCTGGACAAGCTGTT--GGCCTGGATCTGAGCCCTCGTGGAGGTCAAAGCCACCTTTG *** *** ** ** ** *** ** * ** *** ** *** * ENST00000407793.2 GTTTTGGAGGCTGGCAAGATTGGGATATTTGAGAGTCCAACTGGCACTGGGAAGTCCTTA ENST00000457993.1 GTT-------CTGCCATTGCTGC--TGTGTGGAAGTTCACTC----CTG------CCTTT *** *** ** ** * * ** *** ** *** **** ENST00000407793.2 AGTCTTATTTGTGGGGCCCTCTCTTGGCTCCGTGACT---TTGAACAGAAGAAGCGTGAA ENST00000457993.1 --TCCTTTCCCTAGAGCCTCCACC--ACCCCGAGATCACATTTCTCA----CTGCCTTTT ** * * * * *** * * * *** ** ** ** ** * ENST00000407793.2 GAAGAGGCACGACTCCTTGAAACTGGAACTGGCCCCTTACATGATGAGAAAGATGAATCC ENST00000457993.1 GTCT--GCCCAGTTTC-----ACTAGAAGTAGGCCTCATCCTGAC-AGGCAGCTGCACCA * ** * * * *** *** * * ** * *** ** ** ** * * ENST00000407793.2 CTGTGT----CTGTCTTCTTCCTGCGAAGGGGCTGCAGGCACCCCGAGGCCTGCTGGAGA ENST00000457993.1 CTGCCTGGCGCTGTGCCCTTCCTTTG---------------CTCT---GCCCGCTGGAGA *** * **** ****** * * * *** ******** ENST00000407793.2 ACCGGCCTGGGTTACTCAGTTTGTGCAGAAGAAAGAAGAGAGGGACCTGGTGGACCGACT ENST00000457993.1 --CGGTGTTTGTCA-TGGGCCTGGTCTGCAG----------GGATCCTGCTA-------C *** * ** * * * ** * * ** ** **** * ENST00000407793.2 AAAGGCGGAGCAGGCCAGGAGGAAGCAGCGAGAAGAACGCCTGCAGCAGCTGCAGCACAG ENST00000457993.1 AAAGGTGAAAC---CCAGGAG-----AGTGTGGAG----TCCAGAGT-GTTGC----CAG ***** * * * ******* ** * * ** * ** * *** *** ENST00000407793.2 GGTGCAG-CTCAAGTATGCAGCCAAGCGCCTGAGGCAGGAAGAAGAAGAAAGAGAGAATC ENST00000457993.1 GACCCAGGCACAGGCATT------AGTGCCCGTTG----------GAGAAAACGGGAATC * *** * ** * ** ** *** * * ***** * ***** ENST00000407793.2 TCCTCCGCCTCAGCAGGGAGATGCTAGAGACAGGCC---CGGAGGCTGAGCGGCTGGAGC ENST00000457993.1 CC------------AAAGAAATGGTGGGTCCTGGCCATCCGTGAGATCTTC--CCAGGGC * * ** *** * * * **** ** * * * * * ** ENST00000407793.2 AGCTGGAGTCTGGGGAGGAGGAGCTGGTCCTCGCCGAATACGAGAGTGATGAGGAGAAAA ENST00000457993.1 AGCTCCCCTCTGTGGAACCCAATCTGTCTTCCATC------------------------- **** **** *** * *** * * ENST00000407793.2 AGGTGGCGAGCAGAGTGGATGAGGATGAGGATGACCTGGAGGAAGAACACATAACTAAGA ENST00000457993.1 ----------CTGTGTGGCCGAGGGCCAGGCTTCTC-----------------ACTAGGC * * **** **** *** * * **** * ENST00000407793.2 TTTATTACTGTAGTCGGACACACTCCCAGCTGGCCCAGTTTGTGCATGAGGTGAAGAAGA ENST00000457993.1 CT--CTGCAGGAGGCTGCCATTTGTCCTGCCCACCTTCTTAGAA-GCGAGACGGAGCAGA * * * * ** * * ** ** ** ** ** * *** * ** *** ENST00000407793.2 GCCCCTTTGGCAAGGATGTTCGGCTGGTCTCCCTTGGCTCCCGGCAGAACCTTTGTGTAA ENST00000457993.1 -CCCATCTGCTA-----------CTGCCCTTTCT-----------ATAA--------TAA *** * ** * *** ** ** * ** *** ENST00000407793.2 ATGAAGACGTGAAAAGCCTAGGTTCTGTGCAGCTTATCAACGACCGCTGTGTGGACATGC ENST00000457993.1 CTAAAGTT------AGCT---GCCCTGGACTATTCACC-----CCCTAGTCTCAATTTAA * *** *** * *** * * * * ** ** * * * ENST00000407793.2 AGAGAAGCAGGCACGAGAAGAAGAAAGGAGCTGAGGAGGAGAAGCCAAAGAGGAGGAGGC ENST00000457993.1 AAAGATCCC--CATG----------------------------GCCACAGGGCCCCTGCC * *** * ** * **** ** * * * ENST00000407793.2 AGGAGAAGCAGGCAGCCTGCCCCTTCTACAACCACGAGCAGATGGGCCTTCTCCGGGATG ENST00000457993.1 TGGGG--GCTTGTCACCTCCCCCACCTTCTTCC---------TGAGTCA-CTCC----TG ** * ** * *** **** ** * ** ** * * **** ** ENST00000407793.2 AGGCCCTGGCAGAGGTGAAGGACATGGAGCAGCTGCTGGCCCTTGGGAAGGAGGCCCGGG ENST00000457993.1 CAGCCTTGCT------------CCCTAACCTGCCCCACAGCCTTG---------CCTGGA *** ** * * * ** * ***** ** ** ENST00000407793.2 CCTGTCCCTATTACGGGAGCCGCCTTGCCA-TCCCTGCAGCCCAGCTGGTGGTGCTGCCC ENST00000457993.1 --TGTCTATCTCCCTGG---CTTGGTGCCAGTTCCTCCA----AGTCGATGGCACCTCCC **** * * * ** * ***** * *** ** ** * *** * *** ENST00000407793.2 TATCAGATGCTGCTGCATGCGGCCACTCG-GCAGGCCGCGGG-CATC--CGGCTGCAGGA ENST00000457993.1 -------TCCCTCT-----CAACCACTTGAGCAAACTCCAAGACATCTTCTACCCCAACA * * ** * ***** * *** * * * **** * * ** * ENST00000407793.2 CCAGGTGGTGATCATCGACGAGGCGCACAACCTGATCGACACCATCACGGGCATGCACAG ENST00000457993.1 CCAG----CAATTGT-GCCAAGGGCCATTAGGCTCTCAGCATGACTATTTTTAGAGACCC **** ** * * * *** ** * ** ** * * * ** ENST00000407793.2 CGTGGAGGTCAGCGGCTCCCAGCTCTGCCAG-GCCCATTCCCAGCTGCTGCAGTACGTGG ENST00000457993.1 CGTGTCTGTCACTGAAACCTT-TTTTGTGGGAGACTATTCCTCCCATCTGCAACAGCTG- **** **** * ** * ** * * * ***** * ***** * ** ENST00000407793.2 AGCGATACGGGAAGCGTTTGAAGGCCAAGAACCTGATGTACCTGAAGCAGATCCTGTATT ENST00000457993.1 --------------CCCCTG----CTAACTGCCCTTCTCTCCT--------CCCTCT-CA * ** * ** ** *** *** * ENST00000407793.2 TGCTGGAGAAATTCGTGGCTGTGCTAGGGGGGAACATTAAGCAAAATCCCAATACACAGA ENST00000457993.1 TCCCAGAGAAACAGGT--------CAGCTGGGAGC-TTCTGC----CCCCACTGCCTAGG * * ****** ** ** **** * ** ** **** * * ** ENST00000407793.2 GTCTGTCACAGACAGGGACGGAGCTGAAGACCATCA-ACGACTTTCTCTTCCAGAGCCAG ENST00000457993.1 GACCAACAGGGGCAGGAG-GCAGTCACTGACCCCGAGACGTTTGCATCCTGCACAGCTAG * * ** * **** * ** **** * *** * ** * ** *** ** ENST00000407793.2 ATCGACAACATCAACCTGTTCAAGGTGCAGCGATACTGTGAGAAGAGCATGATCAGCAGA ENST00000457993.1 AG-------GTCC-TTTATTAAAAGCACA------CTGT----------TGGTTTCTGCT * ** * ** ** * ** **** ** * ENST00000407793.2 AAGCTCTTTGGATTCACTGAACGGTACGGAGCAGTGTTCTCA-------TCCCGGGAGCA ENST00000457993.1 CAGTTCTTT------ATTGATTGGTGT---GCCGTTTTCTCTGGAAGCCTCTTAAGAGAA ** ***** * *** *** ** ** ***** ** *** * ENST00000407793.2 GCCCAAACTGGC------TGGGTTTCAGCAATTCCTGCAGAGCCTGCAGCCCAGGACGAC ENST00000457993.1 GAACACAGTGGCGCAGGCTGGGTGG-AGCCGTCCCCCCA-----TGAAGTACAGGCAGAC * ** * **** ***** *** * ** ** ** ** **** *** ENST00000407793.2 TGAAGCTCTTGCAGCCCCTGCAGACGAGAGTCAGGCCAGCACCCTGCGACCAGCTTCTCC ENST00000457993.1 AGAAGTCCCCGC---CCCAGCTGTGTGGCCTCAAGCCAGCCTTCCGC-------TCCTTG **** * ** *** ** * * *** ****** * ** * ** ENST00000407793.2 A--CTGATGCACATCCAAGGCT--TCCTGGCAGCTCTCACTACGGCCAACCAGGAC--GG ENST00000457993.1 AAGCTGGTCTCCACACAGTGCTGGTTCCGTCACCCCCTCCCAGGG--AAGCAGGTCTGAG * *** * ** ** *** * * * ** * * * * ** ** **** * * ENST00000407793.2 CAGGGTCATCCTGAGCCGCCAAGGCAGCCTCAGTCAGAGCACCCTGAAGTTTTTGCTCCT ENST00000457993.1 CAGC-TTGTCCTG-GCTGT-------GTCCATGTCAGAGCAAC--GG----------CCC *** * ***** ** * * * ********* * * ** ENST00000407793.2 GAATCCAGCTGTGCACTTTGCCCAAGTGGTGAAGGAATGCCGGGCAGTGGTCATTGCGGG ENST00000457993.1 AAGTCTGGGTCTG------------GGGGGGAAGG--TGTCATGGAGC--CCCCT----A * ** * * ** * ** ***** ** * * ** * * ENST00000407793.2 GGGTACCATGCAGCCGGTGTCTGACTTCCGGCAGCAGCTGCTGGCCTGTGCCGGGGTGGA ENST00000457993.1 GGATTCC---CAGTCA-TCCTCGTCCTCCT-CTGC--CTG-TGGC---TGCTGCGGTGGC ** * ** *** * * * * *** * ** *** **** *** * ***** ENST00000407793.2 AGCTGAGCGCGTGGTGGAGTTTTCCTGTGGTCACGTGATCCCTCCAGACAACATCCTGCC ENST00000457993.1 GGCAGAG-GAGGGATGGAGTCT-------GACACACG---------GGCAAAG----GCT ** *** * * * ****** * * *** * * *** ** ENST00000407793.2 CCTCGTCATCTGCAGCGGGATCTCCAACCAGCCGCTGGAATTCACGTTCCAGAAAAGAGA ENST00000457993.1 CCTC-----------CGGG-CCCCTCACCAGCCCCAGG---TCCTTTCCCAGAGA----- **** **** * * ******* * ** ** * ***** * ENST00000407793.2 GCTGCCTCAGATGATGGACGAGGTGGGTCGCATTCTCTGTAACCTGTGCGGTGTGGTTCC ENST00000457993.1 --TGCCTG----GAGGGAAAAGGCTGA------------------GTGAGG-GTGGTT-- ***** ** *** *** * *** ** ****** ENST00000407793.2 TGGAGGGGTGGTCTGTTTCTTCCCCTCCTACGAGTACCTGCGCCAGGTCCATGCCCACTG ENST00000457993.1 -GGTGGGAAACCCTGGTTCC-CCCAGCCCCCGGAGACTT-----AAATACAGG------A ** *** *** *** *** ** ** ** * * * ** * ENST00000407793.2 GGAGAAGGGTGGCCTGCTGGGCCGTCTGGCTGCCAGGAAGAAGATATTCCAGGAACCTAA ENST00000457993.1 AGAAAAAGGCAG-------------------GACAGAATTACAATGTGCCGG----CCCA ** ** ** * * *** * * ** * ** * * * ENST00000407793.2 GAGCGCACACCAGGTGGAGCAGGTGCTGCTGGCATATTCCAGGTGCATCCAGGCCTG--T ENST00000457993.1 GGGCGGGCAGC----------GGCCCTGCCT-CCTACCCTTG-CGCCTCATGACCAGCTT * *** ** * ** **** * ** * * ** ** * ** * * ENST00000407793.2 GGCCAGGAGA---GAGGCCAGGTG---ACAGGGGCCC-TGCTCCTCTCTGTGGTTGGAGG ENST00000457993.1 GTTGAAGAGATCCGACATCAAGTGCCCACCTTGGCTCGTGGCTCTCACTGCAACGGGAAA * * **** ** ** *** ** *** * ** *** *** *** ENST00000407793.2 ---AAAGAT--GAGTGAAGGGATCAACTTCTCTGACAACCTAGGCCGGTGTGTGGTGATG ENST00000457993.1 GTCACAGACTGGGGTGAAGAGTTCAG--TCACATGCGACC---GGTGGCTCCCTGTCCCC * *** * ****** * *** ** * * *** * ** ** ENST00000407793.2 GTGGGCATGCCCTTCCCCAACATCAGGTCTGCAGAGCTGCAGGAGAAGATGGCCTACTTG ENST00000457993.1 ACCCCCATGACACTCCCCAGC------CCTCCAAGGCCACTGTG-----TTTCCCAGTTA **** * ****** * ** ** ** * * * ** * ** ENST00000407793.2 GATCAAACCCTCAGCC----CCCGGCCAGGCACCCCCAGGGAAGGCTCTGGTGGAGAACC ENST00000457993.1 GCTCAGAGCCTCAGTCGATCCCTGACCCAGCACT--------GGGCACTGATGAGAAAGC * *** * ****** * ** * ** **** *** *** ** ** * ENST00000407793.2 TG-TGCATGAAG-GCCGTCAACCAGTC----CATAGGCAGGGCCATCAGGCAC-CAGAAG ENST00000457993.1 GGCTGTTTGAGGAGCCACCTCCCAGCCACCTCGGGGACAGGGCCA--GGGTGTGCAGCAC * ** *** * *** * **** * * * ******** ** *** * ENST00000407793.2 GATTTTGCCAGCGTAGTGCTCCTGGACCAGCGATATGCCCGGCCCCCTGTCCTGG-CCAA ENST00000457993.1 CACTGTACGA---TGGGGAAACTGGCCCAGAGAGGTG--AGGCAGCTTGCCTGGGGTCAC * * * * * * * * **** **** ** ** *** * ** * ** ** ENST00000407793.2 GCTGCCGGCCTGGATCCGAGCCCGTGTGGAGG-TCAAAGCTA-----CCTTTGGCCCCGC ENST00000457993.1 AGAGCAAGGCAAAAGCAGCGCTGG-GTACAAGCTCAAAACCATAGTGCCCAGGGCACTGC ** * * * * * ** * ** * * ***** * * ** *** * ** ENST00000407793.2 CATTGCTGCTGTGCAGAAGTTTCACCGGGAGAA-GTCGGCCTCTTCCTGATGGGCAACCA ENST00000457993.1 CGCTGCAG--GCGCAGGCATCGCATCACACCAGTGTCTGCGT--TCACAGCAGGCATCAT * *** * * **** * ** * * *** ** * ** **** * ENST00000407793.2 CACCACTGCCT-----GGCGCCGTGCCCTTCCTTTGTCCTGCCCGCTGGAGAC---AGTG ENST00000457993.1 CAGTA--GCCTCCAGAGGCCTCAGGTCCAGTCTCTAAAAATATCTCAGGAGGCTGCAGTG ** * **** *** * * ** ** * * * **** * **** ENST00000407793.2 T-------TTGTCGTGGGC--------GTGGTCTGCGGGGAT---CCTGTTACAA----- ENST00000457993.1 GCTGACCATTGCCTTGGACCGCTCTTGGCAGTCGAAGAAGATTCTCCTGTCACAGTTTGA *** * *** * * *** * *** ***** *** ENST00000407793.2 ---AGGTGAAACCCAGGAGGAGAGTGTGGAGTCCAGAGTG-CTGCCAGGACCCAGGCACA ENST00000457993.1 GCTGGGTGAGCTTAGAGAGGAAAGC------TCCACTATGGCTCCCA--AACCAGGAAGG ***** ***** ** **** ** ** *** * ***** * ENST00000407793.2 GGCGTTAGCTCCCGTAGGAGAAAATGGGGGAATCCTGAATGAACAGTGGGTCCTGGCTGT ENST00000457993.1 AGCCATAGCCCAGGCAGGAGG--GCTGAGGACCTCTGG---------------TGGCAGC ** **** * * ***** * *** *** **** * ENST00000407793.2 CCTTGGGGCGTTCCAGGGCAGCTCCCCTCCTGGAA-TAGAATCTTTCTTTCCATCCTGCA ENST00000457993.1 CC--AGGGC-TTCCA--GCATGTGCCCTAGGGGAAGCAGGGG--------CCAGCTGGCA ** **** ***** *** * **** **** ** *** * *** ENST00000407793.2 TGGCTGAGAGCCAGGCTTCC--TTCCTGGTCTCCGCAGGAGGCTGTGGCAGCTGTGGCAT ENST00000457993.1 AGAGCAGGGGTTGGGCAGAAAGCACCCGGTGGACTCAGG--GCTGGAGGGGAGGAGGCGA * * * *** ** *** * **** **** * * * *** ENST00000407793.2 CCACTGTGGCATCTCCGTCCTGCCCACCTTCTTAAGAGGCGAGATGGAGCAGGCCCATCT ENST00000457993.1 TC-TTGCC-CAAGGCCCTCC-GACCGCAGGCTCCAG-GGCCCGCTCACCTTGCTCCTGCT * ** ** ** *** * ** * ** ** *** * * * ** ** ENST00000407793.2 GCCTCTGCCCTTTCTAGCCAAGGTTATAGCTGCCCTGGACTGCTCA-------CTCTCTG ENST00000457993.1 CCTTCTGCTTCTTCTTCTCCAGCTT-TCGCTCCTTCATGCTGCGCAGCTTGGCCTTGCCG * ***** **** * ** ** * *** * **** ** ** * * ENST00000407793.2 GT---CTCAATTTAA--AATGATCCATGGCCACAGGGCTC--CTGCCCAGGGGCTTGTCA ENST00000457993.1 ATGCCCCCAGCTTGGCGGATGGACTCTAGCAGAGTGGCCCGGCCACCGGAGGGGTCGACC * * ** ** *** * * ** *** * * ** *** * * * ENST00000407793.2 CCTTCCC------CTCCTCCTTCCTGAGTCACTCCTTCAGTAGAAGGCCCTGCTCCCTAT ENST00000457993.1 ACTTCCCTGGGAGCTCCCTGGACTGGAGCCGGGAGGTGGGGAACAGGGCAAGGAGGAAAG ****** **** * *** * * * * *** * * * ENST00000407793.2 CCTGTCCCACAGCCCTGCCTGGATTTGTATCCTTGGCTTCGTGCCAGTTCCTCCAAGTCT ENST00000457993.1 GCTGCTC---AGGCAGGGCTGG----GGAAGCTTA-CTGTGTCCAAGAGCCTGCTGG--- *** * ** * * **** * * *** ** ** * ** *** * * ENST00000407793.2 ATGGCACCTCCCTCCCTCTCAACCACTTGAGCAAACTCCAAGACACCTTCTACCCCAACA ENST00000457993.1 GAGGGAAGTCACCTCCCCTCAAAC----GAG-GAGCCCCACG-------CTGGG--GAGG ** * ** * ** ***** * *** * * *** * ** * ENST00000407793.2 CCAGCAATTATGCCAAGGGCCGT-TAGGCTCTCAACA-TGACTATAGAGACCCCGTGTCA ENST00000457993.1 CCAG-ACCTTTG---AAGACTGTGTGGGGCCTGGGCACTGACTTCCGCAACCACCTG--A **** * * ** * * * ** * ** ** ** ***** * *** * ** * ENST00000407793.2 TCACGGAGACCTTTGTTCCTGTGGGAAAATA-TCCCTCCCACCTGCAACAGCTGCC--CC ENST00000457993.1 GCGCGGGCA-------TCCTGTGTGCAGATACTCCCTGCTTCCT-CTCTAGCCCCCACCC * *** * ******* * * *** ***** * *** * *** ** ** ENST00000407793.2 TGCTGA-CTG--CGCCTGTCTTCTCC---CTCTGAC---CCCAGAGAAAGGGGCTGTGGT ENST00000457993.1 TGCAGAGCTGGACCCCTGAGCTAGCCATGCTCTGACAGTCTCAGTTGCACACA-TG-AGC *** ** *** * **** * ** ******* * *** * ** * ENST00000407793.2 CAGCTG--GGATCTTCTGCCACC-------ATCAGGGACAAACGGGGG----CAGGAGGA ENST00000457993.1 CAGCAGAGGGGTTTTGTGCCACTTCTGGATGCTAGGGTTACACTGGGAGATACAGCAGTG **** * ** * ** ****** **** * ** *** *** ** ENST00000407793.2 AAGTC--ACTGA----TGCCCAGATGT---------TTGCATCCTGCACAGCTATAGGTC ENST00000457993.1 AAGCTGAAATGAAAAATGTGTTGCTGTAGTTTGTTATTAGACCCCTTCTTTCCATTGGT- *** * *** ** * *** ** * ** * ** *** ENST00000407793.2 CTTAAATAAAAGTGTG----CTG-----TTGGTT- ENST00000457993.1 -TTAATTAGGAATGAGGAACCCAGAGCCTCACTTG **** ** * ** * * * **